LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HVX0_LEIIN
TriTrypDb:
LINF_140007800
Length:
963

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005819 spindle 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HVX0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVX0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 9
GO:0005488 binding 1 9
GO:0008270 zinc ion binding 6 9
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0046914 transition metal ion binding 5 9
GO:0097159 organic cyclic compound binding 2 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 673 677 PF00656 0.473
CLV_C14_Caspase3-7 87 91 PF00656 0.492
CLV_C14_Caspase3-7 925 929 PF00656 0.682
CLV_C14_Caspase3-7 930 934 PF00656 0.631
CLV_NRD_NRD_1 165 167 PF00675 0.507
CLV_NRD_NRD_1 222 224 PF00675 0.440
CLV_NRD_NRD_1 438 440 PF00675 0.378
CLV_NRD_NRD_1 459 461 PF00675 0.419
CLV_NRD_NRD_1 467 469 PF00675 0.409
CLV_NRD_NRD_1 540 542 PF00675 0.631
CLV_NRD_NRD_1 562 564 PF00675 0.500
CLV_NRD_NRD_1 599 601 PF00675 0.403
CLV_NRD_NRD_1 614 616 PF00675 0.323
CLV_NRD_NRD_1 634 636 PF00675 0.283
CLV_NRD_NRD_1 662 664 PF00675 0.427
CLV_NRD_NRD_1 772 774 PF00675 0.404
CLV_PCSK_FUR_1 220 224 PF00082 0.397
CLV_PCSK_FUR_1 465 469 PF00082 0.456
CLV_PCSK_KEX2_1 165 167 PF00082 0.544
CLV_PCSK_KEX2_1 191 193 PF00082 0.462
CLV_PCSK_KEX2_1 222 224 PF00082 0.439
CLV_PCSK_KEX2_1 288 290 PF00082 0.427
CLV_PCSK_KEX2_1 438 440 PF00082 0.378
CLV_PCSK_KEX2_1 458 460 PF00082 0.241
CLV_PCSK_KEX2_1 467 469 PF00082 0.393
CLV_PCSK_KEX2_1 540 542 PF00082 0.631
CLV_PCSK_KEX2_1 562 564 PF00082 0.500
CLV_PCSK_KEX2_1 614 616 PF00082 0.592
CLV_PCSK_KEX2_1 634 636 PF00082 0.283
CLV_PCSK_KEX2_1 662 664 PF00082 0.541
CLV_PCSK_KEX2_1 772 774 PF00082 0.411
CLV_PCSK_KEX2_1 921 923 PF00082 0.633
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.482
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.427
CLV_PCSK_PC1ET2_1 921 923 PF00082 0.633
CLV_PCSK_PC7_1 630 636 PF00082 0.566
CLV_PCSK_PC7_1 658 664 PF00082 0.520
CLV_PCSK_SKI1_1 276 280 PF00082 0.505
CLV_PCSK_SKI1_1 37 41 PF00082 0.481
CLV_PCSK_SKI1_1 397 401 PF00082 0.351
CLV_PCSK_SKI1_1 412 416 PF00082 0.361
CLV_PCSK_SKI1_1 431 435 PF00082 0.400
CLV_PCSK_SKI1_1 562 566 PF00082 0.369
CLV_PCSK_SKI1_1 594 598 PF00082 0.433
CLV_PCSK_SKI1_1 710 714 PF00082 0.419
CLV_PCSK_SKI1_1 823 827 PF00082 0.510
CLV_Separin_Metazoa 233 237 PF03568 0.489
DEG_APCC_DBOX_1 214 222 PF00400 0.366
DEG_APCC_DBOX_1 466 474 PF00400 0.428
DEG_APCC_DBOX_1 641 649 PF00400 0.462
DEG_APCC_DBOX_1 764 772 PF00400 0.370
DEG_COP1_1 205 214 PF00400 0.525
DEG_Nend_Nbox_1 1 3 PF02207 0.516
DEG_ODPH_VHL_1 507 519 PF01847 0.428
DEG_SPOP_SBC_1 860 864 PF00917 0.672
DOC_ANK_TNKS_1 923 930 PF00023 0.648
DOC_CYCLIN_RxL_1 428 437 PF00134 0.459
DOC_CYCLIN_yClb5_NLxxxL_5 349 358 PF00134 0.469
DOC_CYCLIN_yCln2_LP_2 22 28 PF00134 0.414
DOC_CYCLIN_yCln2_LP_2 354 360 PF00134 0.509
DOC_MAPK_DCC_7 642 650 PF00069 0.526
DOC_MAPK_gen_1 165 173 PF00069 0.458
DOC_MAPK_gen_1 597 606 PF00069 0.363
DOC_MAPK_gen_1 736 745 PF00069 0.396
DOC_MAPK_gen_1 772 778 PF00069 0.382
DOC_MAPK_gen_1 798 806 PF00069 0.395
DOC_MAPK_MEF2A_6 223 232 PF00069 0.423
DOC_MAPK_MEF2A_6 600 608 PF00069 0.358
DOC_MAPK_MEF2A_6 736 745 PF00069 0.371
DOC_MAPK_NFAT4_5 601 609 PF00069 0.357
DOC_MAPK_RevD_3 602 615 PF00069 0.444
DOC_PP1_RVXF_1 50 57 PF00149 0.316
DOC_PP2B_LxvP_1 18 21 PF13499 0.354
DOC_PP2B_LxvP_1 208 211 PF13499 0.382
DOC_PP2B_LxvP_1 354 357 PF13499 0.521
DOC_PP2B_LxvP_1 358 361 PF13499 0.512
DOC_PP4_FxxP_1 199 202 PF00568 0.578
DOC_PP4_FxxP_1 415 418 PF00568 0.384
DOC_USP7_MATH_1 226 230 PF00917 0.329
DOC_USP7_MATH_1 475 479 PF00917 0.464
DOC_USP7_MATH_1 860 864 PF00917 0.742
DOC_USP7_UBL2_3 187 191 PF12436 0.437
DOC_USP7_UBL2_3 597 601 PF12436 0.396
DOC_WW_Pin1_4 311 316 PF00397 0.584
DOC_WW_Pin1_4 421 426 PF00397 0.379
DOC_WW_Pin1_4 831 836 PF00397 0.543
LIG_14-3-3_CanoR_1 115 121 PF00244 0.283
LIG_14-3-3_CanoR_1 168 174 PF00244 0.465
LIG_14-3-3_CanoR_1 220 226 PF00244 0.513
LIG_14-3-3_CanoR_1 227 233 PF00244 0.445
LIG_14-3-3_CanoR_1 402 407 PF00244 0.458
LIG_14-3-3_CanoR_1 662 670 PF00244 0.421
LIG_14-3-3_CanoR_1 710 719 PF00244 0.334
LIG_14-3-3_CanoR_1 773 779 PF00244 0.468
LIG_14-3-3_CanoR_1 97 101 PF00244 0.477
LIG_APCC_ABBA_1 743 748 PF00400 0.333
LIG_BRCT_BRCA1_1 436 440 PF00533 0.523
LIG_BRCT_BRCA1_1 477 481 PF00533 0.341
LIG_BRCT_BRCA1_1 821 825 PF00533 0.523
LIG_BRCT_BRCA1_1 92 96 PF00533 0.510
LIG_DLG_GKlike_1 402 409 PF00625 0.474
LIG_FHA_1 229 235 PF00498 0.306
LIG_FHA_1 525 531 PF00498 0.564
LIG_FHA_1 547 553 PF00498 0.557
LIG_FHA_1 711 717 PF00498 0.342
LIG_FHA_1 724 730 PF00498 0.382
LIG_FHA_1 778 784 PF00498 0.435
LIG_FHA_1 80 86 PF00498 0.474
LIG_FHA_1 952 958 PF00498 0.670
LIG_FHA_2 183 189 PF00498 0.524
