LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase - putative
Species:
Leishmania infantum
UniProt:
A4HW07_LEIIN
TriTrypDb:
LINF_140012000
Length:
280

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 36
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 26
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 25
GO:0110165 cellular anatomical entity 1 26
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HW07
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW07

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 28
GO:0006629 lipid metabolic process 3 28
GO:0006631 fatty acid metabolic process 4 28
GO:0006633 fatty acid biosynthetic process 5 28
GO:0008152 metabolic process 1 28
GO:0008610 lipid biosynthetic process 4 28
GO:0009058 biosynthetic process 2 28
GO:0009987 cellular process 1 28
GO:0016053 organic acid biosynthetic process 4 28
GO:0019752 carboxylic acid metabolic process 5 28
GO:0032787 monocarboxylic acid metabolic process 6 28
GO:0043436 oxoacid metabolic process 4 28
GO:0044237 cellular metabolic process 2 28
GO:0044238 primary metabolic process 2 28
GO:0044249 cellular biosynthetic process 3 28
GO:0044255 cellular lipid metabolic process 3 28
GO:0044281 small molecule metabolic process 2 28
GO:0044283 small molecule biosynthetic process 3 28
GO:0046394 carboxylic acid biosynthetic process 5 28
GO:0071704 organic substance metabolic process 2 28
GO:0072330 monocarboxylic acid biosynthetic process 6 28
GO:1901576 organic substance biosynthetic process 3 28
GO:0000038 very long-chain fatty acid metabolic process 5 3
GO:0001676 long-chain fatty acid metabolic process 5 3
GO:0006643 membrane lipid metabolic process 4 3
GO:0006665 sphingolipid metabolic process 4 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0019367 fatty acid elongation, saturated fatty acid 7 3
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 3
GO:0030148 sphingolipid biosynthetic process 5 3
GO:0030497 fatty acid elongation 6 3
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 3
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 3
GO:0042759 long-chain fatty acid biosynthetic process 6 3
GO:0042761 very long-chain fatty acid biosynthetic process 6 3
GO:0046467 membrane lipid biosynthetic process 4 3
GO:1901564 organonitrogen compound metabolic process 3 3
GO:1901566 organonitrogen compound biosynthetic process 4 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 28
GO:0004312 fatty acid synthase activity 5 28
GO:0009922 fatty acid elongase activity 6 28
GO:0016740 transferase activity 2 28
GO:0016746 acyltransferase activity 3 28
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 28
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 28

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 264 266 PF00675 0.309
CLV_NRD_NRD_1 272 274 PF00675 0.505
CLV_PCSK_KEX2_1 272 274 PF00082 0.491
CLV_PCSK_KEX2_1 278 280 PF00082 0.543
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.554
CLV_PCSK_SKI1_1 191 195 PF00082 0.324
DEG_Nend_UBRbox_3 1 3 PF02207 0.360
DOC_AGCK_PIF_1 152 157 PF00069 0.405
DOC_CYCLIN_yCln2_LP_2 192 198 PF00134 0.542
DOC_MAPK_gen_1 190 200 PF00069 0.445
DOC_MAPK_MEF2A_6 194 202 PF00069 0.469
DOC_MAPK_MEF2A_6 240 247 PF00069 0.335
DOC_MAPK_RevD_3 260 273 PF00069 0.464
DOC_PP1_RVXF_1 107 113 PF00149 0.405
DOC_PP1_RVXF_1 135 141 PF00149 0.547
DOC_PP4_FxxP_1 40 43 PF00568 0.335
DOC_USP7_MATH_1 274 278 PF00917 0.696
DOC_USP7_UBL2_3 190 194 PF12436 0.481
DOC_WW_Pin1_4 272 277 PF00397 0.672
LIG_14-3-3_CanoR_1 265 270 PF00244 0.504
LIG_Actin_WH2_2 64 81 PF00022 0.462
LIG_APCC_ABBA_1 250 255 PF00400 0.372
LIG_BRCT_BRCA1_1 253 257 PF00533 0.298
LIG_BRCT_BRCA1_2 253 259 PF00533 0.379
LIG_EH1_1 171 179 PF00400 0.372
LIG_FHA_1 105 111 PF00498 0.225
LIG_FHA_1 126 132 PF00498 0.456
LIG_FHA_1 146 152 PF00498 0.276
LIG_FHA_1 239 245 PF00498 0.431
LIG_FHA_2 97 103 PF00498 0.238
LIG_HCF-1_HBM_1 9 12 PF13415 0.251
LIG_LIR_Gen_1 127 138 PF02991 0.496
LIG_LIR_Gen_1 142 152 PF02991 0.384
LIG_LIR_Gen_1 176 187 PF02991 0.316
LIG_LIR_Nem_3 142 147 PF02991 0.334
LIG_LIR_Nem_3 149 155 PF02991 0.310
LIG_LIR_Nem_3 176 182 PF02991 0.311
LIG_LIR_Nem_3 186 192 PF02991 0.454
LIG_LIR_Nem_3 70 75 PF02991 0.315
LIG_Pex14_1 3 7 PF04695 0.352
LIG_Pex14_2 140 144 PF04695 0.386
LIG_Pex14_2 253 257 PF04695 0.302
LIG_SH2_CRK 189 193 PF00017 0.421
LIG_SH2_PTP2 199 202 PF00017 0.347
LIG_SH2_PTP2 261 264 PF00017 0.550
LIG_SH2_STAP1 106 110 PF00017 0.260
LIG_SH2_STAT3 155 158 PF00017 0.326
LIG_SH2_STAT5 106 109 PF00017 0.272
LIG_SH2_STAT5 150 153 PF00017 0.331
LIG_SH2_STAT5 172 175 PF00017 0.342
LIG_SH2_STAT5 181 184 PF00017 0.298
LIG_SH2_STAT5 199 202 PF00017 0.374
LIG_SH2_STAT5 217 220 PF00017 0.235
LIG_SH2_STAT5 246 249 PF00017 0.320
LIG_SH2_STAT5 251 254 PF00017 0.302
LIG_SH2_STAT5 261 264 PF00017 0.430
LIG_SH2_STAT5 30 33 PF00017 0.315
LIG_SH2_STAT5 35 38 PF00017 0.306
LIG_SH3_3 268 274 PF00018 0.614
LIG_SH3_3 77 83 PF00018 0.344
LIG_TYR_ITAM 186 202 PF00017 0.354
LIG_UBA3_1 116 121 PF00899 0.313
LIG_UBA3_1 252 259 PF00899 0.338
LIG_UBA3_1 45 53 PF00899 0.513
LIG_WRC_WIRS_1 97 102 PF05994 0.306
MOD_CDC14_SPxK_1 275 278 PF00782 0.710
MOD_CDK_SPxK_1 272 278 PF00069 0.689
MOD_CDK_SPxxK_3 272 279 PF00069 0.740
MOD_CK1_1 232 238 PF00069 0.314
MOD_CK1_1 70 76 PF00069 0.223
MOD_CK2_1 96 102 PF00069 0.260
MOD_CMANNOS 62 65 PF00535 0.388
MOD_GlcNHglycan 133 136 PF01048 0.313
MOD_GlcNHglycan 214 217 PF01048 0.399
MOD_GlcNHglycan 231 234 PF01048 0.527
MOD_GlcNHglycan 236 239 PF01048 0.536
MOD_GSK3_1 234 241 PF00069 0.339
MOD_N-GLC_2 229 231 PF02516 0.354
MOD_NEK2_1 105 110 PF00069 0.222
MOD_NEK2_1 117 122 PF00069 0.319
MOD_NEK2_1 125 130 PF00069 0.460
MOD_NEK2_1 131 136 PF00069 0.451
MOD_NEK2_1 173 178 PF00069 0.317
MOD_NEK2_1 198 203 PF00069 0.506
MOD_NEK2_1 212 217 PF00069 0.294
MOD_NEK2_1 38 43 PF00069 0.319
MOD_NEK2_1 67 72 PF00069 0.307
MOD_NEK2_1 93 98 PF00069 0.241
MOD_PIKK_1 238 244 PF00454 0.386
MOD_PK_1 265 271 PF00069 0.508
MOD_PKA_1 265 271 PF00069 0.577
MOD_Plk_4 125 131 PF00069 0.462
MOD_Plk_4 139 145 PF00069 0.287
MOD_Plk_4 146 152 PF00069 0.273
MOD_Plk_4 159 165 PF00069 0.153
MOD_Plk_4 173 179 PF00069 0.242
MOD_Plk_4 67 73 PF00069 0.225
MOD_ProDKin_1 272 278 PF00069 0.674
TRG_DiLeu_BaLyEn_6 80 85 PF01217 0.439
TRG_ENDOCYTIC_2 179 182 PF00928 0.324
TRG_ENDOCYTIC_2 189 192 PF00928 0.451
TRG_ENDOCYTIC_2 199 202 PF00928 0.130
TRG_ENDOCYTIC_2 35 38 PF00928 0.303
TRG_ENDOCYTIC_2 75 78 PF00928 0.383
TRG_ER_diArg_1 271 273 PF00400 0.747
TRG_NES_CRM1_1 242 255 PF08389 0.438
TRG_Pf-PMV_PEXEL_1 86 91 PF00026 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 25% 95%
A0A0N0P5E5 Leptomonas seymouri 34% 94%
A0A0N0P7D1 Leptomonas seymouri 32% 84%
A0A0N0P7D6 Leptomonas seymouri 44% 97%
A0A0N0P7R2 Leptomonas seymouri 36% 92%
A0A0N1HZJ8 Leptomonas seymouri 28% 86%
A0A0N1I9H5 Leptomonas seymouri 73% 100%
A0A0N1IIZ8 Leptomonas seymouri 24% 91%
A0A0N1ILQ4 Leptomonas seymouri 39% 96%
A0A0N1IM10 Leptomonas seymouri 50% 98%
A0A0N1PDR8 Leptomonas seymouri 31% 100%
A0A0N1PFE8 Leptomonas seymouri 58% 100%
A0A0S4IS29 Bodo saltans 35% 100%
A0A0S4IVJ6 Bodo saltans 32% 88%
A0A0S4IVS6 Bodo saltans 31% 99%
A0A0S4IW98 Bodo saltans 34% 88%
A0A0S4J4C4 Bodo saltans 24% 100%
A0A0S4JH58 Bodo saltans 28% 93%
A0A1X0NNK7 Trypanosomatidae 33% 98%
A0A1X0NNL0 Trypanosomatidae 45% 93%
A0A1X0NNM4 Trypanosomatidae 40% 98%
A0A1X0NNM5 Trypanosomatidae 30% 91%
A0A1X0NP89 Trypanosomatidae 30% 88%
A0A3Q8I8T7 Leishmania donovani 27% 71%
A0A3Q8I9T2 Leishmania donovani 31% 75%
A0A3Q8I9U9 Leishmania donovani 31% 86%
A0A3Q8I9X8 Leishmania donovani 32% 84%
A0A3Q8IC05 Leishmania donovani 31% 92%
A0A3Q8ID51 Leishmania donovani 30% 71%
A0A3Q8IIA9 Leishmania donovani 60% 99%
A0A3R7KG78 Trypanosoma rangeli 29% 99%
A0A3R7MJR2 Trypanosoma rangeli 42% 100%
A0A3R7NSQ3 Trypanosoma rangeli 48% 97%
A0A3S5H6R7 Leishmania donovani 53% 98%
A0A3S5H6R8 Leishmania donovani 36% 95%
A0A3S7WSY8 Leishmania donovani 100% 100%
A0A3S7WSZ1 Leishmania donovani 34% 94%
A0A3S7WT03 Leishmania donovani 34% 94%
A0A3S7WT05 Leishmania donovani 25% 92%
A0A3S7WT16 Leishmania donovani 30% 87%
A0A422NNP1 Trypanosoma rangeli 30% 93%
A4H7M1 Leishmania braziliensis 22% 100%
A4H7M2 Leishmania braziliensis 83% 100%
A4H7M3 Leishmania braziliensis 55% 100%
A4H7M4 Leishmania braziliensis 59% 100%
A4H7M5 Leishmania braziliensis 36% 100%
A4H7M6 Leishmania braziliensis 32% 100%
A4H7M7 Leishmania braziliensis 30% 100%
A4H7M8 Leishmania braziliensis 32% 73%
A4H7M9 Leishmania braziliensis 28% 69%
A4H7N0 Leishmania braziliensis 35% 100%
A4HW06 Leishmania infantum 25% 92%
A4HW08 Leishmania infantum 53% 98%
A4HW09 Leishmania infantum 60% 99%
A4HW10 Leishmania infantum 36% 95%
A4HW12 Leishmania infantum 33% 84%
A4HW13 Leishmania infantum 31% 86%
A4HW14 Leishmania infantum 30% 87%
A4HW15 Leishmania infantum 31% 75%
A4HW16 Leishmania infantum 30% 75%
A4HW17 Leishmania infantum 28% 71%
A4HW18 Leishmania infantum 31% 92%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 93%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 92%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AGL0 Leishmania infantum 33% 94%
E9AGL2 Leishmania infantum 34% 94%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
G5EEE5 Caenorhabditis elegans 26% 97%
O35949 Mus musculus 31% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 90%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 81%
P49191 Caenorhabditis elegans 30% 88%
Q03574 Caenorhabditis elegans 30% 96%
Q20300 Caenorhabditis elegans 30% 100%
Q20303 Caenorhabditis elegans 31% 100%
Q32NI8 Xenopus laevis 26% 95%
Q4QFQ9 Leishmania major 31% 100%
Q4QFR0 Leishmania major 28% 100%
Q4QFR2 Leishmania major 32% 75%
Q4QFR3 Leishmania major 30% 100%
Q4QFR4 Leishmania major 30% 100%
Q4QFR5 Leishmania major 33% 100%
Q4QFR6 Leishmania major 35% 100%
Q4QFR7 Leishmania major 36% 100%
Q4QFR8 Leishmania major 57% 99%
Q4QFR9 Leishmania major 53% 100%
Q4QFS0 Leishmania major 95% 100%
Q4QFS1 Leishmania major 23% 100%
Q4R516 Macaca fascicularis 27% 94%
Q5RFL5 Pongo abelii 27% 94%
Q5ZJR8 Gallus gallus 33% 100%
Q6PC64 Danio rerio 32% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 77%
Q86JM5 Dictyostelium discoideum 26% 95%
Q8BHI7 Mus musculus 28% 94%
Q920L5 Mus musculus 34% 100%
Q920L6 Rattus norvegicus 37% 100%
Q920L7 Rattus norvegicus 28% 94%
Q9H5J4 Homo sapiens 33% 100%
Q9HB03 Homo sapiens 30% 100%
Q9NYP7 Homo sapiens 27% 94%
Q9VV87 Drosophila melanogaster 30% 89%
Q9XVQ9 Caenorhabditis elegans 29% 100%
V5BE99 Trypanosoma cruzi 31% 98%
V5BIX9 Trypanosoma cruzi 41% 100%
V5BND3 Trypanosoma cruzi 31% 93%
V5DF68 Trypanosoma cruzi 47% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS