LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter - putative
Species:
Leishmania infantum
UniProt:
A4HVY0_LEIIN
TriTrypDb:
LINF_140008800
Length:
607

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Annotations by Jardim et al.

Transporters, Plasma-membrane choline transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 15
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A4HVY0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVY0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 15
GO:0022857 transmembrane transporter activity 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.429
CLV_NRD_NRD_1 317 319 PF00675 0.204
CLV_NRD_NRD_1 595 597 PF00675 0.428
CLV_PCSK_KEX2_1 317 319 PF00082 0.204
CLV_PCSK_KEX2_1 595 597 PF00082 0.428
CLV_PCSK_SKI1_1 320 324 PF00082 0.285
CLV_PCSK_SKI1_1 81 85 PF00082 0.390
DEG_SPOP_SBC_1 231 235 PF00917 0.340
DEG_SPOP_SBC_1 303 307 PF00917 0.409
DEG_SPOP_SBC_1 413 417 PF00917 0.310
DEG_SPOP_SBC_1 441 445 PF00917 0.417
DOC_CYCLIN_RxL_1 248 258 PF00134 0.480
DOC_CYCLIN_RxL_1 317 326 PF00134 0.488
DOC_CYCLIN_yCln2_LP_2 197 203 PF00134 0.434
DOC_MAPK_gen_1 317 327 PF00069 0.487
DOC_PP1_RVXF_1 221 228 PF00149 0.252
DOC_PP1_RVXF_1 249 256 PF00149 0.480
DOC_PP2B_LxvP_1 197 200 PF13499 0.391
DOC_PP2B_PxIxI_1 363 369 PF00149 0.235
DOC_PP4_FxxP_1 552 555 PF00568 0.400
DOC_SPAK_OSR1_1 435 439 PF12202 0.429
DOC_USP7_MATH_1 168 172 PF00917 0.453
DOC_USP7_MATH_1 203 207 PF00917 0.431
DOC_USP7_MATH_1 259 263 PF00917 0.263
DOC_USP7_MATH_1 311 315 PF00917 0.543
DOC_USP7_MATH_1 330 334 PF00917 0.161
DOC_USP7_MATH_1 429 433 PF00917 0.305
DOC_USP7_MATH_1 517 521 PF00917 0.343
DOC_USP7_MATH_1 555 559 PF00917 0.306
DOC_WW_Pin1_4 207 212 PF00397 0.519
DOC_WW_Pin1_4 287 292 PF00397 0.235
DOC_WW_Pin1_4 551 556 PF00397 0.211
LIG_14-3-3_CanoR_1 17 27 PF00244 0.616
LIG_14-3-3_CanoR_1 301 309 PF00244 0.445
LIG_14-3-3_CanoR_1 317 323 PF00244 0.512
LIG_14-3-3_CanoR_1 412 421 PF00244 0.263
LIG_14-3-3_CanoR_1 442 451 PF00244 0.481
LIG_14-3-3_CanoR_1 48 56 PF00244 0.623
LIG_Actin_WH2_2 169 186 PF00022 0.307
LIG_BIR_II_1 1 5 PF00653 0.713
LIG_BRCT_BRCA1_1 264 268 PF00533 0.270
LIG_BRCT_BRCA1_1 332 336 PF00533 0.263
LIG_BRCT_BRCA1_1 500 504 PF00533 0.422
LIG_BRCT_BRCA1_1 548 552 PF00533 0.375
LIG_deltaCOP1_diTrp_1 103 107 PF00928 0.592
LIG_deltaCOP1_diTrp_1 114 121 PF00928 0.453
LIG_EH1_1 119 127 PF00400 0.186
LIG_EH1_1 541 549 PF00400 0.344
LIG_eIF4E_1 240 246 PF01652 0.302
LIG_FHA_1 231 237 PF00498 0.292
LIG_FHA_1 288 294 PF00498 0.338
LIG_FHA_1 304 310 PF00498 0.466
LIG_FHA_1 38 44 PF00498 0.615
LIG_FHA_1 489 495 PF00498 0.445
LIG_FHA_1 507 513 PF00498 0.285
LIG_FHA_1 526 532 PF00498 0.224
LIG_FHA_1 560 566 PF00498 0.479
LIG_FHA_2 140 146 PF00498 0.306
LIG_FHA_2 21 27 PF00498 0.607
LIG_FHA_2 441 447 PF00498 0.471
LIG_FHA_2 62 68 PF00498 0.614
LIG_LIR_Apic_2 549 555 PF02991 0.475
LIG_LIR_Gen_1 114 124 PF02991 0.456
LIG_LIR_Gen_1 333 342 PF02991 0.364
LIG_LIR_Gen_1 432 441 PF02991 0.263
LIG_LIR_Gen_1 448 459 PF02991 0.361
LIG_LIR_Gen_1 490 500 PF02991 0.465
LIG_LIR_Gen_1 501 512 PF02991 0.429
LIG_LIR_Gen_1 562 572 PF02991 0.505
LIG_LIR_Gen_1 580 590 PF02991 0.414
LIG_LIR_Nem_3 114 119 PF02991 0.459
LIG_LIR_Nem_3 265 271 PF02991 0.326
LIG_LIR_Nem_3 333 337 PF02991 0.351
LIG_LIR_Nem_3 415 421 PF02991 0.302
LIG_LIR_Nem_3 432 436 PF02991 0.257
LIG_LIR_Nem_3 448 454 PF02991 0.535
LIG_LIR_Nem_3 490 495 PF02991 0.457
LIG_LIR_Nem_3 501 507 PF02991 0.426
LIG_LIR_Nem_3 550 556 PF02991 0.318
LIG_LIR_Nem_3 562 567 PF02991 0.415
LIG_LIR_Nem_3 577 581 PF02991 0.491
LIG_LYPXL_yS_3 363 366 PF13949 0.263
LIG_NRBOX 282 288 PF00104 0.270
LIG_NRBOX 522 528 PF00104 0.235
LIG_PCNA_yPIPBox_3 251 264 PF02747 0.419
LIG_Pex14_1 116 120 PF04695 0.370
LIG_Pex14_2 500 504 PF04695 0.463
LIG_SH2_CRK 240 244 PF00017 0.345
LIG_SH2_CRK 472 476 PF00017 0.463
LIG_SH2_CRK 553 557 PF00017 0.345
LIG_SH2_CRK 582 586 PF00017 0.502
LIG_SH2_GRB2like 468 471 PF00017 0.463
LIG_SH2_NCK_1 553 557 PF00017 0.323
LIG_SH2_SRC 158 161 PF00017 0.258
LIG_SH2_SRC 484 487 PF00017 0.477
LIG_SH2_STAP1 39 43 PF00017 0.675
LIG_SH2_STAP1 582 586 PF00017 0.498
LIG_SH2_STAT3 249 252 PF00017 0.477
LIG_SH2_STAT3 296 299 PF00017 0.322
LIG_SH2_STAT5 28 31 PF00017 0.636
LIG_SH2_STAT5 296 299 PF00017 0.253
LIG_SH2_STAT5 39 42 PF00017 0.594
LIG_SH2_STAT5 394 397 PF00017 0.285
LIG_SH2_STAT5 468 471 PF00017 0.445
LIG_SH2_STAT5 484 487 PF00017 0.445
LIG_SH2_STAT5 564 567 PF00017 0.399
LIG_SH2_STAT5 592 595 PF00017 0.577
LIG_SH3_3 31 37 PF00018 0.665
LIG_SH3_3 399 405 PF00018 0.245
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.337
LIG_SUMO_SIM_anti_2 312 317 PF11976 0.445
LIG_SUMO_SIM_par_1 522 528 PF11976 0.346
LIG_TYR_ITIM 238 243 PF00017 0.334
LIG_TYR_ITIM 361 366 PF00017 0.235
LIG_TYR_ITIM 551 556 PF00017 0.323
LIG_Vh1_VBS_1 367 385 PF01044 0.335
LIG_WRC_WIRS_1 430 435 PF05994 0.263
MOD_CK1_1 2 8 PF00069 0.693
MOD_CK1_1 206 212 PF00069 0.475
MOD_CK1_1 262 268 PF00069 0.359
MOD_CK1_1 326 332 PF00069 0.345
MOD_CK1_1 417 423 PF00069 0.294
MOD_CK1_1 50 56 PF00069 0.645
MOD_CK1_1 554 560 PF00069 0.325
MOD_CK2_1 574 580 PF00069 0.517
MOD_CK2_1 97 103 PF00069 0.646
MOD_GlcNHglycan 257 260 PF01048 0.313
MOD_GlcNHglycan 264 267 PF01048 0.357
MOD_GlcNHglycan 328 331 PF01048 0.303
MOD_GlcNHglycan 357 360 PF01048 0.439
MOD_GlcNHglycan 378 381 PF01048 0.269
MOD_GlcNHglycan 500 503 PF01048 0.237
MOD_GlcNHglycan 519 522 PF01048 0.164
MOD_GlcNHglycan 52 55 PF01048 0.568
MOD_GlcNHglycan 95 98 PF01048 0.436
MOD_GSK3_1 203 210 PF00069 0.459
MOD_GSK3_1 227 234 PF00069 0.372
MOD_GSK3_1 255 262 PF00069 0.345
MOD_GSK3_1 326 333 PF00069 0.336
MOD_GSK3_1 413 420 PF00069 0.285
MOD_GSK3_1 437 444 PF00069 0.451
MOD_GSK3_1 46 53 PF00069 0.793
MOD_GSK3_1 525 532 PF00069 0.335
MOD_GSK3_1 542 549 PF00069 0.281
MOD_GSK3_1 551 558 PF00069 0.288
MOD_GSK3_1 597 604 PF00069 0.570
MOD_GSK3_1 88 95 PF00069 0.584
MOD_N-GLC_1 18 23 PF02516 0.449
MOD_NEK2_1 20 25 PF00069 0.618
MOD_NEK2_1 255 260 PF00069 0.361
MOD_NEK2_1 304 309 PF00069 0.490
MOD_NEK2_1 323 328 PF00069 0.285
MOD_NEK2_1 352 357 PF00069 0.331
MOD_NEK2_1 437 442 PF00069 0.520
MOD_NEK2_1 542 547 PF00069 0.349
MOD_NEK2_1 574 579 PF00069 0.489
MOD_NEK2_1 92 97 PF00069 0.609
MOD_NEK2_2 168 173 PF00069 0.342
MOD_NEK2_2 559 564 PF00069 0.483
MOD_PIKK_1 590 596 PF00454 0.521
MOD_PKA_2 411 417 PF00069 0.276
MOD_PKA_2 441 447 PF00069 0.498
MOD_PKA_2 47 53 PF00069 0.643
MOD_Plk_1 597 603 PF00069 0.568
MOD_Plk_4 232 238 PF00069 0.385
MOD_Plk_4 259 265 PF00069 0.355
MOD_Plk_4 304 310 PF00069 0.542
MOD_Plk_4 311 317 PF00069 0.485
MOD_Plk_4 344 350 PF00069 0.349
MOD_Plk_4 389 395 PF00069 0.310
MOD_Plk_4 39 45 PF00069 0.610
MOD_Plk_4 422 428 PF00069 0.290
MOD_Plk_4 429 435 PF00069 0.279
MOD_Plk_4 488 494 PF00069 0.505
MOD_Plk_4 542 548 PF00069 0.300
MOD_Plk_4 559 565 PF00069 0.418
MOD_Plk_4 597 603 PF00069 0.568
MOD_Plk_4 88 94 PF00069 0.577
MOD_ProDKin_1 207 213 PF00069 0.512
MOD_ProDKin_1 287 293 PF00069 0.235
MOD_ProDKin_1 551 557 PF00069 0.211
TRG_DiLeu_BaEn_1 490 495 PF01217 0.488
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.263
TRG_DiLeu_BaLyEn_6 347 352 PF01217 0.194
TRG_ENDOCYTIC_2 214 217 PF00928 0.430
TRG_ENDOCYTIC_2 240 243 PF00928 0.350
TRG_ENDOCYTIC_2 363 366 PF00928 0.392
TRG_ENDOCYTIC_2 472 475 PF00928 0.447
TRG_ENDOCYTIC_2 553 556 PF00928 0.323
TRG_ENDOCYTIC_2 564 567 PF00928 0.431
TRG_ENDOCYTIC_2 582 585 PF00928 0.497
TRG_ER_diArg_1 107 110 PF00400 0.618
TRG_ER_diArg_1 316 318 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.327

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA24 Leptomonas seymouri 55% 100%
A0A0S4KHP0 Bodo saltans 32% 100%
A0A3Q8I9V7 Leishmania donovani 99% 100%
A0A3R7MAJ2 Trypanosoma rangeli 29% 100%
A0A3S7XAV8 Leishmania donovani 34% 100%
A4H7J7 Leishmania braziliensis 78% 100%
A4HP90 Leishmania braziliensis 36% 100%
A4IDJ5 Leishmania infantum 34% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q4Q1K0 Leishmania major 34% 100%
Q4QFU7 Leishmania major 93% 100%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS