Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase - putative

Species:

Leishmania infantum

UniProt:

A4HW14_LEIIN

TriTrypDb:

LINF_140012800

Length:

323

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Annotations by Jardim et al.

Fatty acid metabolism, Elongation of fatty acids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 47
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	43
GO:0110165	cellular anatomical entity	1	45
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A4HW14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW14

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	48
GO:0006629	lipid metabolic process	3	48
GO:0006631	fatty acid metabolic process	4	48
GO:0006633	fatty acid biosynthetic process	5	48
GO:0008152	metabolic process	1	48
GO:0008610	lipid biosynthetic process	4	48
GO:0009058	biosynthetic process	2	48
GO:0009987	cellular process	1	48
GO:0016053	organic acid biosynthetic process	4	48
GO:0019752	carboxylic acid metabolic process	5	48
GO:0032787	monocarboxylic acid metabolic process	6	48
GO:0043436	oxoacid metabolic process	4	48
GO:0044237	cellular metabolic process	2	48
GO:0044238	primary metabolic process	2	48
GO:0044249	cellular biosynthetic process	3	48
GO:0044255	cellular lipid metabolic process	3	48
GO:0044281	small molecule metabolic process	2	48
GO:0044283	small molecule biosynthetic process	3	48
GO:0046394	carboxylic acid biosynthetic process	5	48
GO:0071704	organic substance metabolic process	2	48
GO:0072330	monocarboxylic acid biosynthetic process	6	48
GO:1901576	organic substance biosynthetic process	3	48
GO:0000038	very long-chain fatty acid metabolic process	5	5
GO:0006643	membrane lipid metabolic process	4	5
GO:0006665	sphingolipid metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0019367	fatty acid elongation, saturated fatty acid	7	5
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	5
GO:0030148	sphingolipid biosynthetic process	5	5
GO:0030497	fatty acid elongation	6	5
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	5
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	5
GO:0042761	very long-chain fatty acid biosynthetic process	6	5
GO:0046467	membrane lipid biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	48
GO:0004312	fatty acid synthase activity	5	48
GO:0009922	fatty acid elongase activity	6	48
GO:0016740	transferase activity	2	48
GO:0016746	acyltransferase activity	3	48
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	48
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.370
CLV_NRD_NRD_1	112	114	PF00675	0.366
CLV_NRD_NRD_1	147	149	PF00675	0.366
CLV_PCSK_KEX2_1	112	114	PF00082	0.366
CLV_PCSK_KEX2_1	147	149	PF00082	0.366
CLV_PCSK_SKI1_1	277	281	PF00082	0.424
CLV_PCSK_SKI1_1	297	301	PF00082	0.166
DEG_Nend_UBRbox_2	1	3	PF02207	0.305
DOC_CDC14_PxL_1	78	86	PF14671	0.271
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.451
DOC_MAPK_gen_1	176	182	PF00069	0.451
DOC_MAPK_MEF2A_6	235	243	PF00069	0.437
DOC_PP1_RVXF_1	175	182	PF00149	0.459
DOC_USP7_MATH_1	197	201	PF00917	0.389
DOC_USP7_MATH_1	306	310	PF00917	0.646
DOC_USP7_UBL2_3	300	304	PF12436	0.467
DOC_USP7_UBL2_3	47	51	PF12436	0.476
DOC_WW_Pin1_4	105	110	PF00397	0.368
DOC_WW_Pin1_4	304	309	PF00397	0.613
LIG_Actin_WH2_2	89	104	PF00022	0.304
LIG_APCC_ABBA_1	138	143	PF00400	0.166
LIG_BRCT_BRCA1_1	45	49	PF00533	0.197
LIG_BRCT_BRCA1_2	45	51	PF00533	0.197
LIG_EH1_1	185	193	PF00400	0.329
LIG_EH1_1	212	220	PF00400	0.301
LIG_FHA_1	167	173	PF00498	0.285
LIG_FHA_1	187	193	PF00498	0.285
LIG_FHA_1	3	9	PF00498	0.377
LIG_FHA_1	58	64	PF00498	0.527
LIG_GBD_Chelix_1	33	41	PF00786	0.307
LIG_GBD_Chelix_1	63	71	PF00786	0.394
LIG_LIR_Gen_1	168	179	PF02991	0.305
LIG_LIR_Gen_1	242	251	PF02991	0.377
LIG_LIR_Gen_1	285	294	PF02991	0.310
LIG_LIR_Gen_1	35	45	PF02991	0.317
LIG_LIR_Gen_1	70	79	PF02991	0.311
LIG_LIR_Nem_3	168	174	PF02991	0.293
LIG_LIR_Nem_3	217	223	PF02991	0.320
LIG_LIR_Nem_3	242	246	PF02991	0.315
LIG_LIR_Nem_3	285	290	PF02991	0.293
LIG_LIR_Nem_3	318	322	PF02991	0.535
LIG_LIR_Nem_3	35	41	PF02991	0.271
LIG_LIR_Nem_3	70	75	PF02991	0.327
LIG_PCNA_PIPBox_1	1	10	PF02747	0.385
LIG_Pex14_2	290	294	PF04695	0.309
LIG_REV1ctd_RIR_1	291	301	PF16727	0.360
LIG_SH2_CRK	230	234	PF00017	0.533
LIG_SH2_CRK	79	83	PF00017	0.307
LIG_SH2_NCK_1	85	89	PF00017	0.342
LIG_SH2_STAP1	230	234	PF00017	0.505
LIG_SH2_STAT3	261	264	PF00017	0.336
LIG_SH2_STAT5	103	106	PF00017	0.378
LIG_SH2_STAT5	193	196	PF00017	0.328
LIG_SH2_STAT5	220	223	PF00017	0.324
LIG_SH2_STAT5	258	261	PF00017	0.331
LIG_SH2_STAT5	283	286	PF00017	0.277
LIG_SH2_STAT5	298	301	PF00017	0.449
LIG_SH2_STAT5	38	41	PF00017	0.294
LIG_SH2_STAT5	79	82	PF00017	0.328
LIG_SH3_3	113	119	PF00018	0.351
LIG_SH3_3	12	18	PF00018	0.385
LIG_SH3_3	233	239	PF00018	0.432
LIG_SH3_3	85	91	PF00018	0.307
LIG_SUMO_SIM_par_1	67	73	PF11976	0.303
LIG_TYR_ITIM	284	289	PF00017	0.326
LIG_Vh1_VBS_1	30	48	PF01044	0.181
LIG_WRC_WIRS_1	240	245	PF05994	0.387
LIG_WRC_WIRS_1	71	76	PF05994	0.390
MOD_CDK_SPxxK_3	105	112	PF00069	0.166
MOD_CK1_1	133	139	PF00069	0.262
MOD_CK1_1	200	206	PF00069	0.252
MOD_CK1_1	70	76	PF00069	0.356
MOD_CK2_1	91	97	PF00069	0.347
MOD_CMANNOS	195	198	PF00535	0.197
MOD_GlcNHglycan	150	153	PF01048	0.455
MOD_GlcNHglycan	203	206	PF01048	0.461
MOD_GlcNHglycan	304	307	PF01048	0.491
MOD_GlcNHglycan	308	311	PF01048	0.498
MOD_GlcNHglycan	93	96	PF01048	0.459
MOD_GSK3_1	126	133	PF00069	0.258
MOD_GSK3_1	197	204	PF00069	0.317
MOD_GSK3_1	302	309	PF00069	0.625
MOD_N-GLC_1	105	110	PF02516	0.531
MOD_N-GLC_1	148	153	PF02516	0.511
MOD_NEK2_1	134	139	PF00069	0.245
MOD_NEK2_1	158	163	PF00069	0.315
MOD_NEK2_1	166	171	PF00069	0.314
MOD_NEK2_1	199	204	PF00069	0.263
MOD_NEK2_1	282	287	PF00069	0.283
MOD_NEK2_1	293	298	PF00069	0.291
MOD_NEK2_1	67	72	PF00069	0.319
MOD_PKA_2	130	136	PF00069	0.267
MOD_PKA_2	271	277	PF00069	0.244
MOD_Plk_1	134	140	PF00069	0.273
MOD_Plk_4	186	192	PF00069	0.318
MOD_Plk_4	214	220	PF00069	0.292
MOD_Plk_4	250	256	PF00069	0.282
MOD_Plk_4	282	288	PF00069	0.304
MOD_Plk_4	45	51	PF00069	0.286
MOD_Plk_4	67	73	PF00069	0.324
MOD_ProDKin_1	105	111	PF00069	0.368
MOD_ProDKin_1	304	310	PF00069	0.614
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.456
TRG_ENDOCYTIC_2	185	188	PF00928	0.305
TRG_ENDOCYTIC_2	222	225	PF00928	0.305
TRG_ENDOCYTIC_2	230	233	PF00928	0.451
TRG_ENDOCYTIC_2	286	289	PF00928	0.296
TRG_ENDOCYTIC_2	38	41	PF00928	0.293
TRG_ENDOCYTIC_2	78	81	PF00928	0.312
TRG_ENDOCYTIC_2	85	88	PF00928	0.261
TRG_ER_diArg_1	111	113	PF00400	0.166
TRG_ER_diArg_1	146	148	PF00400	0.166
TRG_ER_diArg_1	294	297	PF00400	0.423
TRG_ER_diLys_1	320	323	PF00400	0.631
TRG_NLS_MonoCore_2	300	305	PF00514	0.543
TRG_NLS_MonoExtC_3	299	304	PF00514	0.455
TRG_NLS_MonoExtN_4	297	304	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	38%	100%
A0A0N0P7D1	Leptomonas seymouri	48%	97%
A0A0N0P7D6	Leptomonas seymouri	29%	100%
A0A0N0P7R2	Leptomonas seymouri	45%	100%
A0A0N1HZJ8	Leptomonas seymouri	37%	100%
A0A0N1I9H5	Leptomonas seymouri	30%	100%
A0A0N1ILQ4	Leptomonas seymouri	35%	100%
A0A0N1IM10	Leptomonas seymouri	28%	100%
A0A0N1PDR8	Leptomonas seymouri	36%	100%
A0A0S4IS29	Bodo saltans	40%	100%
A0A0S4IVJ6	Bodo saltans	32%	100%
A0A0S4IVS6	Bodo saltans	39%	100%
A0A0S4IW98	Bodo saltans	42%	100%
A0A1X0NNK7	Trypanosomatidae	40%	100%
A0A1X0NNL0	Trypanosomatidae	36%	100%
A0A1X0NNM4	Trypanosomatidae	31%	100%
A0A1X0NNM5	Trypanosomatidae	48%	100%
A0A1X0NP89	Trypanosomatidae	41%	100%
A0A3Q8I8T7	Leishmania donovani	31%	82%
A0A3Q8I9T2	Leishmania donovani	28%	86%
A0A3Q8I9U9	Leishmania donovani	39%	99%
A0A3Q8I9X8	Leishmania donovani	51%	96%
A0A3Q8IC05	Leishmania donovani	36%	100%
A0A3Q8ID51	Leishmania donovani	27%	81%
A0A3Q8IIA9	Leishmania donovani	29%	100%
A0A3R7KG78	Trypanosoma rangeli	41%	100%
A0A3R7MJR2	Trypanosoma rangeli	35%	100%
A0A3R7NSQ3	Trypanosoma rangeli	34%	100%
A0A3S5H6R7	Leishmania donovani	29%	100%
A0A3S5H6R8	Leishmania donovani	32%	100%
A0A3S7WSY8	Leishmania donovani	30%	100%
A0A3S7WSZ1	Leishmania donovani	44%	100%
A0A3S7WT03	Leishmania donovani	47%	100%
A0A3S7WT16	Leishmania donovani	100%	100%
A0A422NNP1	Trypanosoma rangeli	47%	100%
A0A422NYI1	Trypanosoma rangeli	25%	100%
A0JNC4	Bos taurus	26%	100%
A1L3X0	Homo sapiens	27%	100%
A4H7M2	Leishmania braziliensis	28%	93%
A4H7M3	Leishmania braziliensis	30%	92%
A4H7M4	Leishmania braziliensis	30%	95%
A4H7M5	Leishmania braziliensis	32%	100%
A4H7M6	Leishmania braziliensis	43%	100%
A4H7M7	Leishmania braziliensis	78%	100%
A4H7M8	Leishmania braziliensis	29%	99%
A4H7M9	Leishmania braziliensis	32%	100%
A4H7N0	Leishmania braziliensis	36%	96%
A4HW07	Leishmania infantum	30%	96%
A4HW08	Leishmania infantum	29%	90%
A4HW09	Leishmania infantum	29%	90%
A4HW10	Leishmania infantum	32%	100%
A4HW12	Leishmania infantum	51%	100%
A4HW13	Leishmania infantum	39%	100%
A4HW15	Leishmania infantum	28%	86%
A4HW16	Leishmania infantum	27%	86%
A4HW17	Leishmania infantum	31%	82%
A4HW18	Leishmania infantum	36%	100%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D4ADY9	Rattus norvegicus	26%	100%
E8NHR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AGL0	Leishmania infantum	47%	100%
E9AGL2	Leishmania infantum	44%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	95%
G5EEE5	Caenorhabditis elegans	30%	100%
O35949	Mus musculus	32%	100%
P49191	Caenorhabditis elegans	35%	100%
Q03574	Caenorhabditis elegans	29%	100%
Q20300	Caenorhabditis elegans	29%	100%
Q4QFQ9	Leishmania major	36%	93%
Q4QFR0	Leishmania major	30%	100%
Q4QFR1	Leishmania major	27%	100%
Q4QFR2	Leishmania major	28%	100%
Q4QFR3	Leishmania major	94%	100%
Q4QFR4	Leishmania major	39%	100%
Q4QFR5	Leishmania major	52%	100%
Q4QFR6	Leishmania major	47%	100%
Q4QFR7	Leishmania major	32%	100%
Q4QFR8	Leishmania major	31%	93%
Q4QFR9	Leishmania major	29%	91%
Q4QFS0	Leishmania major	29%	96%
Q4QFS1	Leishmania major	24%	100%
Q5ZJR8	Gallus gallus	32%	100%
Q6PC64	Danio rerio	33%	100%
Q920L5	Mus musculus	30%	100%
Q920L6	Rattus norvegicus	30%	100%
Q9D2Y9	Mus musculus	26%	100%
Q9H5J4	Homo sapiens	30%	100%
Q9HB03	Homo sapiens	30%	100%
Q9VV87	Drosophila melanogaster	33%	100%
Q9XVQ9	Caenorhabditis elegans	29%	100%
V5BE99	Trypanosoma cruzi	41%	100%
V5BIX9	Trypanosoma cruzi	37%	100%
V5BND3	Trypanosoma cruzi	46%	100%
V5DF68	Trypanosoma cruzi	37%	100%