Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 36 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 74 |
| NetGPI | no | yes: 0, no: 75 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 66 |
| GO:0110165 | cellular anatomical entity | 1 | 69 |
| GO:0005737 | cytoplasm | 2 | 3 |
Related structures:
AlphaFold database: A4HW16
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 76 |
| GO:0006629 | lipid metabolic process | 3 | 76 |
| GO:0006631 | fatty acid metabolic process | 4 | 76 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 76 |
| GO:0008152 | metabolic process | 1 | 76 |
| GO:0008610 | lipid biosynthetic process | 4 | 76 |
| GO:0009058 | biosynthetic process | 2 | 76 |
| GO:0009987 | cellular process | 1 | 76 |
| GO:0016053 | organic acid biosynthetic process | 4 | 76 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 76 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 76 |
| GO:0043436 | oxoacid metabolic process | 4 | 76 |
| GO:0044237 | cellular metabolic process | 2 | 76 |
| GO:0044238 | primary metabolic process | 2 | 76 |
| GO:0044249 | cellular biosynthetic process | 3 | 76 |
| GO:0044255 | cellular lipid metabolic process | 3 | 76 |
| GO:0044281 | small molecule metabolic process | 2 | 76 |
| GO:0044283 | small molecule biosynthetic process | 3 | 76 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 76 |
| GO:0071704 | organic substance metabolic process | 2 | 76 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 76 |
| GO:1901576 | organic substance biosynthetic process | 3 | 76 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 10 |
| GO:0006643 | membrane lipid metabolic process | 4 | 10 |
| GO:0006665 | sphingolipid metabolic process | 4 | 10 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 10 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 10 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 10 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 10 |
| GO:0030497 | fatty acid elongation | 6 | 10 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 10 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 10 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 10 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 10 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 10 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 10 |
| GO:0001676 | long-chain fatty acid metabolic process | 5 | 2 |
| GO:0042759 | long-chain fatty acid biosynthetic process | 6 | 2 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 76 |
| GO:0004312 | fatty acid synthase activity | 5 | 76 |
| GO:0009922 | fatty acid elongase activity | 6 | 76 |
| GO:0016740 | transferase activity | 2 | 76 |
| GO:0016746 | acyltransferase activity | 3 | 76 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 76 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 76 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 16 | 18 | PF00675 | 0.454 |
| CLV_NRD_NRD_1 | 180 | 182 | PF00675 | 0.344 |
| CLV_NRD_NRD_1 | 235 | 237 | PF00675 | 0.297 |
| CLV_NRD_NRD_1 | 364 | 366 | PF00675 | 0.457 |
| CLV_NRD_NRD_1 | 54 | 56 | PF00675 | 0.356 |
| CLV_PCSK_FUR_1 | 14 | 18 | PF00082 | 0.450 |
| CLV_PCSK_KEX2_1 | 16 | 18 | PF00082 | 0.597 |
| CLV_PCSK_KEX2_1 | 354 | 356 | PF00082 | 0.348 |
| CLV_PCSK_KEX2_1 | 54 | 56 | PF00082 | 0.346 |
| CLV_PCSK_PC1ET2_1 | 354 | 356 | PF00082 | 0.340 |
| CLV_PCSK_SKI1_1 | 146 | 150 | PF00082 | 0.472 |
| CLV_PCSK_SKI1_1 | 24 | 28 | PF00082 | 0.584 |
| CLV_PCSK_SKI1_1 | 88 | 92 | PF00082 | 0.533 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.411 |
| DOC_CKS1_1 | 166 | 171 | PF01111 | 0.501 |
| DOC_CYCLIN_RxL_1 | 345 | 353 | PF00134 | 0.405 |
| DOC_MAPK_gen_1 | 54 | 61 | PF00069 | 0.448 |
| DOC_MAPK_MEF2A_6 | 240 | 248 | PF00069 | 0.506 |
| DOC_MAPK_MEF2A_6 | 54 | 61 | PF00069 | 0.517 |
| DOC_MAPK_NFAT4_5 | 54 | 62 | PF00069 | 0.407 |
| DOC_MAPK_RevD_3 | 40 | 55 | PF00069 | 0.210 |
| DOC_PP1_RVXF_1 | 180 | 187 | PF00149 | 0.502 |
| DOC_PP4_FxxP_1 | 46 | 49 | PF00568 | 0.365 |
| DOC_USP7_MATH_1 | 206 | 210 | PF00917 | 0.356 |
| DOC_USP7_MATH_1 | 305 | 309 | PF00917 | 0.230 |
| DOC_WW_Pin1_4 | 138 | 143 | PF00397 | 0.345 |
| DOC_WW_Pin1_4 | 165 | 170 | PF00397 | 0.486 |
| LIG_14-3-3_CanoR_1 | 181 | 187 | PF00244 | 0.549 |
| LIG_14-3-3_CanoR_1 | 54 | 60 | PF00244 | 0.556 |
| LIG_Actin_WH2_2 | 223 | 238 | PF00022 | 0.465 |
| LIG_BRCT_BRCA1_1 | 154 | 158 | PF00533 | 0.253 |
| LIG_BRCT_BRCA1_1 | 315 | 319 | PF00533 | 0.236 |
| LIG_eIF4E_1 | 225 | 231 | PF01652 | 0.397 |
| LIG_FHA_1 | 139 | 145 | PF00498 | 0.348 |
| LIG_FHA_1 | 166 | 172 | PF00498 | 0.346 |
| LIG_FHA_1 | 301 | 307 | PF00498 | 0.218 |
| LIG_FHA_1 | 75 | 81 | PF00498 | 0.392 |
| LIG_GBD_Chelix_1 | 193 | 201 | PF00786 | 0.228 |
| LIG_Integrin_isoDGR_2 | 22 | 24 | PF01839 | 0.448 |
| LIG_KLC1_Yacidic_2 | 349 | 353 | PF13176 | 0.427 |
| LIG_LIR_Gen_1 | 173 | 184 | PF02991 | 0.338 |
| LIG_LIR_Gen_1 | 195 | 206 | PF02991 | 0.454 |
| LIG_LIR_Gen_1 | 222 | 231 | PF02991 | 0.446 |
| LIG_LIR_Gen_1 | 261 | 270 | PF02991 | 0.402 |
| LIG_LIR_Gen_1 | 338 | 347 | PF02991 | 0.337 |
| LIG_LIR_Nem_3 | 173 | 179 | PF02991 | 0.354 |
| LIG_LIR_Nem_3 | 195 | 201 | PF02991 | 0.401 |
| LIG_LIR_Nem_3 | 222 | 228 | PF02991 | 0.347 |
| LIG_LIR_Nem_3 | 261 | 266 | PF02991 | 0.345 |
| LIG_LIR_Nem_3 | 277 | 283 | PF02991 | 0.277 |
| LIG_LIR_Nem_3 | 28 | 33 | PF02991 | 0.321 |
| LIG_LIR_Nem_3 | 288 | 294 | PF02991 | 0.199 |
| LIG_LIR_Nem_3 | 338 | 342 | PF02991 | 0.329 |
| LIG_LIR_Nem_3 | 76 | 81 | PF02991 | 0.395 |
| LIG_LIR_Nem_3 | 9 | 13 | PF02991 | 0.301 |
| LIG_LYPXL_SIV_4 | 35 | 43 | PF13949 | 0.180 |
| LIG_PDZ_Class_2 | 369 | 374 | PF00595 | 0.497 |
| LIG_Pex14_1 | 200 | 204 | PF04695 | 0.286 |
| LIG_Pex14_2 | 219 | 223 | PF04695 | 0.461 |
| LIG_Pex14_2 | 279 | 283 | PF04695 | 0.220 |
| LIG_Pex14_2 | 343 | 347 | PF04695 | 0.353 |
| LIG_PTB_Apo_2 | 273 | 280 | PF02174 | 0.224 |
| LIG_Rb_pABgroove_1 | 146 | 154 | PF01858 | 0.187 |
| LIG_REV1ctd_RIR_1 | 277 | 285 | PF16727 | 0.214 |
| LIG_SH2_CRK | 339 | 343 | PF00017 | 0.494 |
| LIG_SH2_CRK | 36 | 40 | PF00017 | 0.372 |
| LIG_SH2_GRB2like | 274 | 277 | PF00017 | 0.221 |
| LIG_SH2_PTP2 | 198 | 201 | PF00017 | 0.457 |
| LIG_SH2_PTP2 | 259 | 262 | PF00017 | 0.455 |
| LIG_SH2_STAP1 | 274 | 278 | PF00017 | 0.371 |
| LIG_SH2_STAP1 | 36 | 40 | PF00017 | 0.408 |
| LIG_SH2_STAT5 | 165 | 168 | PF00017 | 0.367 |
| LIG_SH2_STAT5 | 198 | 201 | PF00017 | 0.380 |
| LIG_SH2_STAT5 | 218 | 221 | PF00017 | 0.299 |
| LIG_SH2_STAT5 | 225 | 228 | PF00017 | 0.354 |
| LIG_SH2_STAT5 | 259 | 262 | PF00017 | 0.357 |
| LIG_SH2_STAT5 | 263 | 266 | PF00017 | 0.342 |
| LIG_SH2_STAT5 | 294 | 297 | PF00017 | 0.224 |
| LIG_SH2_STAT5 | 339 | 342 | PF00017 | 0.342 |
| LIG_SH2_STAT5 | 351 | 354 | PF00017 | 0.486 |
| LIG_SH2_STAT5 | 41 | 44 | PF00017 | 0.342 |
| LIG_SH2_STAT5 | 47 | 50 | PF00017 | 0.349 |
| LIG_SH3_3 | 238 | 244 | PF00018 | 0.477 |
| LIG_SH3_3 | 28 | 34 | PF00018 | 0.366 |
| LIG_TRFH_1 | 268 | 272 | PF08558 | 0.231 |
| LIG_UBA3_1 | 162 | 167 | PF00899 | 0.385 |
| LIG_UBA3_1 | 175 | 182 | PF00899 | 0.367 |
| LIG_UBA3_1 | 232 | 237 | PF00899 | 0.422 |
| LIG_UBA3_1 | 342 | 348 | PF00899 | 0.365 |
| LIG_WRC_WIRS_1 | 220 | 225 | PF05994 | 0.240 |
| LIG_WRC_WIRS_1 | 93 | 98 | PF05994 | 0.380 |
| MOD_CK1_1 | 299 | 305 | PF00069 | 0.229 |
| MOD_CK1_1 | 324 | 330 | PF00069 | 0.352 |
| MOD_CK1_1 | 73 | 79 | PF00069 | 0.389 |
| MOD_CK1_1 | 92 | 98 | PF00069 | 0.173 |
| MOD_CK2_1 | 137 | 143 | PF00069 | 0.322 |
| MOD_CK2_1 | 96 | 102 | PF00069 | 0.247 |
| MOD_GlcNHglycan | 106 | 109 | PF01048 | 0.494 |
| MOD_GlcNHglycan | 153 | 157 | PF01048 | 0.470 |
| MOD_GlcNHglycan | 18 | 21 | PF01048 | 0.562 |
| MOD_GlcNHglycan | 208 | 211 | PF01048 | 0.497 |
| MOD_GSK3_1 | 152 | 159 | PF00069 | 0.289 |
| MOD_GSK3_1 | 296 | 303 | PF00069 | 0.229 |
| MOD_GSK3_1 | 70 | 77 | PF00069 | 0.393 |
| MOD_GSK3_1 | 92 | 99 | PF00069 | 0.330 |
| MOD_NEK2_1 | 103 | 108 | PF00069 | 0.327 |
| MOD_NEK2_1 | 171 | 176 | PF00069 | 0.371 |
| MOD_NEK2_1 | 219 | 224 | PF00069 | 0.367 |
| MOD_NEK2_1 | 235 | 240 | PF00069 | 0.561 |
| MOD_NEK2_1 | 258 | 263 | PF00069 | 0.372 |
| MOD_NEK2_1 | 26 | 31 | PF00069 | 0.316 |
| MOD_NEK2_1 | 335 | 340 | PF00069 | 0.324 |
| MOD_NEK2_1 | 70 | 75 | PF00069 | 0.359 |
| MOD_NEK2_1 | 96 | 101 | PF00069 | 0.337 |
| MOD_NEK2_2 | 274 | 279 | PF00069 | 0.367 |
| MOD_OFUCOSY | 322 | 328 | PF10250 | 0.419 |
| MOD_PIKK_1 | 305 | 311 | PF00454 | 0.209 |
| MOD_PKA_1 | 16 | 22 | PF00069 | 0.261 |
| MOD_PKA_2 | 16 | 22 | PF00069 | 0.261 |
| MOD_PKA_2 | 235 | 241 | PF00069 | 0.440 |
| MOD_PKB_1 | 14 | 22 | PF00069 | 0.257 |
| MOD_Plk_1 | 146 | 152 | PF00069 | 0.283 |
| MOD_Plk_1 | 357 | 363 | PF00069 | 0.711 |
| MOD_Plk_2-3 | 147 | 153 | PF00069 | 0.187 |
| MOD_Plk_4 | 147 | 153 | PF00069 | 0.266 |
| MOD_Plk_4 | 171 | 177 | PF00069 | 0.316 |
| MOD_Plk_4 | 182 | 188 | PF00069 | 0.493 |
| MOD_Plk_4 | 200 | 206 | PF00069 | 0.319 |
| MOD_Plk_4 | 219 | 225 | PF00069 | 0.302 |
| MOD_Plk_4 | 261 | 267 | PF00069 | 0.328 |
| MOD_Plk_4 | 274 | 280 | PF00069 | 0.314 |
| MOD_Plk_4 | 296 | 302 | PF00069 | 0.229 |
| MOD_Plk_4 | 35 | 41 | PF00069 | 0.349 |
| MOD_Plk_4 | 357 | 363 | PF00069 | 0.710 |
| MOD_Plk_4 | 70 | 76 | PF00069 | 0.363 |
| MOD_ProDKin_1 | 138 | 144 | PF00069 | 0.345 |
| MOD_ProDKin_1 | 165 | 171 | PF00069 | 0.486 |
| TRG_ENDOCYTIC_2 | 190 | 193 | PF00928 | 0.368 |
| TRG_ENDOCYTIC_2 | 198 | 201 | PF00928 | 0.382 |
| TRG_ENDOCYTIC_2 | 204 | 207 | PF00928 | 0.327 |
| TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.345 |
| TRG_ENDOCYTIC_2 | 259 | 262 | PF00928 | 0.398 |
| TRG_ENDOCYTIC_2 | 263 | 266 | PF00928 | 0.378 |
| TRG_ENDOCYTIC_2 | 339 | 342 | PF00928 | 0.330 |
| TRG_ENDOCYTIC_2 | 36 | 39 | PF00928 | 0.339 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.371 |
| TRG_ENDOCYTIC_2 | 84 | 87 | PF00928 | 0.313 |
| TRG_ER_diArg_1 | 13 | 16 | PF00400 | 0.252 |
| TRG_Pf-PMV_PEXEL_1 | 125 | 129 | PF00026 | 0.575 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5E5 | Leptomonas seymouri | 32% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 30% | 100% |
| A0A0N0P7D6 | Leptomonas seymouri | 27% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 30% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 30% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 29% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 30% | 100% |
| A0A0S4IVS6 | Bodo saltans | 31% | 100% |
| A0A0S4IW98 | Bodo saltans | 32% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 33% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 32% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 32% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 69% | 95% |
| A0A3Q8I9T2 | Leishmania donovani | 75% | 100% |
| A0A3Q8I9U9 | Leishmania donovani | 31% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 31% | 100% |
| A0A3Q8IC05 | Leishmania donovani | 33% | 100% |
| A0A3Q8ID51 | Leishmania donovani | 99% | 94% |
| A0A3Q8IIA9 | Leishmania donovani | 30% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 27% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 31% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 30% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 31% | 100% |
| A0A3S7WT03 | Leishmania donovani | 31% | 100% |
| A0A3S7WT16 | Leishmania donovani | 27% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 30% | 100% |
| A4H7M2 | Leishmania braziliensis | 30% | 100% |
| A4H7M3 | Leishmania braziliensis | 30% | 100% |
| A4H7M4 | Leishmania braziliensis | 28% | 100% |
| A4H7M6 | Leishmania braziliensis | 30% | 88% |
| A4H7M7 | Leishmania braziliensis | 29% | 96% |
| A4H7M8 | Leishmania braziliensis | 70% | 100% |
| A4H7M9 | Leishmania braziliensis | 63% | 100% |
| A4H7N0 | Leishmania braziliensis | 34% | 83% |
| A4HW07 | Leishmania infantum | 30% | 100% |
| A4HW08 | Leishmania infantum | 31% | 100% |
| A4HW09 | Leishmania infantum | 30% | 100% |
| A4HW12 | Leishmania infantum | 32% | 97% |
| A4HW13 | Leishmania infantum | 31% | 93% |
| A4HW14 | Leishmania infantum | 27% | 97% |
| A4HW15 | Leishmania infantum | 76% | 100% |
| A4HW17 | Leishmania infantum | 70% | 95% |
| A4HW18 | Leishmania infantum | 33% | 100% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 26% | 100% |
| E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 93% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 93% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 73% | 100% |
| E9AGL0 | Leishmania infantum | 31% | 100% |
| E9AGL2 | Leishmania infantum | 31% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 89% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 89% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 97% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 93% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 98% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 66% | 100% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 89% |
| Q4QFQ9 | Leishmania major | 32% | 83% |
| Q4QFR0 | Leishmania major | 68% | 100% |
| Q4QFR1 | Leishmania major | 95% | 100% |
| Q4QFR2 | Leishmania major | 74% | 100% |
| Q4QFR3 | Leishmania major | 28% | 97% |
| Q4QFR4 | Leishmania major | 30% | 93% |
| Q4QFR5 | Leishmania major | 31% | 100% |
| Q4QFR6 | Leishmania major | 30% | 87% |
| Q4QFR9 | Leishmania major | 30% | 100% |
| Q4QFS0 | Leishmania major | 30% | 100% |
| V5BE99 | Trypanosoma cruzi | 31% | 100% |
| V5BIX9 | Trypanosoma cruzi | 29% | 100% |
| V5BND3 | Trypanosoma cruzi | 30% | 100% |