Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LSD1 zinc finger containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HW05_LEIIN

TriTrypDb:

LINF_140011800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HW05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.621
CLV_NRD_NRD_1	121	123	PF00675	0.800
CLV_NRD_NRD_1	133	135	PF00675	0.602
CLV_NRD_NRD_1	141	143	PF00675	0.672
CLV_NRD_NRD_1	182	184	PF00675	0.628
CLV_NRD_NRD_1	205	207	PF00675	0.569
CLV_PCSK_KEX2_1	121	123	PF00082	0.800
CLV_PCSK_KEX2_1	132	134	PF00082	0.616
CLV_PCSK_KEX2_1	140	142	PF00082	0.659
CLV_PCSK_KEX2_1	181	183	PF00082	0.633
CLV_PCSK_KEX2_1	205	207	PF00082	0.577
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.563
CLV_PCSK_PC7_1	128	134	PF00082	0.649
CLV_PCSK_SKI1_1	13	17	PF00082	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	73	76	PF00134	0.507
DOC_MAPK_MEF2A_6	214	221	PF00069	0.677
DOC_PP2B_LxvP_1	49	52	PF13499	0.397
DOC_PP2B_LxvP_1	73	76	PF13499	0.507
DOC_USP7_MATH_1	194	198	PF00917	0.699
DOC_USP7_MATH_1	76	80	PF00917	0.557
DOC_WW_Pin1_4	187	192	PF00397	0.574
LIG_14-3-3_CanoR_1	13	18	PF00244	0.335
LIG_14-3-3_CanoR_1	133	139	PF00244	0.706
LIG_14-3-3_CanoR_1	41	49	PF00244	0.389
LIG_BIR_III_4	165	169	PF00653	0.650
LIG_BRCT_BRCA1_1	134	138	PF00533	0.655
LIG_EVH1_1	74	78	PF00568	0.524
LIG_FHA_1	14	20	PF00498	0.453
LIG_FHA_1	216	222	PF00498	0.540
LIG_FHA_1	53	59	PF00498	0.530
LIG_FHA_1	87	93	PF00498	0.542
LIG_FHA_2	158	164	PF00498	0.643
LIG_FHA_2	63	69	PF00498	0.423
LIG_MYND_1	98	102	PF01753	0.784
LIG_SH2_STAT3	9	12	PF00017	0.335
LIG_SH2_STAT5	195	198	PF00017	0.684
LIG_SH2_STAT5	94	97	PF00017	0.608
LIG_SH3_2	98	103	PF14604	0.657
LIG_SH3_3	185	191	PF00018	0.674
LIG_SH3_3	72	78	PF00018	0.532
LIG_SH3_3	92	98	PF00018	0.589
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.516
LIG_SUMO_SIM_par_1	217	223	PF11976	0.530
LIG_TRAF2_1	144	147	PF00917	0.652
LIG_WW_2	75	78	PF00397	0.539
LIG_WW_3	100	104	PF00397	0.709
MOD_CK1_1	198	204	PF00069	0.755
MOD_CK1_1	96	102	PF00069	0.614
MOD_CK2_1	141	147	PF00069	0.749
MOD_Cter_Amidation	130	133	PF01082	0.646
MOD_Cter_Amidation	179	182	PF01082	0.593
MOD_GlcNHglycan	134	137	PF01048	0.679
MOD_GlcNHglycan	176	179	PF01048	0.588
MOD_GlcNHglycan	197	200	PF01048	0.774
MOD_GSK3_1	113	120	PF00069	0.760
MOD_GSK3_1	194	201	PF00069	0.769
MOD_NEK2_1	117	122	PF00069	0.740
MOD_NEK2_1	220	225	PF00069	0.526
MOD_NEK2_2	20	25	PF00069	0.335
MOD_PKA_1	121	127	PF00069	0.741
MOD_PKA_1	132	138	PF00069	0.582
MOD_PKA_1	141	147	PF00069	0.627
MOD_PKA_1	182	188	PF00069	0.628
MOD_PKA_2	121	127	PF00069	0.702
MOD_PKA_2	132	138	PF00069	0.554
MOD_PKA_2	141	147	PF00069	0.655
MOD_PKA_2	182	188	PF00069	0.656
MOD_PKA_2	40	46	PF00069	0.406
MOD_PKB_1	132	140	PF00069	0.702
MOD_Plk_1	157	163	PF00069	0.653
MOD_Plk_4	157	163	PF00069	0.653
MOD_Plk_4	215	221	PF00069	0.563
MOD_ProDKin_1	187	193	PF00069	0.576
TRG_ER_diArg_1	102	105	PF00400	0.663
TRG_ER_diArg_1	121	123	PF00400	0.540
TRG_ER_diArg_1	132	134	PF00400	0.607
TRG_ER_diArg_1	140	142	PF00400	0.688
TRG_ER_diArg_1	25	28	PF00400	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B1	Leptomonas seymouri	46%	100%
A0A3Q8IBZ4	Leishmania donovani	99%	100%
A4H7M0	Leishmania braziliensis	68%	99%
E9APQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFS2	Leishmania major	90%	100%