LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Ion channel - putative
Species:
Leishmania infantum
UniProt:
A4HVZ5_LEIIN
TriTrypDb:
LINF_140010700
Length:
504

Annotations

Annotations by Jardim et al.

Transporters, Ion channel, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HVZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 13
GO:0005216 monoatomic ion channel activity 4 13
GO:0005227 calcium activated cation channel activity 6 13
GO:0005261 monoatomic cation channel activity 5 13
GO:0005267 potassium channel activity 6 13
GO:0008324 monoatomic cation transmembrane transporter activity 4 13
GO:0015075 monoatomic ion transmembrane transporter activity 3 13
GO:0015079 potassium ion transmembrane transporter activity 6 13
GO:0015267 channel activity 4 13
GO:0015269 calcium-activated potassium channel activity 7 13
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 13
GO:0016286 small conductance calcium-activated potassium channel activity 8 13
GO:0022803 passive transmembrane transporter activity 3 13
GO:0022836 gated channel activity 5 13
GO:0022839 monoatomic ion gated channel activity 6 13
GO:0022857 transmembrane transporter activity 2 13
GO:0022890 inorganic cation transmembrane transporter activity 4 13
GO:0046873 metal ion transmembrane transporter activity 5 13
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 219 223 PF00656 0.339
CLV_MEL_PAP_1 3 9 PF00089 0.409
CLV_NRD_NRD_1 339 341 PF00675 0.356
CLV_NRD_NRD_1 398 400 PF00675 0.546
CLV_NRD_NRD_1 472 474 PF00675 0.479
CLV_NRD_NRD_1 485 487 PF00675 0.431
CLV_PCSK_KEX2_1 168 170 PF00082 0.419
CLV_PCSK_KEX2_1 315 317 PF00082 0.390
CLV_PCSK_KEX2_1 339 341 PF00082 0.356
CLV_PCSK_KEX2_1 398 400 PF00082 0.546
CLV_PCSK_KEX2_1 472 474 PF00082 0.488
CLV_PCSK_PC1ET2_1 168 170 PF00082 0.419
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.432
CLV_PCSK_SKI1_1 405 409 PF00082 0.551
CLV_PCSK_SKI1_1 454 458 PF00082 0.570
DEG_Nend_UBRbox_2 1 3 PF02207 0.642
DEG_SCF_FBW7_1 369 376 PF00400 0.759
DEG_SPOP_SBC_1 392 396 PF00917 0.782
DEG_SPOP_SBC_1 435 439 PF00917 0.758
DOC_MAPK_gen_1 312 321 PF00069 0.582
DOC_MAPK_MEF2A_6 315 323 PF00069 0.638
DOC_PP4_MxPP_1 128 131 PF00568 0.531
DOC_USP7_MATH_1 106 110 PF00917 0.668
DOC_USP7_MATH_1 170 174 PF00917 0.637
DOC_USP7_MATH_1 435 439 PF00917 0.766
DOC_USP7_MATH_1 465 469 PF00917 0.716
DOC_WW_Pin1_4 109 114 PF00397 0.539
DOC_WW_Pin1_4 272 277 PF00397 0.655
DOC_WW_Pin1_4 369 374 PF00397 0.724
DOC_WW_Pin1_4 376 381 PF00397 0.721
DOC_WW_Pin1_4 388 393 PF00397 0.660
DOC_WW_Pin1_4 408 413 PF00397 0.703
LIG_14-3-3_CanoR_1 160 167 PF00244 0.583
LIG_14-3-3_CanoR_1 169 175 PF00244 0.531
LIG_14-3-3_CanoR_1 178 183 PF00244 0.458
LIG_14-3-3_CanoR_1 186 190 PF00244 0.486
LIG_14-3-3_CanoR_1 247 254 PF00244 0.333
LIG_14-3-3_CanoR_1 279 285 PF00244 0.628
LIG_14-3-3_CanoR_1 29 34 PF00244 0.640
LIG_14-3-3_CanoR_1 351 357 PF00244 0.637
LIG_14-3-3_CanoR_1 365 370 PF00244 0.692
LIG_14-3-3_CanoR_1 398 404 PF00244 0.728
LIG_14-3-3_CanoR_1 494 502 PF00244 0.739
LIG_Actin_WH2_2 356 372 PF00022 0.728
LIG_APCC_ABBA_1 401 406 PF00400 0.720
LIG_BRCT_BRCA1_1 319 323 PF00533 0.643
LIG_CaM_IQ_9 299 314 PF13499 0.561
LIG_Clathr_ClatBox_1 30 34 PF01394 0.643
LIG_FHA_1 161 167 PF00498 0.622
LIG_FHA_1 247 253 PF00498 0.323
LIG_FHA_1 25 31 PF00498 0.598
LIG_FHA_1 285 291 PF00498 0.637
LIG_FHA_1 469 475 PF00498 0.625
LIG_FHA_1 478 484 PF00498 0.585
LIG_FHA_2 273 279 PF00498 0.602
LIG_FHA_2 353 359 PF00498 0.645
LIG_GBD_Chelix_1 202 210 PF00786 0.439
LIG_GBD_Chelix_1 70 78 PF00786 0.423
LIG_LIR_Gen_1 136 147 PF02991 0.426
LIG_LIR_Gen_1 151 158 PF02991 0.363
LIG_LIR_Gen_1 320 328 PF02991 0.629
LIG_LIR_Gen_1 400 409 PF02991 0.729
LIG_LIR_Nem_3 136 142 PF02991 0.419
LIG_LIR_Nem_3 144 149 PF02991 0.376
LIG_LIR_Nem_3 151 157 PF02991 0.310
LIG_LIR_Nem_3 230 236 PF02991 0.305
LIG_LIR_Nem_3 320 326 PF02991 0.645
LIG_LIR_Nem_3 334 338 PF02991 0.547
LIG_LIR_Nem_3 400 404 PF02991 0.726
LIG_MYND_3 442 446 PF01753 0.783
LIG_Pex14_1 244 248 PF04695 0.339
LIG_Pex14_2 185 189 PF04695 0.645
LIG_Pex14_2 201 205 PF04695 0.469
LIG_SH2_PTP2 152 155 PF00017 0.370
LIG_SH2_SRC 152 155 PF00017 0.398
LIG_SH2_SRC 220 223 PF00017 0.375
LIG_SH2_STAP1 220 224 PF00017 0.365
LIG_SH2_STAP1 236 240 PF00017 0.355
LIG_SH2_STAT5 152 155 PF00017 0.345
LIG_SH2_STAT5 157 160 PF00017 0.406
LIG_SH2_STAT5 225 228 PF00017 0.297
LIG_SH2_STAT5 309 312 PF00017 0.590
LIG_SH2_STAT5 354 357 PF00017 0.651
LIG_SH3_3 374 380 PF00018 0.743
LIG_SH3_3 413 419 PF00018 0.767
LIG_SH3_3 96 102 PF00018 0.611
LIG_SUMO_SIM_anti_2 478 485 PF11976 0.666
LIG_SUMO_SIM_par_1 29 34 PF11976 0.634
LIG_SUMO_SIM_par_1 74 79 PF11976 0.355
LIG_TYR_ITIM 234 239 PF00017 0.304
LIG_WRC_WIRS_1 143 148 PF05994 0.472
MOD_CDK_SPK_2 373 378 PF00069 0.743
MOD_CDK_SPK_2 388 393 PF00069 0.720
MOD_CDK_SPxxK_3 272 279 PF00069 0.600
MOD_CK1_1 109 115 PF00069 0.552
MOD_CK1_1 162 168 PF00069 0.624
MOD_CK1_1 334 340 PF00069 0.607
MOD_CK1_1 352 358 PF00069 0.529
MOD_CK1_1 364 370 PF00069 0.700
MOD_CK1_1 376 382 PF00069 0.716
MOD_CK1_1 386 392 PF00069 0.713
MOD_CK1_1 437 443 PF00069 0.755
MOD_CK1_1 468 474 PF00069 0.660
MOD_CK2_1 210 216 PF00069 0.295
MOD_CK2_1 272 278 PF00069 0.612
MOD_CK2_1 495 501 PF00069 0.726
MOD_Cter_Amidation 396 399 PF01082 0.554
MOD_GlcNHglycan 385 388 PF01048 0.587
MOD_GlcNHglycan 458 461 PF01048 0.562
MOD_GlcNHglycan 463 466 PF01048 0.522
MOD_GlcNHglycan 62 65 PF01048 0.671
MOD_GSK3_1 109 116 PF00069 0.435
MOD_GSK3_1 156 163 PF00069 0.526
MOD_GSK3_1 20 27 PF00069 0.681
MOD_GSK3_1 280 287 PF00069 0.610
MOD_GSK3_1 327 334 PF00069 0.551
MOD_GSK3_1 361 368 PF00069 0.679
MOD_GSK3_1 369 376 PF00069 0.719
MOD_GSK3_1 379 386 PF00069 0.626
MOD_GSK3_1 388 395 PF00069 0.607
MOD_GSK3_1 408 415 PF00069 0.720
MOD_GSK3_1 434 441 PF00069 0.744
MOD_GSK3_1 454 461 PF00069 0.701
MOD_GSK3_1 497 504 PF00069 0.691
MOD_GSK3_1 97 104 PF00069 0.608
MOD_NEK2_1 156 161 PF00069 0.481
MOD_NEK2_1 185 190 PF00069 0.556
MOD_NEK2_1 210 215 PF00069 0.313
MOD_NEK2_1 226 231 PF00069 0.219
MOD_NEK2_1 284 289 PF00069 0.586
MOD_NEK2_1 326 331 PF00069 0.548
MOD_NEK2_1 349 354 PF00069 0.589
MOD_NEK2_1 385 390 PF00069 0.770
MOD_NEK2_1 456 461 PF00069 0.783
MOD_NEK2_1 477 482 PF00069 0.614
MOD_NEK2_1 495 500 PF00069 0.639
MOD_NEK2_1 55 60 PF00069 0.313
MOD_NEK2_1 76 81 PF00069 0.340
MOD_NEK2_2 106 111 PF00069 0.655
MOD_PIKK_1 160 166 PF00454 0.600
MOD_PIKK_1 24 30 PF00454 0.693
MOD_PIKK_1 327 333 PF00454 0.519
MOD_PKA_2 159 165 PF00069 0.616
MOD_PKA_2 185 191 PF00069 0.585
MOD_PKA_2 246 252 PF00069 0.350
MOD_PKA_2 350 356 PF00069 0.639
MOD_PKA_2 364 370 PF00069 0.686
MOD_PKA_2 397 403 PF00069 0.766
MOD_Plk_1 216 222 PF00069 0.362
MOD_Plk_1 36 42 PF00069 0.567
MOD_Plk_1 477 483 PF00069 0.626
MOD_Plk_2-3 216 222 PF00069 0.304
MOD_Plk_4 113 119 PF00069 0.384
MOD_Plk_4 142 148 PF00069 0.381
MOD_Plk_4 162 168 PF00069 0.573
MOD_Plk_4 178 184 PF00069 0.488
MOD_Plk_4 185 191 PF00069 0.558
MOD_Plk_4 240 246 PF00069 0.327
MOD_Plk_4 263 269 PF00069 0.399
MOD_Plk_4 280 286 PF00069 0.562
MOD_Plk_4 479 485 PF00069 0.668
MOD_Plk_4 55 61 PF00069 0.341
MOD_ProDKin_1 109 115 PF00069 0.460
MOD_ProDKin_1 272 278 PF00069 0.655
MOD_ProDKin_1 369 375 PF00069 0.725
MOD_ProDKin_1 376 382 PF00069 0.721
MOD_ProDKin_1 388 394 PF00069 0.657
MOD_ProDKin_1 408 414 PF00069 0.704
MOD_SUMO_for_1 311 314 PF00179 0.632
MOD_SUMO_rev_2 400 409 PF00179 0.763
TRG_DiLeu_BaEn_1 446 451 PF01217 0.723
TRG_ENDOCYTIC_2 152 155 PF00928 0.332
TRG_ENDOCYTIC_2 236 239 PF00928 0.307
TRG_ER_diArg_1 338 340 PF00400 0.539
TRG_ER_diArg_1 472 474 PF00400 0.642
TRG_Pf-PMV_PEXEL_1 336 341 PF00026 0.373
TRG_Pf-PMV_PEXEL_1 448 453 PF00026 0.589

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3W7 Leptomonas seymouri 62% 98%
A0A0S4IWT9 Bodo saltans 30% 95%
A0A0S4IZM8 Bodo saltans 36% 100%
A0A1X0NNP7 Trypanosomatidae 28% 94%
A0A1X0NP80 Trypanosomatidae 38% 100%
A0A3Q8I9U0 Leishmania donovani 100% 100%
A0A422NNJ1 Trypanosoma rangeli 40% 100%
A0A422NNK5 Trypanosoma rangeli 31% 98%
A4H7L1 Leishmania braziliensis 76% 100%
E9APP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QFT2 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS