Amastin surface glycofamily protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4HVZ0_LEIIN

TriTrypDb:

LINF_140010200

Length:

274

Annotations

LeishMANIAdb annotations

Structurally similar to the amastin family proteins, but with a rather divergent sequence. Also seems to be related to mammalian clarin proteins.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Phosphorylation

Promastigote: 17

Expansion

Sequence features

A4HVZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.608
CLV_NRD_NRD_1	214	216	PF00675	0.758
CLV_NRD_NRD_1	22	24	PF00675	0.564
CLV_NRD_NRD_1	29	31	PF00675	0.464
CLV_PCSK_KEX2_1	22	24	PF00082	0.569
CLV_PCSK_KEX2_1	29	31	PF00082	0.518
CLV_PCSK_SKI1_1	37	41	PF00082	0.506
DEG_Nend_UBRbox_1	1	4	PF02207	0.805
DOC_MAPK_gen_1	45	52	PF00069	0.578
DOC_MAPK_MEF2A_6	45	52	PF00069	0.578
DOC_PP2B_LxvP_1	40	43	PF13499	0.629
DOC_USP7_UBL2_3	216	220	PF12436	0.446
LIG_14-3-3_CanoR_1	22	28	PF00244	0.821
LIG_14-3-3_CanoR_1	256	261	PF00244	0.678
LIG_BRCT_BRCA1_1	101	105	PF00533	0.423
LIG_BRCT_BRCA1_1	225	229	PF00533	0.476
LIG_FHA_1	141	147	PF00498	0.414
LIG_FHA_1	165	171	PF00498	0.467
LIG_FHA_1	174	180	PF00498	0.561
LIG_FHA_1	53	59	PF00498	0.467
LIG_FHA_1	76	82	PF00498	0.421
LIG_LIR_Gen_1	139	150	PF02991	0.432
LIG_LIR_Gen_1	156	166	PF02991	0.500
LIG_LIR_Gen_1	174	181	PF02991	0.527
LIG_LIR_Gen_1	185	195	PF02991	0.430
LIG_LIR_Gen_1	221	230	PF02991	0.420
LIG_LIR_Gen_1	244	253	PF02991	0.443
LIG_LIR_Gen_1	60	69	PF02991	0.539
LIG_LIR_Nem_3	156	161	PF02991	0.476
LIG_LIR_Nem_3	174	178	PF02991	0.527
LIG_LIR_Nem_3	185	190	PF02991	0.430
LIG_LIR_Nem_3	221	225	PF02991	0.414
LIG_LIR_Nem_3	226	232	PF02991	0.378
LIG_LIR_Nem_3	244	248	PF02991	0.412
LIG_LIR_Nem_3	60	64	PF02991	0.539
LIG_Pex14_2	225	229	PF04695	0.423
LIG_Pex14_2	241	245	PF04695	0.444
LIG_PTB_Apo_2	130	137	PF02174	0.372
LIG_Rb_LxCxE_1	38	60	PF01857	0.564
LIG_SH2_CRK	158	162	PF00017	0.444
LIG_SH2_STAP1	142	146	PF00017	0.414
LIG_SH2_STAP1	201	205	PF00017	0.450
LIG_SH2_STAP1	249	253	PF00017	0.523
LIG_SH2_STAT5	126	129	PF00017	0.437
LIG_SH2_STAT5	142	145	PF00017	0.413
LIG_SH2_STAT5	222	225	PF00017	0.411
LIG_SH2_STAT5	249	252	PF00017	0.504
LIG_SH2_STAT5	41	44	PF00017	0.639
LIG_Sin3_3	61	68	PF02671	0.423
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.505
LIG_SUMO_SIM_par_1	187	193	PF11976	0.444
LIG_WRC_WIRS_1	58	63	PF05994	0.423
MOD_CK1_1	138	144	PF00069	0.398
MOD_CK1_1	156	162	PF00069	0.325
MOD_CK1_1	17	23	PF00069	0.777
MOD_CK1_1	204	210	PF00069	0.546
MOD_CK2_1	94	100	PF00069	0.507
MOD_Cter_Amidation	213	216	PF01082	0.763
MOD_GlcNHglycan	90	93	PF01048	0.618
MOD_GSK3_1	10	17	PF00069	0.760
MOD_GSK3_1	115	122	PF00069	0.431
MOD_GSK3_1	136	143	PF00069	0.401
MOD_GSK3_1	18	25	PF00069	0.765
MOD_GSK3_1	190	197	PF00069	0.382
MOD_GSK3_1	204	211	PF00069	0.479
MOD_GSK3_1	243	250	PF00069	0.543
MOD_N-GLC_1	208	213	PF02516	0.753
MOD_NEK2_1	105	110	PF00069	0.352
MOD_NEK2_1	18	23	PF00069	0.838
MOD_NEK2_1	208	213	PF00069	0.556
MOD_NEK2_1	225	230	PF00069	0.302
MOD_NEK2_1	231	236	PF00069	0.444
MOD_NEK2_1	241	246	PF00069	0.444
MOD_NEK2_1	52	57	PF00069	0.468
MOD_NEK2_1	94	99	PF00069	0.470
MOD_NEK2_2	116	121	PF00069	0.521
MOD_PKA_1	22	28	PF00069	0.740
MOD_PKA_1	29	35	PF00069	0.706
MOD_PKA_2	18	24	PF00069	0.768
MOD_PKA_2	29	35	PF00069	0.628
MOD_Plk_1	13	19	PF00069	0.761
MOD_Plk_1	173	179	PF00069	0.578
MOD_Plk_1	208	214	PF00069	0.557
MOD_Plk_4	105	111	PF00069	0.400
MOD_Plk_4	140	146	PF00069	0.402
MOD_Plk_4	156	162	PF00069	0.543
MOD_Plk_4	208	214	PF00069	0.529
MOD_Plk_4	256	262	PF00069	0.672
MOD_SUMO_rev_2	259	267	PF00179	0.666
TRG_ENDOCYTIC_2	142	145	PF00928	0.429
TRG_ENDOCYTIC_2	158	161	PF00928	0.444
TRG_ENDOCYTIC_2	222	225	PF00928	0.411
TRG_ENDOCYTIC_2	249	252	PF00928	0.504
TRG_ER_diArg_1	22	24	PF00400	0.841
TRG_NES_CRM1_1	86	100	PF08389	0.504
TRG_NLS_MonoExtN_4	29	34	PF00514	0.743
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B8	Leptomonas seymouri	71%	99%
A0A3S5H6R5	Leishmania donovani	98%	100%
A0A3S7WSV8	Leishmania donovani	100%	100%
A4H7K8	Leishmania braziliensis	77%	100%
A4H7K9	Leishmania braziliensis	78%	100%
A4HVZ1	Leishmania infantum	97%	100%
E9APP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9APP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFT6	Leishmania major	92%	100%
Q4QFT7	Leishmania major	93%	100%