LeishMANIAdb
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Putative threonine synthase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative threonine synthase
Gene product:
threonine synthase - putative
Species:
Leishmania infantum
UniProt:
A4HVX7_LEIIN
TriTrypDb:
LINF_140008500
Length:
676

Annotations

Annotations by Jardim et al.

Amino acid metabolism, threonine synthase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HVX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006520 amino acid metabolic process 3 2
GO:0006566 threonine metabolic process 6 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0008652 amino acid biosynthetic process 4 2
GO:0009058 biosynthetic process 2 2
GO:0009066 aspartate family amino acid metabolic process 5 2
GO:0009067 aspartate family amino acid biosynthetic process 6 2
GO:0009088 threonine biosynthetic process 7 2
GO:0009987 cellular process 1 2
GO:0016053 organic acid biosynthetic process 4 2
GO:0019752 carboxylic acid metabolic process 5 2
GO:0043436 oxoacid metabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0044283 small molecule biosynthetic process 3 2
GO:0046394 carboxylic acid biosynthetic process 5 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
GO:1901605 alpha-amino acid metabolic process 4 2
GO:1901607 alpha-amino acid biosynthetic process 5 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004795 threonine synthase activity 5 9
GO:0016829 lyase activity 2 9
GO:0016835 carbon-oxygen lyase activity 3 9
GO:0016838 carbon-oxygen lyase activity, acting on phosphates 4 9
GO:0005488 binding 1 2
GO:0019842 vitamin binding 3 2
GO:0030170 pyridoxal phosphate binding 4 2
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 2
GO:0043168 anion binding 3 2
GO:0070279 vitamin B6 binding 3 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.447
CLV_C14_Caspase3-7 212 216 PF00656 0.625
CLV_C14_Caspase3-7 503 507 PF00656 0.280
CLV_NRD_NRD_1 429 431 PF00675 0.342
CLV_PCSK_KEX2_1 97 99 PF00082 0.606
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.545
CLV_PCSK_SKI1_1 12 16 PF00082 0.411
CLV_PCSK_SKI1_1 19 23 PF00082 0.346
CLV_PCSK_SKI1_1 340 344 PF00082 0.263
CLV_PCSK_SKI1_1 531 535 PF00082 0.340
CLV_PCSK_SKI1_1 565 569 PF00082 0.572
CLV_PCSK_SKI1_1 651 655 PF00082 0.474
CLV_PCSK_SKI1_1 82 86 PF00082 0.389
DEG_APCC_DBOX_1 81 89 PF00400 0.382
DEG_Nend_Nbox_1 1 3 PF02207 0.402
DEG_SPOP_SBC_1 459 463 PF00917 0.330
DOC_CKS1_1 196 201 PF01111 0.333
DOC_CYCLIN_RxL_1 340 347 PF00134 0.284
DOC_CYCLIN_RxL_1 470 482 PF00134 0.250
DOC_CYCLIN_RxL_1 79 87 PF00134 0.456
DOC_PP2B_PxIxI_1 463 469 PF00149 0.250
DOC_PP4_FxxP_1 226 229 PF00568 0.545
DOC_PP4_FxxP_1 242 245 PF00568 0.118
