Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVZ7_LEIIN

TriTrypDb:

LINF_140010900

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HVZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.411
CLV_C14_Caspase3-7	195	199	PF00656	0.415
CLV_MEL_PAP_1	156	162	PF00089	0.576
CLV_NRD_NRD_1	324	326	PF00675	0.402
CLV_PCSK_KEX2_1	324	326	PF00082	0.402
CLV_PCSK_SKI1_1	135	139	PF00082	0.715
CLV_PCSK_SKI1_1	205	209	PF00082	0.625
CLV_PCSK_SKI1_1	272	276	PF00082	0.475
CLV_PCSK_SKI1_1	50	54	PF00082	0.603
DEG_SPOP_SBC_1	259	263	PF00917	0.386
DEG_SPOP_SBC_1	28	32	PF00917	0.460
DOC_CYCLIN_RxL_1	201	212	PF00134	0.419
DOC_CYCLIN_RxL_1	304	318	PF00134	0.599
DOC_MAPK_gen_1	308	317	PF00069	0.596
DOC_MAPK_HePTP_8	307	319	PF00069	0.571
DOC_MAPK_HePTP_8	9	21	PF00069	0.483
DOC_MAPK_MEF2A_6	12	21	PF00069	0.540
DOC_MAPK_MEF2A_6	209	218	PF00069	0.386
DOC_MAPK_MEF2A_6	310	319	PF00069	0.593
DOC_PP2B_LxvP_1	35	38	PF13499	0.443
DOC_PP2B_PxIxI_1	304	310	PF00149	0.583
DOC_USP7_MATH_1	259	263	PF00917	0.386
DOC_USP7_MATH_1	28	32	PF00917	0.493
DOC_WW_Pin1_4	246	251	PF00397	0.440
DOC_WW_Pin1_4	29	34	PF00397	0.535
LIG_14-3-3_CanoR_1	12	17	PF00244	0.467
LIG_14-3-3_CanoR_1	166	170	PF00244	0.464
LIG_14-3-3_CanoR_1	209	214	PF00244	0.425
LIG_14-3-3_CanoR_1	243	252	PF00244	0.405
LIG_14-3-3_CanoR_1	324	332	PF00244	0.610
LIG_14-3-3_CanoR_1	56	62	PF00244	0.375
LIG_Actin_WH2_2	153	168	PF00022	0.402
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BIR_III_4	219	223	PF00653	0.475
LIG_Clathr_ClatBox_1	314	318	PF01394	0.589
LIG_deltaCOP1_diTrp_1	223	226	PF00928	0.373
LIG_DLG_GKlike_1	209	216	PF00625	0.370
LIG_FAT_LD_1	282	290	PF03623	0.305
LIG_FHA_1	208	214	PF00498	0.464
LIG_FHA_1	230	236	PF00498	0.374
LIG_FHA_1	273	279	PF00498	0.335
LIG_FHA_1	314	320	PF00498	0.595
LIG_FHA_2	232	238	PF00498	0.447
LIG_GBD_Chelix_1	95	103	PF00786	0.580
LIG_LIR_Gen_1	15	24	PF02991	0.476
LIG_LIR_Gen_1	223	233	PF02991	0.426
LIG_LIR_Nem_3	131	137	PF02991	0.478
LIG_LIR_Nem_3	15	19	PF02991	0.481
LIG_LIR_Nem_3	223	229	PF02991	0.425
LIG_LIR_Nem_3	231	236	PF02991	0.437
LIG_LIR_Nem_3	60	66	PF02991	0.381
LIG_LIR_Nem_3	74	80	PF02991	0.373
LIG_LIR_Nem_3	81	86	PF02991	0.352
LIG_LYPXL_yS_3	83	86	PF13949	0.369
LIG_NRBOX	16	22	PF00104	0.573
LIG_NRBOX	284	290	PF00104	0.422
LIG_Pex14_2	188	192	PF04695	0.486
LIG_SH2_CRK	271	275	PF00017	0.277
LIG_SH2_GRB2like	189	192	PF00017	0.491
LIG_SH2_SRC	196	199	PF00017	0.416
LIG_SH2_STAT5	189	192	PF00017	0.496
LIG_SH2_STAT5	196	199	PF00017	0.393
LIG_SH2_STAT5	233	236	PF00017	0.475
LIG_SH2_STAT5	277	280	PF00017	0.355
LIG_SH2_STAT5	63	66	PF00017	0.420
LIG_SH2_STAT5	85	88	PF00017	0.356
LIG_SH3_3	22	28	PF00018	0.480
LIG_SH3_3	293	299	PF00018	0.305
LIG_Sin3_3	16	23	PF02671	0.482
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.462
LIG_SUMO_SIM_anti_2	283	289	PF11976	0.376
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.590
LIG_SUMO_SIM_par_1	313	318	PF11976	0.589
LIG_TRAF2_1	337	340	PF00917	0.630
LIG_TYR_ITSM	79	86	PF00017	0.391
MOD_CK1_1	105	111	PF00069	0.458
MOD_CK1_1	246	252	PF00069	0.479
MOD_CK1_1	29	35	PF00069	0.554
MOD_CK1_1	350	356	PF00069	0.808
MOD_CK1_1	69	75	PF00069	0.463
MOD_CK2_1	231	237	PF00069	0.452
MOD_CK2_1	333	339	PF00069	0.642
MOD_GlcNHglycan	104	107	PF01048	0.591
MOD_GlcNHglycan	110	113	PF01048	0.618
MOD_GlcNHglycan	246	249	PF01048	0.633
MOD_GlcNHglycan	326	329	PF01048	0.459
MOD_GlcNHglycan	353	356	PF01048	0.523
MOD_GlcNHglycan	66	69	PF01048	0.627
MOD_GlcNHglycan	87	90	PF01048	0.619
MOD_GlcNHglycan	92	95	PF01048	0.568
MOD_GSK3_1	101	108	PF00069	0.415
MOD_GSK3_1	129	136	PF00069	0.416
MOD_GSK3_1	231	238	PF00069	0.368
MOD_GSK3_1	259	266	PF00069	0.386
MOD_GSK3_1	27	34	PF00069	0.544
MOD_GSK3_1	335	342	PF00069	0.640
MOD_GSK3_1	345	352	PF00069	0.718
MOD_GSK3_1	57	64	PF00069	0.386
MOD_GSK3_1	75	82	PF00069	0.420
MOD_N-GLC_1	108	113	PF02516	0.639
MOD_N-GLC_1	190	195	PF02516	0.695
MOD_N-GLC_1	201	206	PF02516	0.707
MOD_N-GLC_1	243	248	PF02516	0.619
MOD_N-GLC_1	61	66	PF02516	0.595
MOD_NEK2_1	102	107	PF00069	0.530
MOD_NEK2_1	165	170	PF00069	0.402
MOD_NEK2_1	192	197	PF00069	0.510
MOD_NEK2_1	207	212	PF00069	0.448
MOD_NEK2_1	229	234	PF00069	0.432
MOD_NEK2_1	235	240	PF00069	0.408
MOD_NEK2_2	61	66	PF00069	0.382
MOD_PIKK_1	159	165	PF00454	0.415
MOD_PIKK_1	263	269	PF00454	0.420
MOD_PIKK_1	318	324	PF00454	0.599
MOD_PKA_1	324	330	PF00069	0.601
MOD_PKA_2	165	171	PF00069	0.405
MOD_PKA_2	208	214	PF00069	0.385
MOD_PKA_2	324	330	PF00069	0.601
MOD_PKA_2	350	356	PF00069	0.736
MOD_PKA_2	5	11	PF00069	0.489
MOD_PKB_1	345	353	PF00069	0.693
MOD_Plk_1	108	114	PF00069	0.441
MOD_Plk_1	61	67	PF00069	0.386
MOD_Plk_4	12	18	PF00069	0.562
MOD_Plk_4	133	139	PF00069	0.469
MOD_Plk_4	173	179	PF00069	0.433
MOD_Plk_4	209	215	PF00069	0.426
MOD_Plk_4	231	237	PF00069	0.493
MOD_Plk_4	31	37	PF00069	0.559
MOD_Plk_4	61	67	PF00069	0.400
MOD_ProDKin_1	246	252	PF00069	0.442
MOD_ProDKin_1	29	35	PF00069	0.537
MOD_SUMO_rev_2	119	125	PF00179	0.404
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.415
TRG_ENDOCYTIC_2	189	192	PF00928	0.474
TRG_ENDOCYTIC_2	233	236	PF00928	0.487
TRG_ENDOCYTIC_2	271	274	PF00928	0.405
TRG_ENDOCYTIC_2	83	86	PF00928	0.369
TRG_ER_diArg_1	307	310	PF00400	0.620
TRG_ER_diArg_1	323	325	PF00400	0.554
TRG_ER_diArg_1	346	349	PF00400	0.776

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9R5	Leishmania donovani	100%	100%
A4H7L3	Leishmania braziliensis	28%	74%
E9APP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9APQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	74%