Polynucleotide 5'-triphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA capping enzyme - beta chain - putative

Species:

Leishmania infantum

UniProt:

A4HVY6_LEIIN

TriTrypDb:

LINF_140009600

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004651	polynucleotide 5'-phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.667
CLV_NRD_NRD_1	138	140	PF00675	0.452
CLV_PCSK_KEX2_1	159	161	PF00082	0.564
CLV_PCSK_KEX2_1	355	357	PF00082	0.493
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.564
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.493
CLV_PCSK_SKI1_1	227	231	PF00082	0.541
CLV_PCSK_SKI1_1	348	352	PF00082	0.356
CLV_PCSK_SKI1_1	57	61	PF00082	0.477
DEG_APCC_DBOX_1	56	64	PF00400	0.471
DEG_Nend_UBRbox_4	1	3	PF02207	0.535
DOC_CKS1_1	315	320	PF01111	0.685
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.712
DOC_MAPK_gen_1	252	261	PF00069	0.430
DOC_MAPK_gen_1	89	97	PF00069	0.724
DOC_MAPK_MEF2A_6	148	155	PF00069	0.616
DOC_MAPK_MEF2A_6	232	240	PF00069	0.629
DOC_MAPK_MEF2A_6	74	81	PF00069	0.573
DOC_MAPK_MEF2A_6	89	97	PF00069	0.724
DOC_PP1_RVXF_1	274	281	PF00149	0.566
DOC_PP2B_LxvP_1	23	26	PF13499	0.495
DOC_PP2B_LxvP_1	93	96	PF13499	0.719
DOC_USP7_MATH_1	248	252	PF00917	0.567
DOC_USP7_MATH_1	255	259	PF00917	0.567
DOC_USP7_MATH_1	285	289	PF00917	0.596
DOC_USP7_MATH_1	294	298	PF00917	0.668
DOC_USP7_MATH_1	31	35	PF00917	0.519
DOC_USP7_MATH_1	361	365	PF00917	0.502
DOC_USP7_MATH_1	378	382	PF00917	0.647
DOC_WW_Pin1_4	296	301	PF00397	0.771
DOC_WW_Pin1_4	314	319	PF00397	0.681
DOC_WW_Pin1_4	66	71	PF00397	0.513
DOC_WW_Pin1_4	98	103	PF00397	0.560
LIG_14-3-3_CanoR_1	254	260	PF00244	0.515
LIG_14-3-3_CanoR_1	263	268	PF00244	0.330
LIG_14-3-3_CanoR_1	329	339	PF00244	0.605
LIG_CtBP_PxDLS_1	237	241	PF00389	0.670
LIG_eIF4E_2	281	287	PF01652	0.601
LIG_EVH1_2	26	30	PF00568	0.542
LIG_FHA_1	196	202	PF00498	0.670
LIG_FHA_1	268	274	PF00498	0.455
LIG_FHA_1	315	321	PF00498	0.661
LIG_FHA_1	336	342	PF00498	0.497
LIG_FHA_1	367	373	PF00498	0.632
LIG_FHA_1	392	398	PF00498	0.579
LIG_FHA_2	13	19	PF00498	0.680
LIG_FHA_2	136	142	PF00498	0.577
LIG_FHA_2	335	341	PF00498	0.535
LIG_FHA_2	394	400	PF00498	0.768
LIG_FHA_2	71	77	PF00498	0.610
LIG_GBD_Chelix_1	55	63	PF00786	0.468
LIG_LIR_Apic_2	277	283	PF02991	0.567
LIG_LIR_Gen_1	288	296	PF02991	0.663
LIG_LIR_Nem_3	353	357	PF02991	0.536
LIG_NRBOX	346	352	PF00104	0.356
LIG_PCNA_PIPBox_1	158	167	PF02747	0.333
LIG_Pex14_1	354	358	PF04695	0.480
LIG_Pex14_2	6	10	PF04695	0.496
LIG_SH2_CRK	165	169	PF00017	0.703
LIG_SH2_CRK	192	196	PF00017	0.568
LIG_SH2_STAT5	289	292	PF00017	0.733
LIG_SH2_STAT5	366	369	PF00017	0.491
LIG_SH2_STAT5	415	418	PF00017	0.446
LIG_SH3_3	184	190	PF00018	0.676
LIG_SH3_3	96	102	PF00018	0.685
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.520
LIG_SUMO_SIM_par_1	15	20	PF11976	0.494
LIG_SUMO_SIM_par_1	236	242	PF11976	0.636
LIG_SUMO_SIM_par_1	336	342	PF11976	0.508
LIG_SUMO_SIM_par_1	94	101	PF11976	0.603
MOD_CK1_1	231	237	PF00069	0.485
MOD_CK1_1	272	278	PF00069	0.517
MOD_CK1_1	391	397	PF00069	0.672
MOD_CK2_1	182	188	PF00069	0.721
MOD_CK2_1	285	291	PF00069	0.633
MOD_CK2_1	330	336	PF00069	0.640
MOD_CK2_1	70	76	PF00069	0.581
MOD_GlcNHglycan	204	207	PF01048	0.597
MOD_GlcNHglycan	34	37	PF01048	0.503
MOD_GlcNHglycan	363	366	PF01048	0.480
MOD_GlcNHglycan	369	372	PF01048	0.550
MOD_GSK3_1	195	202	PF00069	0.664
MOD_GSK3_1	263	270	PF00069	0.460
MOD_GSK3_1	310	317	PF00069	0.685
MOD_GSK3_1	330	337	PF00069	0.650
MOD_GSK3_1	361	368	PF00069	0.441
MOD_GSK3_1	373	380	PF00069	0.530
MOD_GSK3_1	384	391	PF00069	0.672
MOD_GSK3_1	66	73	PF00069	0.510
MOD_NEK2_1	105	110	PF00069	0.296
MOD_NEK2_1	19	24	PF00069	0.572
MOD_NEK2_1	195	200	PF00069	0.594
MOD_NEK2_1	269	274	PF00069	0.439
MOD_NEK2_1	367	372	PF00069	0.552
MOD_NEK2_1	403	408	PF00069	0.687
MOD_NEK2_1	85	90	PF00069	0.579
MOD_NEK2_2	384	389	PF00069	0.677
MOD_PIKK_1	195	201	PF00454	0.605
MOD_PIKK_1	267	273	PF00454	0.553
MOD_PK_1	263	269	PF00069	0.490
MOD_PK_1	80	86	PF00069	0.579
MOD_PKA_2	255	261	PF00069	0.512
MOD_PKB_1	252	260	PF00069	0.519
MOD_Plk_1	12	18	PF00069	0.524
MOD_Plk_1	335	341	PF00069	0.542
MOD_Plk_1	384	390	PF00069	0.676
MOD_Plk_4	12	18	PF00069	0.539
MOD_Plk_4	269	275	PF00069	0.448
MOD_Plk_4	304	310	PF00069	0.663
MOD_Plk_4	403	409	PF00069	0.726
MOD_Plk_4	80	86	PF00069	0.579
MOD_ProDKin_1	296	302	PF00069	0.772
MOD_ProDKin_1	314	320	PF00069	0.685
MOD_ProDKin_1	66	72	PF00069	0.515
MOD_ProDKin_1	98	104	PF00069	0.550
TRG_DiLeu_BaEn_1	412	417	PF01217	0.447
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.594
TRG_ENDOCYTIC_2	165	168	PF00928	0.691
TRG_ENDOCYTIC_2	192	195	PF00928	0.569
TRG_ENDOCYTIC_2	289	292	PF00928	0.655
TRG_NES_CRM1_1	49	64	PF08389	0.475
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D6	Leptomonas seymouri	37%	100%
A0A3Q8ID33	Leishmania donovani	100%	100%
A4H7K3	Leishmania braziliensis	79%	100%
E9APN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFU1	Leishmania major	92%	100%