LIG_FHA_2 261 267 PF00498 0.446
LIG_FHA_2 946 952 PF00498 0.783
LIG_LIR_Apic_2 196 202 PF02991 0.568
LIG_LIR_Apic_2 257 261 PF02991 0.421
LIG_LIR_Apic_2 413 418 PF02991 0.367
LIG_LIR_Gen_1 181 190 PF02991 0.388
LIG_LIR_Gen_1 277 285 PF02991 0.491
LIG_LIR_Gen_1 374 384 PF02991 0.354
LIG_LIR_Gen_1 405 414 PF02991 0.392
LIG_LIR_Gen_1 442 450 PF02991 0.336
LIG_LIR_Gen_1 478 489 PF02991 0.362
LIG_LIR_Gen_1 496 504 PF02991 0.379
LIG_LIR_Gen_1 777 787 PF02991 0.367
LIG_LIR_Gen_1 842 851 PF02991 0.584
LIG_LIR_LC3C_4 205 210 PF02991 0.457
LIG_LIR_Nem_3 172 177 PF02991 0.391
LIG_LIR_Nem_3 181 186 PF02991 0.410
LIG_LIR_Nem_3 277 282 PF02991 0.491
LIG_LIR_Nem_3 374 380 PF02991 0.406
LIG_LIR_Nem_3 405 409 PF02991 0.431
LIG_LIR_Nem_3 442 446 PF02991 0.343
LIG_LIR_Nem_3 478 484 PF02991 0.334
LIG_LIR_Nem_3 496 500 PF02991 0.327
LIG_LIR_Nem_3 569 575 PF02991 0.533
LIG_LIR_Nem_3 718 722 PF02991 0.447
LIG_LIR_Nem_3 738 743 PF02991 0.213
LIG_LIR_Nem_3 777 782 PF02991 0.355
LIG_LIR_Nem_3 786 791 PF02991 0.511
LIG_LIR_Nem_3 842 846 PF02991 0.567
LIG_MLH1_MIPbox_1 477 481 PF16413 0.341
LIG_MLH1_MIPbox_1 821 825 PF16413 0.529
LIG_PCNA_PIPBox_1 427 436 PF02747 0.519
LIG_REV1ctd_RIR_1 822 830 PF16727 0.564
LIG_RPA_C_Fungi 454 466 PF08784 0.486
LIG_SH2_CRK 138 142 PF00017 0.444
LIG_SH2_CRK 183 187 PF00017 0.441
LIG_SH2_CRK 406 410 PF00017 0.391
LIG_SH2_CRK 497 501 PF00017 0.390
LIG_SH2_CRK 637 641 PF00017 0.522
LIG_SH2_CRK 788 792 PF00017 0.503
LIG_SH2_CRK 843 847 PF00017 0.641
LIG_SH2_NCK_1 158 162 PF00017 0.406
LIG_SH2_NCK_1 497 501 PF00017 0.374
LIG_SH2_NCK_1 843 847 PF00017 0.598
LIG_SH2_PTP2 258 261 PF00017 0.461
LIG_SH2_STAP1 138 142 PF00017 0.469
LIG_SH2_STAP1 350 354 PF00017 0.419
LIG_SH2_STAP1 377 381 PF00017 0.356
LIG_SH2_STAP1 788 792 PF00017 0.395
LIG_SH2_STAT5 110 113 PF00017 0.339
LIG_SH2_STAT5 170 173 PF00017 0.392
LIG_SH2_STAT5 258 261 PF00017 0.501
LIG_SH2_STAT5 342 345 PF00017 0.382
LIG_SH2_STAT5 767 770 PF00017 0.463
LIG_SH2_STAT5 781 784 PF00017 0.263
LIG_SH3_3 174 180 PF00018 0.496
LIG_SH3_3 250 256 PF00018 0.591
LIG_SH3_3 388 394 PF00018 0.413
LIG_SH3_3 523 529 PF00018 0.544
LIG_SUMO_SIM_anti_2 205 212 PF11976 0.479
LIG_SUMO_SIM_anti_2 231 236 PF11976 0.313
LIG_SUMO_SIM_anti_2 448 454 PF11976 0.366
LIG_SUMO_SIM_anti_2 801 808 PF11976 0.506
LIG_SUMO_SIM_par_1 205 212 PF11976 0.529
LIG_SUMO_SIM_par_1 801 808 PF11976 0.506
LIG_SxIP_EBH_1 238 247 PF03271 0.453
LIG_TRAF2_1 122 125 PF00917 0.626
LIG_TRAF2_1 376 379 PF00917 0.431
LIG_TRAF2_1 938 941 PF00917 0.641
LIG_TRAF2_1 948 951 PF00917 0.501
LIG_TRFH_1 406 410 PF08558 0.347
LIG_TYR_ITIM 136 141 PF00017 0.581
LIG_WRC_WIRS_1 716 721 PF05994 0.483
MOD_CK1_1 119 125 PF00069 0.514
MOD_CK1_1 543 549 PF00069 0.638
MOD_CK1_1 641 647 PF00069 0.555
MOD_CK1_1 723 729 PF00069 0.479
MOD_CK1_1 79 85 PF00069 0.435
MOD_CK1_1 896 902 PF00069 0.639
MOD_CK2_1 119 125 PF00069 0.598
MOD_CK2_1 127 133 PF00069 0.616
MOD_CK2_1 260 266 PF00069 0.403
MOD_CK2_1 66 72 PF00069 0.576
MOD_CK2_1 842 848 PF00069 0.552
MOD_CK2_1 945 951 PF00069 0.703
MOD_GlcNHglycan 130 133 PF01048 0.500
MOD_GlcNHglycan 18 21 PF01048 0.251
MOD_GlcNHglycan 3 6 PF01048 0.591
MOD_GlcNHglycan 344 347 PF01048 0.503
MOD_GlcNHglycan 546 549 PF01048 0.658
MOD_GlcNHglycan 60 63 PF01048 0.517
MOD_GlcNHglycan 904 907 PF01048 0.681
MOD_GSK3_1 115 122 PF00069 0.455
MOD_GSK3_1 169 176 PF00069 0.455
MOD_GSK3_1 294 301 PF00069 0.546
MOD_GSK3_1 338 345 PF00069 0.571
MOD_GSK3_1 484 491 PF00069 0.490
MOD_GSK3_1 540 547 PF00069 0.682
MOD_GSK3_1 58 65 PF00069 0.544
MOD_GSK3_1 751 758 PF00069 0.476
MOD_GSK3_1 860 867 PF00069 0.703
MOD_LATS_1 539 545 PF00433 0.663
MOD_N-GLC_1 249 254 PF02516 0.602
MOD_N-GLC_1 33 38 PF02516 0.483
MOD_N-GLC_1 622 627 PF02516 0.607
MOD_N-GLC_1 723 728 PF02516 0.508
MOD_N-GLC_2 513 515 PF02516 0.477
MOD_N-GLC_2 568 570 PF02516 0.434
MOD_NEK2_1 1 6 PF00069 0.602
MOD_NEK2_1 173 178 PF00069 0.379
MOD_NEK2_1 221 226 PF00069 0.475
MOD_NEK2_1 274 279 PF00069 0.517
MOD_NEK2_1 327 332 PF00069 0.618
MOD_NEK2_1 349 354 PF00069 0.429
MOD_NEK2_1 433 438 PF00069 0.482
MOD_NEK2_1 488 493 PF00069 0.544
MOD_NEK2_1 66 71 PF00069 0.587
MOD_NEK2_1 720 725 PF00069 0.502
MOD_NEK2_1 735 740 PF00069 0.327
MOD_NEK2_1 746 751 PF00069 0.347
MOD_NEK2_1 771 776 PF00069 0.487
MOD_NEK2_1 96 101 PF00069 0.384
MOD_NEK2_2 116 121 PF00069 0.528
MOD_NEK2_2 281 286 PF00069 0.374
MOD_NEK2_2 383 388 PF00069 0.371
MOD_NEK2_2 410 415 PF00069 0.347
MOD_NEK2_2 475 480 PF00069 0.461
MOD_PIKK_1 850 856 PF00454 0.594
MOD_PKA_1 540 546 PF00069 0.657
MOD_PKA_2 214 220 PF00069 0.373
MOD_PKA_2 221 227 PF00069 0.381
MOD_PKA_2 434 440 PF00069 0.454
MOD_PKA_2 540 546 PF00069 0.641
MOD_PKA_2 641 647 PF00069 0.464
MOD_PKA_2 735 741 PF00069 0.242
MOD_PKA_2 771 777 PF00069 0.504
MOD_PKA_2 893 899 PF00069 0.652
MOD_PKA_2 96 102 PF00069 0.500
MOD_PKB_1 458 466 PF00069 0.501
MOD_PKB_1 943 951 PF00069 0.619
MOD_Plk_1 249 255 PF00069 0.601
MOD_Plk_1 33 39 PF00069 0.449
MOD_Plk_1 62 68 PF00069 0.601
MOD_Plk_1 888 894 PF00069 0.769
MOD_Plk_4 103 109 PF00069 0.503
MOD_Plk_4 142 148 PF00069 0.420
MOD_Plk_4 169 175 PF00069 0.493
MOD_Plk_4 214 220 PF00069 0.505
MOD_Plk_4 240 246 PF00069 0.491
MOD_Plk_4 254 260 PF00069 0.587
MOD_Plk_4 338 344 PF00069 0.471
MOD_Plk_4 410 416 PF00069 0.420
MOD_Plk_4 475 481 PF00069 0.334
MOD_Plk_4 715 721 PF00069 0.481
MOD_Plk_4 774 780 PF00069 0.363
MOD_Plk_4 799 805 PF00069 0.368
MOD_ProDKin_1 311 317 PF00069 0.589
MOD_ProDKin_1 421 427 PF00069 0.371
MOD_ProDKin_1 831 837 PF00069 0.543
MOD_SUMO_for_1 261 264 PF00179 0.465
TRG_DiLeu_BaEn_1 442 447 PF01217 0.374
TRG_DiLeu_BaEn_4 502 508 PF01217 0.406
TRG_ENDOCYTIC_2 138 141 PF00928 0.459
TRG_ENDOCYTIC_2 170 173 PF00928 0.361
TRG_ENDOCYTIC_2 183 186 PF00928 0.343
TRG_ENDOCYTIC_2 377 380 PF00928 0.347
TRG_ENDOCYTIC_2 406 409 PF00928 0.355
TRG_ENDOCYTIC_2 497 500 PF00928 0.380
TRG_ENDOCYTIC_2 637 640 PF00928 0.520
TRG_ENDOCYTIC_2 788 791 PF00928 0.504
TRG_ENDOCYTIC_2 843 846 PF00928 0.664
TRG_ER_diArg_1 165 167 PF00400 0.468
TRG_ER_diArg_1 219 222 PF00400 0.402
TRG_ER_diArg_1 438 440 PF00400 0.378
TRG_ER_diArg_1 457 460 PF00400 0.272
TRG_ER_diArg_1 465 468 PF00400 0.402
TRG_ER_diArg_1 562 564 PF00400 0.502
TRG_ER_diArg_1 614 616 PF00400 0.611
TRG_ER_diArg_1 661 663 PF00400 0.531
TRG_ER_diArg_1 771 773 PF00400 0.406
TRG_ER_diArg_1 821 824 PF00400 0.410
TRG_NLS_MonoCore_2 920 925 PF00514 0.666
TRG_NLS_MonoExtC_3 919 924 PF00514 0.757
TRG_NLS_MonoExtN_4 918 925 PF00514 0.752
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 468 472 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 563 567 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 638 643 PF00026 0.526

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCK9 Leptomonas seymouri 73% 100%
A0A0S4IYU3 Bodo saltans 27% 83%
A0A1X0NQD8 Trypanosomatidae 46% 91%
A0A3S7WST9 Leishmania donovani 99% 100%
A0A422NXF4 Trypanosoma rangeli 47% 95%
A4H7I7 Leishmania braziliensis 88% 99%
C9ZT54 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 93%
E9APM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QFV7 Leishmania major 96% 100%
V5BHS0 Trypanosoma cruzi 48% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS