Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 18 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 68 |
| NetGPI | no | yes: 0, no: 69 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 60 |
| GO:0110165 | cellular anatomical entity | 1 | 63 |
| GO:0005737 | cytoplasm | 2 | 3 |
Related structures:
AlphaFold database: A4HW17
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 70 |
| GO:0006629 | lipid metabolic process | 3 | 70 |
| GO:0006631 | fatty acid metabolic process | 4 | 70 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 70 |
| GO:0008152 | metabolic process | 1 | 70 |
| GO:0008610 | lipid biosynthetic process | 4 | 70 |
| GO:0009058 | biosynthetic process | 2 | 70 |
| GO:0009987 | cellular process | 1 | 70 |
| GO:0016053 | organic acid biosynthetic process | 4 | 70 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 70 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 70 |
| GO:0043436 | oxoacid metabolic process | 4 | 70 |
| GO:0044237 | cellular metabolic process | 2 | 70 |
| GO:0044238 | primary metabolic process | 2 | 70 |
| GO:0044249 | cellular biosynthetic process | 3 | 70 |
| GO:0044255 | cellular lipid metabolic process | 3 | 70 |
| GO:0044281 | small molecule metabolic process | 2 | 70 |
| GO:0044283 | small molecule biosynthetic process | 3 | 70 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 70 |
| GO:0071704 | organic substance metabolic process | 2 | 70 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 70 |
| GO:1901576 | organic substance biosynthetic process | 3 | 70 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 10 |
| GO:0006643 | membrane lipid metabolic process | 4 | 10 |
| GO:0006665 | sphingolipid metabolic process | 4 | 10 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 10 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 10 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 10 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 10 |
| GO:0030497 | fatty acid elongation | 6 | 10 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 10 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 10 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 10 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 10 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 10 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 10 |
| GO:0001676 | long-chain fatty acid metabolic process | 5 | 2 |
| GO:0042759 | long-chain fatty acid biosynthetic process | 6 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 70 |
| GO:0004312 | fatty acid synthase activity | 5 | 70 |
| GO:0009922 | fatty acid elongase activity | 6 | 70 |
| GO:0016740 | transferase activity | 2 | 70 |
| GO:0016746 | acyltransferase activity | 3 | 70 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 70 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 70 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 175 | 177 | PF00675 | 0.318 |
| CLV_NRD_NRD_1 | 230 | 232 | PF00675 | 0.270 |
| CLV_NRD_NRD_1 | 359 | 361 | PF00675 | 0.430 |
| CLV_NRD_NRD_1 | 46 | 48 | PF00675 | 0.283 |
| CLV_PCSK_KEX2_1 | 349 | 351 | PF00082 | 0.301 |
| CLV_PCSK_KEX2_1 | 46 | 48 | PF00082 | 0.258 |
| CLV_PCSK_PC1ET2_1 | 349 | 351 | PF00082 | 0.303 |
| CLV_PCSK_SKI1_1 | 134 | 138 | PF00082 | 0.454 |
| CLV_PCSK_SKI1_1 | 16 | 20 | PF00082 | 0.574 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.435 |
| DOC_CKS1_1 | 161 | 166 | PF01111 | 0.473 |
| DOC_CKS1_1 | 379 | 384 | PF01111 | 0.555 |
| DOC_CKS1_1 | 4 | 9 | PF01111 | 0.473 |
| DOC_CYCLIN_RxL_1 | 340 | 348 | PF00134 | 0.423 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 57 | 66 | PF00134 | 0.369 |
| DOC_MAPK_MEF2A_6 | 235 | 243 | PF00069 | 0.469 |
| DOC_MAPK_RevD_3 | 32 | 47 | PF00069 | 0.184 |
| DOC_PP1_RVXF_1 | 175 | 182 | PF00149 | 0.477 |
| DOC_PP4_FxxP_1 | 38 | 41 | PF00568 | 0.331 |
| DOC_USP7_MATH_1 | 300 | 304 | PF00917 | 0.203 |
| DOC_WW_Pin1_4 | 115 | 120 | PF00397 | 0.331 |
| DOC_WW_Pin1_4 | 160 | 165 | PF00397 | 0.459 |
| DOC_WW_Pin1_4 | 3 | 8 | PF00397 | 0.441 |
| DOC_WW_Pin1_4 | 378 | 383 | PF00397 | 0.553 |
| LIG_14-3-3_CanoR_1 | 134 | 139 | PF00244 | 0.296 |
| LIG_14-3-3_CanoR_1 | 176 | 182 | PF00244 | 0.528 |
| LIG_Actin_WH2_2 | 218 | 233 | PF00022 | 0.440 |
| LIG_BIR_III_2 | 20 | 24 | PF00653 | 0.166 |
| LIG_BRCT_BRCA1_1 | 101 | 105 | PF00533 | 0.161 |
| LIG_BRCT_BRCA1_1 | 149 | 153 | PF00533 | 0.215 |
| LIG_BRCT_BRCA1_1 | 310 | 314 | PF00533 | 0.210 |
| LIG_deltaCOP1_diTrp_1 | 2 | 10 | PF00928 | 0.472 |
| LIG_eIF4E_1 | 220 | 226 | PF01652 | 0.409 |
| LIG_eIF4E_1 | 74 | 80 | PF01652 | 0.355 |
| LIG_FHA_1 | 137 | 143 | PF00498 | 0.317 |
| LIG_FHA_1 | 161 | 167 | PF00498 | 0.322 |
| LIG_FHA_1 | 296 | 302 | PF00498 | 0.193 |
| LIG_FHA_1 | 379 | 385 | PF00498 | 0.546 |
| LIG_FHA_1 | 52 | 58 | PF00498 | 0.536 |
| LIG_KLC1_Yacidic_2 | 344 | 348 | PF13176 | 0.400 |
| LIG_LIR_Apic_2 | 113 | 117 | PF02991 | 0.163 |
| LIG_LIR_Gen_1 | 168 | 179 | PF02991 | 0.314 |
| LIG_LIR_Gen_1 | 198 | 207 | PF02991 | 0.368 |
| LIG_LIR_Gen_1 | 217 | 226 | PF02991 | 0.400 |
| LIG_LIR_Gen_1 | 256 | 265 | PF02991 | 0.394 |
| LIG_LIR_Gen_1 | 333 | 342 | PF02991 | 0.312 |
| LIG_LIR_Nem_3 | 168 | 174 | PF02991 | 0.322 |
| LIG_LIR_Nem_3 | 198 | 202 | PF02991 | 0.319 |
| LIG_LIR_Nem_3 | 217 | 223 | PF02991 | 0.322 |
| LIG_LIR_Nem_3 | 24 | 28 | PF02991 | 0.367 |
| LIG_LIR_Nem_3 | 256 | 261 | PF02991 | 0.322 |
| LIG_LIR_Nem_3 | 272 | 278 | PF02991 | 0.198 |
| LIG_LIR_Nem_3 | 283 | 289 | PF02991 | 0.170 |
| LIG_LIR_Nem_3 | 333 | 337 | PF02991 | 0.290 |
| LIG_LIR_Nem_3 | 68 | 73 | PF02991 | 0.359 |
| LIG_PDZ_Class_1 | 387 | 392 | PF00595 | 0.554 |
| LIG_Pex14_1 | 195 | 199 | PF04695 | 0.450 |
| LIG_Pex14_2 | 214 | 218 | PF04695 | 0.394 |
| LIG_Pex14_2 | 274 | 278 | PF04695 | 0.194 |
| LIG_Pex14_2 | 338 | 342 | PF04695 | 0.321 |
| LIG_Pex14_2 | 80 | 84 | PF04695 | 0.330 |
| LIG_PTB_Apo_2 | 109 | 116 | PF02174 | 0.166 |
| LIG_PTB_Apo_2 | 268 | 275 | PF02174 | 0.199 |
| LIG_PTB_Phospho_1 | 109 | 115 | PF10480 | 0.166 |
| LIG_REV1ctd_RIR_1 | 272 | 280 | PF16727 | 0.185 |
| LIG_SH2_CRK | 28 | 32 | PF00017 | 0.355 |
| LIG_SH2_CRK | 334 | 338 | PF00017 | 0.466 |
| LIG_SH2_GRB2like | 269 | 272 | PF00017 | 0.196 |
| LIG_SH2_PTP2 | 199 | 202 | PF00017 | 0.309 |
| LIG_SH2_PTP2 | 254 | 257 | PF00017 | 0.437 |
| LIG_SH2_SRC | 115 | 118 | PF00017 | 0.331 |
| LIG_SH2_SRC | 33 | 36 | PF00017 | 0.459 |
| LIG_SH2_STAP1 | 138 | 142 | PF00017 | 0.241 |
| LIG_SH2_STAP1 | 269 | 273 | PF00017 | 0.344 |
| LIG_SH2_STAP1 | 28 | 32 | PF00017 | 0.390 |
| LIG_SH2_STAT3 | 138 | 141 | PF00017 | 0.171 |
| LIG_SH2_STAT3 | 74 | 77 | PF00017 | 0.171 |
| LIG_SH2_STAT5 | 138 | 141 | PF00017 | 0.265 |
| LIG_SH2_STAT5 | 160 | 163 | PF00017 | 0.332 |
| LIG_SH2_STAT5 | 193 | 196 | PF00017 | 0.348 |
| LIG_SH2_STAT5 | 199 | 202 | PF00017 | 0.263 |
| LIG_SH2_STAT5 | 213 | 216 | PF00017 | 0.270 |
| LIG_SH2_STAT5 | 220 | 223 | PF00017 | 0.329 |
| LIG_SH2_STAT5 | 254 | 257 | PF00017 | 0.329 |
| LIG_SH2_STAT5 | 258 | 261 | PF00017 | 0.318 |
| LIG_SH2_STAT5 | 289 | 292 | PF00017 | 0.197 |
| LIG_SH2_STAT5 | 33 | 36 | PF00017 | 0.312 |
| LIG_SH2_STAT5 | 334 | 337 | PF00017 | 0.310 |
| LIG_SH2_STAT5 | 346 | 349 | PF00017 | 0.454 |
| LIG_SH2_STAT5 | 55 | 58 | PF00017 | 0.552 |
| LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.314 |
| LIG_SH3_3 | 197 | 203 | PF00018 | 0.171 |
| LIG_SH3_3 | 20 | 26 | PF00018 | 0.366 |
| LIG_SH3_3 | 233 | 239 | PF00018 | 0.456 |
| LIG_SH3_3 | 376 | 382 | PF00018 | 0.766 |
| LIG_TRFH_1 | 199 | 203 | PF08558 | 0.163 |
| LIG_TRFH_1 | 263 | 267 | PF08558 | 0.205 |
| LIG_TYR_ITIM | 31 | 36 | PF00017 | 0.263 |
| LIG_UBA3_1 | 157 | 162 | PF00899 | 0.353 |
| LIG_UBA3_1 | 170 | 177 | PF00899 | 0.319 |
| LIG_UBA3_1 | 227 | 232 | PF00899 | 0.394 |
| LIG_UBA3_1 | 337 | 343 | PF00899 | 0.334 |
| LIG_UBA3_1 | 79 | 87 | PF00899 | 0.273 |
| LIG_WRC_WIRS_1 | 215 | 220 | PF05994 | 0.213 |
| MOD_CK1_1 | 294 | 300 | PF00069 | 0.202 |
| MOD_CK1_1 | 319 | 325 | PF00069 | 0.318 |
| MOD_CK1_1 | 65 | 71 | PF00069 | 0.345 |
| MOD_GlcNHglycan | 13 | 16 | PF01048 | 0.532 |
| MOD_GlcNHglycan | 148 | 152 | PF01048 | 0.453 |
| MOD_GlcNHglycan | 203 | 206 | PF01048 | 0.471 |
| MOD_GSK3_1 | 147 | 154 | PF00069 | 0.267 |
| MOD_GSK3_1 | 291 | 298 | PF00069 | 0.202 |
| MOD_GSK3_1 | 6 | 13 | PF00069 | 0.423 |
| MOD_GSK3_1 | 65 | 72 | PF00069 | 0.343 |
| MOD_GSK3_1 | 95 | 102 | PF00069 | 0.341 |
| MOD_NEK2_1 | 10 | 15 | PF00069 | 0.422 |
