Elongation of fatty acids protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase - putative

Species:

Leishmania infantum

UniProt:

A4HW06_LEIIN

TriTrypDb:

LINF_140011900

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 54

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 47
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	42
GO:0110165	cellular anatomical entity	1	43
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HW06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW06

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	48
GO:0006629	lipid metabolic process	3	48
GO:0006631	fatty acid metabolic process	4	48
GO:0006633	fatty acid biosynthetic process	5	48
GO:0008152	metabolic process	1	48
GO:0008610	lipid biosynthetic process	4	48
GO:0009058	biosynthetic process	2	48
GO:0009987	cellular process	1	48
GO:0016053	organic acid biosynthetic process	4	48
GO:0019752	carboxylic acid metabolic process	5	48
GO:0032787	monocarboxylic acid metabolic process	6	48
GO:0043436	oxoacid metabolic process	4	48
GO:0044237	cellular metabolic process	2	48
GO:0044238	primary metabolic process	2	48
GO:0044249	cellular biosynthetic process	3	48
GO:0044255	cellular lipid metabolic process	3	48
GO:0044281	small molecule metabolic process	2	48
GO:0044283	small molecule biosynthetic process	3	48
GO:0046394	carboxylic acid biosynthetic process	5	48
GO:0071704	organic substance metabolic process	2	48
GO:0072330	monocarboxylic acid biosynthetic process	6	48
GO:1901576	organic substance biosynthetic process	3	48
GO:0000038	very long-chain fatty acid metabolic process	5	6
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0006643	membrane lipid metabolic process	4	6
GO:0006665	sphingolipid metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0019367	fatty acid elongation, saturated fatty acid	7	6
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	6
GO:0030148	sphingolipid biosynthetic process	5	6
GO:0030497	fatty acid elongation	6	6
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	6
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	6
GO:0042759	long-chain fatty acid biosynthetic process	6	3
GO:0042761	very long-chain fatty acid biosynthetic process	6	6
GO:0046467	membrane lipid biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	48
GO:0004312	fatty acid synthase activity	5	48
GO:0009922	fatty acid elongase activity	6	48
GO:0016740	transferase activity	2	48
GO:0016746	acyltransferase activity	3	48
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	48
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.371
CLV_NRD_NRD_1	50	52	PF00675	0.286
CLV_PCSK_KEX2_1	167	169	PF00082	0.377
CLV_PCSK_KEX2_1	50	52	PF00082	0.277
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.189
CLV_PCSK_SKI1_1	209	213	PF00082	0.424
CLV_PCSK_SKI1_1	233	237	PF00082	0.358
CLV_PCSK_SKI1_1	272	276	PF00082	0.419
DOC_MAPK_gen_1	122	130	PF00069	0.317
DOC_MAPK_gen_1	230	238	PF00069	0.409
DOC_MAPK_MEF2A_6	233	240	PF00069	0.482
DOC_MAPK_NFAT4_5	233	241	PF00069	0.385
DOC_PP1_RVXF_1	41	48	PF00149	0.539
DOC_USP7_MATH_1	298	302	PF00917	0.756
DOC_USP7_MATH_1	72	76	PF00917	0.543
DOC_USP7_MATH_1	92	96	PF00917	0.161
DOC_WW_Pin1_4	155	160	PF00397	0.514
LIG_14-3-3_CanoR_1	262	268	PF00244	0.373
LIG_14-3-3_CanoR_1	43	48	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BIR_III_4	57	61	PF00653	0.374
LIG_FHA_1	112	118	PF00498	0.299
LIG_FHA_1	144	150	PF00498	0.485
LIG_FHA_1	185	191	PF00498	0.308
LIG_FHA_1	200	206	PF00498	0.333
LIG_FHA_1	278	284	PF00498	0.443
LIG_FHA_1	80	86	PF00498	0.370
LIG_GBD_Chelix_1	85	93	PF00786	0.194
LIG_LIR_Gen_1	110	117	PF02991	0.346
LIG_LIR_Gen_1	145	156	PF02991	0.484
LIG_LIR_Gen_1	192	203	PF02991	0.290
LIG_LIR_Gen_1	32	38	PF02991	0.265
LIG_LIR_Gen_1	81	90	PF02991	0.275
LIG_LIR_Gen_1	95	103	PF02991	0.203
LIG_LIR_LC3C_4	82	87	PF02991	0.185
LIG_LIR_Nem_3	10	14	PF02991	0.221
LIG_LIR_Nem_3	145	151	PF02991	0.487
LIG_LIR_Nem_3	172	178	PF02991	0.374
LIG_LIR_Nem_3	192	198	PF02991	0.349
LIG_LIR_Nem_3	250	255	PF02991	0.330
LIG_LIR_Nem_3	81	86	PF02991	0.329
LIG_LIR_Nem_3	95	99	PF02991	0.329
LIG_PALB2_WD40_1	171	179	PF16756	0.419
LIG_PTB_Apo_2	106	113	PF02174	0.345
LIG_SH2_CRK	83	87	PF00017	0.362
LIG_SH2_GRB2like	255	258	PF00017	0.332
LIG_SH2_NCK_1	77	81	PF00017	0.398
LIG_SH2_STAP1	252	256	PF00017	0.389
LIG_SH2_STAT3	14	17	PF00017	0.382
LIG_SH2_STAT3	213	216	PF00017	0.419
LIG_SH2_STAT5	127	130	PF00017	0.334
LIG_SH2_STAT5	154	157	PF00017	0.538
LIG_SH2_STAT5	183	186	PF00017	0.337
LIG_SH2_STAT5	19	22	PF00017	0.288
LIG_SH2_STAT5	258	261	PF00017	0.301
LIG_SH2_STAT5	278	281	PF00017	0.338
LIG_SH2_STAT5	29	32	PF00017	0.322
LIG_SH2_STAT5	34	37	PF00017	0.313
LIG_SH2_STAT5	7	10	PF00017	0.348
LIG_SH2_STAT5	77	80	PF00017	0.503
LIG_SH3_3	153	159	PF00018	0.513
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.223
LIG_SUMO_SIM_par_1	234	239	PF11976	0.561
LIG_TRAF2_1	159	162	PF00917	0.532
LIG_TRFH_1	96	100	PF08558	0.179
LIG_WRC_WIRS_1	144	149	PF05994	0.516
LIG_WRC_WIRS_1	198	203	PF05994	0.185
LIG_WRC_WIRS_1	93	98	PF05994	0.246
MOD_CK1_1	189	195	PF00069	0.271
MOD_CK1_1	247	253	PF00069	0.348
MOD_CK1_1	3	9	PF00069	0.393
MOD_CK1_1	66	72	PF00069	0.498
MOD_CK1_1	75	81	PF00069	0.483
MOD_GlcNHglycan	132	135	PF01048	0.443
MOD_GlcNHglycan	205	208	PF01048	0.295
MOD_GlcNHglycan	246	249	PF01048	0.408
MOD_GSK3_1	107	114	PF00069	0.307
MOD_GSK3_1	186	193	PF00069	0.365
MOD_GSK3_1	199	206	PF00069	0.416
MOD_GSK3_1	222	229	PF00069	0.388
MOD_GSK3_1	247	254	PF00069	0.311
MOD_GSK3_1	3	10	PF00069	0.262
MOD_GSK3_1	75	82	PF00069	0.493
MOD_N-GLC_1	256	261	PF02516	0.528
MOD_NEK2_1	102	107	PF00069	0.323
MOD_NEK2_1	111	116	PF00069	0.286
MOD_NEK2_1	130	135	PF00069	0.318
MOD_NEK2_1	184	189	PF00069	0.304
MOD_NEK2_1	197	202	PF00069	0.331
MOD_NEK2_1	203	208	PF00069	0.344
MOD_NEK2_1	277	282	PF00069	0.311
MOD_NEK2_2	29	34	PF00069	0.419
MOD_NEK2_2	72	77	PF00069	0.517
MOD_PKA_2	169	175	PF00069	0.540
MOD_PKA_2	298	304	PF00069	0.755
MOD_Plk_4	102	108	PF00069	0.278
MOD_Plk_4	143	149	PF00069	0.472
MOD_Plk_4	247	253	PF00069	0.272
MOD_Plk_4	29	35	PF00069	0.329
MOD_Plk_4	3	9	PF00069	0.234
MOD_Plk_4	43	49	PF00069	0.481
MOD_Plk_4	92	98	PF00069	0.315
MOD_ProDKin_1	155	161	PF00069	0.514
MOD_SUMO_rev_2	158	166	PF00179	0.389
TRG_ENDOCYTIC_2	127	130	PF00928	0.309
TRG_ENDOCYTIC_2	34	37	PF00928	0.332
TRG_ENDOCYTIC_2	83	86	PF00928	0.364
TRG_ER_diArg_1	166	168	PF00400	0.552
TRG_ER_diLys_1	302	305	PF00400	0.730
TRG_NLS_MonoExtC_3	49	54	PF00514	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9H5	Leptomonas seymouri	24%	100%
A0A0N1IIZ8	Leptomonas seymouri	67%	99%
A0A0N1ILQ4	Leptomonas seymouri	24%	100%
A0A0N1IM10	Leptomonas seymouri	23%	100%
A0A0S4IS29	Bodo saltans	21%	100%
A0A0S4IVS6	Bodo saltans	23%	100%
A0A0S4IW98	Bodo saltans	24%	96%
A0A1X0NNL0	Trypanosomatidae	24%	100%
A0A1X0NNM4	Trypanosomatidae	25%	100%
A0A3Q8I9U9	Leishmania donovani	22%	94%
A0A3Q8IIA9	Leishmania donovani	23%	100%
A0A3R7KG78	Trypanosoma rangeli	25%	100%
A0A3R7MJR2	Trypanosoma rangeli	26%	100%
A0A3R7NSQ3	Trypanosoma rangeli	24%	100%
A0A3S5H6R7	Leishmania donovani	23%	100%
A0A3S5H6R8	Leishmania donovani	26%	100%
A0A3S7WSY8	Leishmania donovani	25%	100%
A0A3S7WSZ1	Leishmania donovani	24%	100%
A0A3S7WT05	Leishmania donovani	100%	100%
A0A422NNP1	Trypanosoma rangeli	25%	100%
A4H7M1	Leishmania braziliensis	80%	100%
A4H7M2	Leishmania braziliensis	24%	98%
A4H7M3	Leishmania braziliensis	22%	99%
A4H7M4	Leishmania braziliensis	22%	100%
A4H7M5	Leishmania braziliensis	24%	100%
A4HW07	Leishmania infantum	25%	100%
A4HW08	Leishmania infantum	23%	100%
A4HW09	Leishmania infantum	23%	100%
A4HW10	Leishmania infantum	25%	100%
A4HW13	Leishmania infantum	21%	94%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9APQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	99%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4QFR4	Leishmania major	21%	100%
Q4QFR7	Leishmania major	25%	100%
Q4QFR8	Leishmania major	25%	100%
Q4QFR9	Leishmania major	23%	99%
Q4QFS0	Leishmania major	25%	100%
Q4QFS1	Leishmania major	94%	100%
V5BE99	Trypanosoma cruzi	23%	100%
V5BIX9	Trypanosoma cruzi	25%	100%
V5DF68	Trypanosoma cruzi	25%	100%