Ribosomal protein L21

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal prokaryotic L21 protein - putative

Species:

Leishmania infantum

UniProt:

A4HW22_LEIIN

TriTrypDb:

LINF_140013600

Length:

186

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosomal L21

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HW22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW22

PDB structure(s): 7aih_L , 7am2_L , 7ane_L

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.485
CLV_NRD_NRD_1	102	104	PF00675	0.321
CLV_PCSK_KEX2_1	101	103	PF00082	0.357
CLV_PCSK_KEX2_1	87	89	PF00082	0.286
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.284
CLV_PCSK_SKI1_1	52	56	PF00082	0.308
CLV_PCSK_SKI1_1	71	75	PF00082	0.311
DEG_APCC_DBOX_1	100	108	PF00400	0.364
DEG_APCC_DBOX_1	51	59	PF00400	0.224
DEG_APCC_DBOX_1	70	78	PF00400	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DOC_CKS1_1	96	101	PF01111	0.325
DOC_CYCLIN_RxL_1	65	75	PF00134	0.300
DOC_MAPK_gen_1	87	95	PF00069	0.300
DOC_PP1_RVXF_1	100	107	PF00149	0.403
DOC_PP2B_LxvP_1	45	48	PF13499	0.413
DOC_PP4_FxxP_1	96	99	PF00568	0.325
DOC_USP7_MATH_1	48	52	PF00917	0.418
DOC_USP7_UBL2_3	164	168	PF12436	0.540
DOC_WW_Pin1_4	32	37	PF00397	0.362
DOC_WW_Pin1_4	95	100	PF00397	0.325
LIG_14-3-3_CanoR_1	65	73	PF00244	0.300
LIG_14-3-3_CanoR_1	90	96	PF00244	0.283
LIG_FHA_1	78	84	PF00498	0.304
LIG_FHA_2	151	157	PF00498	0.453
LIG_LIR_Apic_2	94	99	PF02991	0.300
LIG_LIR_Gen_1	165	174	PF02991	0.462
LIG_LIR_Nem_3	132	137	PF02991	0.419
LIG_LIR_Nem_3	156	161	PF02991	0.455
LIG_LIR_Nem_3	165	169	PF02991	0.407
LIG_PCNA_PIPBox_1	89	98	PF02747	0.281
LIG_PTB_Apo_2	146	153	PF02174	0.415
LIG_SH2_CRK	134	138	PF00017	0.432
LIG_SH2_STAP1	158	162	PF00017	0.533
LIG_SH2_STAT5	26	29	PF00017	0.351
LIG_SH3_3	119	125	PF00018	0.514
LIG_SH3_3	58	64	PF00018	0.309
LIG_SH3_3	66	72	PF00018	0.287
LIG_SUMO_SIM_par_1	91	98	PF11976	0.362
LIG_ULM_U2AF65_1	101	107	PF00076	0.413
MOD_CDK_SPxK_1	95	101	PF00069	0.325
MOD_CDK_SPxxK_3	95	102	PF00069	0.325
MOD_CK1_1	94	100	PF00069	0.438
MOD_Cter_Amidation	99	102	PF01082	0.314
MOD_GlcNHglycan	172	175	PF01048	0.456
MOD_GlcNHglycan	3	6	PF01048	0.538
MOD_GSK3_1	1	8	PF00069	0.608
MOD_GSK3_1	91	98	PF00069	0.311
MOD_NEK2_1	1	6	PF00069	0.469
MOD_PKA_2	64	70	PF00069	0.309
MOD_PKA_2	77	83	PF00069	0.257
MOD_Plk_4	111	117	PF00069	0.198
MOD_Plk_4	123	129	PF00069	0.351
MOD_Plk_4	91	97	PF00069	0.317
MOD_ProDKin_1	32	38	PF00069	0.362
MOD_ProDKin_1	95	101	PF00069	0.325
MOD_SUMO_rev_2	82	89	PF00179	0.285
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.409
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.281
TRG_ENDOCYTIC_2	134	137	PF00928	0.432
TRG_ER_diArg_1	101	103	PF00400	0.385
TRG_ER_diArg_1	116	119	PF00400	0.264
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q1	Leptomonas seymouri	85%	98%
A0A0S4J1N8	Bodo saltans	62%	80%
A0A1X0NP52	Trypanosomatidae	65%	100%
A0A3R7MRT3	Trypanosoma rangeli	72%	100%
A0A3S7WT24	Leishmania donovani	100%	100%
A4H7N3	Leishmania braziliensis	92%	100%
C9ZT11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	78%
E9APS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QFQ5	Leishmania major	95%	100%