LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Pyridine nucleotide-disulphide oxidoreductase - putative
Species:
Leishmania infantum
UniProt:
A4HVY7_LEIIN
TriTrypDb:
LINF_140009700
Length:
550

Annotations

Annotations by Jardim et al.

Oxidoreductase, pyridine nucleotide-disulphide oxidoreductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0000166 nucleotide binding 3 1
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity 4 1
GO:0005488 binding 1 1
GO:0009055 electron transfer activity 3 1
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3 1
GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 249 253 PF00656 0.337
CLV_C14_Caspase3-7 399 403 PF00656 0.403
CLV_MEL_PAP_1 529 535 PF00089 0.381
CLV_NRD_NRD_1 104 106 PF00675 0.273
CLV_NRD_NRD_1 151 153 PF00675 0.313
CLV_NRD_NRD_1 227 229 PF00675 0.310
CLV_NRD_NRD_1 313 315 PF00675 0.649
CLV_NRD_NRD_1 388 390 PF00675 0.536
CLV_PCSK_KEX2_1 104 106 PF00082 0.280
CLV_PCSK_KEX2_1 115 117 PF00082 0.257
CLV_PCSK_KEX2_1 172 174 PF00082 0.416
CLV_PCSK_KEX2_1 227 229 PF00082 0.436
CLV_PCSK_KEX2_1 313 315 PF00082 0.649
CLV_PCSK_KEX2_1 346 348 PF00082 0.476
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.287
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.416
CLV_PCSK_PC1ET2_1 346 348 PF00082 0.510
CLV_PCSK_PC7_1 111 117 PF00082 0.287
CLV_PCSK_SKI1_1 243 247 PF00082 0.397
CLV_PCSK_SKI1_1 304 308 PF00082 0.657
CLV_PCSK_SKI1_1 442 446 PF00082 0.359
CLV_PCSK_SKI1_1 517 521 PF00082 0.529
DEG_APCC_DBOX_1 303 311 PF00400 0.630
DEG_Nend_Nbox_1 1 3 PF02207 0.515
DEG_SPOP_SBC_1 263 267 PF00917 0.656
DOC_CYCLIN_yClb5_NLxxxL_5 235 244 PF00134 0.295
DOC_MAPK_gen_1 101 109 PF00069 0.357
DOC_MAPK_gen_1 472 482 PF00069 0.467
DOC_MAPK_MEF2A_6 20 29 PF00069 0.662
DOC_MAPK_MEF2A_6 204 211 PF00069 0.318
DOC_MAPK_MEF2A_6 233 242 PF00069 0.284
DOC_MAPK_MEF2A_6 472 480 PF00069 0.390
DOC_PP2B_LxvP_1 29 32 PF13499 0.624
DOC_PP2B_PxIxI_1 473 479 PF00149 0.382
DOC_PP4_FxxP_1 515 518 PF00568 0.391
DOC_USP7_MATH_1 263 267 PF00917 0.665
DOC_USP7_MATH_1 270 274 PF00917 0.543
DOC_USP7_MATH_1 289 293 PF00917 0.595
DOC_WW_Pin1_4 265 270 PF00397 0.657
DOC_WW_Pin1_4 372 377 PF00397 0.489
DOC_WW_Pin1_4 486 491 PF00397 0.348
LIG_14-3-3_CanoR_1 247 255 PF00244 0.332
LIG_14-3-3_CanoR_1 271 279 PF00244 0.612
LIG_14-3-3_CanoR_1 304 312 PF00244 0.443
LIG_14-3-3_CanoR_1 406 411 PF00244 0.338
LIG_Actin_WH2_2 102 117 PF00022 0.272
LIG_Actin_WH2_2 120 137 PF00022 0.272
LIG_BIR_III_4 484 488 PF00653 0.316
LIG_CaM_NSCaTE_8 302 309 PF13499 0.429
LIG_EH1_1 4 12 PF00400 0.579
LIG_EH1_1 404 412 PF00400 0.339
LIG_eIF4E_1 405 411 PF01652 0.342
LIG_FHA_1 119 125 PF00498 0.287
LIG_FHA_1 281 287 PF00498 0.656
LIG_FHA_1 31 37 PF00498 0.446
LIG_FHA_1 439 445 PF00498 0.552
LIG_FHA_1 455 461 PF00498 0.502
LIG_FHA_1 540 546 PF00498 0.427
LIG_FHA_1 81 87 PF00498 0.298
LIG_FHA_2 247 253 PF00498 0.288
LIG_FHA_2 70 76 PF00498 0.302
LIG_LIR_Apic_2 514 518 PF02991 0.385
LIG_LIR_Gen_1 139 148 PF02991 0.308
LIG_LIR_Gen_1 322 332 PF02991 0.433
LIG_LIR_Gen_1 362 371 PF02991 0.356
LIG_LIR_Nem_3 139 145 PF02991 0.308
LIG_LIR_Nem_3 322 328 PF02991 0.487
LIG_LIR_Nem_3 362 368 PF02991 0.345
LIG_LIR_Nem_3 443 448 PF02991 0.361
LIG_LIR_Nem_3 76 82 PF02991 0.272
LIG_NRBOX 409 415 PF00104 0.346
LIG_PCNA_PIPBox_1 106 115 PF02747 0.416
LIG_PCNA_yPIPBox_3 333 343 PF02747 0.559
LIG_PDZ_Class_1 545 550 PF00595 0.486
LIG_Pex14_2 365 369 PF04695 0.348
LIG_Rb_pABgroove_1 63 71 PF01858 0.291
LIG_SH2_CRK 142 146 PF00017 0.272
LIG_SH2_CRK 325 329 PF00017 0.414
LIG_SH2_STAP1 142 146 PF00017 0.272
LIG_SH2_STAP1 321 325 PF00017 0.390
LIG_SH2_STAT3 521 524 PF00017 0.429
LIG_SH2_STAT5 113 116 PF00017 0.272
LIG_SH2_STAT5 133 136 PF00017 0.145
LIG_SH2_STAT5 367 370 PF00017 0.337
LIG_SH2_STAT5 510 513 PF00017 0.503
LIG_SH3_3 217 223 PF00018 0.287
LIG_SH3_3 251 257 PF00018 0.603
LIG_SH3_3 276 282 PF00018 0.617
LIG_SH3_3 283 289 PF00018 0.567
LIG_SH3_3 449 455 PF00018 0.366
LIG_SUMO_SIM_anti_2 33 39 PF11976 0.425
LIG_TYR_ITIM 140 145 PF00017 0.272
LIG_TYR_ITIM 323 328 PF00017 0.398
LIG_UBA3_1 86 95 PF00899 0.320
MOD_CDC14_SPxK_1 268 271 PF00782 0.660
MOD_CDK_SPK_2 372 377 PF00069 0.482
MOD_CDK_SPxK_1 265 271 PF00069 0.658
MOD_CK1_1 13 19 PF00069 0.562
MOD_CK1_1 265 271 PF00069 0.658
MOD_CK1_1 291 297 PF00069 0.648
MOD_CK1_1 305 311 PF00069 0.506
MOD_CK1_1 450 456 PF00069 0.475
MOD_CK2_1 434 440 PF00069 0.403
MOD_CK2_1 497 503 PF00069 0.431
MOD_Cter_Amidation 344 347 PF01082 0.456
MOD_GlcNHglycan 12 15 PF01048 0.514
MOD_GlcNHglycan 164 167 PF01048 0.332
MOD_GlcNHglycan 491 494 PF01048 0.391
MOD_GlcNHglycan 7 10 PF01048 0.564
MOD_GSK3_1 114 121 PF00069 0.337
MOD_GSK3_1 156 163 PF00069 0.276
MOD_GSK3_1 302 309 PF00069 0.600
MOD_GSK3_1 434 441 PF00069 0.428
MOD_GSK3_1 450 457 PF00069 0.442
MOD_GSK3_1 489 496 PF00069 0.446
MOD_LATS_1 241 247 PF00433 0.220
MOD_LATS_1 404 410 PF00433 0.344
MOD_N-GLC_1 23 28 PF02516 0.664
MOD_NEK2_1 114 119 PF00069 0.353
MOD_NEK2_1 177 182 PF00069 0.287
MOD_NEK2_1 200 205 PF00069 0.333
MOD_NEK2_1 306 311 PF00069 0.682
MOD_NEK2_1 5 10 PF00069 0.588
MOD_NEK2_1 69 74 PF00069 0.287
MOD_NEK2_2 497 502 PF00069 0.435
MOD_PIKK_1 531 537 PF00454 0.513
MOD_PKA_2 246 252 PF00069 0.287
MOD_PKA_2 270 276 PF00069 0.622
MOD_PKA_2 405 411 PF00069 0.342
MOD_PKA_2 423 429 PF00069 0.332
MOD_PKA_2 531 537 PF00069 0.384
MOD_PKB_1 160 168 PF00069 0.416
MOD_Plk_1 160 166 PF00069 0.346
MOD_Plk_1 23 29 PF00069 0.663
MOD_Plk_1 289 295 PF00069 0.643
MOD_Plk_1 506 512 PF00069 0.449
MOD_Plk_1 69 75 PF00069 0.257
MOD_Plk_4 120 126 PF00069 0.307
MOD_Plk_4 306 312 PF00069 0.572
MOD_Plk_4 32 38 PF00069 0.491
MOD_Plk_4 334 340 PF00069 0.479
MOD_Plk_4 406 412 PF00069 0.340
MOD_Plk_4 447 453 PF00069 0.381
MOD_Plk_4 454 460 PF00069 0.426
MOD_Plk_4 64 70 PF00069 0.272
MOD_ProDKin_1 265 271 PF00069 0.659
MOD_ProDKin_1 372 378 PF00069 0.484
MOD_ProDKin_1 486 492 PF00069 0.354
MOD_SUMO_rev_2 165 174 PF00179 0.332
MOD_SUMO_rev_2 382 388 PF00179 0.449
MOD_SUMO_rev_2 70 79 PF00179 0.334
TRG_DiLeu_BaLyEn_6 240 245 PF01217 0.220
TRG_ENDOCYTIC_2 142 145 PF00928 0.272
TRG_ENDOCYTIC_2 325 328 PF00928 0.364
TRG_ER_diArg_1 104 106 PF00400 0.287
TRG_ER_diArg_1 312 314 PF00400 0.655
TRG_Pf-PMV_PEXEL_1 442 447 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3U1 Leptomonas seymouri 76% 100%
A0A0S4KJN5 Bodo saltans 43% 100%
A0A1X0NNQ7 Trypanosomatidae 57% 100%
A0A3Q8I8R3 Leishmania donovani 100% 100%
A0A422MYM5 Trypanosoma rangeli 56% 100%
A4H7K4 Leishmania braziliensis 89% 100%
C9ZT37 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9APN9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QFU0 Leishmania major 96% 100%
V5AXT2 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS