LeishMANIAdb
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Putative immunodominant antigen

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative immunodominant antigen
Gene product:
tc40 antigen-like
Species:
Leishmania infantum
UniProt:
A4HW35_LEIIN
TriTrypDb:
LINF_140015400
Length:
861

Annotations

Annotations by Jardim et al.

Membrane associated proteins, immunodominant antigen

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0020022 acidocalcisome 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HW35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW35

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 597 601 PF00656 0.510
CLV_NRD_NRD_1 495 497 PF00675 0.517
CLV_NRD_NRD_1 50 52 PF00675 0.403
CLV_NRD_NRD_1 621 623 PF00675 0.556
CLV_NRD_NRD_1 668 670 PF00675 0.510
CLV_NRD_NRD_1 850 852 PF00675 0.498
CLV_PCSK_KEX2_1 495 497 PF00082 0.519
CLV_PCSK_KEX2_1 50 52 PF00082 0.357
CLV_PCSK_KEX2_1 620 622 PF00082 0.552
CLV_PCSK_KEX2_1 850 852 PF00082 0.504
CLV_PCSK_SKI1_1 16 20 PF00082 0.450
CLV_PCSK_SKI1_1 290 294 PF00082 0.411
CLV_PCSK_SKI1_1 350 354 PF00082 0.503
CLV_PCSK_SKI1_1 385 389 PF00082 0.665
CLV_PCSK_SKI1_1 467 471 PF00082 0.537
CLV_PCSK_SKI1_1 616 620 PF00082 0.523
CLV_PCSK_SKI1_1 63 67 PF00082 0.408
CLV_PCSK_SKI1_1 733 737 PF00082 0.487
CLV_PCSK_SKI1_1 784 788 PF00082 0.379
CLV_PCSK_SKI1_1 822 826 PF00082 0.482
CLV_PCSK_SKI1_1 850 854 PF00082 0.438
CLV_Separin_Metazoa 617 621 PF03568 0.538
DEG_APCC_DBOX_1 690 698 PF00400 0.469
DEG_APCC_DBOX_1 849 857 PF00400 0.432
DEG_SCF_FBW7_2 379 386 PF00400 0.511
DEG_SPOP_SBC_1 260 264 PF00917 0.529
DEG_SPOP_SBC_1 396 400 PF00917 0.677
DEG_SPOP_SBC_1 446 450 PF00917 0.572
DOC_CKS1_1 628 633 PF01111 0.510
DOC_MAPK_gen_1 48 55 PF00069 0.345
DOC_PP1_RVXF_1 75 82 PF00149 0.437
DOC_PP2B_LxvP_1 575 578 PF13499 0.511
DOC_PP4_FxxP_1 141 144 PF00568 0.464
DOC_PP4_FxxP_1 403 406 PF00568 0.600
DOC_USP7_MATH_1 2 6 PF00917 0.495
DOC_USP7_MATH_1 209 213 PF00917 0.398
DOC_USP7_MATH_1 251 255 PF00917 0.612
DOC_USP7_MATH_1 259 263 PF00917 0.503
DOC_USP7_MATH_1 268 272 PF00917 0.361
DOC_USP7_MATH_1 374 378 PF00917 0.675
DOC_USP7_MATH_1 396 400 PF00917 0.739
DOC_USP7_MATH_1 404 408 PF00917 0.554
DOC_USP7_MATH_1 417 421 PF00917 0.587
DOC_USP7_MATH_1 429 433 PF00917 0.610
DOC_USP7_MATH_1 436 440 PF00917 0.694
