Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVZ8_LEIIN

TriTrypDb:

LINF_140011000

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HVZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.766
CLV_NRD_NRD_1	226	228	PF00675	0.701
CLV_NRD_NRD_1	331	333	PF00675	0.445
CLV_NRD_NRD_1	41	43	PF00675	0.713
CLV_NRD_NRD_1	416	418	PF00675	0.520
CLV_NRD_NRD_1	422	424	PF00675	0.514
CLV_NRD_NRD_1	433	435	PF00675	0.509
CLV_PCSK_KEX2_1	226	228	PF00082	0.701
CLV_PCSK_KEX2_1	329	331	PF00082	0.437
CLV_PCSK_KEX2_1	41	43	PF00082	0.713
CLV_PCSK_KEX2_1	416	418	PF00082	0.511
CLV_PCSK_KEX2_1	422	424	PF00082	0.486
CLV_PCSK_KEX2_1	456	458	PF00082	0.598
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.532
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.626
CLV_PCSK_SKI1_1	126	130	PF00082	0.688
CLV_PCSK_SKI1_1	167	171	PF00082	0.634
CLV_PCSK_SKI1_1	299	303	PF00082	0.400
CLV_PCSK_SKI1_1	318	322	PF00082	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.646
DEG_SCF_FBW7_1	340	347	PF00400	0.676
DOC_CDC14_PxL_1	267	275	PF14671	0.418
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.480
DOC_MAPK_gen_1	223	231	PF00069	0.492
DOC_MAPK_MEF2A_6	51	58	PF00069	0.513
DOC_MAPK_MEF2A_6	9	18	PF00069	0.474
DOC_PP1_RVXF_1	165	172	PF00149	0.431
DOC_PP1_SILK_1	452	457	PF00149	0.824
DOC_PP2B_LxvP_1	108	111	PF13499	0.541
DOC_PP2B_LxvP_1	20	23	PF13499	0.567
DOC_PP2B_LxvP_1	272	275	PF13499	0.480
DOC_PP2B_PxIxI_1	53	59	PF00149	0.488
DOC_PP4_FxxP_1	476	479	PF00568	0.683
DOC_USP7_MATH_1	202	206	PF00917	0.497
DOC_USP7_MATH_1	344	348	PF00917	0.717
DOC_USP7_MATH_1	391	395	PF00917	0.768
DOC_USP7_MATH_1	63	67	PF00917	0.534
DOC_USP7_UBL2_3	299	303	PF12436	0.688
DOC_USP7_UBL2_3	321	325	PF12436	0.703
DOC_WW_Pin1_4	238	243	PF00397	0.400
DOC_WW_Pin1_4	255	260	PF00397	0.438
DOC_WW_Pin1_4	30	35	PF00397	0.424
DOC_WW_Pin1_4	340	345	PF00397	0.672
DOC_WW_Pin1_4	354	359	PF00397	0.687
DOC_WW_Pin1_4	367	372	PF00397	0.667
DOC_WW_Pin1_4	434	439	PF00397	0.826
DOC_WW_Pin1_4	469	474	PF00397	0.717
LIG_14-3-3_CanoR_1	150	156	PF00244	0.440
LIG_14-3-3_CanoR_1	332	340	PF00244	0.663
LIG_14-3-3_CanoR_1	362	371	PF00244	0.665
LIG_14-3-3_CanoR_1	434	438	PF00244	0.752
LIG_14-3-3_CanoR_1	457	464	PF00244	0.699
LIG_14-3-3_CanoR_1	483	487	PF00244	0.732
LIG_BIR_III_2	31	35	PF00653	0.420
LIG_BIR_III_4	217	221	PF00653	0.533
LIG_BRCT_BRCA1_1	121	125	PF00533	0.495
LIG_BRCT_BRCA1_1	65	69	PF00533	0.530
LIG_FHA_1	116	122	PF00498	0.472
LIG_FHA_1	15	21	PF00498	0.528
LIG_FHA_1	172	178	PF00498	0.443
LIG_FHA_1	211	217	PF00498	0.453
LIG_FHA_1	24	30	PF00498	0.627
LIG_FHA_2	231	237	PF00498	0.520
LIG_FHA_2	249	255	PF00498	0.330
LIG_FHA_2	443	449	PF00498	0.741
LIG_FHA_2	93	99	PF00498	0.487
LIG_GBD_Chelix_1	282	290	PF00786	0.445
LIG_IRF3_LxIS_1	282	289	PF10401	0.410
LIG_LIR_Apic_2	475	479	PF02991	0.684
LIG_LIR_Gen_1	258	267	PF02991	0.455
LIG_LIR_LC3C_4	279	284	PF02991	0.288
LIG_LIR_Nem_3	122	128	PF02991	0.523
LIG_LIR_Nem_3	225	231	PF02991	0.462
LIG_LIR_Nem_3	258	264	PF02991	0.454
LIG_MYND_1	271	275	PF01753	0.283
LIG_NRBOX	14	20	PF00104	0.674
LIG_NRBOX	286	292	PF00104	0.282
LIG_PCNA_yPIPBox_3	9	19	PF02747	0.450
LIG_PDZ_Class_2	483	488	PF00595	0.780
LIG_Pex14_1	115	119	PF04695	0.541
LIG_Pex14_2	180	184	PF04695	0.425
LIG_Pex14_2	69	73	PF04695	0.497
LIG_RPA_C_Fungi	411	423	PF08784	0.667
LIG_SH2_GRB2like	181	184	PF00017	0.517
LIG_SH2_GRB2like	192	195	PF00017	0.491
LIG_SH2_SRC	234	237	PF00017	0.627
LIG_SH2_STAP1	224	228	PF00017	0.613
LIG_SH2_STAT3	188	191	PF00017	0.472
LIG_SH2_STAT5	119	122	PF00017	0.571
LIG_SH2_STAT5	181	184	PF00017	0.517
LIG_SH2_STAT5	224	227	PF00017	0.601
LIG_SH2_STAT5	234	237	PF00017	0.543
LIG_SH2_STAT5	294	297	PF00017	0.464
LIG_SH2_STAT5	36	39	PF00017	0.508
LIG_SH3_3	1	7	PF00018	0.616
LIG_SH3_3	236	242	PF00018	0.564
LIG_SH3_3	443	449	PF00018	0.719
LIG_SH3_4	299	306	PF00018	0.616
LIG_Sin3_3	25	32	PF02671	0.539
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.437
LIG_SUMO_SIM_par_1	212	217	PF11976	0.467
LIG_SUMO_SIM_par_1	274	279	PF11976	0.393
LIG_SUMO_SIM_par_1	283	289	PF11976	0.298
LIG_SUMO_SIM_par_1	52	59	PF11976	0.647
LIG_UBA3_1	291	299	PF00899	0.602
LIG_WRPW_2	198	201	PF00400	0.564
MOD_CDK_SPK_2	340	345	PF00069	0.627
MOD_CDK_SPK_2	367	372	PF00069	0.663
MOD_CDK_SPxxK_3	238	245	PF00069	0.575
MOD_CK1_1	336	342	PF00069	0.624
MOD_CK1_1	365	371	PF00069	0.653
MOD_CK1_1	394	400	PF00069	0.766
MOD_CK1_1	430	436	PF00069	0.744
MOD_CK1_1	437	443	PF00069	0.642
MOD_CK1_1	460	466	PF00069	0.827
MOD_CK1_1	469	475	PF00069	0.592
MOD_CK2_1	230	236	PF00069	0.489
MOD_CK2_1	92	98	PF00069	0.654
MOD_DYRK1A_RPxSP_1	238	242	PF00069	0.565
MOD_GlcNHglycan	121	124	PF01048	0.619
MOD_GlcNHglycan	278	281	PF01048	0.393
MOD_GlcNHglycan	335	338	PF01048	0.605
MOD_GlcNHglycan	351	354	PF01048	0.470
MOD_GlcNHglycan	372	375	PF01048	0.686
MOD_GlcNHglycan	379	382	PF01048	0.732
MOD_GlcNHglycan	465	468	PF01048	0.802
MOD_GSK3_1	115	122	PF00069	0.622
MOD_GSK3_1	248	255	PF00069	0.554
MOD_GSK3_1	336	343	PF00069	0.597
MOD_GSK3_1	344	351	PF00069	0.611
MOD_GSK3_1	361	368	PF00069	0.541
MOD_GSK3_1	399	406	PF00069	0.772
MOD_GSK3_1	423	430	PF00069	0.771
MOD_GSK3_1	433	440	PF00069	0.635
MOD_GSK3_1	456	463	PF00069	0.822
MOD_LATS_1	421	427	PF00433	0.783
MOD_N-GLC_1	115	120	PF02516	0.610
MOD_N-GLC_1	182	187	PF02516	0.522
MOD_N-GLC_1	193	198	PF02516	0.496
MOD_N-GLC_1	210	215	PF02516	0.541
MOD_N-GLC_1	63	68	PF02516	0.682
MOD_NEK2_1	14	19	PF00069	0.555
MOD_NEK2_1	252	257	PF00069	0.655
MOD_NEK2_1	286	291	PF00069	0.410
MOD_NEK2_1	348	353	PF00069	0.562
MOD_NEK2_1	450	455	PF00069	0.654
MOD_NEK2_1	84	89	PF00069	0.678
MOD_PIKK_1	394	400	PF00454	0.801
MOD_PKA_1	422	428	PF00069	0.659
MOD_PKA_1	456	462	PF00069	0.709
MOD_PKA_2	222	228	PF00069	0.455
MOD_PKA_2	344	350	PF00069	0.739
MOD_PKA_2	361	367	PF00069	0.478
MOD_PKA_2	406	412	PF00069	0.817
MOD_PKA_2	422	428	PF00069	0.570
MOD_PKA_2	433	439	PF00069	0.621
MOD_PKA_2	456	462	PF00069	0.822
MOD_PKA_2	482	488	PF00069	0.599
MOD_Plk_1	115	121	PF00069	0.602
MOD_Plk_1	193	199	PF00069	0.555
MOD_Plk_1	210	216	PF00069	0.513
MOD_Plk_4	124	130	PF00069	0.637
MOD_Plk_4	14	20	PF00069	0.499
MOD_Plk_4	230	236	PF00069	0.503
MOD_Plk_4	248	254	PF00069	0.392
MOD_Plk_4	344	350	PF00069	0.668
MOD_Plk_4	406	412	PF00069	0.782
MOD_Plk_4	450	456	PF00069	0.780
MOD_Plk_4	65	71	PF00069	0.523
MOD_Plk_4	85	91	PF00069	0.354
MOD_ProDKin_1	238	244	PF00069	0.488
MOD_ProDKin_1	255	261	PF00069	0.543
MOD_ProDKin_1	30	36	PF00069	0.520
MOD_ProDKin_1	340	346	PF00069	0.588
MOD_ProDKin_1	354	360	PF00069	0.609
MOD_ProDKin_1	367	373	PF00069	0.579
MOD_ProDKin_1	434	440	PF00069	0.803
MOD_ProDKin_1	469	475	PF00069	0.646
MOD_SUMO_for_1	302	305	PF00179	0.613
MOD_SUMO_for_1	310	313	PF00179	0.527
MOD_SUMO_for_1	320	323	PF00179	0.426
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.516
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.612
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.501
TRG_ENDOCYTIC_2	181	184	PF00928	0.517
TRG_ENDOCYTIC_2	228	231	PF00928	0.642
TRG_ER_diArg_1	226	228	PF00400	0.628
TRG_ER_diArg_1	330	332	PF00400	0.546
TRG_ER_diArg_1	422	424	PF00400	0.695
TRG_NLS_MonoCore_2	328	333	PF00514	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W9	Leptomonas seymouri	35%	100%
A0A3S7WSX8	Leishmania donovani	99%	100%
A4H7L3	Leishmania braziliensis	71%	100%
E9APQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFS9	Leishmania major	87%	94%