RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW04_LEIIN

TriTrypDb:

LINF_140011700

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.635
CLV_C14_Caspase3-7	221	225	PF00656	0.638
CLV_C14_Caspase3-7	430	434	PF00656	0.585
CLV_C14_Caspase3-7	444	448	PF00656	0.439
CLV_NRD_NRD_1	313	315	PF00675	0.663
CLV_NRD_NRD_1	320	322	PF00675	0.532
CLV_NRD_NRD_1	369	371	PF00675	0.667
CLV_NRD_NRD_1	379	381	PF00675	0.602
CLV_NRD_NRD_1	440	442	PF00675	0.589
CLV_NRD_NRD_1	467	469	PF00675	0.659
CLV_NRD_NRD_1	484	486	PF00675	0.599
CLV_NRD_NRD_1	578	580	PF00675	0.618
CLV_NRD_NRD_1	585	587	PF00675	0.547
CLV_NRD_NRD_1	588	590	PF00675	0.537
CLV_NRD_NRD_1	84	86	PF00675	0.515
CLV_PCSK_FUR_1	438	442	PF00082	0.592
CLV_PCSK_FUR_1	482	486	PF00082	0.711
CLV_PCSK_FUR_1	586	590	PF00082	0.530
CLV_PCSK_KEX2_1	239	241	PF00082	0.475
CLV_PCSK_KEX2_1	313	315	PF00082	0.663
CLV_PCSK_KEX2_1	325	327	PF00082	0.452
CLV_PCSK_KEX2_1	369	371	PF00082	0.667
CLV_PCSK_KEX2_1	379	381	PF00082	0.602
CLV_PCSK_KEX2_1	440	442	PF00082	0.589
CLV_PCSK_KEX2_1	456	458	PF00082	0.435
CLV_PCSK_KEX2_1	467	469	PF00082	0.528
CLV_PCSK_KEX2_1	484	486	PF00082	0.599
CLV_PCSK_KEX2_1	548	550	PF00082	0.613
CLV_PCSK_KEX2_1	578	580	PF00082	0.618
CLV_PCSK_KEX2_1	585	587	PF00082	0.547
CLV_PCSK_KEX2_1	588	590	PF00082	0.537
CLV_PCSK_KEX2_1	84	86	PF00082	0.515
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.475
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.561
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.625
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.613
CLV_PCSK_PC7_1	321	327	PF00082	0.558
CLV_PCSK_PC7_1	365	371	PF00082	0.661
CLV_PCSK_SKI1_1	117	121	PF00082	0.477
CLV_PCSK_SKI1_1	239	243	PF00082	0.485
CLV_PCSK_SKI1_1	281	285	PF00082	0.688
CLV_PCSK_SKI1_1	313	317	PF00082	0.578
CLV_PCSK_SKI1_1	322	326	PF00082	0.501
CLV_PCSK_SKI1_1	468	472	PF00082	0.692
CLV_PCSK_SKI1_1	548	552	PF00082	0.626
CLV_PCSK_SKI1_1	578	582	PF00082	0.611
CLV_PCSK_SKI1_1	84	88	PF00082	0.514
CLV_TASPASE1	136	142	PF01112	0.465
DEG_APCC_DBOX_1	116	124	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SCF_FBW7_1	550	555	PF00400	0.597
DEG_SPOP_SBC_1	251	255	PF00917	0.745
DOC_CKS1_1	98	103	PF01111	0.537
DOC_CYCLIN_RxL_1	307	320	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.578
DOC_MAPK_gen_1	346	354	PF00069	0.633
DOC_MAPK_gen_1	467	474	PF00069	0.601
DOC_MAPK_gen_1	84	91	PF00069	0.513
DOC_MAPK_MEF2A_6	346	354	PF00069	0.633
DOC_MAPK_MEF2A_6	467	476	PF00069	0.668
DOC_MAPK_MEF2A_6	84	93	PF00069	0.516
DOC_MAPK_NFAT4_5	84	92	PF00069	0.514
DOC_PP2B_LxvP_1	422	425	PF13499	0.693
DOC_PP2B_LxvP_1	470	473	PF13499	0.639
DOC_USP7_MATH_1	102	106	PF00917	0.564
DOC_USP7_MATH_1	188	192	PF00917	0.733
DOC_USP7_MATH_1	208	212	PF00917	0.496
DOC_USP7_MATH_1	251	255	PF00917	0.692
DOC_USP7_MATH_1	381	385	PF00917	0.691
DOC_USP7_MATH_1	580	584	PF00917	0.557
DOC_WW_Pin1_4	13	18	PF00397	0.534
DOC_WW_Pin1_4	160	165	PF00397	0.792
DOC_WW_Pin1_4	184	189	PF00397	0.721
DOC_WW_Pin1_4	255	260	PF00397	0.811
DOC_WW_Pin1_4	300	305	PF00397	0.656
DOC_WW_Pin1_4	34	39	PF00397	0.586
DOC_WW_Pin1_4	40	45	PF00397	0.554
DOC_WW_Pin1_4	409	414	PF00397	0.654
DOC_WW_Pin1_4	494	499	PF00397	0.698
DOC_WW_Pin1_4	530	535	PF00397	0.761
DOC_WW_Pin1_4	548	553	PF00397	0.450
DOC_WW_Pin1_4	91	96	PF00397	0.534
DOC_WW_Pin1_4	97	102	PF00397	0.542
LIG_14-3-3_CanoR_1	214	223	PF00244	0.688
LIG_14-3-3_CanoR_1	250	259	PF00244	0.722
LIG_14-3-3_CanoR_1	260	268	PF00244	0.695
LIG_14-3-3_CanoR_1	30	34	PF00244	0.577
LIG_14-3-3_CanoR_1	313	318	PF00244	0.508
LIG_14-3-3_CanoR_1	394	402	PF00244	0.756
LIG_14-3-3_CanoR_1	564	568	PF00244	0.600
LIG_14-3-3_CanoR_1	578	587	PF00244	0.502
LIG_BRCT_BRCA1_1	257	261	PF00533	0.763
LIG_BRCT_BRCA1_1	293	297	PF00533	0.670
LIG_CtBP_PxDLS_1	95	99	PF00389	0.541
LIG_deltaCOP1_diTrp_1	114	121	PF00928	0.473
LIG_FHA_1	156	162	PF00498	0.759
LIG_FHA_1	275	281	PF00498	0.662
LIG_FHA_1	397	403	PF00498	0.743
LIG_FHA_1	469	475	PF00498	0.636
LIG_FHA_1	579	585	PF00498	0.615
LIG_FHA_2	216	222	PF00498	0.756
LIG_FHA_2	428	434	PF00498	0.607
LIG_LIR_Gen_1	258	269	PF02991	0.784
LIG_LIR_Gen_1	553	563	PF02991	0.594
LIG_LIR_Gen_1	67	75	PF02991	0.513
LIG_LIR_Nem_3	114	119	PF02991	0.494
LIG_LIR_Nem_3	258	264	PF02991	0.768
LIG_LIR_Nem_3	538	544	PF02991	0.750
LIG_LIR_Nem_3	553	559	PF02991	0.463
LIG_LIR_Nem_3	67	71	PF02991	0.514
LIG_MYND_1	420	424	PF01753	0.693
LIG_SH2_NCK_1	461	465	PF00017	0.488
LIG_SH2_PTP2	68	71	PF00017	0.514
LIG_SH2_SRC	418	421	PF00017	0.705
LIG_SH2_SRC	461	464	PF00017	0.489
LIG_SH2_STAT5	122	125	PF00017	0.516
LIG_SH2_STAT5	268	271	PF00017	0.612
LIG_SH2_STAT5	418	421	PF00017	0.705
LIG_SH2_STAT5	68	71	PF00017	0.528
LIG_SH2_STAT5	88	91	PF00017	0.511
LIG_SH3_3	261	267	PF00018	0.774
LIG_SH3_3	35	41	PF00018	0.595
LIG_SH3_3	375	381	PF00018	0.634
LIG_SH3_3	422	428	PF00018	0.688
LIG_SH3_3	469	475	PF00018	0.660
LIG_SH3_3	508	514	PF00018	0.573
LIG_SH3_3	98	104	PF00018	0.575
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.514
LIG_SUMO_SIM_par_1	94	100	PF11976	0.539
LIG_TRFH_1	121	125	PF08558	0.499
LIG_TYR_ITIM	66	71	PF00017	0.515
LIG_TYR_ITIM	86	91	PF00017	0.510
LIG_WW_1	265	268	PF00397	0.589
MOD_CDC14_SPxK_1	497	500	PF00782	0.699
MOD_CDK_SPK_2	255	260	PF00069	0.711
MOD_CDK_SPK_2	530	535	PF00069	0.579
MOD_CDK_SPxK_1	494	500	PF00069	0.700
MOD_CDK_SPxxK_3	160	167	PF00069	0.644
MOD_CDK_SPxxK_3	300	307	PF00069	0.643
MOD_CK1_1	103	109	PF00069	0.549
MOD_CK1_1	15	21	PF00069	0.533
MOD_CK1_1	171	177	PF00069	0.699
MOD_CK1_1	191	197	PF00069	0.504
MOD_CK1_1	213	219	PF00069	0.713
MOD_CK1_1	252	258	PF00069	0.759
MOD_CK1_1	382	388	PF00069	0.761
MOD_CK1_1	390	396	PF00069	0.657
MOD_CK1_1	403	409	PF00069	0.599
MOD_CK1_1	42	48	PF00069	0.575
MOD_CK1_1	94	100	PF00069	0.566
MOD_Cter_Amidation	82	85	PF01082	0.514
MOD_GlcNHglycan	130	133	PF01048	0.621
MOD_GlcNHglycan	152	155	PF01048	0.559
MOD_GlcNHglycan	244	247	PF01048	0.631
MOD_GlcNHglycan	381	384	PF01048	0.659
MOD_GlcNHglycan	390	393	PF01048	0.588
MOD_GlcNHglycan	516	519	PF01048	0.645
MOD_GlcNHglycan	81	84	PF01048	0.513
MOD_GSK3_1	124	131	PF00069	0.564
MOD_GSK3_1	140	147	PF00069	0.563
MOD_GSK3_1	167	174	PF00069	0.736
MOD_GSK3_1	184	191	PF00069	0.555
MOD_GSK3_1	209	216	PF00069	0.686
MOD_GSK3_1	249	256	PF00069	0.803
MOD_GSK3_1	287	294	PF00069	0.758
MOD_GSK3_1	384	391	PF00069	0.715
MOD_GSK3_1	394	401	PF00069	0.638
MOD_GSK3_1	402	409	PF00069	0.569
MOD_GSK3_1	423	430	PF00069	0.626
MOD_GSK3_1	548	555	PF00069	0.614
MOD_GSK3_1	96	103	PF00069	0.562
MOD_N-GLC_1	274	279	PF02516	0.586
MOD_NEK2_1	112	117	PF00069	0.446
MOD_NEK2_1	128	133	PF00069	0.625
MOD_NEK2_1	140	145	PF00069	0.590
MOD_NEK2_1	209	214	PF00069	0.584
MOD_NEK2_1	242	247	PF00069	0.623
MOD_NEK2_1	293	298	PF00069	0.701
MOD_NEK2_1	404	409	PF00069	0.649
MOD_NEK2_1	478	483	PF00069	0.687
MOD_NEK2_1	89	94	PF00069	0.543
MOD_NEK2_1	96	101	PF00069	0.538
MOD_NEK2_2	580	585	PF00069	0.557
MOD_PIKK_1	155	161	PF00454	0.833
MOD_PIKK_1	259	265	PF00454	0.753
MOD_PIKK_1	423	429	PF00454	0.679
MOD_PKA_1	313	319	PF00069	0.509
MOD_PKA_1	379	385	PF00069	0.677
MOD_PKA_1	578	584	PF00069	0.615
MOD_PKA_2	213	219	PF00069	0.688
MOD_PKA_2	249	255	PF00069	0.701
MOD_PKA_2	259	265	PF00069	0.747
MOD_PKA_2	29	35	PF00069	0.572
MOD_PKA_2	313	319	PF00069	0.564
MOD_PKA_2	379	385	PF00069	0.690
MOD_PKA_2	387	393	PF00069	0.641
MOD_PKA_2	509	515	PF00069	0.642
MOD_PKA_2	563	569	PF00069	0.639
MOD_PKA_2	578	584	PF00069	0.436
MOD_PKB_1	248	256	PF00069	0.675
MOD_Plk_1	232	238	PF00069	0.579
MOD_Plk_1	274	280	PF00069	0.588
MOD_Plk_1	339	345	PF00069	0.652
MOD_Plk_1	468	474	PF00069	0.601
MOD_Plk_1	552	558	PF00069	0.609
MOD_Plk_4	140	146	PF00069	0.604
MOD_Plk_4	233	239	PF00069	0.501
MOD_Plk_4	275	281	PF00069	0.603
MOD_Plk_4	313	319	PF00069	0.509
MOD_Plk_4	354	360	PF00069	0.665
MOD_Plk_4	552	558	PF00069	0.651
MOD_Plk_4	563	569	PF00069	0.509
MOD_Plk_4	64	70	PF00069	0.531
MOD_ProDKin_1	100	106	PF00069	0.535
MOD_ProDKin_1	13	19	PF00069	0.535
MOD_ProDKin_1	160	166	PF00069	0.793
MOD_ProDKin_1	184	190	PF00069	0.722
MOD_ProDKin_1	255	261	PF00069	0.809
MOD_ProDKin_1	300	306	PF00069	0.648
MOD_ProDKin_1	34	40	PF00069	0.587
MOD_ProDKin_1	409	415	PF00069	0.655
MOD_ProDKin_1	494	500	PF00069	0.700
MOD_ProDKin_1	530	536	PF00069	0.762
MOD_ProDKin_1	548	554	PF00069	0.448
MOD_ProDKin_1	91	97	PF00069	0.537
MOD_SUMO_rev_2	320	327	PF00179	0.559
MOD_SUMO_rev_2	451	458	PF00179	0.616
MOD_SUMO_rev_2	543	550	PF00179	0.658
TRG_DiLeu_BaEn_4	229	235	PF01217	0.615
TRG_DiLeu_BaEn_4	362	368	PF01217	0.644
TRG_DiLeu_BaEn_4	453	459	PF01217	0.622
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.529
TRG_ENDOCYTIC_2	331	334	PF00928	0.579
TRG_ENDOCYTIC_2	68	71	PF00928	0.514
TRG_ENDOCYTIC_2	88	91	PF00928	0.511
TRG_ER_diArg_1	247	250	PF00400	0.665
TRG_ER_diArg_1	312	314	PF00400	0.665
TRG_ER_diArg_1	378	380	PF00400	0.756
TRG_ER_diArg_1	438	441	PF00400	0.596
TRG_ER_diArg_1	466	468	PF00400	0.659
TRG_ER_diArg_1	482	485	PF00400	0.593
TRG_ER_diArg_1	577	579	PF00400	0.612
TRG_ER_diArg_1	584	586	PF00400	0.543
TRG_ER_diArg_1	587	589	PF00400	0.532
TRG_ER_diArg_1	84	86	PF00400	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSY4	Leishmania donovani	99%	100%
A4H7L9	Leishmania braziliensis	59%	100%
E9APQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFS3	Leishmania major	75%	100%