| MOD_NEK2_1 | 123 | 128 | PF00069 | 0.275 |
| MOD_NEK2_1 | 166 | 171 | PF00069 | 0.344 |
| MOD_NEK2_1 | 214 | 219 | PF00069 | 0.333 |
| MOD_NEK2_1 | 230 | 235 | PF00069 | 0.522 |
| MOD_NEK2_1 | 253 | 258 | PF00069 | 0.346 |
| MOD_NEK2_1 | 330 | 335 | PF00069 | 0.306 |
| MOD_NEK2_1 | 51 | 56 | PF00069 | 0.490 |
| MOD_NEK2_1 | 62 | 67 | PF00069 | 0.332 |
| MOD_NEK2_1 | 89 | 94 | PF00069 | 0.318 |
| MOD_NEK2_2 | 269 | 274 | PF00069 | 0.378 |
| MOD_NEK2_2 | 95 | 100 | PF00069 | 0.353 |
| MOD_OFUCOSY | 317 | 323 | PF10250 | 0.391 |
| MOD_PIKK_1 | 300 | 306 | PF00454 | 0.182 |
| MOD_PKA_2 | 230 | 236 | PF00069 | 0.414 |
| MOD_PKA_2 | 99 | 105 | PF00069 | 0.333 |
| MOD_Plk_1 | 352 | 358 | PF00069 | 0.665 |
| MOD_Plk_1 | 51 | 57 | PF00069 | 0.459 |
| MOD_Plk_4 | 166 | 172 | PF00069 | 0.287 |
| MOD_Plk_4 | 177 | 183 | PF00069 | 0.462 |
| MOD_Plk_4 | 195 | 201 | PF00069 | 0.287 |
| MOD_Plk_4 | 214 | 220 | PF00069 | 0.274 |
| MOD_Plk_4 | 256 | 262 | PF00069 | 0.308 |
| MOD_Plk_4 | 269 | 275 | PF00069 | 0.243 |
| MOD_Plk_4 | 291 | 297 | PF00069 | 0.202 |
| MOD_Plk_4 | 352 | 358 | PF00069 | 0.642 |
| MOD_Plk_4 | 62 | 68 | PF00069 | 0.332 |
| MOD_Plk_4 | 69 | 75 | PF00069 | 0.333 |
| MOD_ProDKin_1 | 115 | 121 | PF00069 | 0.331 |
| MOD_ProDKin_1 | 160 | 166 | PF00069 | 0.459 |
| MOD_ProDKin_1 | 3 | 9 | PF00069 | 0.439 |
| MOD_ProDKin_1 | 378 | 384 | PF00069 | 0.553 |
| MOD_SUMO_for_1 | 370 | 373 | PF00179 | 0.503 |
| MOD_SUMO_rev_2 | 362 | 370 | PF00179 | 0.664 |
| TRG_ENDOCYTIC_2 | 185 | 188 | PF00928 | 0.324 |
| TRG_ENDOCYTIC_2 | 199 | 202 | PF00928 | 0.286 |
| TRG_ENDOCYTIC_2 | 222 | 225 | PF00928 | 0.321 |
| TRG_ENDOCYTIC_2 | 254 | 257 | PF00928 | 0.366 |
| TRG_ENDOCYTIC_2 | 258 | 261 | PF00928 | 0.353 |
| TRG_ENDOCYTIC_2 | 28 | 31 | PF00928 | 0.307 |
| TRG_ENDOCYTIC_2 | 33 | 36 | PF00928 | 0.307 |
| TRG_ENDOCYTIC_2 | 334 | 337 | PF00928 | 0.297 |
| TRG_ENDOCYTIC_2 | 73 | 76 | PF00928 | 0.360 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5E5 | Leptomonas seymouri | 34% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 29% | 100% |
| A0A0N0P7D6 | Leptomonas seymouri | 30% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 36% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 30% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 28% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 28% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 31% | 100% |
| A0A0S4IVS6 | Bodo saltans | 31% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 33% | 100% |
| A0A1X0NNM4 | Trypanosomatidae | 28% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 34% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 34% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 98% | 100% |
| A0A3Q8I9T2 | Leishmania donovani | 67% | 100% |
| A0A3Q8I9U9 | Leishmania donovani | 32% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 31% | 100% |
| A0A3Q8IC05 | Leishmania donovani | 36% | 100% |
| A0A3Q8ID51 | Leishmania donovani | 73% | 99% |
| A0A3Q8IIA9 | Leishmania donovani | 28% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 28% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 30% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 26% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 28% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 32% | 100% |
| A0A3S7WT03 | Leishmania donovani | 33% | 100% |
| A0A3S7WT16 | Leishmania donovani | 31% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 31% | 100% |
| A4H7M2 | Leishmania braziliensis | 29% | 100% |
| A4H7M3 | Leishmania braziliensis | 26% | 100% |
| A4H7M6 | Leishmania braziliensis | 32% | 88% |
| A4H7M7 | Leishmania braziliensis | 31% | 91% |
| A4H7M8 | Leishmania braziliensis | 61% | 100% |
| A4H7M9 | Leishmania braziliensis | 81% | 100% |
| A4H7N0 | Leishmania braziliensis | 36% | 80% |
| A4HW07 | Leishmania infantum | 28% | 100% |
| A4HW08 | Leishmania infantum | 26% | 100% |
| A4HW09 | Leishmania infantum | 28% | 100% |
| A4HW12 | Leishmania infantum | 32% | 88% |
| A4HW13 | Leishmania infantum | 32% | 93% |
| A4HW14 | Leishmania infantum | 31% | 94% |
| A4HW15 | Leishmania infantum | 67% | 100% |
| A4HW16 | Leishmania infantum | 70% | 100% |
| A4HW18 | Leishmania infantum | 36% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 30% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 69% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 66% | 100% |
| E9AGL0 | Leishmania infantum | 34% | 100% |
| E9AGL2 | Leishmania infantum | 32% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 27% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 87% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 87% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 88% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 94% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 98% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 88% | 100% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 88% |
| Q4QFQ9 | Leishmania major | 35% | 79% |
| Q4QFR0 | Leishmania major | 95% | 100% |
| Q4QFR1 | Leishmania major | 70% | 100% |
| Q4QFR2 | Leishmania major | 66% | 100% |
| Q4QFR3 | Leishmania major | 31% | 96% |
| Q4QFR4 | Leishmania major | 32% | 93% |
| Q4QFR5 | Leishmania major | 32% | 100% |
| Q4QFR6 | Leishmania major | 32% | 88% |
| Q4QFR8 | Leishmania major | 29% | 100% |
| Q4QFR9 | Leishmania major | 27% | 100% |
| Q4QFS0 | Leishmania major | 28% | 100% |
| Q9XVQ9 | Caenorhabditis elegans | 28% | 100% |
| V5BE99 | Trypanosoma cruzi | 35% | 100% |
| V5BIX9 | Trypanosoma cruzi | 30% | 100% |
| V5BND3 | Trypanosoma cruzi | 32% | 100% |
| V5DF68 | Trypanosoma cruzi | 29% | 100% |