Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVX2_LEIIN

TriTrypDb:

LINF_140008000

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.488
CLV_NRD_NRD_1	195	197	PF00675	0.469
CLV_NRD_NRD_1	82	84	PF00675	0.753
CLV_PCSK_KEX2_1	195	197	PF00082	0.469
CLV_PCSK_KEX2_1	82	84	PF00082	0.665
DOC_MAPK_gen_1	195	203	PF00069	0.374
DOC_MAPK_gen_1	227	233	PF00069	0.505
DOC_USP7_MATH_1	149	153	PF00917	0.567
DOC_USP7_MATH_1	46	50	PF00917	0.504
DOC_USP7_UBL2_3	17	21	PF12436	0.465
DOC_USP7_UBL2_3	228	232	PF12436	0.504
DOC_WW_Pin1_4	144	149	PF00397	0.651
DOC_WW_Pin1_4	42	47	PF00397	0.511
DOC_WW_Pin1_4	77	82	PF00397	0.586
LIG_14-3-3_CanoR_1	195	200	PF00244	0.439
LIG_14-3-3_CanoR_1	96	100	PF00244	0.542
LIG_Actin_WH2_2	174	191	PF00022	0.473
LIG_FHA_1	112	118	PF00498	0.743
LIG_FHA_1	13	19	PF00498	0.423
LIG_FHA_1	176	182	PF00498	0.427
LIG_FHA_1	196	202	PF00498	0.209
LIG_FHA_2	42	48	PF00498	0.512
LIG_FHA_2	58	64	PF00498	0.439
LIG_LIR_Gen_1	209	216	PF02991	0.447
LIG_LIR_Gen_1	49	59	PF02991	0.511
LIG_LIR_Nem_3	198	203	PF02991	0.449
LIG_LIR_Nem_3	209	213	PF02991	0.418
LIG_LIR_Nem_3	214	220	PF02991	0.392
LIG_LIR_Nem_3	49	55	PF02991	0.497
LIG_NRBOX	71	77	PF00104	0.512
LIG_Pex14_1	4	8	PF04695	0.597
LIG_Pex14_2	206	210	PF04695	0.428
LIG_SH2_CRK	52	56	PF00017	0.519
LIG_SH2_STAP1	8	12	PF00017	0.532
LIG_SH2_STAT3	161	164	PF00017	0.399
LIG_SH2_STAT5	161	164	PF00017	0.441
LIG_SH2_STAT5	19	22	PF00017	0.398
LIG_SH2_STAT5	52	55	PF00017	0.508
LIG_SH3_3	106	112	PF00018	0.733
LIG_TYR_ITIM	50	55	PF00017	0.499
MOD_CDC14_SPxK_1	80	83	PF00782	0.572
MOD_CDK_SPK_2	77	82	PF00069	0.586
MOD_CDK_SPxK_1	77	83	PF00069	0.539
MOD_CK1_1	27	33	PF00069	0.471
MOD_CK1_1	3	9	PF00069	0.555
MOD_CK1_1	87	93	PF00069	0.672
MOD_CK2_1	102	108	PF00069	0.639
MOD_CK2_1	129	135	PF00069	0.745
MOD_CK2_1	206	212	PF00069	0.440
MOD_CK2_1	3	9	PF00069	0.529
MOD_GlcNHglycan	26	29	PF01048	0.377
MOD_GlcNHglycan	5	8	PF01048	0.580
MOD_GlcNHglycan	86	89	PF01048	0.691
MOD_GSK3_1	140	147	PF00069	0.732
MOD_GSK3_1	177	184	PF00069	0.457
MOD_GSK3_1	42	49	PF00069	0.504
MOD_NEK2_1	177	182	PF00069	0.424
MOD_NEK2_1	50	55	PF00069	0.517
MOD_NMyristoyl	1	7	PF02799	0.549
MOD_PKA_1	195	201	PF00069	0.444
MOD_PKA_2	195	201	PF00069	0.444
MOD_PKA_2	95	101	PF00069	0.510
MOD_Plk_1	211	217	PF00069	0.437
MOD_Plk_2-3	187	193	PF00069	0.438
MOD_Plk_4	177	183	PF00069	0.452
MOD_Plk_4	195	201	PF00069	0.444
MOD_Plk_4	46	52	PF00069	0.534
MOD_ProDKin_1	144	150	PF00069	0.645
MOD_ProDKin_1	42	48	PF00069	0.512
MOD_ProDKin_1	77	83	PF00069	0.597
MOD_SUMO_for_1	226	229	PF00179	0.496
TRG_DiLeu_BaEn_1	221	226	PF01217	0.472
TRG_DiLeu_BaEn_2	167	173	PF01217	0.361
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.506
TRG_ENDOCYTIC_2	174	177	PF00928	0.333
TRG_ENDOCYTIC_2	52	55	PF00928	0.508
TRG_ER_diArg_1	81	83	PF00400	0.737
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F1	Leptomonas seymouri	51%	67%
A0A3Q8IBX5	Leishmania donovani	100%	100%
A4H7I9	Leishmania braziliensis	85%	100%
C9ZT50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QFV5	Leishmania major	95%	100%
V5AXT5	Trypanosoma cruzi	31%	100%