Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVY3_LEIIN

TriTrypDb:

LINF_140009300

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.479
CLV_NRD_NRD_1	109	111	PF00675	0.650
CLV_NRD_NRD_1	160	162	PF00675	0.413
CLV_PCSK_KEX2_1	109	111	PF00082	0.720
CLV_PCSK_KEX2_1	160	162	PF00082	0.413
CLV_PCSK_SKI1_1	160	164	PF00082	0.459
DOC_CYCLIN_yCln2_LP_2	135	138	PF00134	0.545
DOC_PP2B_LxvP_1	135	138	PF13499	0.592
DOC_USP7_MATH_1	116	120	PF00917	0.656
DOC_USP7_MATH_1	63	67	PF00917	0.572
DOC_USP7_MATH_1	90	94	PF00917	0.503
LIG_14-3-3_CanoR_1	92	102	PF00244	0.514
LIG_Actin_WH2_2	12	30	PF00022	0.488
LIG_BIR_III_2	52	56	PF00653	0.447
LIG_FHA_1	74	80	PF00498	0.617
LIG_FHA_2	182	188	PF00498	0.474
LIG_LIR_Gen_1	97	105	PF02991	0.486
LIG_LIR_Nem_3	157	162	PF02991	0.446
LIG_LIR_Nem_3	97	103	PF02991	0.481
LIG_SH2_CRK	159	163	PF00017	0.458
LIG_SH2_STAT5	143	146	PF00017	0.487
LIG_SH3_3	120	126	PF00018	0.648
LIG_SH3_3	134	140	PF00018	0.574
LIG_SUMO_SIM_par_1	101	106	PF11976	0.484
LIG_SUMO_SIM_par_1	62	68	PF11976	0.517
MOD_CK1_1	130	136	PF00069	0.714
MOD_CK1_1	71	77	PF00069	0.706
MOD_CK1_1	93	99	PF00069	0.458
MOD_CK2_1	74	80	PF00069	0.647
MOD_GlcNHglycan	105	108	PF01048	0.535
MOD_GlcNHglycan	127	130	PF01048	0.625
MOD_GlcNHglycan	149	152	PF01048	0.447
MOD_GlcNHglycan	24	27	PF01048	0.451
MOD_GlcNHglycan	70	73	PF01048	0.587
MOD_GlcNHglycan	76	79	PF01048	0.623
MOD_GSK3_1	142	149	PF00069	0.477
MOD_GSK3_1	53	60	PF00069	0.540
MOD_GSK3_1	63	70	PF00069	0.606
MOD_GSK3_1	90	97	PF00069	0.486
MOD_NEK2_1	181	186	PF00069	0.399
MOD_NEK2_1	32	37	PF00069	0.532
MOD_NEK2_1	67	72	PF00069	0.511
MOD_PIKK_1	116	122	PF00454	0.684
MOD_PIKK_1	65	71	PF00454	0.488
MOD_PKA_2	93	99	PF00069	0.532
MOD_PKB_1	20	28	PF00069	0.415
MOD_PKB_1	92	100	PF00069	0.499
TRG_ENDOCYTIC_2	159	162	PF00928	0.451
TRG_ER_diArg_1	159	161	PF00400	0.429
TRG_NLS_MonoExtN_4	109	114	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD9	Leptomonas seymouri	46%	99%
A0A1X0NP94	Trypanosomatidae	29%	85%
A0A3Q8I9Q7	Leishmania donovani	99%	100%
A4H7K0	Leishmania braziliensis	74%	100%
E9APN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFU4	Leishmania major	93%	100%