Protein phosphatase 2C-like protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania infantum

UniProt:

A4HW33_LEIIN

TriTrypDb:

LINF_140015000

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HW33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW33

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.761
CLV_C14_Caspase3-7	491	495	PF00656	0.669
CLV_NRD_NRD_1	192	194	PF00675	0.630
CLV_NRD_NRD_1	2	4	PF00675	0.552
CLV_NRD_NRD_1	214	216	PF00675	0.699
CLV_NRD_NRD_1	408	410	PF00675	0.720
CLV_NRD_NRD_1	5	7	PF00675	0.538
CLV_NRD_NRD_1	596	598	PF00675	0.400
CLV_NRD_NRD_1	659	661	PF00675	0.348
CLV_NRD_NRD_1	724	726	PF00675	0.280
CLV_NRD_NRD_1	795	797	PF00675	0.418
CLV_NRD_NRD_1	944	946	PF00675	0.617
CLV_NRD_NRD_1	98	100	PF00675	0.689
CLV_PCSK_FUR_1	657	661	PF00082	0.259
CLV_PCSK_FUR_1	96	100	PF00082	0.557
CLV_PCSK_KEX2_1	110	112	PF00082	0.506
CLV_PCSK_KEX2_1	192	194	PF00082	0.593
CLV_PCSK_KEX2_1	214	216	PF00082	0.721
CLV_PCSK_KEX2_1	408	410	PF00082	0.720
CLV_PCSK_KEX2_1	596	598	PF00082	0.400
CLV_PCSK_KEX2_1	657	659	PF00082	0.280
CLV_PCSK_KEX2_1	724	726	PF00082	0.280
CLV_PCSK_KEX2_1	795	797	PF00082	0.418
CLV_PCSK_KEX2_1	98	100	PF00082	0.689
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.554
CLV_PCSK_SKI1_1	243	247	PF00082	0.672
CLV_PCSK_SKI1_1	307	311	PF00082	0.607
CLV_PCSK_SKI1_1	426	430	PF00082	0.523
CLV_PCSK_SKI1_1	544	548	PF00082	0.533
CLV_PCSK_SKI1_1	633	637	PF00082	0.280
CLV_PCSK_SKI1_1	699	703	PF00082	0.280
CLV_PCSK_SKI1_1	725	729	PF00082	0.280
CLV_PCSK_SKI1_1	844	848	PF00082	0.280
CLV_PCSK_SKI1_1	957	961	PF00082	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SPOP_SBC_1	314	318	PF00917	0.699
DOC_MAPK_DCC_7	501	509	PF00069	0.653
DOC_MAPK_gen_1	724	735	PF00069	0.280
DOC_MAPK_MEF2A_6	501	509	PF00069	0.653
DOC_MAPK_MEF2A_6	544	552	PF00069	0.521
DOC_PP2B_LxvP_1	310	313	PF13499	0.604
DOC_PP4_FxxP_1	64	67	PF00568	0.602
DOC_USP7_MATH_1	121	125	PF00917	0.582
DOC_USP7_MATH_1	169	173	PF00917	0.574
DOC_USP7_MATH_1	21	25	PF00917	0.536
DOC_USP7_MATH_1	230	234	PF00917	0.669
DOC_USP7_MATH_1	269	273	PF00917	0.637
DOC_USP7_MATH_1	283	287	PF00917	0.472
DOC_USP7_MATH_1	314	318	PF00917	0.702
DOC_USP7_MATH_1	368	372	PF00917	0.649
DOC_USP7_MATH_1	490	494	PF00917	0.640
DOC_USP7_MATH_1	510	514	PF00917	0.455
DOC_USP7_MATH_1	68	72	PF00917	0.585
DOC_USP7_MATH_1	789	793	PF00917	0.379
DOC_USP7_MATH_1	944	948	PF00917	0.533
DOC_USP7_UBL2_3	125	129	PF12436	0.504
DOC_WW_Pin1_4	135	140	PF00397	0.578
DOC_WW_Pin1_4	263	268	PF00397	0.686
DOC_WW_Pin1_4	322	327	PF00397	0.596
DOC_WW_Pin1_4	355	360	PF00397	0.600
DOC_WW_Pin1_4	36	41	PF00397	0.609
DOC_WW_Pin1_4	364	369	PF00397	0.602
DOC_WW_Pin1_4	447	452	PF00397	0.650
DOC_WW_Pin1_4	63	68	PF00397	0.723
DOC_WW_Pin1_4	755	760	PF00397	0.327
DOC_WW_Pin1_4	787	792	PF00397	0.361
DOC_WW_Pin1_4	847	852	PF00397	0.280
DOC_WW_Pin1_4	864	869	PF00397	0.280
LIG_14-3-3_CanoR_1	161	167	PF00244	0.575
LIG_14-3-3_CanoR_1	206	210	PF00244	0.582
LIG_14-3-3_CanoR_1	214	222	PF00244	0.546
LIG_14-3-3_CanoR_1	23	30	PF00244	0.481
LIG_14-3-3_CanoR_1	231	236	PF00244	0.571
LIG_14-3-3_CanoR_1	77	85	PF00244	0.471
LIG_14-3-3_CanoR_1	945	949	PF00244	0.597
LIG_Actin_WH2_2	238	255	PF00022	0.672
LIG_Actin_WH2_2	7	25	PF00022	0.466
LIG_BIR_III_4	762	766	PF00653	0.248
LIG_BRCT_BRCA1_1	769	773	PF00533	0.400
LIG_FHA_1	136	142	PF00498	0.628
LIG_FHA_1	206	212	PF00498	0.642
LIG_FHA_1	24	30	PF00498	0.526
LIG_FHA_1	359	365	PF00498	0.644
LIG_FHA_1	400	406	PF00498	0.714
LIG_FHA_1	478	484	PF00498	0.556
LIG_FHA_1	543	549	PF00498	0.483
LIG_FHA_1	838	844	PF00498	0.280
LIG_FHA_1	848	854	PF00498	0.280
LIG_FHA_2	236	242	PF00498	0.673
LIG_FHA_2	563	569	PF00498	0.280
LIG_FHA_2	629	635	PF00498	0.280
LIG_Integrin_isoDGR_2	399	401	PF01839	0.653
LIG_Integrin_isoDGR_2	963	965	PF01839	0.533
LIG_LIR_Apic_2	63	67	PF02991	0.538
LIG_LIR_Gen_1	187	196	PF02991	0.524
LIG_LIR_Gen_1	568	579	PF02991	0.280
LIG_LIR_Gen_1	634	641	PF02991	0.270
LIG_LIR_Gen_1	820	830	PF02991	0.280
LIG_LIR_Nem_3	187	191	PF02991	0.521
LIG_LIR_Nem_3	568	574	PF02991	0.280
LIG_LIR_Nem_3	634	639	PF02991	0.280
LIG_LIR_Nem_3	820	825	PF02991	0.280
LIG_LIR_Nem_3	828	834	PF02991	0.280
LIG_LIR_Nem_3	845	849	PF02991	0.280
LIG_MYND_1	139	143	PF01753	0.683
LIG_MYND_1	247	251	PF01753	0.562
LIG_Pex14_1	605	609	PF04695	0.280
LIG_Pex14_2	751	755	PF04695	0.280
LIG_Pex14_2	842	846	PF04695	0.280
LIG_PTAP_UEV_1	383	388	PF05743	0.610
LIG_SH2_CRK	188	192	PF00017	0.526
LIG_SH2_GRB2like	155	158	PF00017	0.578
LIG_SH2_SRC	57	60	PF00017	0.507
LIG_SH2_STAP1	207	211	PF00017	0.576
LIG_SH2_STAP1	52	56	PF00017	0.493
LIG_SH2_STAT5	155	158	PF00017	0.617
LIG_SH2_STAT5	188	191	PF00017	0.705
LIG_SH2_STAT5	207	210	PF00017	0.592
LIG_SH2_STAT5	609	612	PF00017	0.280
LIG_SH2_STAT5	691	694	PF00017	0.280
LIG_SH2_STAT5	849	852	PF00017	0.280
LIG_SH3_3	137	143	PF00018	0.617
LIG_SH3_3	161	167	PF00018	0.575
LIG_SH3_3	381	387	PF00018	0.613
LIG_SH3_3	432	438	PF00018	0.514
LIG_SH3_3	499	505	PF00018	0.710
LIG_SH3_3	53	59	PF00018	0.510
LIG_SH3_3	850	856	PF00018	0.280
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.400
LIG_SUMO_SIM_anti_2	893	899	PF11976	0.298
LIG_SUMO_SIM_par_1	207	212	PF11976	0.460
LIG_SUMO_SIM_par_1	585	591	PF11976	0.400
LIG_SUMO_SIM_par_1	740	745	PF11976	0.280
LIG_SxIP_EBH_1	313	327	PF03271	0.707
LIG_TRAF2_1	764	767	PF00917	0.339
LIG_TRAF2_1	835	838	PF00917	0.280
LIG_UBA3_1	635	642	PF00899	0.280
LIG_WW_3	267	271	PF00397	0.673
MOD_CDK_SPK_2	322	327	PF00069	0.707
MOD_CDK_SPxxK_3	263	270	PF00069	0.708
MOD_CDK_SPxxK_3	355	362	PF00069	0.550
MOD_CK1_1	132	138	PF00069	0.741
MOD_CK1_1	286	292	PF00069	0.547
MOD_CK1_1	322	328	PF00069	0.605
MOD_CK1_1	358	364	PF00069	0.610
MOD_CK1_1	367	373	PF00069	0.595
MOD_CK1_1	485	491	PF00069	0.678
MOD_CK1_1	542	548	PF00069	0.560
MOD_CK1_1	60	66	PF00069	0.556
MOD_CK1_1	783	789	PF00069	0.248
MOD_CK1_1	864	870	PF00069	0.370
MOD_CK1_1	939	945	PF00069	0.543
MOD_CK1_1	947	953	PF00069	0.612
MOD_CK2_1	382	388	PF00069	0.591
MOD_CK2_1	485	491	PF00069	0.696
MOD_CK2_1	628	634	PF00069	0.280
MOD_CK2_1	832	838	PF00069	0.280
MOD_CK2_1	947	953	PF00069	0.495
MOD_Cter_Amidation	212	215	PF01082	0.621
MOD_Cter_Amidation	4	7	PF01082	0.604
MOD_Cter_Amidation	594	597	PF01082	0.400
MOD_Cter_Amidation	655	658	PF01082	0.280
MOD_GlcNHglycan	210	214	PF01048	0.591
MOD_GlcNHglycan	218	221	PF01048	0.583
MOD_GlcNHglycan	222	225	PF01048	0.581
MOD_GlcNHglycan	271	274	PF01048	0.661
MOD_GlcNHglycan	310	313	PF01048	0.612
MOD_GlcNHglycan	370	373	PF01048	0.613
MOD_GlcNHglycan	384	387	PF01048	0.493
MOD_GlcNHglycan	441	445	PF01048	0.592
MOD_GlcNHglycan	487	490	PF01048	0.714
MOD_GlcNHglycan	520	524	PF01048	0.662
MOD_GlcNHglycan	541	544	PF01048	0.597
MOD_GlcNHglycan	555	558	PF01048	0.280
MOD_GlcNHglycan	654	657	PF01048	0.281
MOD_GlcNHglycan	671	674	PF01048	0.219
MOD_GlcNHglycan	70	73	PF01048	0.642
MOD_GlcNHglycan	782	786	PF01048	0.286
MOD_GlcNHglycan	818	822	PF01048	0.280
MOD_GlcNHglycan	859	862	PF01048	0.280
MOD_GlcNHglycan	90	93	PF01048	0.438
MOD_GlcNHglycan	912	915	PF01048	0.514
MOD_GlcNHglycan	918	921	PF01048	0.560
MOD_GlcNHglycan	938	941	PF01048	0.728
MOD_GSK3_1	106	113	PF00069	0.480
MOD_GSK3_1	115	122	PF00069	0.610
MOD_GSK3_1	205	212	PF00069	0.560
MOD_GSK3_1	216	223	PF00069	0.601
MOD_GSK3_1	231	238	PF00069	0.503
MOD_GSK3_1	315	322	PF00069	0.688
MOD_GSK3_1	341	348	PF00069	0.773
MOD_GSK3_1	364	371	PF00069	0.651
MOD_GSK3_1	382	389	PF00069	0.466
MOD_GSK3_1	490	497	PF00069	0.657
MOD_GSK3_1	538	545	PF00069	0.592
MOD_GSK3_1	624	631	PF00069	0.280
MOD_GSK3_1	671	678	PF00069	0.400
MOD_GSK3_1	705	712	PF00069	0.280
MOD_GSK3_1	783	790	PF00069	0.348
MOD_GSK3_1	857	864	PF00069	0.400
MOD_GSK3_1	88	95	PF00069	0.519
MOD_GSK3_1	924	931	PF00069	0.686
MOD_GSK3_1	932	939	PF00069	0.595
MOD_N-GLC_1	106	111	PF02516	0.534
MOD_N-GLC_1	292	297	PF02516	0.711
MOD_N-GLC_1	574	579	PF02516	0.259
MOD_N-GLC_1	60	65	PF02516	0.567
MOD_N-GLC_1	652	657	PF02516	0.339
MOD_N-GLC_1	68	73	PF02516	0.528
MOD_N-GLC_1	780	785	PF02516	0.253
MOD_N-GLC_1	893	898	PF02516	0.298
MOD_N-GLC_2	876	878	PF02516	0.280
MOD_NEK2_1	106	111	PF00069	0.554
MOD_NEK2_1	209	214	PF00069	0.477
MOD_NEK2_1	22	27	PF00069	0.475
MOD_NEK2_1	431	436	PF00069	0.559
MOD_NEK2_1	476	481	PF00069	0.574
MOD_NEK2_1	482	487	PF00069	0.587
MOD_NEK2_1	574	579	PF00069	0.259
MOD_NEK2_1	624	629	PF00069	0.280
MOD_NEK2_1	742	747	PF00069	0.280
MOD_NEK2_1	803	808	PF00069	0.280
