Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iguana/Dzip1-like DAZ-interacting protein N-terminal - putative

Species:

Leishmania infantum

UniProt:

A4HVY5_LEIIN

TriTrypDb:

LINF_140009500

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005814	centriole	5	6
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HVY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.518
CLV_NRD_NRD_1	179	181	PF00675	0.644
CLV_NRD_NRD_1	357	359	PF00675	0.576
CLV_NRD_NRD_1	816	818	PF00675	0.593
CLV_PCSK_KEX2_1	126	128	PF00082	0.518
CLV_PCSK_KEX2_1	181	183	PF00082	0.668
CLV_PCSK_KEX2_1	357	359	PF00082	0.576
CLV_PCSK_KEX2_1	816	818	PF00082	0.593
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.587
CLV_PCSK_SKI1_1	120	124	PF00082	0.321
CLV_PCSK_SKI1_1	127	131	PF00082	0.443
CLV_PCSK_SKI1_1	27	31	PF00082	0.342
DEG_APCC_DBOX_1	250	258	PF00400	0.587
DEG_APCC_DBOX_1	356	364	PF00400	0.562
DEG_COP1_1	554	562	PF00400	0.650
DEG_ODPH_VHL_1	669	680	PF01847	0.681
DEG_SPOP_SBC_1	285	289	PF00917	0.711
DEG_SPOP_SBC_1	585	589	PF00917	0.603
DEG_SPOP_SBC_1	608	612	PF00917	0.692
DEG_SPOP_SBC_1	650	654	PF00917	0.687
DEG_SPOP_SBC_1	799	803	PF00917	0.611
DOC_CDC14_PxL_1	745	753	PF14671	0.682
DOC_CKS1_1	404	409	PF01111	0.635
DOC_CKS1_1	456	461	PF01111	0.694
DOC_CKS1_1	523	528	PF01111	0.597
DOC_CKS1_1	56	61	PF01111	0.542
DOC_CKS1_1	562	567	PF01111	0.634
DOC_CKS1_1	784	789	PF01111	0.658
DOC_CYCLIN_RxL_1	123	133	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	562	568	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	751	757	PF00134	0.691
DOC_MAPK_gen_1	248	256	PF00069	0.581
DOC_MAPK_gen_1	357	363	PF00069	0.565
DOC_MAPK_MEF2A_6	14	23	PF00069	0.542
DOC_MAPK_MEF2A_6	251	258	PF00069	0.587
DOC_MAPK_NFAT4_5	251	259	PF00069	0.589
DOC_PP1_RVXF_1	12	18	PF00149	0.542
DOC_PP2B_LxvP_1	453	456	PF13499	0.699
DOC_PP2B_LxvP_1	457	460	PF13499	0.655
DOC_PP2B_LxvP_1	464	467	PF13499	0.565
DOC_PP2B_LxvP_1	493	496	PF13499	0.667
DOC_PP2B_LxvP_1	550	553	PF13499	0.617
DOC_PP2B_LxvP_1	727	730	PF13499	0.659
DOC_PP2B_LxvP_1	751	754	PF13499	0.687
DOC_PP4_FxxP_1	746	749	PF00568	0.553
DOC_SPAK_OSR1_1	811	815	PF12202	0.588
DOC_USP7_MATH_1	188	192	PF00917	0.666
DOC_USP7_MATH_1	223	227	PF00917	0.626
DOC_USP7_MATH_1	261	265	PF00917	0.663
DOC_USP7_MATH_1	286	290	PF00917	0.620
DOC_USP7_MATH_1	310	314	PF00917	0.650
DOC_USP7_MATH_1	389	393	PF00917	0.667
DOC_USP7_MATH_1	497	501	PF00917	0.682
DOC_USP7_MATH_1	516	520	PF00917	0.513
DOC_USP7_MATH_1	536	540	PF00917	0.584
DOC_USP7_MATH_1	555	559	PF00917	0.524
DOC_USP7_MATH_1	585	589	PF00917	0.703
DOC_USP7_MATH_1	590	594	PF00917	0.690
DOC_USP7_MATH_1	635	639	PF00917	0.661
DOC_USP7_MATH_1	651	655	PF00917	0.687
DOC_USP7_MATH_1	659	663	PF00917	0.628
DOC_USP7_MATH_1	775	779	PF00917	0.696
DOC_USP7_MATH_1	785	789	PF00917	0.593
DOC_USP7_MATH_1	793	797	PF00917	0.505
DOC_USP7_MATH_1	799	803	PF00917	0.539
DOC_USP7_UBL2_3	119	123	PF12436	0.542
DOC_WW_Pin1_4	186	191	PF00397	0.690
DOC_WW_Pin1_4	197	202	PF00397	0.602
DOC_WW_Pin1_4	265	270	PF00397	0.712
DOC_WW_Pin1_4	289	294	PF00397	0.686
DOC_WW_Pin1_4	300	305	PF00397	0.558
DOC_WW_Pin1_4	387	392	PF00397	0.686
DOC_WW_Pin1_4	396	401	PF00397	0.623
DOC_WW_Pin1_4	403	408	PF00397	0.532
DOC_WW_Pin1_4	455	460	PF00397	0.687
DOC_WW_Pin1_4	469	474	PF00397	0.569
DOC_WW_Pin1_4	522	527	PF00397	0.657
DOC_WW_Pin1_4	530	535	PF00397	0.677
DOC_WW_Pin1_4	55	60	PF00397	0.542
DOC_WW_Pin1_4	551	556	PF00397	0.691
DOC_WW_Pin1_4	561	566	PF00397	0.591
DOC_WW_Pin1_4	568	573	PF00397	0.554
DOC_WW_Pin1_4	586	591	PF00397	0.563
DOC_WW_Pin1_4	633	638	PF00397	0.663
DOC_WW_Pin1_4	641	646	PF00397	0.648
DOC_WW_Pin1_4	672	677	PF00397	0.666
DOC_WW_Pin1_4	714	719	PF00397	0.668
DOC_WW_Pin1_4	740	745	PF00397	0.668
DOC_WW_Pin1_4	768	773	PF00397	0.622
DOC_WW_Pin1_4	783	788	PF00397	0.587
LIG_14-3-3_CanoR_1	110	118	PF00244	0.542
LIG_14-3-3_CanoR_1	126	130	PF00244	0.357
LIG_14-3-3_CanoR_1	182	188	PF00244	0.607
LIG_14-3-3_CanoR_1	263	269	PF00244	0.665
LIG_14-3-3_CanoR_1	27	37	PF00244	0.574
LIG_14-3-3_CanoR_1	687	691	PF00244	0.628
LIG_Actin_WH2_2	356	373	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BIR_III_1	1	5	PF00653	0.542
LIG_BIR_III_3	1	5	PF00653	0.542
LIG_BRCT_BRCA1_1	2	6	PF00533	0.566
LIG_BRCT_BRCA1_1	808	812	PF00533	0.539
LIG_Clathr_ClatBox_1	20	24	PF01394	0.542
LIG_Clathr_ClatBox_1	360	364	PF01394	0.559
LIG_CtBP_PxDLS_1	450	454	PF00389	0.668
LIG_EVH1_1	464	468	PF00568	0.613
LIG_EVH1_1	594	598	PF00568	0.604
LIG_FHA_1	156	162	PF00498	0.663
LIG_FHA_1	197	203	PF00498	0.578
LIG_FHA_1	404	410	PF00498	0.636
LIG_FHA_1	554	560	PF00498	0.698
LIG_FHA_1	562	568	PF00498	0.644
LIG_FHA_1	587	593	PF00498	0.694
LIG_FHA_1	617	623	PF00498	0.702
LIG_FHA_1	655	661	PF00498	0.681
LIG_FHA_2	30	36	PF00498	0.540
LIG_FHA_2	313	319	PF00498	0.698
LIG_FHA_2	48	54	PF00498	0.542
LIG_FHA_2	721	727	PF00498	0.710
LIG_GSK3_LRP6_1	387	392	PF00069	0.654
LIG_LIR_Apic_2	158	163	PF02991	0.561
LIG_LIR_Apic_2	743	749	PF02991	0.553
LIG_LIR_Apic_2	769	773	PF02991	0.705
LIG_LIR_Gen_1	3	13	PF02991	0.443
LIG_LIR_Nem_3	16	20	PF02991	0.539
LIG_LIR_Nem_3	3	9	PF02991	0.443
LIG_LIR_Nem_3	796	800	PF02991	0.644
LIG_MYND_1	451	455	PF01753	0.702
LIG_MYND_1	491	495	PF01753	0.672
LIG_PDZ_Class_2	815	820	PF00595	0.571
LIG_PROFILIN_1	459	465	PF00235	0.581
LIG_PTB_Apo_2	40	47	PF02174	0.542
LIG_SH2_PTP2	160	163	PF00017	0.504
LIG_SH2_STAP1	132	136	PF00017	0.518
LIG_SH2_STAP1	78	82	PF00017	0.542
LIG_SH2_STAT3	134	137	PF00017	0.487
LIG_SH2_STAT3	540	543	PF00017	0.722
LIG_SH2_STAT5	160	163	PF00017	0.616
LIG_SH2_STAT5	164	167	PF00017	0.573
LIG_SH2_STAT5	484	487	PF00017	0.649
LIG_SH2_STAT5	683	686	PF00017	0.693
LIG_SH2_STAT5	75	78	PF00017	0.542
LIG_SH3_1	329	335	PF00018	0.571
LIG_SH3_3	184	190	PF00018	0.644
LIG_SH3_3	198	204	PF00018	0.597
LIG_SH3_3	209	215	PF00018	0.574
LIG_SH3_3	268	274	PF00018	0.716
LIG_SH3_3	287	293	PF00018	0.549
LIG_SH3_3	294	300	PF00018	0.631
LIG_SH3_3	329	335	PF00018	0.634
LIG_SH3_3	383	389	PF00018	0.692
LIG_SH3_3	397	403	PF00018	0.556
LIG_SH3_3	417	423	PF00018	0.462
LIG_SH3_3	453	459	PF00018	0.699
LIG_SH3_3	460	466	PF00018	0.609
LIG_SH3_3	472	478	PF00018	0.514
LIG_SH3_3	549	555	PF00018	0.704
LIG_SH3_3	562	568	PF00018	0.574
LIG_SH3_3	589	595	PF00018	0.671
LIG_SH3_3	700	706	PF00018	0.679
LIG_SH3_3	715	721	PF00018	0.677
LIG_SH3_3	726	732	PF00018	0.576
LIG_SH3_3	746	752	PF00018	0.608
LIG_SH3_3	769	775	PF00018	0.682
LIG_SH3_3	781	787	PF00018	0.603
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.588
LIG_SUMO_SIM_par_1	19	24	PF11976	0.561
LIG_UBA3_1	82	89	PF00899	0.542
LIG_WRC_WIRS_1	794	799	PF05994	0.646
MOD_CK1_1	112	118	PF00069	0.542
MOD_CK1_1	174	180	PF00069	0.550
MOD_CK1_1	264	270	PF00069	0.707
MOD_CK1_1	289	295	PF00069	0.627
MOD_CK1_1	313	319	PF00069	0.631
MOD_CK1_1	444	450	PF00069	0.702
MOD_CK1_1	47	53	PF00069	0.542
MOD_CK1_1	500	506	PF00069	0.701
MOD_CK1_1	519	525	PF00069	0.547
MOD_CK1_1	528	534	PF00069	0.603
MOD_CK1_1	571	577	PF00069	0.684
MOD_CK1_1	588	594	PF00069	0.552
MOD_CK1_1	611	617	PF00069	0.697
MOD_CK1_1	618	624	PF00069	0.628
MOD_CK1_1	638	644	PF00069	0.498
MOD_CK1_1	654	660	PF00069	0.685
MOD_CK1_1	662	668	PF00069	0.629
MOD_CK1_1	672	678	PF00069	0.514
MOD_CK1_1	685	691	PF00069	0.611
MOD_CK1_1	766	772	PF00069	0.699
MOD_CK1_1	801	807	PF00069	0.665
MOD_CK2_1	312	318	PF00069	0.672
MOD_CK2_1	47	53	PF00069	0.542
MOD_CK2_1	720	726	PF00069	0.707
MOD_GlcNHglycan	146	149	PF01048	0.694
MOD_GlcNHglycan	282	285	PF01048	0.643
MOD_GlcNHglycan	312	315	PF01048	0.619
MOD_GlcNHglycan	336	340	PF01048	0.542
MOD_GlcNHglycan	391	394	PF01048	0.677
MOD_GlcNHglycan	446	449	PF01048	0.676
MOD_GlcNHglycan	502	505	PF01048	0.632
MOD_GlcNHglycan	510	513	PF01048	0.637
MOD_GlcNHglycan	641	644	PF01048	0.694
MOD_GlcNHglycan	653	656	PF01048	0.669
MOD_GlcNHglycan	664	667	PF01048	0.565
MOD_GlcNHglycan	688	691	PF01048	0.584
MOD_GlcNHglycan	787	790	PF01048	0.655
MOD_GSK3_1	121	128	PF00069	0.636
MOD_GSK3_1	182	189	PF00069	0.651
MOD_GSK3_1	219	226	PF00069	0.638
MOD_GSK3_1	259	266	PF00069	0.650
MOD_GSK3_1	280	287	PF00069	0.615
MOD_GSK3_1	29	36	PF00069	0.569
MOD_GSK3_1	306	313	PF00069	0.679
MOD_GSK3_1	482	489	PF00069	0.651
MOD_GSK3_1	525	532	PF00069	0.635
MOD_GSK3_1	551	558	PF00069	0.679
MOD_GSK3_1	571	578	PF00069	0.552
MOD_GSK3_1	584	591	PF00069	0.587
MOD_GSK3_1	607	614	PF00069	0.694
MOD_GSK3_1	633	640	PF00069	0.676
MOD_GSK3_1	646	653	PF00069	0.668
MOD_GSK3_1	679	686	PF00069	0.645
MOD_GSK3_1	706	713	PF00069	0.672
MOD_GSK3_1	762	769	PF00069	0.627
MOD_GSK3_1	798	805	PF00069	0.668
MOD_N-GLC_1	183	188	PF02516	0.651
MOD_N-GLC_1	343	348	PF02516	0.576
MOD_N-GLC_1	612	617	PF02516	0.698
MOD_N-GLC_1	763	768	PF02516	0.611
MOD_NEK2_1	144	149	PF00069	0.651
MOD_NEK2_1	259	264	PF00069	0.637
MOD_NEK2_1	28	33	PF00069	0.587
MOD_NEK2_1	370	375	PF00069	0.571
MOD_NEK2_1	409	414	PF00069	0.679
MOD_NEK2_1	529	534	PF00069	0.698
MOD_NEK2_1	616	621	PF00069	0.708
MOD_NEK2_1	639	644	PF00069	0.651
MOD_NEK2_1	738	743	PF00069	0.686
MOD_NEK2_1	756	761	PF00069	0.513
MOD_NEK2_1	800	805	PF00069	0.672
MOD_NEK2_2	793	798	PF00069	0.622
MOD_PIKK_1	121	127	PF00454	0.628
MOD_PIKK_1	205	211	PF00454	0.647
MOD_PIKK_1	261	267	PF00454	0.616
MOD_PIKK_1	497	503	PF00454	0.707
MOD_PIKK_1	711	717	PF00454	0.683
MOD_PIKK_1	76	82	PF00454	0.542
MOD_PKA_2	109	115	PF00069	0.542
MOD_PKA_2	125	131	PF00069	0.355
MOD_PKA_2	370	376	PF00069	0.577
MOD_PKA_2	47	53	PF00069	0.542
MOD_PKA_2	686	692	PF00069	0.628
MOD_PKA_2	738	744	PF00069	0.658
MOD_PKB_1	180	188	PF00069	0.633
MOD_Plk_1	183	189	PF00069	0.533
MOD_Plk_1	335	341	PF00069	0.581
MOD_Plk_1	612	618	PF00069	0.699
MOD_Plk_1	725	731	PF00069	0.599
MOD_Plk_1	763	769	PF00069	0.613
MOD_Plk_4	155	161	PF00069	0.587
MOD_Plk_4	207	213	PF00069	0.686
MOD_Plk_4	377	383	PF00069	0.656
MOD_Plk_4	679	685	PF00069	0.682
MOD_Plk_4	699	705	PF00069	0.496
MOD_ProDKin_1	186	192	PF00069	0.692
MOD_ProDKin_1	197	203	PF00069	0.599
MOD_ProDKin_1	265	271	PF00069	0.714
MOD_ProDKin_1	289	295	PF00069	0.685
MOD_ProDKin_1	300	306	PF00069	0.561
MOD_ProDKin_1	387	393	PF00069	0.688
MOD_ProDKin_1	396	402	PF00069	0.620
MOD_ProDKin_1	403	409	PF00069	0.537
MOD_ProDKin_1	455	461	PF00069	0.684
MOD_ProDKin_1	469	475	PF00069	0.569
MOD_ProDKin_1	522	528	PF00069	0.658
MOD_ProDKin_1	530	536	PF00069	0.676
MOD_ProDKin_1	55	61	PF00069	0.542
MOD_ProDKin_1	551	557	PF00069	0.691
MOD_ProDKin_1	561	567	PF00069	0.593
MOD_ProDKin_1	568	574	PF00069	0.556
MOD_ProDKin_1	586	592	PF00069	0.563
MOD_ProDKin_1	633	639	PF00069	0.661
MOD_ProDKin_1	641	647	PF00069	0.649
MOD_ProDKin_1	672	678	PF00069	0.666
MOD_ProDKin_1	714	720	PF00069	0.666
MOD_ProDKin_1	740	746	PF00069	0.668
MOD_ProDKin_1	768	774	PF00069	0.618
MOD_ProDKin_1	783	789	PF00069	0.585
TRG_DiLeu_BaEn_1	103	108	PF01217	0.542
TRG_DiLeu_BaEn_1	252	257	PF01217	0.586
TRG_ENDOCYTIC_2	605	608	PF00928	0.665
TRG_ER_diArg_1	179	182	PF00400	0.583
TRG_ER_diArg_1	232	235	PF00400	0.579
TRG_ER_diArg_1	356	358	PF00400	0.568
TRG_ER_diArg_1	816	818	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSW0	Leishmania donovani	99%	100%
A4H7K2	Leishmania braziliensis	64%	97%
E9APN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4QFU2	Leishmania major	89%	99%