Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-terminal conserved domain of Nudc./CS domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HVY8_LEIIN

TriTrypDb:

LINF_140009900

Length:

322

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HVY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.594
CLV_C14_Caspase3-7	268	272	PF00656	0.427
CLV_NRD_NRD_1	108	110	PF00675	0.345
CLV_NRD_NRD_1	304	306	PF00675	0.552
CLV_NRD_NRD_1	32	34	PF00675	0.183
CLV_NRD_NRD_1	45	47	PF00675	0.480
CLV_NRD_NRD_1	63	65	PF00675	0.482
CLV_PCSK_KEX2_1	45	47	PF00082	0.536
CLV_PCSK_SKI1_1	163	167	PF00082	0.286
CLV_PCSK_SKI1_1	246	250	PF00082	0.450
CLV_PCSK_SKI1_1	64	68	PF00082	0.524
CLV_Separin_Metazoa	302	306	PF03568	0.353
DEG_APCC_DBOX_1	175	183	PF00400	0.473
DEG_SPOP_SBC_1	192	196	PF00917	0.383
DOC_MAPK_DCC_7	176	184	PF00069	0.399
DOC_MAPK_gen_1	185	193	PF00069	0.384
DOC_MAPK_MEF2A_6	176	184	PF00069	0.413
DOC_MAPK_MEF2A_6	185	193	PF00069	0.394
DOC_MAPK_MEF2A_6	5	13	PF00069	0.383
DOC_PIKK_1	263	270	PF02985	0.442
DOC_PP4_FxxP_1	38	41	PF00568	0.383
DOC_USP7_MATH_1	262	266	PF00917	0.441
DOC_USP7_MATH_1	44	48	PF00917	0.443
DOC_USP7_MATH_1	80	84	PF00917	0.517
DOC_USP7_UBL2_3	288	292	PF12436	0.542
LIG_14-3-3_CanoR_1	275	279	PF00244	0.389
LIG_14-3-3_CanoR_1	33	41	PF00244	0.383
LIG_14-3-3_CanoR_1	45	49	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_deltaCOP1_diTrp_1	243	249	PF00928	0.413
LIG_DLG_GKlike_1	5	13	PF00625	0.450
LIG_FHA_1	229	235	PF00498	0.396
LIG_FHA_1	80	86	PF00498	0.424
LIG_FHA_2	223	229	PF00498	0.383
LIG_FHA_2	292	298	PF00498	0.374
LIG_FHA_2	37	43	PF00498	0.434
LIG_LIR_Apic_2	35	41	PF02991	0.383
LIG_LIR_Gen_1	212	219	PF02991	0.368
LIG_LIR_Gen_1	3	14	PF02991	0.233
LIG_LIR_Nem_3	212	217	PF02991	0.383
LIG_LIR_Nem_3	243	248	PF02991	0.270
LIG_LIR_Nem_3	25	31	PF02991	0.415
LIG_PCNA_PIPBox_1	49	58	PF02747	0.433
LIG_PCNA_yPIPBox_3	299	308	PF02747	0.481
LIG_PCNA_yPIPBox_3	45	56	PF02747	0.494
LIG_Pex14_1	245	249	PF04695	0.406
LIG_SH2_CRK	214	218	PF00017	0.425
LIG_SH2_STAP1	161	165	PF00017	0.218
LIG_SH2_STAT5	164	167	PF00017	0.450
LIG_SH2_STAT5	55	58	PF00017	0.540
LIG_SH3_3	172	178	PF00018	0.413
LIG_SUMO_SIM_anti_2	82	93	PF11976	0.489
LIG_SUMO_SIM_par_1	230	235	PF11976	0.394
LIG_TRAF2_1	169	172	PF00917	0.394
LIG_TRAF2_1	90	93	PF00917	0.417
LIG_WRC_WIRS_1	24	29	PF05994	0.383
MOD_CK1_1	196	202	PF00069	0.393
MOD_CK1_1	79	85	PF00069	0.532
MOD_CK2_1	166	172	PF00069	0.383
MOD_CK2_1	291	297	PF00069	0.382
MOD_CK2_1	80	86	PF00069	0.480
MOD_CK2_1	87	93	PF00069	0.426
MOD_GlcNHglycan	78	81	PF01048	0.607
MOD_GSK3_1	187	194	PF00069	0.496
MOD_GSK3_1	228	235	PF00069	0.402
MOD_GSK3_1	32	39	PF00069	0.397
MOD_GSK3_1	76	83	PF00069	0.626
MOD_NEK2_1	166	171	PF00069	0.409
MOD_NEK2_1	314	319	PF00069	0.385
MOD_NEK2_2	244	249	PF00069	0.410
MOD_PIKK_1	164	170	PF00454	0.383
MOD_PIKK_1	314	320	PF00454	0.445
MOD_PIKK_1	36	42	PF00454	0.407
MOD_PK_1	187	193	PF00069	0.399
MOD_PKA_2	274	280	PF00069	0.386
MOD_PKA_2	32	38	PF00069	0.383
MOD_PKA_2	44	50	PF00069	0.357
MOD_PKA_2	80	86	PF00069	0.643
MOD_Plk_4	187	193	PF00069	0.399
MOD_Plk_4	228	234	PF00069	0.398
MOD_Plk_4	23	29	PF00069	0.363
MOD_Plk_4	244	250	PF00069	0.311
MOD_Plk_4	5	11	PF00069	0.425
MOD_SUMO_rev_2	119	125	PF00179	0.485
TRG_ENDOCYTIC_2	214	217	PF00928	0.425
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P482	Leptomonas seymouri	75%	97%
A0A0S4KFL2	Bodo saltans	57%	100%
A0A1X0NNN1	Trypanosomatidae	64%	100%
A0A3R7KDG6	Trypanosoma rangeli	64%	100%
A0A3S5H6R4	Leishmania donovani	100%	100%
A4H7K5	Leishmania braziliensis	85%	100%
C9ZT35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9APP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
O35685	Mus musculus	44%	97%
Q17QG2	Bos taurus	45%	97%
Q4QFT9	Leishmania major	96%	100%
Q5RB75	Pongo abelii	30%	89%
Q5ZIN1	Gallus gallus	45%	94%
Q63525	Rattus norvegicus	44%	97%
Q8IVD9	Homo sapiens	30%	89%
Q8R1N4	Mus musculus	30%	89%
Q9VVA6	Drosophila melanogaster	37%	97%
Q9Y266	Homo sapiens	44%	97%
V5BHT5	Trypanosoma cruzi	65%	77%