Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW03_LEIIN

TriTrypDb:

LINF_140011600

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HW03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.663
CLV_C14_Caspase3-7	69	73	PF00656	0.583
CLV_NRD_NRD_1	225	227	PF00675	0.485
CLV_NRD_NRD_1	233	235	PF00675	0.474
CLV_NRD_NRD_1	350	352	PF00675	0.543
CLV_NRD_NRD_1	408	410	PF00675	0.688
CLV_NRD_NRD_1	426	428	PF00675	0.519
CLV_PCSK_KEX2_1	225	227	PF00082	0.485
CLV_PCSK_KEX2_1	233	235	PF00082	0.474
CLV_PCSK_KEX2_1	350	352	PF00082	0.543
CLV_PCSK_KEX2_1	408	410	PF00082	0.689
CLV_PCSK_KEX2_1	426	428	PF00082	0.522
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.650
CLV_PCSK_SKI1_1	120	124	PF00082	0.605
CLV_PCSK_SKI1_1	243	247	PF00082	0.407
CLV_PCSK_SKI1_1	333	337	PF00082	0.493
CLV_PCSK_SKI1_1	351	355	PF00082	0.538
CLV_PCSK_SKI1_1	358	362	PF00082	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DEG_SCF_FBW7_2	309	316	PF00400	0.577
DEG_SPOP_SBC_1	121	125	PF00917	0.629
DOC_CDC14_PxL_1	334	342	PF14671	0.563
DOC_CKS1_1	186	191	PF01111	0.494
DOC_CYCLIN_RxL_1	324	332	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.525
DOC_MAPK_gen_1	225	231	PF00069	0.509
DOC_MAPK_HePTP_8	330	342	PF00069	0.570
DOC_MAPK_MEF2A_6	333	342	PF00069	0.489
DOC_PP1_RVXF_1	267	273	PF00149	0.494
DOC_PP2B_LxvP_1	227	230	PF13499	0.412
DOC_PP2B_LxvP_1	335	338	PF13499	0.572
DOC_USP7_MATH_1	121	125	PF00917	0.622
DOC_USP7_MATH_1	402	406	PF00917	0.610
DOC_USP7_MATH_1	70	74	PF00917	0.741
DOC_USP7_MATH_2	277	283	PF00917	0.570
DOC_WW_Pin1_4	112	117	PF00397	0.629
DOC_WW_Pin1_4	128	133	PF00397	0.628
DOC_WW_Pin1_4	145	150	PF00397	0.653
DOC_WW_Pin1_4	185	190	PF00397	0.483
DOC_WW_Pin1_4	218	223	PF00397	0.479
DOC_WW_Pin1_4	238	243	PF00397	0.420
DOC_WW_Pin1_4	309	314	PF00397	0.583
DOC_WW_Pin1_4	426	431	PF00397	0.664
DOC_WW_Pin1_4	45	50	PF00397	0.581
LIG_14-3-3_CanoR_1	12	22	PF00244	0.624
LIG_14-3-3_CanoR_1	120	128	PF00244	0.623
LIG_14-3-3_CanoR_1	269	277	PF00244	0.452
LIG_APCC_ABBAyCdc20_2	166	172	PF00400	0.455
LIG_BRCT_BRCA1_1	219	223	PF00533	0.541
LIG_eIF4E_1	239	245	PF01652	0.474
LIG_FHA_1	233	239	PF00498	0.492
LIG_FHA_1	326	332	PF00498	0.501
LIG_FHA_1	430	436	PF00498	0.632
LIG_FHA_1	46	52	PF00498	0.642
LIG_FHA_1	76	82	PF00498	0.562
LIG_FHA_2	273	279	PF00498	0.480
LIG_FHA_2	310	316	PF00498	0.577
LIG_FHA_2	352	358	PF00498	0.542
LIG_FHA_2	86	92	PF00498	0.708
LIG_GBD_Chelix_1	251	259	PF00786	0.393
LIG_LIR_Gen_1	155	165	PF02991	0.439
LIG_LIR_Gen_1	94	103	PF02991	0.656
LIG_LIR_Nem_3	310	314	PF02991	0.646
LIG_RPA_C_Fungi	244	256	PF08784	0.409
LIG_SH2_CRK	239	243	PF00017	0.412
LIG_SH2_NCK_1	311	315	PF00017	0.583
LIG_SH2_SRC	254	257	PF00017	0.412
LIG_SH2_STAT3	52	55	PF00017	0.630
LIG_SH2_STAT5	254	257	PF00017	0.397
LIG_SH2_STAT5	271	274	PF00017	0.436
LIG_SH2_STAT5	311	314	PF00017	0.608
LIG_SH2_STAT5	334	337	PF00017	0.478
LIG_SH2_STAT5	457	460	PF00017	0.607
LIG_SH2_STAT5	58	61	PF00017	0.714
LIG_SH3_3	100	106	PF00018	0.622
LIG_SH3_3	146	152	PF00018	0.722
LIG_SH3_3	186	192	PF00018	0.480
LIG_SUMO_SIM_par_1	327	332	PF11976	0.501
LIG_TRAF2_1	115	118	PF00917	0.615
LIG_TRAF2_1	132	135	PF00917	0.571
LIG_TRAF2_1	313	316	PF00917	0.570
LIG_TYR_ITIM	309	314	PF00017	0.583
LIG_UBA3_1	340	346	PF00899	0.486
MOD_CDK_SPK_2	238	243	PF00069	0.420
MOD_CDK_SPxxK_3	218	225	PF00069	0.544
MOD_CDK_SPxxK_3	426	433	PF00069	0.635
MOD_CK1_1	136	142	PF00069	0.628
MOD_CK1_1	26	32	PF00069	0.645
MOD_CK1_1	390	396	PF00069	0.679
MOD_CK1_1	429	435	PF00069	0.657
MOD_CK1_1	436	442	PF00069	0.585
MOD_CK1_1	73	79	PF00069	0.691
MOD_CK2_1	112	118	PF00069	0.649
MOD_CK2_1	128	134	PF00069	0.675
MOD_CK2_1	272	278	PF00069	0.463
MOD_CK2_1	309	315	PF00069	0.585
MOD_CK2_1	351	357	PF00069	0.538
MOD_CK2_1	368	374	PF00069	0.603
MOD_Cter_Amidation	231	234	PF01082	0.484
MOD_GlcNHglycan	16	19	PF01048	0.619
MOD_GlcNHglycan	196	199	PF01048	0.823
MOD_GlcNHglycan	213	216	PF01048	0.686
MOD_GlcNHglycan	281	284	PF01048	0.711
MOD_GlcNHglycan	32	35	PF01048	0.609
MOD_GlcNHglycan	389	392	PF01048	0.614
MOD_GlcNHglycan	400	403	PF01048	0.629
MOD_GlcNHglycan	435	438	PF01048	0.546
MOD_GSK3_1	108	115	PF00069	0.692
MOD_GSK3_1	141	148	PF00069	0.757
MOD_GSK3_1	205	212	PF00069	0.688
MOD_GSK3_1	22	29	PF00069	0.593
MOD_GSK3_1	37	44	PF00069	0.646
MOD_GSK3_1	398	405	PF00069	0.641
MOD_GSK3_1	417	424	PF00069	0.541
MOD_GSK3_1	429	436	PF00069	0.515
MOD_GSK3_1	70	77	PF00069	0.691
MOD_NEK2_1	194	199	PF00069	0.729
MOD_NEK2_1	22	27	PF00069	0.489
MOD_NEK2_1	244	249	PF00069	0.380
MOD_NEK2_1	272	277	PF00069	0.523
MOD_NEK2_1	4	9	PF00069	0.602
MOD_NEK2_1	57	62	PF00069	0.698
MOD_NEK2_2	444	449	PF00069	0.611
MOD_PIKK_1	436	442	PF00454	0.603
MOD_PIKK_1	51	57	PF00454	0.661
MOD_PIKK_1	58	64	PF00454	0.647
MOD_PKA_1	64	70	PF00069	0.615
MOD_PKA_2	13	19	PF00069	0.586
MOD_PKA_2	136	142	PF00069	0.616
MOD_PKA_2	192	198	PF00069	0.606
MOD_PKA_2	22	28	PF00069	0.525
MOD_PKA_2	232	238	PF00069	0.594
MOD_PKA_2	416	422	PF00069	0.648
MOD_PKA_2	444	450	PF00069	0.605
MOD_PKB_1	12	20	PF00069	0.574
MOD_PKB_1	415	423	PF00069	0.623
MOD_Plk_1	108	114	PF00069	0.769
MOD_Plk_1	314	320	PF00069	0.543
MOD_Plk_2-3	368	374	PF00069	0.679
MOD_Plk_2-3	86	92	PF00069	0.649
MOD_ProDKin_1	112	118	PF00069	0.628
MOD_ProDKin_1	128	134	PF00069	0.626
MOD_ProDKin_1	145	151	PF00069	0.649
MOD_ProDKin_1	185	191	PF00069	0.492
MOD_ProDKin_1	218	224	PF00069	0.467
MOD_ProDKin_1	238	244	PF00069	0.412
MOD_ProDKin_1	309	315	PF00069	0.585
MOD_ProDKin_1	426	432	PF00069	0.636
MOD_ProDKin_1	45	51	PF00069	0.581
TRG_ENDOCYTIC_2	311	314	PF00928	0.579
TRG_ER_diArg_1	11	14	PF00400	0.681
TRG_ER_diArg_1	224	226	PF00400	0.585
TRG_ER_diArg_1	266	269	PF00400	0.444
TRG_ER_diArg_1	350	352	PF00400	0.543
TRG_ER_diArg_1	408	411	PF00400	0.690
TRG_ER_diArg_1	412	415	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF5	Leptomonas seymouri	47%	100%
A0A3Q8I8S7	Leishmania donovani	100%	100%
A4H7L8	Leishmania braziliensis	74%	99%
E9APQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFS4	Leishmania major	87%	100%