DOC_USP7_MATH_1 446 450 PF00917 0.634
DOC_USP7_MATH_1 542 546 PF00917 0.587
DOC_USP7_MATH_1 558 562 PF00917 0.666
DOC_USP7_MATH_1 566 570 PF00917 0.460
DOC_USP7_MATH_1 578 582 PF00917 0.502
DOC_USP7_MATH_1 606 610 PF00917 0.489
DOC_USP7_MATH_1 659 663 PF00917 0.460
DOC_USP7_MATH_1 700 704 PF00917 0.567
DOC_USP7_MATH_1 87 91 PF00917 0.321
DOC_USP7_UBL2_3 124 128 PF12436 0.363
DOC_USP7_UBL2_3 16 20 PF12436 0.494
DOC_USP7_UBL2_3 821 825 PF12436 0.496
DOC_USP7_UBL2_3 854 858 PF12436 0.419
DOC_WW_Pin1_4 224 229 PF00397 0.419
DOC_WW_Pin1_4 375 380 PF00397 0.663
DOC_WW_Pin1_4 398 403 PF00397 0.622
DOC_WW_Pin1_4 438 443 PF00397 0.725
DOC_WW_Pin1_4 512 517 PF00397 0.462
DOC_WW_Pin1_4 627 632 PF00397 0.518
DOC_WW_Pin1_4 68 73 PF00397 0.448
DOC_WW_Pin1_4 718 723 PF00397 0.574
LIG_14-3-3_CanoR_1 120 124 PF00244 0.370
LIG_14-3-3_CanoR_1 197 207 PF00244 0.442
LIG_14-3-3_CanoR_1 223 228 PF00244 0.449
LIG_14-3-3_CanoR_1 290 295 PF00244 0.419
LIG_14-3-3_CanoR_1 339 344 PF00244 0.481
LIG_14-3-3_CanoR_1 350 355 PF00244 0.465
LIG_14-3-3_CanoR_1 397 402 PF00244 0.579
LIG_14-3-3_CanoR_1 416 426 PF00244 0.583
LIG_14-3-3_CanoR_1 562 570 PF00244 0.567
LIG_14-3-3_CanoR_1 656 662 PF00244 0.516
LIG_14-3-3_CanoR_1 739 747 PF00244 0.409
LIG_14-3-3_CanoR_1 762 768 PF00244 0.482
LIG_Actin_WH2_2 480 497 PF00022 0.594
LIG_Actin_WH2_2 683 700 PF00022 0.465
LIG_APCC_ABBA_1 23 28 PF00400 0.423
LIG_APCC_ABBA_1 307 312 PF00400 0.337
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_BRCT_BRCA1_1 347 351 PF00533 0.512
LIG_BRCT_BRCA1_1 38 42 PF00533 0.377
LIG_BRCT_BRCA1_1 563 567 PF00533 0.523
LIG_BRCT_BRCA1_1 805 809 PF00533 0.400
LIG_BRCT_BRCA1_1 90 94 PF00533 0.466
LIG_eIF4E_1 570 576 PF01652 0.524
LIG_FHA_1 156 162 PF00498 0.377
LIG_FHA_1 171 177 PF00498 0.314
LIG_FHA_1 351 357 PF00498 0.420
LIG_FHA_1 586 592 PF00498 0.462
LIG_FHA_1 674 680 PF00498 0.414
LIG_FHA_2 328 334 PF00498 0.374
LIG_FHA_2 595 601 PF00498 0.560
LIG_FHA_2 631 637 PF00498 0.453
LIG_FHA_2 724 730 PF00498 0.462
LIG_FHA_2 795 801 PF00498 0.442
LIG_GBD_Chelix_1 804 812 PF00786 0.384
LIG_Integrin_RGD_1 322 324 PF01839 0.426
LIG_LIR_Apic_2 400 406 PF02991 0.609
LIG_LIR_Gen_1 137 145 PF02991 0.376
LIG_LIR_Gen_1 204 214 PF02991 0.391
LIG_LIR_Gen_1 348 359 PF02991 0.409
LIG_LIR_Gen_1 745 753 PF02991 0.451
LIG_LIR_Gen_1 75 86 PF02991 0.410
