Putative amino acid permease

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease - putative

Species:

Leishmania infantum

UniProt:

A4HVX4_LEIIN

TriTrypDb:

LINF_140008200

Length:

803

Annotations

Annotations by Jardim et al.

Transporters, Polyamine transporter (putrescine) AAT21

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HVX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX4

Function

Biological processes
Term	Name	Level	Count
GO:0000296	spermine transport	6	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0015695	organic cation transport	5	1
GO:0015846	polyamine transport	5	1
GO:0015847	putrescine transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:1902047	polyamine transmembrane transport	3	1
GO:1903710	spermine transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0015203	polyamine transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0015489	putrescine transmembrane transporter activity	4	1
GO:0015606	spermidine transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	551	555	PF00656	0.762
CLV_C14_Caspase3-7	616	620	PF00656	0.717
CLV_C14_Caspase3-7	635	639	PF00656	0.662
CLV_NRD_NRD_1	304	306	PF00675	0.361
CLV_NRD_NRD_1	61	63	PF00675	0.492
CLV_NRD_NRD_1	73	75	PF00675	0.438
CLV_NRD_NRD_1	793	795	PF00675	0.615
CLV_NRD_NRD_1	80	82	PF00675	0.511
CLV_NRD_NRD_1	86	88	PF00675	0.435
CLV_PCSK_FUR_1	59	63	PF00082	0.536
CLV_PCSK_KEX2_1	304	306	PF00082	0.342
CLV_PCSK_KEX2_1	61	63	PF00082	0.478
CLV_PCSK_KEX2_1	73	75	PF00082	0.444
CLV_PCSK_KEX2_1	80	82	PF00082	0.344
CLV_PCSK_KEX2_1	86	88	PF00082	0.435
CLV_PCSK_SKI1_1	264	268	PF00082	0.398
CLV_PCSK_SKI1_1	272	276	PF00082	0.303
CLV_PCSK_SKI1_1	304	308	PF00082	0.360
CLV_PCSK_SKI1_1	360	364	PF00082	0.560
CLV_PCSK_SKI1_1	447	451	PF00082	0.357
DEG_APCC_DBOX_1	94	102	PF00400	0.560
DEG_Nend_UBRbox_1	1	4	PF02207	0.782
DEG_ODPH_VHL_1	209	222	PF01847	0.376
DEG_SPOP_SBC_1	234	238	PF00917	0.339
DEG_SPOP_SBC_1	593	597	PF00917	0.713
DEG_SPOP_SBC_1	742	746	PF00917	0.740
DEG_SPOP_SBC_1	782	786	PF00917	0.616
DOC_CKS1_1	410	415	PF01111	0.357
DOC_CYCLIN_RxL_1	444	454	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.701
DOC_MAPK_DCC_7	409	419	PF00069	0.438
DOC_MAPK_gen_1	56	66	PF00069	0.743
DOC_MAPK_JIP1_4	467	473	PF00069	0.598
DOC_MAPK_MEF2A_6	264	271	PF00069	0.598
DOC_MAPK_MEF2A_6	309	316	PF00069	0.506
DOC_MAPK_MEF2A_6	59	68	PF00069	0.729
DOC_MAPK_NFAT4_5	309	317	PF00069	0.510
DOC_PP1_RVXF_1	270	277	PF00149	0.559
DOC_PP2B_LxvP_1	583	586	PF13499	0.783
DOC_PP2B_LxvP_1	587	590	PF13499	0.738
DOC_PP2B_LxvP_1	759	762	PF13499	0.763
DOC_PP2B_PxIxI_1	414	420	PF00149	0.438
DOC_USP7_MATH_1	155	159	PF00917	0.501
DOC_USP7_MATH_1	172	176	PF00917	0.501
DOC_USP7_MATH_1	328	332	PF00917	0.357
DOC_USP7_MATH_1	497	501	PF00917	0.310
DOC_USP7_MATH_1	553	557	PF00917	0.694
DOC_USP7_MATH_1	592	596	PF00917	0.753
DOC_USP7_MATH_1	599	603	PF00917	0.785
DOC_USP7_MATH_1	620	624	PF00917	0.764
DOC_USP7_MATH_1	655	659	PF00917	0.781
DOC_USP7_MATH_1	665	669	PF00917	0.669
DOC_USP7_MATH_1	700	704	PF00917	0.815
DOC_USP7_MATH_1	708	712	PF00917	0.748
DOC_USP7_MATH_1	724	728	PF00917	0.791
DOC_USP7_MATH_1	763	767	PF00917	0.763
DOC_WW_Pin1_4	409	414	PF00397	0.357
DOC_WW_Pin1_4	661	666	PF00397	0.781
DOC_WW_Pin1_4	719	724	PF00397	0.797
DOC_WW_Pin1_4	743	748	PF00397	0.791
DOC_WW_Pin1_4	750	755	PF00397	0.749
DOC_WW_Pin1_4	769	774	PF00397	0.759
DOC_WW_Pin1_4	778	783	PF00397	0.718
LIG_14-3-3_CanoR_1	95	104	PF00244	0.598
LIG_Actin_WH2_2	60	75	PF00022	0.718
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.598
LIG_BIR_III_4	619	623	PF00653	0.780
LIG_BRCT_BRCA1_1	258	262	PF00533	0.598
LIG_BRCT_BRCA1_1	429	433	PF00533	0.333
LIG_deltaCOP1_diTrp_1	357	364	PF00928	0.344
LIG_eIF4E_1	444	450	PF01652	0.357
LIG_FHA_1	128	134	PF00498	0.357
LIG_FHA_1	180	186	PF00498	0.501
LIG_FHA_1	380	386	PF00498	0.357
LIG_FHA_1	432	438	PF00498	0.388
LIG_FHA_1	475	481	PF00498	0.486
LIG_FHA_1	669	675	PF00498	0.806
LIG_FHA_1	73	79	PF00498	0.657
LIG_FHA_1	783	789	PF00498	0.768
LIG_FHA_1	98	104	PF00498	0.438
LIG_FHA_2	25	31	PF00498	0.635
LIG_FHA_2	614	620	PF00498	0.746
LIG_FHA_2	633	639	PF00498	0.743
LIG_FHA_2	720	726	PF00498	0.825
LIG_LIR_Gen_1	175	184	PF02991	0.503
LIG_LIR_Gen_1	278	288	PF02991	0.521
LIG_LIR_Gen_1	430	439	PF02991	0.359
LIG_LIR_Gen_1	518	526	PF02991	0.504
LIG_LIR_Nem_3	175	179	PF02991	0.503
LIG_LIR_Nem_3	182	187	PF02991	0.505
LIG_LIR_Nem_3	192	196	PF02991	0.517
LIG_LIR_Nem_3	278	283	PF02991	0.516
LIG_LIR_Nem_3	284	290	PF02991	0.525
LIG_LIR_Nem_3	317	322	PF02991	0.357
LIG_LIR_Nem_3	357	361	PF02991	0.305
LIG_LIR_Nem_3	430	436	PF02991	0.300
LIG_LIR_Nem_3	461	465	PF02991	0.560
LIG_LIR_Nem_3	518	524	PF02991	0.415
LIG_LIR_Nem_3	666	672	PF02991	0.755
LIG_LYPXL_yS_3	193	196	PF13949	0.501
LIG_LYPXL_yS_3	462	465	PF13949	0.560
LIG_MYND_2	747	751	PF01753	0.734
LIG_NRBOX	445	451	PF00104	0.391
LIG_PDZ_Class_1	798	803	PF00595	0.755
LIG_Pex14_1	139	143	PF04695	0.438
LIG_Pex14_1	276	280	PF04695	0.560
LIG_Pex14_2	104	108	PF04695	0.363
LIG_Pex14_2	258	262	PF04695	0.531
LIG_PTB_Apo_2	187	194	PF02174	0.501
LIG_PTB_Phospho_1	187	193	PF10480	0.501
LIG_SH2_CRK	452	456	PF00017	0.357
LIG_SH2_CRK	469	473	PF00017	0.501
LIG_SH2_CRK	521	525	PF00017	0.616
LIG_SH2_GRB2like	287	290	PF00017	0.501
LIG_SH2_NCK_1	287	291	PF00017	0.501
LIG_SH2_NCK_1	469	473	PF00017	0.598
LIG_SH2_PTP2	268	271	PF00017	0.548
LIG_SH2_PTP2	322	325	PF00017	0.438
LIG_SH2_SRC	268	271	PF00017	0.544
LIG_SH2_SRC	287	290	PF00017	0.446
LIG_SH2_STAP1	200	204	PF00017	0.560
LIG_SH2_STAP1	452	456	PF00017	0.357
LIG_SH2_STAT3	200	203	PF00017	0.560
LIG_SH2_STAT3	634	637	PF00017	0.818
LIG_SH2_STAT5	268	271	PF00017	0.548
LIG_SH2_STAT5	319	322	PF00017	0.354
LIG_SH2_STAT5	444	447	PF00017	0.357
LIG_SH2_STAT5	521	524	PF00017	0.537
LIG_SH2_STAT5	634	637	PF00017	0.742
LIG_SH3_1	794	800	PF00018	0.751
LIG_SH3_3	19	25	PF00018	0.676
LIG_SH3_3	297	303	PF00018	0.501
LIG_SH3_3	460	466	PF00018	0.499
LIG_SH3_3	478	484	PF00018	0.441
LIG_SH3_3	793	799	PF00018	0.694
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.438
LIG_SUMO_SIM_anti_2	421	428	PF11976	0.442
LIG_SUMO_SIM_anti_2	477	484	PF11976	0.486
LIG_SUMO_SIM_par_1	312	318	PF11976	0.492
LIG_SxIP_EBH_1	409	420	PF03271	0.438
LIG_TRAF2_1	565	568	PF00917	0.763
LIG_TRAF2_1	625	628	PF00917	0.824
LIG_TRAF2_1	711	714	PF00917	0.794
LIG_TYR_ITIM	266	271	PF00017	0.548
LIG_TYR_ITIM	450	455	PF00017	0.357
LIG_TYR_ITIM	460	465	PF00017	0.501
LIG_UBA3_1	251	260	PF00899	0.376
LIG_ULM_U2AF65_1	272	277	PF00076	0.445
LIG_WRC_WIRS_1	173	178	PF05994	0.514
LIG_WRC_WIRS_1	184	189	PF05994	0.480
MOD_CK1_1	281	287	PF00069	0.508
MOD_CK1_1	421	427	PF00069	0.391
MOD_CK1_1	435	441	PF00069	0.391
MOD_CK1_1	474	480	PF00069	0.505
MOD_CK1_1	493	499	PF00069	0.287
MOD_CK1_1	515	521	PF00069	0.383
MOD_CK1_1	556	562	PF00069	0.765
MOD_CK1_1	664	670	PF00069	0.769
MOD_CK1_1	766	772	PF00069	0.765
MOD_CK1_1	781	787	PF00069	0.631
MOD_CK1_1	8	14	PF00069	0.795
MOD_CK1_1	97	103	PF00069	0.422
MOD_CK2_1	708	714	PF00069	0.765
MOD_CK2_1	719	725	PF00069	0.774
MOD_CMANNOS	609	612	PF00535	0.457
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.763
MOD_GlcNHglycan	123	126	PF01048	0.492
MOD_GlcNHglycan	159	162	PF01048	0.301
MOD_GlcNHglycan	330	333	PF01048	0.357
MOD_GlcNHglycan	369	372	PF01048	0.425
MOD_GlcNHglycan	495	498	PF01048	0.564
MOD_GlcNHglycan	514	517	PF01048	0.274
MOD_GlcNHglycan	540	543	PF01048	0.470
MOD_GlcNHglycan	554	558	PF01048	0.496
MOD_GlcNHglycan	570	573	PF01048	0.487
MOD_GlcNHglycan	6	10	PF01048	0.574
MOD_GlcNHglycan	702	705	PF01048	0.575
MOD_GlcNHglycan	710	713	PF01048	0.540
MOD_GlcNHglycan	714	717	PF01048	0.532
MOD_GlcNHglycan	725	729	PF01048	0.591
MOD_GlcNHglycan	733	736	PF01048	0.594
MOD_GlcNHglycan	776	779	PF01048	0.568
MOD_GlcNHglycan	785	788	PF01048	0.485
MOD_GSK3_1	151	158	PF00069	0.501
MOD_GSK3_1	179	186	PF00069	0.501
MOD_GSK3_1	375	382	PF00069	0.357
MOD_GSK3_1	421	428	PF00069	0.438
MOD_GSK3_1	431	438	PF00069	0.360
MOD_GSK3_1	471	478	PF00069	0.593
MOD_GSK3_1	486	493	PF00069	0.306
MOD_GSK3_1	599	606	PF00069	0.805
MOD_GSK3_1	657	664	PF00069	0.749
MOD_GSK3_1	708	715	PF00069	0.758
MOD_GSK3_1	729	736	PF00069	0.788
MOD_GSK3_1	763	770	PF00069	0.768
MOD_GSK3_1	774	781	PF00069	0.770
MOD_LATS_1	3	9	PF00433	0.736
MOD_N-GLC_1	189	194	PF02516	0.301
MOD_N-GLC_1	604	609	PF02516	0.554
MOD_N-GLC_1	649	654	PF02516	0.573
MOD_N-GLC_1	719	724	PF02516	0.562
MOD_N-GLC_1	788	793	PF02516	0.567
MOD_NEK2_1	163	168	PF00069	0.554
MOD_NEK2_1	314	319	PF00069	0.357
MOD_NEK2_1	374	379	PF00069	0.399
MOD_NEK2_1	418	423	PF00069	0.358
MOD_NEK2_1	425	430	PF00069	0.355
MOD_NEK2_1	431	436	PF00069	0.298
MOD_NEK2_1	439	444	PF00069	0.325
MOD_NEK2_1	48	53	PF00069	0.672
MOD_NEK2_1	490	495	PF00069	0.438
MOD_NEK2_1	57	62	PF00069	0.583
MOD_NEK2_1	632	637	PF00069	0.789
MOD_NEK2_1	656	661	PF00069	0.792
MOD_NEK2_1	731	736	PF00069	0.810
MOD_NEK2_1	790	795	PF00069	0.773
MOD_NEK2_2	678	683	PF00069	0.768
MOD_PIKK_1	604	610	PF00454	0.753
MOD_PIKK_1	620	626	PF00454	0.615
MOD_PIKK_1	633	639	PF00454	0.633
MOD_PKA_1	397	403	PF00069	0.501
MOD_PKA_2	599	605	PF00069	0.736
MOD_PKA_2	72	78	PF00069	0.642
MOD_PKA_2	94	100	PF00069	0.511
MOD_PKB_1	685	693	PF00069	0.794
MOD_Plk_1	189	195	PF00069	0.501
MOD_Plk_1	431	437	PF00069	0.331
MOD_Plk_1	604	610	PF00069	0.656
MOD_Plk_1	678	684	PF00069	0.822
MOD_Plk_4	172	178	PF00069	0.509
MOD_Plk_4	179	185	PF00069	0.491
MOD_Plk_4	235	241	PF00069	0.438
MOD_Plk_4	250	256	PF00069	0.438
MOD_Plk_4	315	321	PF00069	0.333
MOD_Plk_4	418	424	PF00069	0.363
MOD_Plk_4	432	438	PF00069	0.290
MOD_Plk_4	439	445	PF00069	0.406
MOD_Plk_4	451	457	PF00069	0.225
MOD_Plk_4	490	496	PF00069	0.425
MOD_Plk_4	515	521	PF00069	0.390
MOD_ProDKin_1	409	415	PF00069	0.357
MOD_ProDKin_1	661	667	PF00069	0.779
MOD_ProDKin_1	719	725	PF00069	0.797
MOD_ProDKin_1	743	749	PF00069	0.791
MOD_ProDKin_1	750	756	PF00069	0.749
MOD_ProDKin_1	769	775	PF00069	0.759
MOD_ProDKin_1	778	784	PF00069	0.719
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.438
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.357
TRG_ENDOCYTIC_2	193	196	PF00928	0.525
TRG_ENDOCYTIC_2	268	271	PF00928	0.544
TRG_ENDOCYTIC_2	287	290	PF00928	0.446
TRG_ENDOCYTIC_2	361	364	PF00928	0.357
TRG_ENDOCYTIC_2	452	455	PF00928	0.357
TRG_ENDOCYTIC_2	462	465	PF00928	0.501
TRG_ENDOCYTIC_2	521	524	PF00928	0.610
TRG_ER_diArg_1	303	305	PF00400	0.542
TRG_ER_diArg_1	59	62	PF00400	0.676
TRG_ER_diArg_1	682	685	PF00400	0.761
TRG_ER_diArg_1	72	74	PF00400	0.645
TRG_ER_diArg_1	79	81	PF00400	0.647
TRG_ER_diArg_1	85	87	PF00400	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U3	Leptomonas seymouri	64%	99%
A0A3R7M6P3	Trypanosoma rangeli	62%	100%
A0A3S7WSV4	Leishmania donovani	100%	100%
A4H7J1	Leishmania braziliensis	79%	99%
E9APM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q5C8V6	Leishmania major	95%	100%
V5DDZ5	Trypanosoma cruzi	60%	100%