Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVZ2_LEIIN

TriTrypDb:

LINF_140010400

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.424
CLV_C14_Caspase3-7	349	353	PF00656	0.498
CLV_NRD_NRD_1	130	132	PF00675	0.600
CLV_NRD_NRD_1	275	277	PF00675	0.577
CLV_NRD_NRD_1	390	392	PF00675	0.412
CLV_NRD_NRD_1	451	453	PF00675	0.565
CLV_NRD_NRD_1	527	529	PF00675	0.412
CLV_NRD_NRD_1	73	75	PF00675	0.524
CLV_PCSK_KEX2_1	129	131	PF00082	0.632
CLV_PCSK_KEX2_1	275	277	PF00082	0.577
CLV_PCSK_KEX2_1	390	392	PF00082	0.383
CLV_PCSK_KEX2_1	451	453	PF00082	0.565
CLV_PCSK_KEX2_1	73	75	PF00082	0.528
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.461
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.383
CLV_PCSK_SKI1_1	131	135	PF00082	0.466
CLV_PCSK_SKI1_1	316	320	PF00082	0.466
CLV_PCSK_SKI1_1	480	484	PF00082	0.438
DEG_APCC_DBOX_1	139	147	PF00400	0.485
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DEG_SCF_FBW7_1	12	18	PF00400	0.564
DOC_CKS1_1	12	17	PF01111	0.564
DOC_CYCLIN_RxL_1	388	398	PF00134	0.451
DOC_MAPK_gen_1	388	395	PF00069	0.385
DOC_MAPK_MEF2A_6	354	362	PF00069	0.549
DOC_PP2B_LxvP_1	287	290	PF13499	0.452
DOC_PP4_FxxP_1	362	365	PF00568	0.598
DOC_USP7_MATH_1	177	181	PF00917	0.563
DOC_USP7_MATH_1	230	234	PF00917	0.644
DOC_USP7_MATH_1	243	247	PF00917	0.527
DOC_USP7_MATH_1	274	278	PF00917	0.733
DOC_USP7_MATH_1	409	413	PF00917	0.595
DOC_USP7_MATH_1	419	423	PF00917	0.552
DOC_USP7_MATH_1	424	428	PF00917	0.520
DOC_USP7_MATH_1	537	541	PF00917	0.491
DOC_USP7_MATH_1	543	547	PF00917	0.511
DOC_USP7_MATH_1	91	95	PF00917	0.517
DOC_USP7_UBL2_3	388	392	PF12436	0.407
DOC_WW_Pin1_4	105	110	PF00397	0.633
DOC_WW_Pin1_4	11	16	PF00397	0.753
DOC_WW_Pin1_4	184	189	PF00397	0.624
DOC_WW_Pin1_4	445	450	PF00397	0.590
LIG_14-3-3_CanoR_1	260	269	PF00244	0.555
LIG_14-3-3_CanoR_1	354	358	PF00244	0.530
LIG_14-3-3_CanoR_1	73	79	PF00244	0.537
LIG_Actin_WH2_2	326	343	PF00022	0.474
LIG_BIR_III_2	265	269	PF00653	0.652
LIG_BIR_III_4	225	229	PF00653	0.599
LIG_Dynein_DLC8_1	39	45	PF01221	0.668
LIG_FHA_1	145	151	PF00498	0.434
LIG_FHA_1	282	288	PF00498	0.583
LIG_FHA_1	395	401	PF00498	0.446
LIG_FHA_2	115	121	PF00498	0.628
LIG_FHA_2	214	220	PF00498	0.435
LIG_FHA_2	262	268	PF00498	0.581
LIG_FHA_2	370	376	PF00498	0.477
LIG_FHA_2	442	448	PF00498	0.551
LIG_FHA_2	93	99	PF00498	0.642
LIG_GBD_Chelix_1	510	518	PF00786	0.483
LIG_LIR_Apic_2	361	365	PF02991	0.600
LIG_LIR_Nem_3	240	244	PF02991	0.540
LIG_LIR_Nem_3	505	510	PF02991	0.639
LIG_NRBOX	346	352	PF00104	0.525
LIG_PDZ_Class_1	543	548	PF00595	0.521
LIG_SH2_CRK	507	511	PF00017	0.483
LIG_SH2_STAT3	312	315	PF00017	0.432
LIG_SH2_STAT5	503	506	PF00017	0.577
LIG_SH2_STAT5	531	534	PF00017	0.470
LIG_SH3_2	271	276	PF14604	0.616
LIG_SH3_3	185	191	PF00018	0.586
LIG_SH3_3	224	230	PF00018	0.635
LIG_SH3_3	265	271	PF00018	0.657
LIG_TRAF2_1	334	337	PF00917	0.427
LIG_TRAF2_1	372	375	PF00917	0.474
LIG_TRAF2_1	499	502	PF00917	0.406
LIG_TRAF2_1	77	80	PF00917	0.486
LIG_WW_3	267	271	PF00397	0.598
MOD_CDK_SPK_2	105	110	PF00069	0.548
MOD_CDK_SPxK_1	445	451	PF00069	0.588
MOD_CDK_SPxxK_3	445	452	PF00069	0.571
MOD_CK1_1	11	17	PF00069	0.684
MOD_CK1_1	180	186	PF00069	0.584
MOD_CK1_1	187	193	PF00069	0.558
MOD_CK1_1	233	239	PF00069	0.616
MOD_CK1_1	311	317	PF00069	0.634
MOD_CK1_1	426	432	PF00069	0.705
MOD_CK1_1	438	444	PF00069	0.548
MOD_CK1_1	47	53	PF00069	0.671
MOD_CK2_1	213	219	PF00069	0.616
MOD_CK2_1	243	249	PF00069	0.603
MOD_CK2_1	369	375	PF00069	0.488
MOD_CK2_1	441	447	PF00069	0.551
MOD_CK2_1	471	477	PF00069	0.492
MOD_CK2_1	74	80	PF00069	0.503
MOD_CK2_1	92	98	PF00069	0.525
MOD_Cter_Amidation	71	74	PF01082	0.541
MOD_GlcNHglycan	221	225	PF01048	0.579
MOD_GlcNHglycan	252	256	PF01048	0.521
MOD_GlcNHglycan	379	382	PF01048	0.418
MOD_GlcNHglycan	411	414	PF01048	0.612
MOD_GlcNHglycan	420	424	PF01048	0.520
MOD_GlcNHglycan	426	429	PF01048	0.501
MOD_GlcNHglycan	436	440	PF01048	0.514
MOD_GlcNHglycan	46	49	PF01048	0.671
MOD_GlcNHglycan	464	468	PF01048	0.546
MOD_GlcNHglycan	539	542	PF01048	0.490
MOD_GlcNHglycan	82	85	PF01048	0.475
MOD_GlcNHglycan	89	92	PF01048	0.572
MOD_GSK3_1	101	108	PF00069	0.570
MOD_GSK3_1	112	119	PF00069	0.628
MOD_GSK3_1	177	184	PF00069	0.592
MOD_GSK3_1	22	29	PF00069	0.715
MOD_GSK3_1	239	246	PF00069	0.701
MOD_GSK3_1	336	343	PF00069	0.479
MOD_GSK3_1	40	47	PF00069	0.672
MOD_GSK3_1	409	416	PF00069	0.655
MOD_GSK3_1	419	426	PF00069	0.545
MOD_GSK3_1	435	442	PF00069	0.639
MOD_GSK3_1	463	470	PF00069	0.600
MOD_GSK3_1	7	14	PF00069	0.602
MOD_GSK3_1	87	94	PF00069	0.571
MOD_N-GLC_1	121	126	PF02516	0.532
MOD_N-GLC_1	409	414	PF02516	0.566
MOD_N-GLC_2	456	458	PF02516	0.537
MOD_NEK2_1	250	255	PF00069	0.553
MOD_NEK2_1	379	384	PF00069	0.444
MOD_NEK2_1	418	423	PF00069	0.775
MOD_NEK2_1	440	445	PF00069	0.567
MOD_NEK2_1	6	11	PF00069	0.576
MOD_NEK2_2	181	186	PF00069	0.528
MOD_NEK2_2	8	13	PF00069	0.561
MOD_PIKK_1	230	236	PF00454	0.636
MOD_PIKK_1	281	287	PF00454	0.576
MOD_PIKK_1	311	317	PF00454	0.479
MOD_PIKK_1	40	46	PF00454	0.671
MOD_PKA_1	275	281	PF00069	0.570
MOD_PKA_1	73	79	PF00069	0.546
MOD_PKA_2	112	118	PF00069	0.608
MOD_PKA_2	261	267	PF00069	0.576
MOD_PKA_2	274	280	PF00069	0.590
MOD_PKA_2	321	327	PF00069	0.412
MOD_PKA_2	353	359	PF00069	0.528
MOD_PKA_2	40	46	PF00069	0.671
MOD_PKA_2	450	456	PF00069	0.625
MOD_PKA_2	73	79	PF00069	0.546
MOD_PKA_2	80	86	PF00069	0.480
MOD_Plk_1	239	245	PF00069	0.542
MOD_Plk_1	336	342	PF00069	0.484
MOD_Plk_1	413	419	PF00069	0.604
MOD_Plk_2-3	305	311	PF00069	0.424
MOD_Plk_4	413	419	PF00069	0.738
MOD_ProDKin_1	105	111	PF00069	0.633
MOD_ProDKin_1	11	17	PF00069	0.752
MOD_ProDKin_1	184	190	PF00069	0.621
MOD_ProDKin_1	445	451	PF00069	0.588
MOD_SUMO_for_1	133	136	PF00179	0.496
MOD_SUMO_for_1	163	166	PF00179	0.387
TRG_DiLeu_BaEn_1	128	133	PF01217	0.468
TRG_DiLeu_BaEn_1	296	301	PF01217	0.469
TRG_DiLeu_BaEn_4	374	380	PF01217	0.461
TRG_DiLeu_LyEn_5	296	301	PF01217	0.469
TRG_ENDOCYTIC_2	507	510	PF00928	0.617
TRG_ER_diArg_1	130	132	PF00400	0.577
TRG_ER_diArg_1	259	262	PF00400	0.602
TRG_ER_diArg_1	274	276	PF00400	0.541
TRG_ER_diArg_1	52	55	PF00400	0.608
TRG_NES_CRM1_1	291	304	PF08389	0.417
TRG_NLS_MonoExtN_4	388	394	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9D0	Leptomonas seymouri	37%	81%
A0A3S7WSW7	Leishmania donovani	99%	100%
A4H6I2	Leishmania braziliensis	61%	100%
E9APP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QFT5	Leishmania major	86%	100%