Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase - putative

Species:

Leishmania infantum

UniProt:

A4HW08_LEIIN

TriTrypDb:

LINF_140012100

Length:

285

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Annotations by Jardim et al.

Fatty acid metabolism, Elongation of fatty acids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 31
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	30
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HW08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW08

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	33
GO:0006629	lipid metabolic process	3	33
GO:0006631	fatty acid metabolic process	4	33
GO:0006633	fatty acid biosynthetic process	5	33
GO:0008152	metabolic process	1	33
GO:0008610	lipid biosynthetic process	4	33
GO:0009058	biosynthetic process	2	33
GO:0009987	cellular process	1	33
GO:0016053	organic acid biosynthetic process	4	33
GO:0019752	carboxylic acid metabolic process	5	33
GO:0032787	monocarboxylic acid metabolic process	6	33
GO:0043436	oxoacid metabolic process	4	33
GO:0044237	cellular metabolic process	2	33
GO:0044238	primary metabolic process	2	33
GO:0044249	cellular biosynthetic process	3	33
GO:0044255	cellular lipid metabolic process	3	33
GO:0044281	small molecule metabolic process	2	33
GO:0044283	small molecule biosynthetic process	3	33
GO:0046394	carboxylic acid biosynthetic process	5	33
GO:0071704	organic substance metabolic process	2	33
GO:0072330	monocarboxylic acid biosynthetic process	6	33
GO:1901576	organic substance biosynthetic process	3	33
GO:0000038	very long-chain fatty acid metabolic process	5	4
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0006643	membrane lipid metabolic process	4	4
GO:0006665	sphingolipid metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0019367	fatty acid elongation, saturated fatty acid	7	4
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	4
GO:0030148	sphingolipid biosynthetic process	5	4
GO:0030497	fatty acid elongation	6	4
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	4
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	4
GO:0042759	long-chain fatty acid biosynthetic process	6	3
GO:0042761	very long-chain fatty acid biosynthetic process	6	4
GO:0046467	membrane lipid biosynthetic process	4	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901566	organonitrogen compound biosynthetic process	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	33
GO:0004312	fatty acid synthase activity	5	33
GO:0009922	fatty acid elongase activity	6	33
GO:0016740	transferase activity	2	33
GO:0016746	acyltransferase activity	3	33
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	33
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	229	233	PF00082	0.528
CLV_PCSK_SKI1_1	279	283	PF00082	0.198
DEG_Nend_UBRbox_3	1	3	PF02207	0.358
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.523
DOC_MAPK_MEF2A_6	201	209	PF00069	0.458
DOC_MAPK_MEF2A_6	57	64	PF00069	0.495
DOC_PP1_RVXF_1	142	148	PF00149	0.545
DOC_PP2B_LxvP_1	50	53	PF13499	0.523
DOC_PP4_FxxP_1	40	43	PF00568	0.316
DOC_USP7_UBL2_3	44	48	PF12436	0.456
DOC_WW_Pin1_4	56	61	PF00397	0.418
LIG_14-3-3_CanoR_1	146	151	PF00244	0.467
LIG_AP2alpha_1	132	136	PF02296	0.395
LIG_APCC_ABBA_1	264	269	PF00400	0.380
LIG_EH1_1	178	186	PF00400	0.356
LIG_FHA_1	112	118	PF00498	0.215
LIG_FHA_1	133	139	PF00498	0.464
LIG_FHA_1	250	256	PF00498	0.342
LIG_FHA_1	259	265	PF00498	0.399
LIG_FHA_1	66	72	PF00498	0.506
LIG_FHA_1	82	88	PF00498	0.234
LIG_FHA_1	95	101	PF00498	0.265
LIG_LIR_Apic_2	37	43	PF02991	0.366
LIG_LIR_Gen_1	134	145	PF02991	0.491
LIG_LIR_Gen_1	154	164	PF02991	0.367
LIG_LIR_Gen_1	261	271	PF02991	0.290
LIG_LIR_Gen_1	47	56	PF02991	0.485
LIG_LIR_Nem_3	134	140	PF02991	0.461
LIG_LIR_Nem_3	154	160	PF02991	0.313
LIG_LIR_Nem_3	183	189	PF02991	0.325
LIG_LIR_Nem_3	193	199	PF02991	0.462
LIG_LIR_Nem_3	261	266	PF02991	0.283
LIG_LIR_Nem_3	47	52	PF02991	0.493
LIG_LIR_Nem_3	77	82	PF02991	0.302
LIG_Pex14_2	132	136	PF04695	0.395
LIG_Pex14_2	147	151	PF04695	0.372
LIG_Pex14_2	157	161	PF04695	0.341
LIG_Pex14_2	263	267	PF04695	0.294
LIG_SH2_GRB2like	49	52	PF00017	0.523
LIG_SH2_PTP2	159	162	PF00017	0.322
LIG_SH2_PTP2	30	33	PF00017	0.222
LIG_SH2_SRC	224	227	PF00017	0.373
LIG_SH2_STAP1	113	117	PF00017	0.249
LIG_SH2_STAP1	260	264	PF00017	0.266
LIG_SH2_STAT5	113	116	PF00017	0.277
LIG_SH2_STAT5	159	162	PF00017	0.304
LIG_SH2_STAT5	179	182	PF00017	0.346
LIG_SH2_STAT5	186	189	PF00017	0.313
LIG_SH2_STAT5	206	209	PF00017	0.425
LIG_SH2_STAT5	224	227	PF00017	0.284
LIG_SH2_STAT5	230	233	PF00017	0.273
LIG_SH2_STAT5	260	263	PF00017	0.327
LIG_SH2_STAT5	265	268	PF00017	0.309
LIG_SH2_STAT5	30	33	PF00017	0.298
LIG_SH2_STAT5	35	38	PF00017	0.308
LIG_SH2_STAT5	49	52	PF00017	0.418
LIG_SH3_1	57	63	PF00018	0.495
LIG_SH3_3	57	63	PF00018	0.454
LIG_SH3_3	84	90	PF00018	0.360
LIG_UBA3_1	123	128	PF00899	0.320
LIG_UBA3_1	91	96	PF00899	0.328
LIG_WRC_WIRS_1	104	109	PF05994	0.297
LIG_WRC_WIRS_1	35	40	PF05994	0.359
MOD_CK1_1	163	169	PF00069	0.218
MOD_CK1_1	246	252	PF00069	0.306
MOD_CMANNOS	69	72	PF00535	0.374
MOD_GlcNHglycan	221	224	PF01048	0.386
MOD_GlcNHglycan	245	248	PF01048	0.536
MOD_GlcNHglycan	76	79	PF01048	0.363
MOD_GSK3_1	163	170	PF00069	0.304
MOD_GSK3_1	241	248	PF00069	0.314
MOD_N-GLC_1	65	70	PF02516	0.310
MOD_NEK2_1	100	105	PF00069	0.257
MOD_NEK2_1	124	129	PF00069	0.319
MOD_NEK2_1	132	137	PF00069	0.330
MOD_NEK2_1	140	145	PF00069	0.458
MOD_NEK2_1	151	156	PF00069	0.137
MOD_NEK2_1	180	185	PF00069	0.301
MOD_NEK2_1	205	210	PF00069	0.497
MOD_NEK2_1	219	224	PF00069	0.275
MOD_NEK2_1	241	246	PF00069	0.250
MOD_NEK2_1	81	86	PF00069	0.306
MOD_Plk_1	65	71	PF00069	0.492
MOD_Plk_4	132	138	PF00069	0.308
MOD_Plk_4	146	152	PF00069	0.450
MOD_Plk_4	167	173	PF00069	0.289
MOD_Plk_4	180	186	PF00069	0.278
MOD_ProDKin_1	56	62	PF00069	0.418
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.434
TRG_ENDOCYTIC_2	159	162	PF00928	0.326
TRG_ENDOCYTIC_2	186	189	PF00928	0.332
TRG_ENDOCYTIC_2	206	209	PF00928	0.137
TRG_ENDOCYTIC_2	260	263	PF00928	0.280
TRG_ENDOCYTIC_2	30	33	PF00928	0.299
TRG_ENDOCYTIC_2	35	38	PF00928	0.298
TRG_ENDOCYTIC_2	49	52	PF00928	0.457
TRG_ER_diArg_1	276	279	PF00400	0.540
TRG_ER_diLys_1	282	285	PF00400	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	32%	95%
A0A0N0P7D1	Leptomonas seymouri	31%	85%
A0A0N0P7D6	Leptomonas seymouri	42%	99%
A0A0N0P7R2	Leptomonas seymouri	33%	93%
A0A0N1HZJ8	Leptomonas seymouri	27%	88%
A0A0N1I9H5	Leptomonas seymouri	51%	100%
A0A0N1IIZ8	Leptomonas seymouri	25%	93%
A0A0N1ILQ4	Leptomonas seymouri	37%	97%
A0A0N1IM10	Leptomonas seymouri	85%	100%
A0A0N1PDR8	Leptomonas seymouri	27%	100%
A0A0N1PFE8	Leptomonas seymouri	52%	100%
A0A0S4IS29	Bodo saltans	34%	100%
A0A0S4IVJ6	Bodo saltans	28%	90%
A0A0S4IVS6	Bodo saltans	34%	100%
A0A0S4IW98	Bodo saltans	33%	90%
A0A1X0NNK7	Trypanosomatidae	33%	100%
A0A1X0NNL0	Trypanosomatidae	38%	94%
A0A1X0NNM4	Trypanosomatidae	38%	100%
A0A1X0NNM5	Trypanosomatidae	28%	93%
A0A1X0NP89	Trypanosomatidae	26%	89%
A0A3Q8I8T7	Leishmania donovani	26%	73%
A0A3Q8I9T2	Leishmania donovani	29%	76%
A0A3Q8I9U9	Leishmania donovani	28%	87%
A0A3Q8I9X8	Leishmania donovani	32%	85%
A0A3Q8IC05	Leishmania donovani	33%	93%
A0A3Q8ID51	Leishmania donovani	30%	72%
A0A3Q8IIA9	Leishmania donovani	49%	100%
A0A3R7KG78	Trypanosoma rangeli	33%	100%
A0A3R7MJR2	Trypanosoma rangeli	40%	100%
A0A3R7NSQ3	Trypanosoma rangeli	38%	99%
A0A3S5H6R7	Leishmania donovani	100%	100%
A0A3S5H6R8	Leishmania donovani	36%	97%
A0A3S7WSY8	Leishmania donovani	53%	100%
A0A3S7WSZ1	Leishmania donovani	31%	95%
A0A3S7WT03	Leishmania donovani	30%	95%
A0A3S7WT05	Leishmania donovani	23%	93%
A0A3S7WT16	Leishmania donovani	29%	89%
A0A422NNP1	Trypanosoma rangeli	28%	95%
A4H7M1	Leishmania braziliensis	22%	100%
A4H7M2	Leishmania braziliensis	55%	100%
A4H7M3	Leishmania braziliensis	95%	100%
A4H7M4	Leishmania braziliensis	48%	100%
A4H7M5	Leishmania braziliensis	35%	100%
A4H7M6	Leishmania braziliensis	29%	100%
A4H7M7	Leishmania braziliensis	30%	100%
A4H7M8	Leishmania braziliensis	29%	75%
A4H7N0	Leishmania braziliensis	33%	100%
A4HW06	Leishmania infantum	23%	100%
A4HW07	Leishmania infantum	53%	99%
A4HW09	Leishmania infantum	49%	100%
A4HW10	Leishmania infantum	36%	97%
A4HW12	Leishmania infantum	33%	85%
A4HW13	Leishmania infantum	28%	87%
A4HW14	Leishmania infantum	29%	88%
A4HW15	Leishmania infantum	29%	76%
A4HW16	Leishmania infantum	31%	76%
A4HW17	Leishmania infantum	26%	73%
A4HW18	Leishmania infantum	33%	94%
B4QVX4	Drosophila simulans	26%	100%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	93%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AGL0	Leishmania infantum	29%	95%
E9AGL2	Leishmania infantum	31%	95%
E9APQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	99%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
G5EEE5	Caenorhabditis elegans	25%	99%
O35949	Mus musculus	29%	100%
P39540	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	92%
P40319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	83%
P49191	Caenorhabditis elegans	27%	89%
Q20300	Caenorhabditis elegans	30%	100%
Q20303	Caenorhabditis elegans	29%	100%
Q4QFQ9	Leishmania major	33%	100%
Q4QFR2	Leishmania major	31%	100%
Q4QFR3	Leishmania major	29%	100%
Q4QFR4	Leishmania major	27%	100%
Q4QFR5	Leishmania major	33%	100%
Q4QFR6	Leishmania major	29%	100%
Q4QFR7	Leishmania major	36%	100%
Q4QFR8	Leishmania major	49%	100%
Q4QFR9	Leishmania major	99%	100%
Q4QFS0	Leishmania major	54%	99%
Q4QFS1	Leishmania major	23%	100%
Q5ZJR8	Gallus gallus	31%	100%
Q6PC64	Danio rerio	35%	100%
Q920L5	Mus musculus	35%	100%
Q920L6	Rattus norvegicus	35%	100%
Q9H5J4	Homo sapiens	34%	100%
Q9HB03	Homo sapiens	30%	100%
Q9VH58	Drosophila melanogaster	26%	100%
Q9VV87	Drosophila melanogaster	30%	90%
Q9XVQ9	Caenorhabditis elegans	27%	100%
V5BE99	Trypanosoma cruzi	30%	99%
V5BIX9	Trypanosoma cruzi	40%	100%
V5BND3	Trypanosoma cruzi	28%	95%
V5DF68	Trypanosoma cruzi	39%	99%