LeishMANIAdb
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Ion transport protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ion transport protein-like protein
Gene product:
ion transport protein-like protein
Species:
Leishmania infantum
UniProt:
A4HVZ6_LEIIN
TriTrypDb:
LINF_140010800
Length:
499

Annotations

Annotations by Jardim et al.

Transporters, Ion transport -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HVZ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 11
GO:0005216 monoatomic ion channel activity 4 11
GO:0005227 calcium activated cation channel activity 6 11
GO:0005261 monoatomic cation channel activity 5 11
GO:0005267 potassium channel activity 6 11
GO:0008324 monoatomic cation transmembrane transporter activity 4 11
GO:0015075 monoatomic ion transmembrane transporter activity 3 11
GO:0015079 potassium ion transmembrane transporter activity 6 11
GO:0015267 channel activity 4 11
GO:0015269 calcium-activated potassium channel activity 7 11
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 11
GO:0016286 small conductance calcium-activated potassium channel activity 8 11
GO:0022803 passive transmembrane transporter activity 3 11
GO:0022836 gated channel activity 5 11
GO:0022839 monoatomic ion gated channel activity 6 11
GO:0022857 transmembrane transporter activity 2 11
GO:0022890 inorganic cation transmembrane transporter activity 4 11
GO:0046873 metal ion transmembrane transporter activity 5 11
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 230 234 PF00656 0.355
CLV_NRD_NRD_1 14 16 PF00675 0.449
CLV_NRD_NRD_1 319 321 PF00675 0.423
CLV_NRD_NRD_1 322 324 PF00675 0.429
CLV_NRD_NRD_1 353 355 PF00675 0.359
CLV_NRD_NRD_1 421 423 PF00675 0.455
CLV_PCSK_KEX2_1 14 16 PF00082 0.455
CLV_PCSK_KEX2_1 2 4 PF00082 0.468
CLV_PCSK_KEX2_1 353 355 PF00082 0.355
CLV_PCSK_KEX2_1 421 423 PF00082 0.455
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.504
CLV_PCSK_PC7_1 10 16 PF00082 0.401
CLV_PCSK_SKI1_1 117 121 PF00082 0.257
CLV_PCSK_SKI1_1 14 18 PF00082 0.371
CLV_PCSK_SKI1_1 147 151 PF00082 0.523
CLV_PCSK_SKI1_1 3 7 PF00082 0.421
CLV_PCSK_SKI1_1 412 416 PF00082 0.443
DEG_Nend_UBRbox_1 1 4 PF02207 0.599
DEG_SPOP_SBC_1 189 193 PF00917 0.534
DEG_SPOP_SBC_1 445 449 PF00917 0.740
DOC_CKS1_1 137 142 PF01111 0.313
DOC_MAPK_gen_1 204 213 PF00069 0.477
DOC_MAPK_gen_1 306 315 PF00069 0.618
DOC_MAPK_gen_1 333 341 PF00069 0.580
DOC_MAPK_gen_1 398 407 PF00069 0.638
DOC_MAPK_gen_1 421 429 PF00069 0.637
DOC_MAPK_HePTP_8 201 213 PF00069 0.539
DOC_MAPK_MEF2A_6 160 168 PF00069 0.324
DOC_MAPK_MEF2A_6 204 213 PF00069 0.539
DOC_MAPK_MEF2A_6 21 28 PF00069 0.541
DOC_MAPK_MEF2A_6 400 409 PF00069 0.636
DOC_PP1_RVXF_1 256 263 PF00149 0.257
DOC_PP4_FxxP_1 120 123 PF00568 0.302
DOC_USP7_MATH_1 362 366 PF00917 0.573
DOC_USP7_MATH_1 431 435 PF00917 0.691
DOC_USP7_MATH_1 445 449 PF00917 0.729
DOC_USP7_UBL2_3 17 21 PF12436 0.613
DOC_WW_Pin1_4 119 124 PF00397 0.318
DOC_WW_Pin1_4 136 141 PF00397 0.319
DOC_WW_Pin1_4 248 253 PF00397 0.243
LIG_14-3-3_CanoR_1 117 123 PF00244 0.445
LIG_14-3-3_CanoR_1 160 165 PF00244 0.427
LIG_14-3-3_CanoR_1 180 189 PF00244 0.474
LIG_14-3-3_CanoR_1 206 212 PF00244 0.449
LIG_14-3-3_CanoR_1 306 315 PF00244 0.560
LIG_14-3-3_CanoR_1 364 373 PF00244 0.694
LIG_14-3-3_CanoR_1 475 483 PF00244 0.563
LIG_Actin_WH2_2 41 58 PF00022 0.509
LIG_APCC_ABBAyCdc20_2 21 27 PF00400 0.511
LIG_BRCT_BRCA1_1 121 125 PF00533 0.360
LIG_BRCT_BRCA1_1 190 194 PF00533 0.528
LIG_BRCT_BRCA1_1 75 79 PF00533 0.304
LIG_CaM_IQ_9 310 326 PF13499 0.596
LIG_CtBP_PxDLS_1 491 495 PF00389 0.636
LIG_deltaCOP1_diTrp_1 233 239 PF00928 0.243
LIG_EH1_1 126 134 PF00400 0.360
LIG_EH1_1 289 297 PF00400 0.577
LIG_EVH1_2 140 144 PF00568 0.372
LIG_FHA_1 108 114 PF00498 0.524
LIG_FHA_1 190 196 PF00498 0.511
LIG_FHA_1 203 209 PF00498 0.423
LIG_FHA_1 224 230 PF00498 0.324
LIG_FHA_1 336 342 PF00498 0.561
LIG_FHA_1 344 350 PF00498 0.490
LIG_FHA_1 424 430 PF00498 0.658
LIG_FHA_1 475 481 PF00498 0.643
LIG_FHA_1 82 88 PF00498 0.373
LIG_FHA_1 97 103 PF00498 0.451
LIG_FHA_2 292 298 PF00498 0.610
LIG_FHA_2 465 471 PF00498 0.648
LIG_GBD_Chelix_1 259 267 PF00786 0.344
LIG_KLC1_Yacidic_2 22 27 PF13176 0.527
LIG_LIR_Gen_1 122 133 PF02991 0.429
LIG_LIR_Gen_1 139 150 PF02991 0.435
LIG_LIR_Gen_1 22 33 PF02991 0.569
LIG_LIR_Gen_1 238 247 PF02991 0.279
LIG_LIR_Gen_1 268 277 PF02991 0.299
LIG_LIR_Gen_1 278 285 PF02991 0.381
LIG_LIR_Nem_3 139 145 PF02991 0.424
LIG_LIR_Nem_3 22 28 PF02991 0.557
LIG_LIR_Nem_3 233 239 PF02991 0.377
LIG_LIR_Nem_3 244 250 PF02991 0.287
LIG_LIR_Nem_3 278 283 PF02991 0.450
LIG_MLH1_MIPbox_1 121 125 PF16413 0.324
LIG_NRBOX 340 346 PF00104 0.514
LIG_Pex14_1 265 269 PF04695 0.321
LIG_PTB_Apo_2 108 115 PF02174 0.526
LIG_PTB_Apo_2 167 174 PF02174 0.328
LIG_PTB_Phospho_1 167 173 PF10480 0.359
LIG_SH2_CRK 162 166 PF00017 0.324
LIG_SH2_CRK 280 284 PF00017 0.560
LIG_SH2_GRB2like 167 170 PF00017 0.413
LIG_SH2_PTP2 25 28 PF00017 0.585
LIG_SH2_SRC 25 28 PF00017 0.569
LIG_SH2_SRC 30 33 PF00017 0.581
LIG_SH2_STAP1 162 166 PF00017 0.324
LIG_SH2_STAP1 337 341 PF00017 0.600
LIG_SH2_STAT5 124 127 PF00017 0.365
LIG_SH2_STAT5 155 158 PF00017 0.306
LIG_SH2_STAT5 167 170 PF00017 0.400
LIG_SH2_STAT5 173 176 PF00017 0.564
LIG_SH2_STAT5 25 28 PF00017 0.567
LIG_SH2_STAT5 269 272 PF00017 0.349
LIG_SH2_STAT5 337 340 PF00017 0.640
LIG_SH2_STAT5 385 388 PF00017 0.588
LIG_SH3_1 324 330 PF00018 0.596
LIG_SH3_3 324 330 PF00018 0.596
LIG_SUMO_SIM_anti_2 425 431 PF11976 0.654
LIG_SUMO_SIM_par_1 337 342 PF11976 0.589
LIG_SUMO_SIM_par_1 442 450 PF11976 0.594
LIG_SUMO_SIM_par_1 67 73 PF11976 0.402
LIG_TRAF2_1 29 32 PF00917 0.581
LIG_TYR_ITIM 245 250 PF00017 0.338
MOD_CK1_1 107 113 PF00069 0.459
MOD_CK1_1 183 189 PF00069 0.524
MOD_CK1_1 238 244 PF00069 0.346
MOD_CK1_1 253 259 PF00069 0.271
MOD_CK1_1 286 292 PF00069 0.473
MOD_CK1_1 417 423 PF00069 0.515
MOD_CK1_1 449 455 PF00069 0.646
MOD_CK1_1 70 76 PF00069 0.412
MOD_CK2_1 26 32 PF00069 0.466
MOD_CK2_1 291 297 PF00069 0.512
MOD_CK2_1 362 368 PF00069 0.539
MOD_CK2_1 452 458 PF00069 0.669
MOD_CK2_1 464 470 PF00069 0.476
MOD_Cter_Amidation 12 15 PF01082 0.497
MOD_GlcNHglycan 106 109 PF01048 0.434
MOD_GlcNHglycan 182 185 PF01048 0.453
MOD_GlcNHglycan 255 258 PF01048 0.360
MOD_GlcNHglycan 308 311 PF01048 0.376
MOD_GlcNHglycan 349 352 PF01048 0.417
MOD_GlcNHglycan 377 380 PF01048 0.493
MOD_GlcNHglycan 449 452 PF01048 0.592
MOD_GlcNHglycan 483 486 PF01048 0.577
MOD_GlcNHglycan 76 79 PF01048 0.498
MOD_GSK3_1 223 230 PF00069 0.466
MOD_GSK3_1 335 342 PF00069 0.447
MOD_GSK3_1 343 350 PF00069 0.412
MOD_GSK3_1 362 369 PF00069 0.501
MOD_GSK3_1 445 452 PF00069 0.649
MOD_GSK3_1 486 493 PF00069 0.587
MOD_GSK3_1 70 77 PF00069 0.426
MOD_N-GLC_1 227 232 PF02516 0.313
MOD_N-GLC_1 81 86 PF02516 0.360
MOD_NEK2_1 1 6 PF00069 0.581
MOD_NEK2_1 190 195 PF00069 0.379
MOD_NEK2_1 223 228 PF00069 0.410
MOD_NEK2_1 235 240 PF00069 0.329
MOD_NEK2_1 275 280 PF00069 0.343
MOD_NEK2_1 301 306 PF00069 0.508
MOD_NEK2_1 339 344 PF00069 0.414
MOD_NEK2_1 366 371 PF00069 0.541
MOD_NEK2_1 415 420 PF00069 0.617
MOD_NEK2_1 446 451 PF00069 0.759
MOD_NEK2_1 494 499 PF00069 0.667
MOD_NEK2_1 67 72 PF00069 0.315
MOD_NEK2_1 86 91 PF00069 0.329
MOD_PIKK_1 223 229 PF00454 0.313
MOD_PIKK_1 464 470 PF00454 0.489
MOD_PIKK_1 86 92 PF00454 0.394
MOD_PK_1 160 166 PF00069 0.412
MOD_PKA_2 352 358 PF00069 0.464
MOD_PKA_2 464 470 PF00069 0.442
MOD_PKA_2 474 480 PF00069 0.421
MOD_Plk_1 227 233 PF00069 0.429
MOD_Plk_1 26 32 PF00069 0.498
MOD_Plk_1 81 87 PF00069 0.287
MOD_Plk_4 160 166 PF00069 0.383
MOD_Plk_4 190 196 PF00069 0.433
MOD_Plk_4 207 213 PF00069 0.229
MOD_Plk_4 265 271 PF00069 0.378
MOD_Plk_4 278 284 PF00069 0.458
MOD_Plk_4 291 297 PF00069 0.431
MOD_Plk_4 339 345 PF00069 0.421
MOD_Plk_4 423 429 PF00069 0.519
MOD_Plk_4 46 52 PF00069 0.431
MOD_Plk_4 67 73 PF00069 0.331
MOD_Plk_4 81 87 PF00069 0.273
MOD_ProDKin_1 119 125 PF00069 0.318
MOD_ProDKin_1 136 142 PF00069 0.397
MOD_ProDKin_1 248 254 PF00069 0.280
MOD_SUMO_rev_2 464 474 PF00179 0.536
TRG_DiLeu_BaLyEn_6 7 12 PF01217 0.494
TRG_ENDOCYTIC_2 155 158 PF00928 0.306
TRG_ENDOCYTIC_2 162 165 PF00928 0.328
TRG_ENDOCYTIC_2 247 250 PF00928 0.338
TRG_ENDOCYTIC_2 25 28 PF00928 0.439
TRG_ENDOCYTIC_2 269 272 PF00928 0.299
TRG_ENDOCYTIC_2 280 283 PF00928 0.349
TRG_ENDOCYTIC_2 385 388 PF00928 0.488
TRG_ER_diArg_1 14 16 PF00400 0.629
TRG_ER_diArg_1 305 308 PF00400 0.488
TRG_ER_diArg_1 317 320 PF00400 0.474
TRG_ER_diArg_1 352 354 PF00400 0.423
TRG_NLS_MonoExtC_3 319 324 PF00514 0.327
TRG_NLS_MonoExtN_4 318 324 PF00514 0.549
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4A8 Leptomonas seymouri 71% 90%
A0A0S4IWT9 Bodo saltans 34% 94%
A0A1X0NNP7 Trypanosomatidae 44% 93%
A0A3S7WSZ6 Leishmania donovani 100% 100%
A0A422NNK5 Trypanosoma rangeli 42% 97%
A4H7L2 Leishmania braziliensis 80% 100%
E9APP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QFT1 Leishmania major 95% 100%
V5BNC5 Trypanosoma cruzi 42% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS