Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HW00_LEIIN

TriTrypDb:

LINF_140011300

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HW00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HW00

PDB structure(s): 7am2_CD

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.472
CLV_NRD_NRD_1	69	71	PF00675	0.391
CLV_NRD_NRD_1	88	90	PF00675	0.405
CLV_PCSK_KEX2_1	38	40	PF00082	0.449
CLV_PCSK_KEX2_1	69	71	PF00082	0.391
CLV_PCSK_KEX2_1	88	90	PF00082	0.495
CLV_PCSK_PC7_1	35	41	PF00082	0.412
CLV_PCSK_SKI1_1	69	73	PF00082	0.352
DOC_CYCLIN_RxL_1	66	74	PF00134	0.474
DOC_MAPK_gen_1	35	43	PF00069	0.494
DOC_MAPK_gen_1	88	97	PF00069	0.424
DOC_PP1_RVXF_1	105	112	PF00149	0.436
DOC_USP7_UBL2_3	73	77	PF12436	0.421
DOC_WW_Pin1_4	12	17	PF00397	0.487
DOC_WW_Pin1_4	3	8	PF00397	0.680
LIG_14-3-3_CanoR_1	100	109	PF00244	0.397
LIG_FHA_1	13	19	PF00498	0.616
LIG_FHA_1	76	82	PF00498	0.493
LIG_FHA_2	80	86	PF00498	0.495
LIG_LIR_Apic_2	50	56	PF02991	0.400
LIG_LIR_LC3C_4	78	81	PF02991	0.487
LIG_LIR_Nem_3	74	79	PF02991	0.440
LIG_SH2_CRK	68	72	PF00017	0.357
LIG_SH2_CRK	76	80	PF00017	0.494
LIG_SH2_NCK_1	33	37	PF00017	0.544
LIG_SH2_SRC	53	56	PF00017	0.424
LIG_SH2_STAP1	93	97	PF00017	0.403
LIG_SH2_STAT5	33	36	PF00017	0.546
LIG_SH2_STAT5	53	56	PF00017	0.422
LIG_SH3_1	53	59	PF00018	0.376
LIG_SH3_3	53	59	PF00018	0.417
LIG_SUMO_SIM_par_1	77	83	PF11976	0.488
LIG_WW_1	30	33	PF00397	0.573
MOD_CDC14_SPxK_1	6	9	PF00782	0.488
MOD_CDK_SPxK_1	3	9	PF00069	0.499
MOD_CK1_1	99	105	PF00069	0.533
MOD_GSK3_1	75	82	PF00069	0.427
MOD_GSK3_1	95	102	PF00069	0.400
MOD_NEK2_1	95	100	PF00069	0.367
MOD_PIKK_1	48	54	PF00454	0.546
MOD_PKA_2	99	105	PF00069	0.403
MOD_Plk_1	48	54	PF00069	0.427
MOD_Plk_4	75	81	PF00069	0.410
MOD_ProDKin_1	12	18	PF00069	0.481
MOD_ProDKin_1	3	9	PF00069	0.682
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.411
TRG_ENDOCYTIC_2	68	71	PF00928	0.346
TRG_ENDOCYTIC_2	76	79	PF00928	0.497
TRG_ER_diArg_1	38	40	PF00400	0.449
TRG_ER_diArg_1	68	70	PF00400	0.403
TRG_ER_diArg_1	87	89	PF00400	0.476
TRG_NLS_MonoExtC_3	88	94	PF00514	0.376
TRG_NLS_MonoExtN_4	88	93	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX7	Leptomonas seymouri	82%	100%
A0A0S4J267	Bodo saltans	56%	100%
A0A1X0NNN4	Trypanosomatidae	66%	100%
A0A3R7MRR7	Trypanosoma rangeli	65%	100%
A0A3S7WSX5	Leishmania donovani	99%	100%
A4H7L5	Leishmania braziliensis	92%	100%
C9ZT21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9APQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFS7	Leishmania major	98%	100%