Proteasome subunit alpha type

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome alpha 3 subunit - putative

Species:

Leishmania infantum

UniProt:

A4HVX3_LEIIN

TriTrypDb:

LINF_140008100

Length:

285

Annotations

Annotations by Jardim et al.

Proteasome, Proteasome subunit alpha type

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	1
GO:0005839	proteasome core complex	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HVX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX3

PDB structure(s): 6qm7_C , 6qm7_Q , 6qm8_C , 6qm8_Q

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	11
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.468
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.531
DOC_PP4_FxxP_1	107	110	PF00568	0.500
DOC_USP7_UBL2_3	237	241	PF12436	0.573
DOC_WW_Pin1_4	10	15	PF00397	0.451
DOC_WW_Pin1_4	240	245	PF00397	0.375
LIG_14-3-3_CanoR_1	8	13	PF00244	0.441
LIG_14-3-3_CanoR_1	97	105	PF00244	0.447
LIG_AP2alpha_2	234	236	PF02296	0.495
LIG_APCC_ABBA_1	254	259	PF00400	0.466
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_eIF4E_1	136	142	PF01652	0.525
LIG_FHA_1	206	212	PF00498	0.480
LIG_FHA_2	104	110	PF00498	0.459
LIG_FHA_2	188	194	PF00498	0.451
LIG_FHA_2	248	254	PF00498	0.287
LIG_FHA_2	64	70	PF00498	0.501
LIG_LIR_Apic_2	106	110	PF02991	0.464
LIG_LIR_Gen_1	139	148	PF02991	0.544
LIG_LIR_Gen_1	243	254	PF02991	0.506
LIG_LIR_Gen_1	87	98	PF02991	0.451
LIG_LIR_Nem_3	128	133	PF02991	0.435
LIG_LIR_Nem_3	139	143	PF02991	0.420
LIG_LIR_Nem_3	146	151	PF02991	0.395
LIG_LIR_Nem_3	163	168	PF02991	0.385
LIG_LIR_Nem_3	243	249	PF02991	0.386
LIG_LIR_Nem_3	87	93	PF02991	0.444
LIG_Pex14_1	145	149	PF04695	0.500
LIG_Rb_LxCxE_1	114	128	PF01857	0.465
LIG_SH2_CRK	130	134	PF00017	0.439
LIG_SH2_CRK	90	94	PF00017	0.451
LIG_SH2_CRK	95	99	PF00017	0.451
LIG_SH2_SRC	168	171	PF00017	0.480
LIG_SH2_STAP1	23	27	PF00017	0.451
LIG_SH2_STAT3	105	108	PF00017	0.464
LIG_SH2_STAT3	149	152	PF00017	0.500
LIG_SH2_STAT5	105	108	PF00017	0.480
LIG_SH2_STAT5	127	130	PF00017	0.439
LIG_SH3_3	48	54	PF00018	0.544
LIG_SH3_5	158	162	PF00018	0.525
LIG_Sin3_3	89	96	PF02671	0.439
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.448
LIG_SUMO_SIM_par_1	247	253	PF11976	0.376
LIG_TRAF2_1	106	109	PF00917	0.451
LIG_TYR_ITIM	93	98	PF00017	0.480
LIG_TYR_ITSM	126	133	PF00017	0.439
LIG_UBA3_1	195	204	PF00899	0.501
LIG_UBA3_1	248	255	PF00899	0.492
MOD_CDK_SPxxK_3	10	17	PF00069	0.451
MOD_CK1_1	163	169	PF00069	0.525
MOD_CK1_1	7	13	PF00069	0.451
MOD_CK2_1	103	109	PF00069	0.458
MOD_CK2_1	247	253	PF00069	0.368
MOD_CK2_1	63	69	PF00069	0.514
MOD_GlcNHglycan	157	161	PF01048	0.239
MOD_GlcNHglycan	162	165	PF01048	0.239
MOD_GlcNHglycan	66	69	PF01048	0.251
MOD_GlcNHglycan	98	101	PF01048	0.236
MOD_GSK3_1	152	159	PF00069	0.478
MOD_GSK3_1	4	11	PF00069	0.307
MOD_N-GLC_1	187	192	PF02516	0.289
MOD_N-GLC_1	64	69	PF02516	0.258
MOD_PIKK_1	125	131	PF00454	0.439
MOD_PKA_2	7	13	PF00069	0.441
MOD_PKA_2	96	102	PF00069	0.434
MOD_Plk_1	160	166	PF00069	0.480
MOD_Plk_1	187	193	PF00069	0.451
MOD_Plk_2-3	187	193	PF00069	0.517
MOD_Plk_4	136	142	PF00069	0.435
MOD_Plk_4	176	182	PF00069	0.449
MOD_Plk_4	30	36	PF00069	0.454
MOD_ProDKin_1	10	16	PF00069	0.451
MOD_ProDKin_1	240	246	PF00069	0.369
MOD_SUMO_rev_2	252	256	PF00179	0.447
TRG_DiLeu_BaEn_1	192	197	PF01217	0.517
TRG_ENDOCYTIC_2	130	133	PF00928	0.431
TRG_ENDOCYTIC_2	90	93	PF00928	0.448
TRG_ENDOCYTIC_2	95	98	PF00928	0.451
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	39%	100%
A0A0N0P4E6	Leptomonas seymouri	32%	100%
A0A0N1I173	Leptomonas seymouri	38%	100%
A0A0N1I278	Leptomonas seymouri	35%	100%
A0A0N1I2E0	Leptomonas seymouri	29%	100%
A0A0N1ILS9	Leptomonas seymouri	31%	100%
A0A0N1PBJ3	Leptomonas seymouri	83%	100%
A0A0S4INC9	Bodo saltans	30%	100%
A0A0S4IQU5	Bodo saltans	35%	100%
A0A0S4IU58	Bodo saltans	36%	100%
A0A0S4IWG0	Bodo saltans	33%	100%
A0A0S4J6W0	Bodo saltans	27%	100%
A0A0S4JLA2	Bodo saltans	60%	100%
A0A1X0NHF3	Trypanosomatidae	39%	100%
A0A1X0NJ65	Trypanosomatidae	37%	100%
A0A1X0NMF1	Trypanosomatidae	28%	100%
A0A1X0NNS5	Trypanosomatidae	68%	100%
A0A1X0NVU4	Trypanosomatidae	35%	100%
A0A1X0P5Y6	Trypanosomatidae	30%	100%
A0A1X0P853	Trypanosomatidae	30%	100%
A0A3Q8IB07	Leishmania donovani	37%	100%
A0A3Q8IC41	Leishmania donovani	39%	100%
A0A3Q8IFZ3	Leishmania donovani	31%	100%
A0A3R7KUN3	Trypanosoma rangeli	69%	100%
A0A3R7LAV3	Trypanosoma rangeli	35%	100%
A0A3R7MIT1	Trypanosoma rangeli	30%	100%
A0A3S5H6I0	Leishmania donovani	34%	100%
A0A3S5H7H2	Leishmania donovani	30%	100%
A0A3S5IS75	Trypanosoma rangeli	27%	100%
A0A3S7WST4	Leishmania donovani	99%	100%
A0A422N8R3	Trypanosoma rangeli	37%	100%
A0A422N8U2	Trypanosoma rangeli	38%	100%
A0A422P146	Trypanosoma rangeli	29%	100%
A0A6L0XSJ0	Leishmania infantum	29%	100%
A0B5B1	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	24%	100%
A0RXV1	Cenarchaeum symbiosum (strain A)	28%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	24%	100%
A2Y9X7	Oryza sativa subsp. indica	55%	100%
A2YVR7	Oryza sativa subsp. indica	34%	100%
A2YXU2	Oryza sativa subsp. indica	38%	100%
A2Z3I9	Oryza sativa subsp. indica	38%	100%
A3CW55	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	33%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	22%	100%
A4FZT6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	40%	100%
A4H7J0	Leishmania braziliensis	91%	100%
A4H9T4	Leishmania braziliensis	34%	100%
A4HC34	Leishmania braziliensis	36%	100%
A4HFD7	Leishmania braziliensis	30%	100%
A4HLC5	Leishmania braziliensis	40%	100%
A4HNE9	Leishmania braziliensis	29%	100%
A4HP20	Leishmania braziliensis	31%	100%
A4HUT6	Leishmania infantum	34%	100%
A4HZI9	Leishmania infantum	39%	100%
A4I357	Leishmania infantum	30%	100%
A4IDD0	Leishmania infantum	31%	100%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	23%	100%
A4YCU9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	41%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	37%	100%
A6URN9	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	39%	100%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6UT20	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	25%	100%
A6VIP0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	41%	100%
A7I9C7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	36%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	23%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	24%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	29%	100%
A9A846	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	40%	100%
B0R2T2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	38%	100%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	23%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	39%	100%
B8GEZ3	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	32%	100%
C3MQ43	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	45%	100%
C3MVG1	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	45%	100%
C3N5R0	Sulfolobus islandicus (strain M.16.27)	45%	100%
C3NEC6	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	45%	100%
C3NHC6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	45%	100%
C4KHD9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	45%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	39%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	41%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	24%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	26%	100%
C9ZKV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZT49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
C9ZYH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A0Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A0Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A305	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A7M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	23%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	23%	100%
D5EAS6	Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)	27%	100%
E9ACZ6	Leishmania major	31%	100%
E9AFW0	Leishmania major	30%	100%
E9ANH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9APM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AST1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AYS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B713	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4JJE5	Arabidopsis thaliana	41%	100%
O13268	Gallus gallus	35%	100%
O14250	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O14818	Homo sapiens	35%	100%
O16811	Drosophila virilis	35%	100%
O16812	Drosophila virilis	35%	100%
O17586	Caenorhabditis elegans	31%	100%
O23708	Arabidopsis thaliana	34%	100%
O23712	Arabidopsis thaliana	32%	100%
O23715	Arabidopsis thaliana	30%	100%
O24030	Solanum lycopersicum	38%	100%
O24362	Spinacia oleracea	32%	100%
O24616	Arabidopsis thaliana	39%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	39%	100%
O26782	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	38%	100%
O29760	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	35%	100%
O35955	Mus musculus	28%	100%
O42265	Gallus gallus	32%	100%
O44156	Caenorhabditis elegans	28%	100%
O48551	Glycine max	33%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	40%	100%
O59770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O70435	Mus musculus	36%	100%
O73672	Carassius auratus	34%	100%
O81146	Arabidopsis thaliana	33%	100%
O81147	Arabidopsis thaliana	33%	100%
O81148	Arabidopsis thaliana	53%	100%
O81149	Arabidopsis thaliana	39%	100%
O82530	Petunia hybrida	55%	100%
O94517	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O94579	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O96788	Trypanosoma brucei rhodesiense	31%	100%
P0C8Y9	Oryza sativa subsp. indica	55%	100%
P0DKK3	Oryza sativa subsp. japonica	55%	100%
P0DKK4	Oryza sativa subsp. japonica	55%	100%
P17220	Rattus norvegicus	34%	100%
P18053	Drosophila melanogaster	48%	100%
P18420	Rattus norvegicus	32%	100%
P18422	Rattus norvegicus	36%	100%
P21242	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	99%
P21670	Rattus norvegicus	51%	100%
P22769	Drosophila melanogaster	34%	100%
P23638	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P23639	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P24495	Xenopus laevis	36%	100%
P25156	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	34%	100%
P25786	Homo sapiens	30%	100%
P25787	Homo sapiens	34%	100%
P25788	Homo sapiens	36%	100%
P25789	Homo sapiens	51%	100%
P28061	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
P28066	Homo sapiens	36%	100%
P30186	Arabidopsis thaliana	39%	100%
P32379	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P34064	Rattus norvegicus	34%	100%
P34066	Arabidopsis thaliana	33%	100%
P34119	Dictyostelium discoideum	46%	100%
P34120	Dictyostelium discoideum	35%	100%
P40301	Drosophila melanogaster	34%	100%
P40303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P40306	Homo sapiens	31%	100%
P48004	Rattus norvegicus	36%	100%
P49722	Mus musculus	34%	100%
P52427	Spinacia oleracea	51%	100%
P52428	Oryza sativa subsp. japonica	31%	100%
P57697	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	38%	100%
P60900	Homo sapiens	33%	100%
P60901	Rattus norvegicus	33%	100%
P90513	Acanthamoeba castellanii	34%	100%
P92188	Trypanosoma cruzi	31%	100%
Q09682	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q0J006	Oryza sativa subsp. japonica	38%	100%
Q10329	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q10KF0	Oryza sativa subsp. japonica	34%	100%
Q12YV7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	25%	100%
Q18K08	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	38%	100%
Q24178	Drosophila melanogaster	35%	100%
Q27488	Caenorhabditis elegans	38%	100%
Q27562	Dictyostelium discoideum	33%	100%
Q27563	Dictyostelium discoideum	33%	100%
Q27575	Drosophila melanogaster	30%	100%
Q2YDE4	Bos taurus	33%	100%
Q3IPJ1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	39%	100%
Q3T0T1	Bos taurus	29%	100%
Q3T0X5	Bos taurus	30%	100%
Q3T0Y5	Bos taurus	34%	100%
Q3ZBG0	Bos taurus	36%	100%
Q3ZCK9	Bos taurus	51%	100%
Q42134	Arabidopsis thaliana	39%	100%
Q469M6	Methanosarcina barkeri (strain Fusaro / DSM 804)	35%	100%
Q4JB24	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	41%	100%
Q4KM35	Rattus norvegicus	28%	100%
Q4Q1R5	Leishmania major	31%	100%
Q4QC00	Leishmania major	39%	100%
Q4QC13	Leishmania major	38%	100%
Q4QFV4	Leishmania major	98%	100%
Q4QH56	Leishmania major	33%	100%
Q4R3H2	Macaca fascicularis	30%	100%
Q4R7D9	Macaca fascicularis	35%	100%
Q4R932	Macaca fascicularis	50%	100%
Q54DM7	Dictyostelium discoideum	36%	100%
Q54XM7	Dictyostelium discoideum	31%	100%
Q55G04	Dictyostelium discoideum	36%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q58DU5	Bos taurus	36%	100%
Q59565	Methanosarcina thermophila	38%	100%
Q5E987	Bos taurus	36%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	39%	100%
Q5RDH8	Pongo abelii	35%	100%
Q5REN2	Pongo abelii	30%	100%
Q5V1D4	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	37%	100%
Q5V2X8	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	40%	100%
Q5VRG3	Oryza sativa subsp. japonica	55%	100%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	41%	100%
Q6L0W3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	36%	100%
Q6M0L9	Methanococcus maripaludis (strain S2 / LL)	41%	100%
Q6YT00	Oryza sativa subsp. japonica	38%	100%
Q8L4A7	Arabidopsis thaliana	33%	100%
Q8PTU1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	37%	100%
Q8SQP9	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SRU3	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8SRU7	Encephalitozoon cuniculi (strain GB-M1)	34%	100%
Q8TAA3	Homo sapiens	34%	100%
Q8TJB5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	23%	100%
Q8TPX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	38%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	24%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	41%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	42%	100%
Q8X077	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	100%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	23%	100%
Q8ZVM1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	42%	100%
Q94561	Entamoeba histolytica	38%	100%
Q95005	Caenorhabditis elegans	33%	100%
Q95008	Caenorhabditis elegans	34%	100%
Q95083	Drosophila melanogaster	35%	100%
Q975G5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	43%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	25%	100%
Q97BZ8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	34%	100%
Q9CWH6	Mus musculus	32%	100%
Q9GNZ8	Leishmania infantum	37%	100%
Q9GU37	Trypanosoma brucei brucei	28%	100%
Q9LSU0	Oryza sativa subsp. japonica	31%	100%
Q9LSU1	Oryza sativa subsp. japonica	37%	100%
Q9LSU3	Oryza sativa subsp. japonica	33%	100%
Q9M4T8	Glycine max	36%	100%
Q9N599	Caenorhabditis elegans	48%	100%
Q9NDA2	Trypanosoma brucei brucei	35%	100%
Q9PTW9	Carassius auratus	36%	100%
Q9PVQ1	Xenopus laevis	36%	100%
Q9PVY6	Xenopus laevis	36%	100%
Q9QUM9	Mus musculus	33%	100%
Q9R1P0	Mus musculus	51%	100%
Q9R1P4	Mus musculus	30%	100%
Q9SXU1	Cicer arietinum	38%	100%
Q9U793	Trypanosoma brucei brucei	39%	100%
Q9UAB4	Leishmania donovani	29%	100%
Q9UT97	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
Q9UXC6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	43%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	39%	100%
Q9V2V5	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	40%	100%
Q9V2V6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	39%	100%
Q9V5C6	Drosophila melanogaster	30%	100%
Q9VA12	Drosophila melanogaster	39%	100%
Q9XG77	Nicotiana tabacum	31%	100%
Q9XZG5	Trypanosoma brucei brucei	38%	100%
Q9XZJ4	Drosophila melanogaster	30%	100%
Q9YC01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	41%	100%
Q9Z2U0	Mus musculus	36%	100%
Q9Z2U1	Mus musculus	36%	100%
V5AWB3	Trypanosoma cruzi	27%	100%
V5AXS1	Trypanosoma cruzi	71%	100%
V5B1X4	Trypanosoma cruzi	38%	100%
V5B4E8	Trypanosoma cruzi	31%	100%
V5BLX4	Trypanosoma cruzi	38%	100%
V5BW71	Trypanosoma cruzi	35%	91%