Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HW27_LEIIN

TriTrypDb:

LINF_140014100

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW27

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.229
CLV_NRD_NRD_1	168	170	PF00675	0.398
CLV_NRD_NRD_1	335	337	PF00675	0.704
CLV_NRD_NRD_1	44	46	PF00675	0.450
CLV_NRD_NRD_1	538	540	PF00675	0.462
CLV_PCSK_KEX2_1	335	337	PF00082	0.691
CLV_PCSK_KEX2_1	413	415	PF00082	0.426
CLV_PCSK_KEX2_1	540	542	PF00082	0.351
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.369
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.426
CLV_PCSK_SKI1_1	131	135	PF00082	0.369
CLV_PCSK_SKI1_1	153	157	PF00082	0.382
CLV_PCSK_SKI1_1	177	181	PF00082	0.251
CLV_PCSK_SKI1_1	32	36	PF00082	0.545
CLV_PCSK_SKI1_1	557	561	PF00082	0.458
DEG_SCF_FBW7_1	451	458	PF00400	0.406
DEG_SPOP_SBC_1	287	291	PF00917	0.475
DOC_ANK_TNKS_1	473	480	PF00023	0.163
DOC_CYCLIN_RxL_1	174	183	PF00134	0.369
DOC_CYCLIN_RxL_1	29	37	PF00134	0.367
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.419
DOC_MAPK_gen_1	348	357	PF00069	0.268
DOC_MAPK_HePTP_8	345	357	PF00069	0.222
DOC_MAPK_HePTP_8	84	96	PF00069	0.229
DOC_MAPK_MEF2A_6	137	144	PF00069	0.229
DOC_MAPK_MEF2A_6	159	167	PF00069	0.229
DOC_MAPK_MEF2A_6	348	357	PF00069	0.222
DOC_MAPK_MEF2A_6	87	96	PF00069	0.229
DOC_MAPK_NFAT4_5	137	145	PF00069	0.229
DOC_PP1_RVXF_1	208	215	PF00149	0.229
DOC_PP2B_LxvP_1	36	39	PF13499	0.401
DOC_PP2B_LxvP_1	470	473	PF13499	0.229
DOC_PP4_FxxP_1	552	555	PF00568	0.324
DOC_USP7_MATH_1	204	208	PF00917	0.314
DOC_USP7_MATH_1	246	250	PF00917	0.601
DOC_USP7_MATH_1	297	301	PF00917	0.697
DOC_USP7_MATH_1	455	459	PF00917	0.319
DOC_USP7_MATH_1	558	562	PF00917	0.539
DOC_WW_Pin1_4	223	228	PF00397	0.330
DOC_WW_Pin1_4	235	240	PF00397	0.416
DOC_WW_Pin1_4	271	276	PF00397	0.764
DOC_WW_Pin1_4	349	354	PF00397	0.318
DOC_WW_Pin1_4	408	413	PF00397	0.362
DOC_WW_Pin1_4	451	456	PF00397	0.397
DOC_WW_Pin1_4	463	468	PF00397	0.411
DOC_WW_Pin1_4	489	494	PF00397	0.417
LIG_14-3-3_CanoR_1	153	158	PF00244	0.382
LIG_14-3-3_CanoR_1	367	371	PF00244	0.457
LIG_14-3-3_CanoR_1	539	548	PF00244	0.229
LIG_BIR_III_2	318	322	PF00653	0.462
LIG_BIR_III_2	448	452	PF00653	0.229
LIG_BIR_III_4	49	53	PF00653	0.253
LIG_BRCT_BRCA1_1	465	469	PF00533	0.229
LIG_Clathr_ClatBox_1	179	183	PF01394	0.328
LIG_deltaCOP1_diTrp_1	366	373	PF00928	0.212
LIG_eIF4E_1	29	35	PF01652	0.364
LIG_EVH1_1	588	592	PF00568	0.482
LIG_FHA_1	289	295	PF00498	0.599
LIG_FHA_1	360	366	PF00498	0.402
LIG_FHA_1	395	401	PF00498	0.257
LIG_FHA_1	8	14	PF00498	0.384
LIG_FHA_2	361	367	PF00498	0.254
LIG_Integrin_RGD_1	336	338	PF01839	0.510
LIG_LIR_Apic_2	347	353	PF02991	0.265
LIG_LIR_Gen_1	19	29	PF02991	0.573
LIG_LIR_Gen_1	520	530	PF02991	0.229
LIG_LIR_Nem_3	148	152	PF02991	0.316
LIG_LIR_Nem_3	158	163	PF02991	0.320
LIG_LIR_Nem_3	19	24	PF02991	0.570
LIG_LIR_Nem_3	520	526	PF02991	0.229
LIG_LIR_Nem_3	76	80	PF02991	0.247
LIG_MLH1_MIPbox_1	465	469	PF16413	0.229
LIG_MYND_1	451	455	PF01753	0.229
LIG_MYND_1	551	555	PF01753	0.242
LIG_REV1ctd_RIR_1	466	472	PF16727	0.229
LIG_SH2_CRK	152	156	PF00017	0.383
LIG_SH2_CRK	160	164	PF00017	0.359
LIG_SH2_CRK	173	177	PF00017	0.369
LIG_SH2_NCK_1	21	25	PF00017	0.557
LIG_SH2_NCK_1	47	51	PF00017	0.328
LIG_SH2_SRC	47	50	PF00017	0.470
LIG_SH2_STAP1	361	365	PF00017	0.229
LIG_SH2_STAP1	47	51	PF00017	0.403
LIG_SH2_STAT3	219	222	PF00017	0.229
LIG_SH2_STAT5	102	105	PF00017	0.361
LIG_SH2_STAT5	344	347	PF00017	0.344
LIG_SH2_STAT5	361	364	PF00017	0.369
LIG_SH2_STAT5	395	398	PF00017	0.359
LIG_SH2_STAT5	419	422	PF00017	0.262
LIG_SH2_STAT5	54	57	PF00017	0.458
LIG_SH2_STAT5	66	69	PF00017	0.272
LIG_SH3_2	272	277	PF14604	0.506
LIG_SH3_2	382	387	PF14604	0.369
LIG_SH3_3	140	146	PF00018	0.229
LIG_SH3_3	229	235	PF00018	0.418
LIG_SH3_3	240	246	PF00018	0.424
LIG_SH3_3	269	275	PF00018	0.664
LIG_SH3_3	299	305	PF00018	0.554
LIG_SH3_3	379	385	PF00018	0.314
LIG_SH3_3	581	587	PF00018	0.487
LIG_SH3_5	402	406	PF00018	0.229
LIG_SUMO_SIM_par_1	139	145	PF11976	0.314
LIG_SUMO_SIM_par_1	153	158	PF11976	0.186
LIG_SUMO_SIM_par_1	177	183	PF11976	0.229
LIG_SUMO_SIM_par_1	492	499	PF11976	0.229
LIG_SUMO_SIM_par_1	9	14	PF11976	0.511
LIG_TRAF2_1	496	499	PF00917	0.438
LIG_TRAF2_1	58	61	PF00917	0.316
LIG_TYR_ITSM	156	163	PF00017	0.229
LIG_UBA3_1	154	159	PF00899	0.328
LIG_WW_2	586	589	PF00397	0.486
MOD_CDC14_SPxK_1	274	277	PF00782	0.638
MOD_CDC14_SPxK_1	411	414	PF00782	0.229
MOD_CDK_SPK_2	408	413	PF00069	0.229
MOD_CDK_SPxK_1	271	277	PF00069	0.640
MOD_CDK_SPxK_1	408	414	PF00069	0.229
MOD_CK1_1	238	244	PF00069	0.658
MOD_CK1_1	423	429	PF00069	0.256
MOD_CK1_1	76	82	PF00069	0.295
MOD_CK2_1	16	22	PF00069	0.523
MOD_CK2_1	202	208	PF00069	0.377
MOD_CK2_1	246	252	PF00069	0.601
MOD_CK2_1	493	499	PF00069	0.443
MOD_CK2_1	518	524	PF00069	0.325
MOD_GlcNHglycan	215	218	PF01048	0.406
MOD_GlcNHglycan	254	257	PF01048	0.644
MOD_GlcNHglycan	266	272	PF01048	0.542
MOD_GlcNHglycan	299	302	PF01048	0.705
MOD_GlcNHglycan	428	431	PF01048	0.348
MOD_GlcNHglycan	457	460	PF01048	0.398
MOD_GlcNHglycan	487	490	PF01048	0.312
MOD_GlcNHglycan	519	523	PF01048	0.295
MOD_GlcNHglycan	562	565	PF01048	0.668
MOD_GlcNHglycan	567	570	PF01048	0.640
MOD_GlcNHglycan	581	584	PF01048	0.771
MOD_GlcNHglycan	98	101	PF01048	0.293
MOD_GSK3_1	161	168	PF00069	0.440
MOD_GSK3_1	233	240	PF00069	0.553
MOD_GSK3_1	267	274	PF00069	0.658
MOD_GSK3_1	283	290	PF00069	0.646
MOD_GSK3_1	408	415	PF00069	0.430
MOD_GSK3_1	420	427	PF00069	0.365
MOD_GSK3_1	451	458	PF00069	0.334
MOD_GSK3_1	485	492	PF00069	0.315
MOD_GSK3_1	575	582	PF00069	0.716
MOD_GSK3_1	7	14	PF00069	0.514
MOD_NEK2_1	147	152	PF00069	0.365
MOD_NEK2_1	165	170	PF00069	0.245
MOD_NEK2_1	34	39	PF00069	0.395
MOD_NEK2_1	359	364	PF00069	0.298
MOD_NEK2_1	417	422	PF00069	0.229
MOD_NEK2_2	23	28	PF00069	0.342
MOD_PIKK_1	102	108	PF00454	0.377
MOD_PIKK_1	11	17	PF00454	0.458
MOD_PIKK_1	412	418	PF00454	0.326
MOD_PKA_1	540	546	PF00069	0.366
MOD_PKA_2	366	372	PF00069	0.229
MOD_PKA_2	540	546	PF00069	0.263
MOD_PKA_2	7	13	PF00069	0.370
MOD_Plk_1	518	524	PF00069	0.299
MOD_Plk_4	16	22	PF00069	0.551
MOD_Plk_4	23	29	PF00069	0.568
MOD_Plk_4	395	401	PF00069	0.314
MOD_Plk_4	76	82	PF00069	0.254
MOD_ProDKin_1	223	229	PF00069	0.337
MOD_ProDKin_1	235	241	PF00069	0.421
MOD_ProDKin_1	271	277	PF00069	0.766
MOD_ProDKin_1	349	355	PF00069	0.318
MOD_ProDKin_1	408	414	PF00069	0.362
MOD_ProDKin_1	451	457	PF00069	0.397
MOD_ProDKin_1	463	469	PF00069	0.411
MOD_ProDKin_1	489	495	PF00069	0.417
MOD_SUMO_for_1	194	197	PF00179	0.222
TRG_DiLeu_BaEn_1	31	36	PF01217	0.366
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.456
TRG_ENDOCYTIC_2	152	155	PF00928	0.383
TRG_ENDOCYTIC_2	160	163	PF00928	0.359
TRG_ENDOCYTIC_2	173	176	PF00928	0.369
TRG_ENDOCYTIC_2	21	24	PF00928	0.567
TRG_ENDOCYTIC_2	523	526	PF00928	0.393
TRG_ER_diArg_1	538	541	PF00400	0.298
TRG_NLS_MonoExtN_4	538	543	PF00514	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H8	Leptomonas seymouri	26%	81%
A0A0S4JMD1	Bodo saltans	28%	77%
A0A0S4KIN4	Bodo saltans	25%	87%
A0A1X0NZD5	Trypanosomatidae	24%	100%
A0A1X0P1B0	Trypanosomatidae	25%	82%
A4H7N7	Leishmania braziliensis	83%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
V5BPV5	Trypanosoma cruzi	26%	68%
V5DTK9	Trypanosoma cruzi	24%	74%