MOD_NEK2_1	936	941	PF00069	0.726
MOD_NEK2_1	952	957	PF00069	0.409
MOD_NEK2_2	283	288	PF00069	0.620
MOD_NEK2_2	292	297	PF00069	0.551
MOD_NEK2_2	52	57	PF00069	0.495
MOD_PIKK_1	477	483	PF00454	0.635
MOD_PIKK_1	928	934	PF00454	0.621
MOD_PK_1	99	105	PF00069	0.619
MOD_PKA_1	110	116	PF00069	0.506
MOD_PKA_1	214	220	PF00069	0.684
MOD_PKA_2	110	116	PF00069	0.533
MOD_PKA_2	205	211	PF00069	0.606
MOD_PKA_2	214	220	PF00069	0.616
MOD_PKA_2	22	28	PF00069	0.476
MOD_PKA_2	230	236	PF00069	0.613
MOD_PKA_2	269	275	PF00069	0.716
MOD_PKA_2	341	347	PF00069	0.714
MOD_PKA_2	5	11	PF00069	0.463
MOD_PKA_2	562	568	PF00069	0.260
MOD_PKA_2	76	82	PF00069	0.589
MOD_PKA_2	888	894	PF00069	0.280
MOD_PKA_2	910	916	PF00069	0.506
MOD_PKA_2	944	950	PF00069	0.590
MOD_PKB_1	229	237	PF00069	0.571
MOD_PKB_1	517	525	PF00069	0.623
MOD_Plk_1	157	163	PF00069	0.608
MOD_Plk_1	186	192	PF00069	0.525
MOD_Plk_1	52	58	PF00069	0.537
MOD_Plk_1	574	580	PF00069	0.259
MOD_Plk_1	60	66	PF00069	0.504
MOD_Plk_1	817	823	PF00069	0.280
MOD_Plk_1	893	899	PF00069	0.298
MOD_Plk_2-3	888	894	PF00069	0.280
MOD_Plk_4	151	157	PF00069	0.630
MOD_Plk_4	292	298	PF00069	0.709
MOD_Plk_4	315	321	PF00069	0.707
MOD_Plk_4	52	58	PF00069	0.533
MOD_Plk_4	582	588	PF00069	0.280
MOD_Plk_4	60	66	PF00069	0.493
MOD_Plk_4	624	630	PF00069	0.280
MOD_Plk_4	676	682	PF00069	0.280
MOD_Plk_4	893	899	PF00069	0.298
MOD_Plk_4	947	953	PF00069	0.576
MOD_ProDKin_1	135	141	PF00069	0.579
MOD_ProDKin_1	263	269	PF00069	0.685
MOD_ProDKin_1	322	328	PF00069	0.593
MOD_ProDKin_1	355	361	PF00069	0.598
MOD_ProDKin_1	36	42	PF00069	0.605
MOD_ProDKin_1	364	370	PF00069	0.600
MOD_ProDKin_1	447	453	PF00069	0.651
MOD_ProDKin_1	63	69	PF00069	0.726
MOD_ProDKin_1	755	761	PF00069	0.327
MOD_ProDKin_1	787	793	PF00069	0.361
MOD_ProDKin_1	847	853	PF00069	0.280
MOD_ProDKin_1	864	870	PF00069	0.280
MOD_SUMO_rev_2	240	245	PF00179	0.665
MOD_SUMO_rev_2	712	717	PF00179	0.280
MOD_SUMO_rev_2	750	755	PF00179	0.280
MOD_SUMO_rev_2	760	770	PF00179	0.280
TRG_DiLeu_BaEn_3	837	843	PF01217	0.280
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.548
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.714
TRG_ENDOCYTIC_2	188	191	PF00928	0.522
TRG_ER_diArg_1	191	193	PF00400	0.551
TRG_ER_diArg_1	247	250	PF00400	0.562
TRG_ER_diArg_1	516	519	PF00400	0.562
TRG_ER_diArg_1	596	598	PF00400	0.400
TRG_ER_diArg_1	657	660	PF00400	0.280
TRG_ER_diArg_1	724	726	PF00400	0.280
TRG_ER_diArg_1	795	797	PF00400	0.418
TRG_ER_diArg_1	96	99	PF00400	0.615
TRG_NLS_Bipartite_1	945	961	PF00514	0.390
TRG_NLS_MonoExtC_3	2	7	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L7	Leptomonas seymouri	49%	92%
A0A3Q8ID61	Leishmania donovani	100%	100%
A4H7P3	Leishmania braziliensis	70%	97%
E9APT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFP5	Leishmania major	92%	100%