LIG_LIR_Gen_1 779 789 PF02991 0.378
LIG_LIR_Gen_1 806 816 PF02991 0.415
LIG_LIR_Gen_1 92 101 PF02991 0.198
LIG_LIR_Nem_3 137 141 PF02991 0.384
LIG_LIR_Nem_3 204 210 PF02991 0.347
LIG_LIR_Nem_3 293 297 PF02991 0.386
LIG_LIR_Nem_3 348 354 PF02991 0.483
LIG_LIR_Nem_3 39 45 PF02991 0.320
LIG_LIR_Nem_3 564 570 PF02991 0.469
LIG_LIR_Nem_3 75 81 PF02991 0.335
LIG_LIR_Nem_3 779 785 PF02991 0.384
LIG_LIR_Nem_3 806 812 PF02991 0.399
LIG_LIR_Nem_3 92 98 PF02991 0.222
LIG_LYPXL_SIV_4 462 470 PF13949 0.577
LIG_NRBOX 571 577 PF00104 0.519
LIG_Pex14_1 641 645 PF04695 0.469
LIG_Pex14_1 97 101 PF04695 0.368
LIG_Pex14_2 203 207 PF04695 0.463
LIG_SH2_NCK_1 422 426 PF00017 0.567
LIG_SH2_PTP2 95 98 PF00017 0.344
LIG_SH2_STAP1 171 175 PF00017 0.452
LIG_SH2_STAT5 126 129 PF00017 0.286
LIG_SH2_STAT5 45 48 PF00017 0.345
LIG_SH2_STAT5 645 648 PF00017 0.505
LIG_SH2_STAT5 734 737 PF00017 0.447
LIG_SH2_STAT5 746 749 PF00017 0.350
LIG_SH2_STAT5 95 98 PF00017 0.344
LIG_SH3_3 280 286 PF00018 0.487
LIG_SH3_3 411 417 PF00018 0.651
LIG_SH3_3 548 554 PF00018 0.661
LIG_SH3_4 124 131 PF00018 0.421
LIG_SUMO_SIM_anti_2 150 155 PF11976 0.262
LIG_SUMO_SIM_par_1 261 271 PF11976 0.472
LIG_SUMO_SIM_par_1 352 357 PF11976 0.411
LIG_SUMO_SIM_par_1 510 515 PF11976 0.536
LIG_SxIP_EBH_1 406 416 PF03271 0.652
LIG_TRAF2_1 626 629 PF00917 0.472
LIG_TRAF2_1 663 666 PF00917 0.506
LIG_TRAF2_1 683 686 PF00917 0.455
LIG_UBA3_1 151 157 PF00899 0.416
LIG_UBA3_1 852 858 PF00899 0.306
LIG_WRC_WIRS_1 135 140 PF05994 0.399
LIG_WRC_WIRS_1 291 296 PF05994 0.408
LIG_WRC_WIRS_1 804 809 PF05994 0.398
MOD_CDK_SPK_2 627 632 PF00069 0.518
MOD_CDK_SPxK_1 379 385 PF00069 0.509
MOD_CDK_SPxxK_3 438 445 PF00069 0.530
MOD_CK1_1 169 175 PF00069 0.483
MOD_CK1_1 181 187 PF00069 0.388
MOD_CK1_1 195 201 PF00069 0.297
MOD_CK1_1 212 218 PF00069 0.380
MOD_CK1_1 270 276 PF00069 0.482
MOD_CK1_1 372 378 PF00069 0.633
MOD_CK1_1 398 404 PF00069 0.706
MOD_CK1_1 407 413 PF00069 0.511
MOD_CK1_1 418 424 PF00069 0.645
MOD_CK1_1 430 436 PF00069 0.685
MOD_CK1_1 449 455 PF00069 0.623
MOD_CK1_1 5 11 PF00069 0.567
MOD_CK1_1 561 567 PF00069 0.553
MOD_CK1_1 723 729 PF00069 0.503
MOD_CK1_1 88 94 PF00069 0.358
MOD_CK2_1 171 177 PF00069 0.511
MOD_CK2_1 228 234 PF00069 0.376
MOD_CK2_1 630 636 PF00069 0.532
MOD_CK2_1 659 665 PF00069 0.455
MOD_CK2_1 723 729 PF00069 0.470
MOD_CK2_1 770 776 PF00069 0.475
MOD_CK2_1 794 800 PF00069 0.422
MOD_GlcNHglycan 180 183 PF01048 0.568
MOD_GlcNHglycan 203 206 PF01048 0.380
MOD_GlcNHglycan 230 233 PF01048 0.446
MOD_GlcNHglycan 253 256 PF01048 0.634
MOD_GlcNHglycan 263 266 PF01048 0.474
MOD_GlcNHglycan 371 374 PF01048 0.608
MOD_GlcNHglycan 417 420 PF01048 0.551
MOD_GlcNHglycan 427 430 PF01048 0.644
MOD_GlcNHglycan 433 436 PF01048 0.711
MOD_GlcNHglycan 438 441 PF01048 0.693
MOD_GlcNHglycan 467 470 PF01048 0.591
MOD_GlcNHglycan 484 487 PF01048 0.505
MOD_GlcNHglycan 542 545 PF01048 0.627
MOD_GlcNHglycan 661 664 PF01048 0.536
MOD_GlcNHglycan 680 683 PF01048 0.412
MOD_GlcNHglycan 702 705 PF01048 0.571
MOD_GlcNHglycan 87 90 PF01048 0.320
MOD_GSK3_1 14 21 PF00069 0.403
MOD_GSK3_1 162 169 PF00069 0.346
MOD_GSK3_1 191 198 PF00069 0.483
MOD_GSK3_1 2 9 PF00069 0.489
MOD_GSK3_1 208 215 PF00069 0.279
MOD_GSK3_1 218 225 PF00069 0.379
MOD_GSK3_1 239 246 PF00069 0.414
MOD_GSK3_1 296 303 PF00069 0.313
MOD_GSK3_1 346 353 PF00069 0.471
MOD_GSK3_1 368 375 PF00069 0.545
MOD_GSK3_1 404 411 PF00069 0.650
MOD_GSK3_1 425 432 PF00069 0.683
MOD_GSK3_1 445 452 PF00069 0.691
MOD_GSK3_1 471 478 PF00069 0.583
MOD_GSK3_1 538 545 PF00069 0.510
MOD_GSK3_1 578 585 PF00069 0.525
MOD_GSK3_1 723 730 PF00069 0.454
MOD_GSK3_1 738 745 PF00069 0.416
MOD_GSK3_1 770 777 PF00069 0.507
MOD_GSK3_1 85 92 PF00069 0.353
MOD_N-GLC_1 223 228 PF02516 0.456
MOD_N-GLC_1 369 374 PF02516 0.508
MOD_N-GLC_1 471 476 PF02516 0.546
MOD_N-GLC_1 5 10 PF02516 0.446
MOD_N-GLC_1 607 612 PF02516 0.433
MOD_N-GLC_1 657 662 PF02516 0.458
MOD_NEK2_1 162 167 PF00069 0.317
MOD_NEK2_1 199 204 PF00069 0.427
MOD_NEK2_1 218 223 PF00069 0.457
MOD_NEK2_1 243 248 PF00069 0.433
MOD_NEK2_1 267 272 PF00069 0.441
MOD_NEK2_1 300 305 PF00069 0.486
MOD_NEK2_1 327 332 PF00069 0.415
MOD_NEK2_1 482 487 PF00069 0.596
MOD_NEK2_1 538 543 PF00069 0.490
MOD_NEK2_1 607 612 PF00069 0.561
MOD_NEK2_1 650 655 PF00069 0.504
MOD_NEK2_1 657 662 PF00069 0.515
MOD_NEK2_1 856 861 PF00069 0.552
MOD_NEK2_2 119 124 PF00069 0.457
MOD_PIKK_1 673 679 PF00454 0.469
MOD_PIKK_1 738 744 PF00454 0.504
MOD_PIKK_1 784 790 PF00454 0.506
MOD_PK_1 339 345 PF00069 0.465
MOD_PKA_2 119 125 PF00069 0.376
MOD_PKA_2 222 228 PF00069 0.505
MOD_PKA_2 338 344 PF00069 0.454
MOD_PKA_2 396 402 PF00069 0.495
MOD_PKA_2 415 421 PF00069 0.482
MOD_PKA_2 561 567 PF00069 0.578
MOD_PKA_2 591 597 PF00069 0.569
MOD_PKA_2 738 744 PF00069 0.416
MOD_PKA_2 761 767 PF00069 0.486
MOD_Plk_1 192 198 PF00069 0.515
MOD_Plk_1 327 333 PF00069 0.483
MOD_Plk_1 346 352 PF00069 0.425
MOD_Plk_1 471 477 PF00069 0.528
MOD_Plk_1 607 613 PF00069 0.434
MOD_Plk_1 657 663 PF00069 0.514
MOD_Plk_1 778 784 PF00069 0.481
MOD_Plk_2-3 761 767 PF00069 0.541
MOD_Plk_2-3 810 816 PF00069 0.385
MOD_Plk_4 14 20 PF00069 0.530
MOD_Plk_4 171 177 PF00069 0.485
MOD_Plk_4 239 245 PF00069 0.450
MOD_Plk_4 296 302 PF00069 0.381
MOD_Plk_4 327 333 PF00069 0.423
MOD_Plk_4 350 356 PF00069 0.376
MOD_Plk_4 404 410 PF00069 0.645
MOD_Plk_4 723 729 PF00069 0.409
MOD_Plk_4 742 748 PF00069 0.413
MOD_Plk_4 778 784 PF00069 0.493
MOD_Plk_4 803 809 PF00069 0.509
MOD_ProDKin_1 224 230 PF00069 0.411
MOD_ProDKin_1 375 381 PF00069 0.663
MOD_ProDKin_1 398 404 PF00069 0.621
MOD_ProDKin_1 438 444 PF00069 0.724
MOD_ProDKin_1 512 518 PF00069 0.462
MOD_ProDKin_1 627 633 PF00069 0.512
MOD_ProDKin_1 68 74 PF00069 0.445
MOD_ProDKin_1 718 724 PF00069 0.564
MOD_SUMO_for_1 26 29 PF00179 0.496
MOD_SUMO_rev_2 172 181 PF00179 0.430
MOD_SUMO_rev_2 312 317 PF00179 0.314
TRG_DiLeu_BaEn_1 163 168 PF01217 0.386
TRG_DiLeu_BaEn_2 37 43 PF01217 0.425
TRG_DiLeu_BaEn_4 666 672 PF01217 0.414
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.421
TRG_ENDOCYTIC_2 126 129 PF00928 0.286
TRG_ENDOCYTIC_2 746 749 PF00928 0.403
TRG_ENDOCYTIC_2 95 98 PF00928 0.344
TRG_ER_diArg_1 494 496 PF00400 0.505
TRG_ER_diArg_1 619 622 PF00400 0.552
TRG_ER_diArg_1 849 851 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 185 189 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 34 38 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 621 625 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 632 636 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 648 652 PF00026 0.256
TRG_Pf-PMV_PEXEL_1 851 855 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P333 Leptomonas seymouri 70% 99%
A0A0S4JBI5 Bodo saltans 28% 100%
A0A3R7NEG9 Trypanosoma rangeli 32% 95%
A0A3S5H6S3 Leishmania donovani 100% 100%
A4H7P6 Leishmania braziliensis 85% 98%
C9ZSY9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 95%
E9APT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QFP2 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS