NAD(P)-bd_dom domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVX1_LEIIN

TriTrypDb:

LINF_140007900

Length:

280

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HVX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX1

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901004	ubiquinone-6 metabolic process	6	1
GO:1901006	ubiquinone-6 biosynthetic process	7	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.441
CLV_NRD_NRD_1	126	128	PF00675	0.618
CLV_PCSK_KEX2_1	126	128	PF00082	0.627
CLV_PCSK_KEX2_1	142	144	PF00082	0.407
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.407
CLV_PCSK_SKI1_1	126	130	PF00082	0.600
CLV_PCSK_SKI1_1	132	136	PF00082	0.336
CLV_PCSK_SKI1_1	147	151	PF00082	0.328
CLV_PCSK_SKI1_1	169	173	PF00082	0.532
CLV_PCSK_SKI1_1	198	202	PF00082	0.493
DEG_SPOP_SBC_1	16	20	PF00917	0.776
DOC_CYCLIN_yClb1_LxF_4	43	49	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	209	212	PF00134	0.420
DOC_MAPK_MEF2A_6	207	215	PF00069	0.509
DOC_PP2B_LxvP_1	185	188	PF13499	0.521
DOC_PP2B_LxvP_1	208	211	PF13499	0.452
DOC_USP7_MATH_1	16	20	PF00917	0.769
DOC_USP7_MATH_1	176	180	PF00917	0.396
DOC_USP7_UBL2_3	132	136	PF12436	0.546
DOC_WW_Pin1_4	12	17	PF00397	0.742
LIG_Actin_WH2_2	146	163	PF00022	0.394
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_FHA_1	166	172	PF00498	0.432
LIG_FHA_1	182	188	PF00498	0.442
LIG_FHA_1	68	74	PF00498	0.400
LIG_FHA_2	52	58	PF00498	0.542
LIG_LIR_Gen_1	47	53	PF02991	0.434
LIG_LIR_Gen_1	57	65	PF02991	0.408
LIG_LIR_Nem_3	119	124	PF02991	0.472
LIG_LIR_Nem_3	47	51	PF02991	0.450
LIG_LIR_Nem_3	57	63	PF02991	0.402
LIG_MAD2	112	120	PF02301	0.401
LIG_SH2_SRC	83	86	PF00017	0.496
LIG_SH2_STAP1	124	128	PF00017	0.581
LIG_SH2_STAT5	115	118	PF00017	0.423
LIG_SH2_STAT5	133	136	PF00017	0.426
LIG_SH2_STAT5	138	141	PF00017	0.344
LIG_SH3_3	156	162	PF00018	0.343
LIG_SH3_3	98	104	PF00018	0.469
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.369
LIG_SUMO_SIM_par_1	211	216	PF11976	0.367
LIG_UBA3_1	199	207	PF00899	0.548
MOD_CK1_1	11	17	PF00069	0.738
MOD_CK1_1	18	24	PF00069	0.722
MOD_CK1_1	183	189	PF00069	0.488
MOD_CK1_1	2	8	PF00069	0.707
MOD_CK1_1	260	266	PF00069	0.561
MOD_CK1_1	267	273	PF00069	0.548
MOD_CK1_1	67	73	PF00069	0.333
MOD_CK2_1	252	258	PF00069	0.618
MOD_Cter_Amidation	140	143	PF01082	0.363
MOD_GlcNHglycan	1	4	PF01048	0.725
MOD_GlcNHglycan	116	119	PF01048	0.348
MOD_GlcNHglycan	174	177	PF01048	0.520
MOD_GlcNHglycan	20	23	PF01048	0.765
MOD_GlcNHglycan	266	269	PF01048	0.486
MOD_GlcNHglycan	28	31	PF01048	0.639
MOD_GSK3_1	1	8	PF00069	0.727
MOD_GSK3_1	11	18	PF00069	0.751
MOD_GSK3_1	172	179	PF00069	0.493
MOD_GSK3_1	260	267	PF00069	0.593
MOD_GSK3_1	47	54	PF00069	0.446
MOD_NEK2_1	1	6	PF00069	0.773
MOD_NEK2_1	172	177	PF00069	0.594
MOD_NEK2_1	264	269	PF00069	0.493
MOD_PIKK_1	5	11	PF00454	0.709
MOD_PKA_2	160	166	PF00069	0.465
MOD_PKA_2	26	32	PF00069	0.595
MOD_Plk_1	271	277	PF00069	0.593
MOD_Plk_1	67	73	PF00069	0.406
MOD_Plk_2-3	47	53	PF00069	0.436
MOD_Plk_4	160	166	PF00069	0.390
MOD_ProDKin_1	12	18	PF00069	0.742
MOD_SUMO_rev_2	253	263	PF00179	0.447
TRG_ER_diArg_1	126	128	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I087	Leptomonas seymouri	74%	80%
A0A1X0NQ86	Trypanosomatidae	38%	91%
A0A3Q8I8Q3	Leishmania donovani	99%	100%
A0A422NX27	Trypanosoma rangeli	47%	100%
A4H7I8	Leishmania braziliensis	78%	100%
C9ZT51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	96%
E9APM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFV6	Leishmania major	93%	100%
Q9FVR6	Arabidopsis thaliana	29%	95%