DOC_PP4_FxxP_1 400 403 PF00568 0.291
DOC_PP4_FxxP_1 502 505 PF00568 0.392
DOC_PP4_FxxP_1 593 596 PF00568 0.360
DOC_USP7_MATH_1 222 226 PF00917 0.631
DOC_USP7_MATH_1 234 238 PF00917 0.310
DOC_USP7_MATH_1 277 281 PF00917 0.309
DOC_USP7_MATH_1 330 334 PF00917 0.358
DOC_USP7_MATH_1 459 463 PF00917 0.263
DOC_USP7_MATH_1 49 53 PF00917 0.521
DOC_USP7_MATH_1 570 574 PF00917 0.604
DOC_USP7_MATH_1 611 615 PF00917 0.528
DOC_USP7_UBL2_3 631 635 PF12436 0.447
DOC_WW_Pin1_4 168 173 PF00397 0.346
DOC_WW_Pin1_4 195 200 PF00397 0.357
DOC_WW_Pin1_4 204 209 PF00397 0.604
DOC_WW_Pin1_4 307 312 PF00397 0.327
DOC_WW_Pin1_4 460 465 PF00397 0.283
LIG_14-3-3_CanoR_1 107 116 PF00244 0.461
LIG_14-3-3_CanoR_1 187 194 PF00244 0.432
LIG_14-3-3_CanoR_1 454 459 PF00244 0.337
LIG_14-3-3_CanoR_1 65 74 PF00244 0.399
LIG_BRCT_BRCA1_1 222 226 PF00533 0.597
LIG_DCNL_PONY_1 1 4 PF03556 0.364
LIG_FAT_LD_1 489 497 PF03623 0.439
LIG_FHA_1 1 7 PF00498 0.386
LIG_FHA_1 196 202 PF00498 0.367
LIG_FHA_1 261 267 PF00498 0.296
LIG_FHA_1 313 319 PF00498 0.381
LIG_FHA_1 326 332 PF00498 0.232
LIG_FHA_1 455 461 PF00498 0.405
LIG_FHA_1 484 490 PF00498 0.309
LIG_FHA_1 496 502 PF00498 0.309
LIG_FHA_2 135 141 PF00498 0.447
LIG_FHA_2 277 283 PF00498 0.256
LIG_FHA_2 339 345 PF00498 0.330
LIG_FHA_2 501 507 PF00498 0.375
LIG_FHA_2 569 575 PF00498 0.586
LIG_GBD_Chelix_1 488 496 PF00786 0.392
LIG_LIR_Apic_2 223 229 PF02991 0.569
LIG_LIR_Apic_2 240 245 PF02991 0.250
LIG_LIR_Gen_1 113 123 PF02991 0.274
LIG_LIR_Gen_1 271 278 PF02991 0.301
LIG_LIR_Gen_1 440 451 PF02991 0.284
LIG_LIR_Gen_1 475 481 PF02991 0.309
LIG_LIR_Gen_1 587 598 PF02991 0.293
LIG_LIR_Nem_3 113 118 PF02991 0.274
LIG_LIR_Nem_3 173 179 PF02991 0.408
LIG_LIR_Nem_3 246 252 PF02991 0.250
LIG_LIR_Nem_3 271 276 PF02991 0.301
LIG_LIR_Nem_3 370 376 PF02991 0.250
LIG_LIR_Nem_3 440 446 PF02991 0.284
LIG_LIR_Nem_3 475 480 PF02991 0.309
LIG_LIR_Nem_3 56 62 PF02991 0.438
LIG_LIR_Nem_3 587 593 PF02991 0.323
LIG_LYPXL_S_1 175 179 PF13949 0.392
LIG_LYPXL_yS_3 176 179 PF13949 0.392
LIG_PCNA_PIPBox_1 339 348 PF02747 0.243
LIG_PCNA_yPIPBox_3 231 242 PF02747 0.438
LIG_PCNA_yPIPBox_3 339 352 PF02747 0.278
LIG_PCNA_yPIPBox_3 439 447 PF02747 0.392
LIG_PCNA_yPIPBox_3 65 78 PF02747 0.379
LIG_PDZ_Class_1 671 676 PF00595 0.342
LIG_Pex14_2 257 261 PF04695 0.250
LIG_SH2_CRK 443 447 PF00017 0.330
LIG_SH2_PTP2 273 276 PF00017 0.284
LIG_SH2_SRC 154 157 PF00017 0.284
LIG_SH2_SRC 183 186 PF00017 0.364
LIG_SH2_SRC 626 629 PF00017 0.445
LIG_SH2_STAT5 130 133 PF00017 0.343
LIG_SH2_STAT5 145 148 PF00017 0.173
LIG_SH2_STAT5 154 157 PF00017 0.230
LIG_SH2_STAT5 260 263 PF00017 0.223
LIG_SH2_STAT5 273 276 PF00017 0.284
LIG_SH2_STAT5 383 386 PF00017 0.250
LIG_SH2_STAT5 420 423 PF00017 0.343
LIG_SH2_STAT5 479 482 PF00017 0.295
LIG_SH3_1 133 139 PF00018 0.392
LIG_SH3_3 133 139 PF00018 0.327
LIG_SH3_3 193 199 PF00018 0.338
LIG_SH3_3 299 305 PF00018 0.250
LIG_SH3_3 354 360 PF00018 0.330
LIG_SH3_3 388 394 PF00018 0.392
LIG_SH3_3 403 409 PF00018 0.284
LIG_SH3_3 51 57 PF00018 0.431
LIG_SUMO_SIM_anti_2 298 304 PF11976 0.266
LIG_SUMO_SIM_anti_2 402 408 PF11976 0.309
LIG_SUMO_SIM_anti_2 465 470 PF11976 0.250
LIG_SUMO_SIM_par_1 2 7 PF11976 0.514
LIG_SUMO_SIM_par_1 456 463 PF11976 0.330
LIG_SUMO_SIM_par_1 580 587 PF11976 0.321
LIG_TRAF2_1 618 621 PF00917 0.530
LIG_TYR_ITIM 441 446 PF00017 0.343
LIG_TYR_ITSM 172 179 PF00017 0.330
LIG_UBA3_1 424 431 PF00899 0.340
LIG_WRC_WIRS_1 317 322 PF05994 0.392
MOD_CDK_SPxK_1 204 210 PF00069 0.559
MOD_CK1_1 102 108 PF00069 0.421
MOD_CK1_1 110 116 PF00069 0.381
MOD_CK1_1 186 192 PF00069 0.430
MOD_CK1_1 280 286 PF00069 0.250
MOD_CK1_1 32 38 PF00069 0.543
MOD_CK1_1 367 373 PF00069 0.250
MOD_CK1_1 462 468 PF00069 0.434
MOD_CK1_1 537 543 PF00069 0.431
MOD_CK1_1 572 578 PF00069 0.628
MOD_CK1_1 69 75 PF00069 0.505
MOD_CK1_1 87 93 PF00069 0.573
MOD_CK2_1 234 240 PF00069 0.352
MOD_CK2_1 32 38 PF00069 0.496
MOD_CK2_1 338 344 PF00069 0.330
MOD_CK2_1 469 475 PF00069 0.273
MOD_CK2_1 529 535 PF00069 0.307
MOD_CK2_1 70 76 PF00069 0.368
MOD_GlcNHglycan 211 214 PF01048 0.618
MOD_GlcNHglycan 279 282 PF01048 0.250
MOD_GlcNHglycan 288 291 PF01048 0.250
MOD_GlcNHglycan 29 32 PF01048 0.424
MOD_GlcNHglycan 366 369 PF01048 0.250
MOD_GlcNHglycan 38 41 PF01048 0.501
MOD_GlcNHglycan 417 420 PF01048 0.336
MOD_GlcNHglycan 50 54 PF01048 0.495
MOD_GlcNHglycan 537 540 PF01048 0.356
MOD_GlcNHglycan 78 81 PF01048 0.322
MOD_GSK3_1 134 141 PF00069 0.355
MOD_GSK3_1 166 173 PF00069 0.389
MOD_GSK3_1 260 267 PF00069 0.316
MOD_GSK3_1 276 283 PF00069 0.250
MOD_GSK3_1 312 319 PF00069 0.408
MOD_GSK3_1 32 39 PF00069 0.570
MOD_GSK3_1 321 328 PF00069 0.444
MOD_GSK3_1 363 370 PF00069 0.260
MOD_GSK3_1 4 11 PF00069 0.354
MOD_GSK3_1 454 461 PF00069 0.289
MOD_GSK3_1 479 486 PF00069 0.323
MOD_GSK3_1 561 568 PF00069 0.447
MOD_GSK3_1 570 577 PF00069 0.454
MOD_GSK3_1 66 73 PF00069 0.377
MOD_GSK3_1 84 91 PF00069 0.411
MOD_GSK3_1 99 106 PF00069 0.520
MOD_N-GLC_1 234 239 PF02516 0.372
MOD_N-GLC_1 454 459 PF02516 0.305
MOD_NEK2_1 103 108 PF00069 0.253
MOD_NEK2_1 276 281 PF00069 0.262
MOD_NEK2_1 29 34 PF00069 0.360
MOD_NEK2_1 4 9 PF00069 0.349
MOD_NEK2_1 445 450 PF00069 0.273
MOD_NEK2_1 458 463 PF00069 0.314
MOD_NEK2_1 469 474 PF00069 0.250
MOD_NEK2_1 534 539 PF00069 0.395
MOD_NEK2_1 66 71 PF00069 0.401
MOD_NEK2_1 84 89 PF00069 0.507
MOD_NEK2_2 338 343 PF00069 0.250
MOD_NEK2_2 526 531 PF00069 0.284
MOD_PIKK_1 138 144 PF00454 0.250
MOD_PIKK_1 264 270 PF00454 0.347
MOD_PIKK_1 295 301 PF00454 0.392
MOD_PIKK_1 312 318 PF00454 0.392
MOD_PIKK_1 321 327 PF00454 0.367
MOD_PIKK_1 67 73 PF00454 0.250
MOD_PIKK_1 88 94 PF00454 0.374
MOD_PKA_2 186 192 PF00069 0.383
MOD_PKA_2 209 215 PF00069 0.660
MOD_PKA_2 519 525 PF00069 0.272
MOD_PKA_2 8 14 PF00069 0.462
MOD_Plk_1 166 172 PF00069 0.262
MOD_Plk_1 234 240 PF00069 0.377
MOD_Plk_1 454 460 PF00069 0.305
MOD_Plk_1 49 55 PF00069 0.398
MOD_Plk_4 171 177 PF00069 0.401
MOD_Plk_4 234 240 PF00069 0.339
MOD_Plk_4 38 44 PF00069 0.407
MOD_Plk_4 529 535 PF00069 0.336
MOD_Plk_4 99 105 PF00069 0.545
MOD_ProDKin_1 168 174 PF00069 0.346
MOD_ProDKin_1 195 201 PF00069 0.358
MOD_ProDKin_1 204 210 PF00069 0.609
MOD_ProDKin_1 307 313 PF00069 0.327
MOD_ProDKin_1 460 466 PF00069 0.283
MOD_SUMO_rev_2 11 16 PF00179 0.488
TRG_DiLeu_BaEn_2 110 116 PF01217 0.328
TRG_DiLeu_BaLyEn_6 174 179 PF01217 0.280
TRG_DiLeu_BaLyEn_6 196 201 PF01217 0.377
TRG_DiLeu_BaLyEn_6 372 377 PF01217 0.265
TRG_DiLeu_BaLyEn_6 538 543 PF01217 0.289
TRG_ENDOCYTIC_2 176 179 PF00928 0.392
TRG_ENDOCYTIC_2 273 276 PF00928 0.249
TRG_ENDOCYTIC_2 443 446 PF00928 0.343
TRG_ENDOCYTIC_2 626 629 PF00928 0.322
TRG_ENDOCYTIC_2 64 67 PF00928 0.340
TRG_ER_diArg_1 453 456 PF00400 0.284
TRG_NES_CRM1_1 13 25 PF08389 0.347
TRG_Pf-PMV_PEXEL_1 375 379 PF00026 0.265
TRG_Pf-PMV_PEXEL_1 623 628 PF00026 0.344
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZJ2 Leptomonas seymouri 72% 99%
A0A0S4ITY7 Bodo saltans 46% 100%
A0A1X0NNP4 Trypanosomatidae 48% 100%
A0A3Q8II85 Leishmania donovani 100% 100%
A0A422NX69 Trypanosoma rangeli 53% 100%
A4H7J4 Leishmania braziliensis 85% 100%
C9ZT46 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9APM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O24924 Helicobacter pylori (strain ATCC 700392 / 26695) 33% 100%
P16120 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
P23669 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 33% 100%
P29363 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 34% 100%
P37145 Methylobacillus glycogenes 34% 100%
Q00063 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 31% 100%
Q2YDP8 Danio rerio 29% 100%
Q42598 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
Q4QFV0 Leishmania major 95% 100%
Q5M7T9 Rattus norvegicus 29% 100%
Q5R5P3 Pongo abelii 38% 91%
Q5RFE6 Pongo abelii 28% 100%
Q5XH07 Xenopus laevis 27% 100%
Q80W22 Mus musculus 28% 100%
Q86YJ6 Homo sapiens 28% 100%
Q8BH55 Mus musculus 37% 90%
Q8IYQ7 Homo sapiens 38% 91%
Q9BH05 Macaca fascicularis 38% 91%
Q9ZMX5 Helicobacter pylori (strain J99 / ATCC 700824) 32% 100%
V5BD69 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS