LeishMANIAdb
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Cystathionine beta-lyase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cystathionine beta-lyase-like protein
Gene product:
cystathionine beta-lyase-like protein
Species:
Leishmania infantum
UniProt:
A4HVY9_LEIIN
TriTrypDb:
LINF_140010000 *
Length:
519

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVY9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY9

Function

Biological processes
Term Name Level Count
GO:0000096 sulfur amino acid metabolic process 4 8
GO:0000097 sulfur amino acid biosynthetic process 5 8
GO:0006082 organic acid metabolic process 3 8
GO:0006520 amino acid metabolic process 3 8
GO:0006534 cysteine metabolic process 5 8
GO:0006555 methionine metabolic process 5 8
GO:0006790 sulfur compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0008652 amino acid biosynthetic process 4 8
GO:0009058 biosynthetic process 2 8
GO:0009066 aspartate family amino acid metabolic process 5 8
GO:0009067 aspartate family amino acid biosynthetic process 6 8
GO:0009069 serine family amino acid metabolic process 5 8
GO:0009086 methionine biosynthetic process 6 8
GO:0009092 homoserine metabolic process 6 8
GO:0009987 cellular process 1 8
GO:0016053 organic acid biosynthetic process 4 8
GO:0019346 transsulfuration 6 8
GO:0019752 carboxylic acid metabolic process 5 8
GO:0043436 oxoacid metabolic process 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044272 sulfur compound biosynthetic process 4 8
GO:0044281 small molecule metabolic process 2 8
GO:0044283 small molecule biosynthetic process 3 8
GO:0046394 carboxylic acid biosynthetic process 5 8
GO:0050667 homocysteine metabolic process 5 8
GO:0071265 L-methionine biosynthetic process 7 8
GO:0071266 'de novo' L-methionine biosynthetic process 8 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
GO:1901605 alpha-amino acid metabolic process 4 8
GO:1901607 alpha-amino acid biosynthetic process 5 8
GO:0009070 serine family amino acid biosynthetic process 6 1
GO:0019343 cysteine biosynthetic process via cystathionine 7 1
GO:0019344 cysteine biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004121 cystathionine beta-lyase activity 4 8
GO:0005488 binding 1 8
GO:0016829 lyase activity 2 8
GO:0016846 carbon-sulfur lyase activity 3 8
GO:0019842 vitamin binding 3 8
GO:0030170 pyridoxal phosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0070279 vitamin B6 binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:0004123 cystathionine gamma-lyase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 112 114 PF00082 0.512
CLV_PCSK_KEX2_1 339 341 PF00082 0.293
CLV_PCSK_KEX2_1 438 440 PF00082 0.275
CLV_PCSK_KEX2_1 478 480 PF00082 0.344
CLV_PCSK_PC1ET2_1 112 114 PF00082 0.512
CLV_PCSK_PC1ET2_1 339 341 PF00082 0.293
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.275
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.296
CLV_PCSK_SKI1_1 223 227 PF00082 0.275
CLV_PCSK_SKI1_1 248 252 PF00082 0.307
CLV_PCSK_SKI1_1 3 7 PF00082 0.496
CLV_PCSK_SKI1_1 340 344 PF00082 0.254
CLV_PCSK_SKI1_1 448 452 PF00082 0.281
CLV_PCSK_SKI1_1 74 78 PF00082 0.543
DEG_APCC_DBOX_1 73 81 PF00400 0.540
DEG_SCF_FBW7_1 13 20 PF00400 0.531
DOC_AGCK_PIF_2 159 164 PF00069 0.275
DOC_CKS1_1 14 19 PF01111 0.586
DOC_MAPK_gen_1 362 371 PF00069 0.275
DOC_MAPK_gen_1 445 454 PF00069 0.291
DOC_MAPK_HePTP_8 359 371 PF00069 0.275
DOC_MAPK_MEF2A_6 362 371 PF00069 0.275
DOC_MAPK_MEF2A_6 448 456 PF00069 0.275
DOC_PP1_RVXF_1 337 344 PF00149 0.275
DOC_PP4_FxxP_1 151 154 PF00568 0.275
DOC_USP7_MATH_1 190 194 PF00917 0.275
DOC_WW_Pin1_4 13 18 PF00397 0.592
DOC_WW_Pin1_4 261 266 PF00397 0.275
DOC_WW_Pin1_4 294 299 PF00397 0.275
DOC_WW_Pin1_4 402 407 PF00397 0.326
LIG_14-3-3_CanoR_1 223 232 PF00244 0.275
LIG_14-3-3_CanoR_1 362 368 PF00244 0.275
LIG_14-3-3_CanoR_1 387 395 PF00244 0.326
LIG_14-3-3_CanoR_1 420 429 PF00244 0.334
LIG_14-3-3_CanoR_1 487 491 PF00244 0.334
LIG_Actin_WH2_2 284 302 PF00022 0.351
LIG_BRCT_BRCA1_1 439 443 PF00533 0.275
LIG_BRCT_BRCA1_1 94 98 PF00533 0.509
LIG_BRCT_BRCA1_2 94 100 PF00533 0.517
LIG_Clathr_ClatBox_1 259 263 PF01394 0.275
LIG_FHA_1 123 129 PF00498 0.387
LIG_FHA_1 227 233 PF00498 0.305
LIG_FHA_1 242 248 PF00498 0.219
LIG_FHA_1 264 270 PF00498 0.304
LIG_FHA_1 314 320 PF00498 0.314
LIG_FHA_1 364 370 PF00498 0.275
LIG_FHA_1 432 438 PF00498 0.334
LIG_FHA_1 501 507 PF00498 0.334
LIG_FHA_2 14 20 PF00498 0.535
LIG_FHA_2 171 177 PF00498 0.275
LIG_FHA_2 76 82 PF00498 0.532
LIG_LIR_Apic_2 148 154 PF02991 0.275
LIG_LIR_Apic_2 95 99 PF02991 0.539
LIG_LIR_Gen_1 103 111 PF02991 0.452
LIG_LIR_Gen_1 356 364 PF02991 0.275
LIG_LIR_Nem_3 103 107 PF02991 0.484
LIG_LIR_Nem_3 157 162 PF02991 0.275
LIG_LIR_Nem_3 356 361 PF02991 0.275
LIG_Pex14_2 238 242 PF04695 0.275
LIG_SH2_CRK 397 401 PF00017 0.334
LIG_SH2_CRK 96 100 PF00017 0.529
LIG_SH2_SRC 162 165 PF00017 0.334
LIG_SH2_STAT3 86 89 PF00017 0.518
LIG_SH2_STAT5 417 420 PF00017 0.302
LIG_SH2_STAT5 86 89 PF00017 0.510
LIG_SH3_2 108 113 PF14604 0.447
LIG_SH3_3 105 111 PF00018 0.450
LIG_SH3_3 131 137 PF00018 0.381
LIG_SH3_3 234 240 PF00018 0.311
LIG_SH3_3 262 268 PF00018 0.234
LIG_SH3_3 460 466 PF00018 0.277
LIG_SUMO_SIM_par_1 428 434 PF11976 0.311
LIG_TRAF2_1 79 82 PF00917 0.522
LIG_TYR_ITIM 395 400 PF00017 0.275
LIG_UBA3_1 61 69 PF00899 0.544
MOD_CDC14_SPxK_1 297 300 PF00782 0.275
MOD_CDK_SPxK_1 294 300 PF00069 0.275
MOD_CK1_1 311 317 PF00069 0.334
MOD_CK1_1 386 392 PF00069 0.321
MOD_CK1_1 409 415 PF00069 0.298
MOD_CK1_1 421 427 PF00069 0.332
MOD_CK1_1 428 434 PF00069 0.199
MOD_CK1_1 455 461 PF00069 0.318
MOD_CK1_1 470 476 PF00069 0.203
MOD_CK2_1 170 176 PF00069 0.275
MOD_CK2_1 407 413 PF00069 0.288
MOD_CK2_1 458 464 PF00069 0.275
MOD_CK2_1 75 81 PF00069 0.475
MOD_GlcNHglycan 166 169 PF01048 0.275
MOD_GlcNHglycan 192 195 PF01048 0.288
MOD_GlcNHglycan 313 316 PF01048 0.284
MOD_GlcNHglycan 423 426 PF01048 0.283
MOD_GlcNHglycan 65 68 PF01048 0.526
MOD_GSK3_1 1 8 PF00069 0.499
MOD_GSK3_1 102 109 PF00069 0.514
MOD_GSK3_1 13 20 PF00069 0.475
MOD_GSK3_1 164 171 PF00069 0.275
MOD_GSK3_1 197 204 PF00069 0.286
MOD_GSK3_1 207 214 PF00069 0.440
MOD_GSK3_1 223 230 PF00069 0.255
MOD_GSK3_1 287 294 PF00069 0.286
MOD_GSK3_1 386 393 PF00069 0.334
MOD_GSK3_1 402 409 PF00069 0.372
MOD_GSK3_1 421 428 PF00069 0.233
MOD_GSK3_1 433 440 PF00069 0.350
MOD_GSK3_1 63 70 PF00069 0.606
MOD_N-GLC_1 72 77 PF02516 0.577
MOD_NEK2_1 189 194 PF00069 0.275
MOD_NEK2_1 201 206 PF00069 0.352
MOD_NEK2_1 383 388 PF00069 0.346
MOD_NEK2_1 418 423 PF00069 0.334
MOD_NEK2_1 450 455 PF00069 0.275
MOD_NEK2_2 308 313 PF00069 0.334
MOD_PIKK_1 122 128 PF00454 0.390
MOD_PIKK_1 223 229 PF00454 0.288
MOD_PIKK_1 418 424 PF00454 0.296
MOD_PIKK_1 500 506 PF00454 0.334
MOD_PIKK_1 54 60 PF00454 0.424
MOD_PK_1 365 371 PF00069 0.275
MOD_PKA_2 386 392 PF00069 0.311
MOD_PKA_2 486 492 PF00069 0.298
MOD_Plk_1 291 297 PF00069 0.275
MOD_Plk_1 308 314 PF00069 0.275
MOD_Plk_1 72 78 PF00069 0.568
MOD_Plk_4 147 153 PF00069 0.275
MOD_Plk_4 174 180 PF00069 0.334
MOD_Plk_4 197 203 PF00069 0.275
MOD_Plk_4 207 213 PF00069 0.315
MOD_Plk_4 291 297 PF00069 0.275
MOD_Plk_4 425 431 PF00069 0.275
MOD_Plk_4 458 464 PF00069 0.275
MOD_ProDKin_1 13 19 PF00069 0.593
MOD_ProDKin_1 261 267 PF00069 0.275
MOD_ProDKin_1 294 300 PF00069 0.275
MOD_ProDKin_1 402 408 PF00069 0.326
MOD_SUMO_for_1 332 335 PF00179 0.275
MOD_SUMO_for_1 43 46 PF00179 0.383
MOD_SUMO_rev_2 334 341 PF00179 0.334
TRG_DiLeu_BaEn_1 464 469 PF01217 0.275
TRG_DiLeu_BaEn_4 413 419 PF01217 0.351
TRG_DiLeu_BaEn_4 82 88 PF01217 0.515
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.275
TRG_ENDOCYTIC_2 104 107 PF00928 0.478
TRG_ENDOCYTIC_2 218 221 PF00928 0.275
TRG_ENDOCYTIC_2 397 400 PF00928 0.275
TRG_NES_CRM1_1 375 388 PF08389 0.275
TRG_NES_CRM1_1 501 516 PF08389 0.387
TRG_Pf-PMV_PEXEL_1 223 227 PF00026 0.275
TRG_Pf-PMV_PEXEL_1 479 484 PF00026 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0D2YG02 Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) 29% 100%
A0A0J6G7P5 Pseudomonas deceptionensis 37% 100%
A0A0N0P3U0 Leptomonas seymouri 87% 100%
A0A0N0P8H0 Leptomonas seymouri 28% 100%
A0A0N1HW05 Leptomonas seymouri 33% 100%
A0A0N1PG90 Leptomonas seymouri 29% 100%
A0A0S4IZX4 Bodo saltans 31% 100%
A0A1X0NP01 Trypanosomatidae 70% 100%
A0A1X0P5N4 Trypanosomatidae 31% 100%
A0A3Q8ILD8 Leishmania donovani 28% 100%
A0A3R7R3B5 Trypanosoma rangeli 30% 100%
A0A3S7WSY5 Leishmania donovani 100% 100%
A0A3S7X9N0 Leishmania donovani 32% 100%
A2RM21 Lactococcus lactis subsp. cremoris (strain MG1363) 40% 100%
A4H7K6 Leishmania braziliensis 91% 100%
A4HKQ5 Leishmania braziliensis 29% 100%
A4HMZ0 Leishmania braziliensis 32% 100%
A4I885 Leishmania infantum 29% 100%
A4IBL4 Leishmania infantum 32% 100%
C9ZZ26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AFE7 Leishmania major 31% 100%
E9APP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B343 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6K2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O05394 Bacillus subtilis (strain 168) 41% 100%
O13326 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
O31631 Bacillus subtilis (strain 168) 34% 100%
O31632 Bacillus subtilis (strain 168) 43% 100%
O42851 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
O94350 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 100%
P00935 Escherichia coli (strain K12) 37% 100%
P06106 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P06721 Escherichia coli (strain K12) 27% 100%
P0A4K2 Lactococcus lactis subsp. lactis (strain IL1403) 40% 100%
P0C2T9 Lactococcus lactis subsp. cremoris 39% 100%
P13254 Pseudomonas putida 38% 100%
P18757 Rattus norvegicus 39% 100%
P18949 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 100%
P31373 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
P32929 Homo sapiens 39% 100%
P44502 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 100%
P44527 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 26% 100%
P46807 Mycobacterium leprae (strain TN) 37% 100%
P50125 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 30% 100%
P53101 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P53780 Arabidopsis thaliana 48% 100%
P55216 Caenorhabditis elegans 36% 100%
P55217 Arabidopsis thaliana 34% 92%
P55218 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 36% 100%
P56069 Helicobacter pylori (strain ATCC 700392 / 26695) 40% 100%
P66876 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 36% 100%
P94890 Leptospira meyeri 31% 100%
P9WGB4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 32% 100%
P9WGB5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 100%
P9WGB6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 36% 100%
P9WGB7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 36% 100%
Q07703 Bordetella avium 31% 100%
Q19QT7 Sus scrofa 39% 100%
Q1K8G0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 43% 100%
Q1M0P5 Helicobacter pylori 40% 100%
Q4L332 Staphylococcus haemolyticus (strain JCSC1435) 35% 100%
Q4Q511 Leishmania major 29% 100%
Q4QFT8 Leishmania major 99% 100%
Q52811 Rhizobium leguminosarum bv. viciae (strain 3841) 28% 100%
Q55DV9 Dictyostelium discoideum 38% 100%
Q58DW2 Bos taurus 39% 100%
Q59829 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 33% 100%
Q5MNH8 Epichloe uncinata 28% 100%
Q5SJ58 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 29% 100%
Q5SK88 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 30% 100%
Q60HG7 Macaca fascicularis 38% 100%
Q73GL9 Wolbachia pipientis wMel 26% 100%
Q73KL7 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 36% 100%
Q79VI4 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 33% 100%
Q7MX71 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 36% 100%
Q826W3 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 34% 100%
Q83A83 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 38% 100%
Q8J0B2 Epichloe uncinata 29% 100%
Q8L0X4 Fusobacterium nucleatum subsp. polymorphum 34% 100%
Q8RDT4 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 35% 100%
Q8VCN5 Mus musculus 40% 100%
Q92441 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 31% 100%
Q9C876 Arabidopsis thaliana 35% 100%
Q9SGU9 Arabidopsis thaliana 30% 100%
Q9WZY4 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9X0Z7 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 33% 100%
Q9ZMW7 Helicobacter pylori (strain J99 / ATCC 700824) 39% 100%
S0DUX5 Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) 29% 100%
V5DUQ5 Trypanosoma cruzi 30% 100%
W7MS09 Gibberella moniliformis (strain M3125 / FGSC 7600) 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS