LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF4201) - putative
Species:
Leishmania infantum
UniProt:
A4HVW3_LEIIN
TriTrypDb:
LINF_140007000
Length:
443

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0036064 ciliary basal body 3 1
GO:0110165 cellular anatomical entity 1 10
GO:0005856 cytoskeleton 5 9
GO:0043226 organelle 2 9
GO:0043228 non-membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043232 intracellular non-membrane-bounded organelle 4 9

Expansion

Sequence features

A4HVW3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVW3

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 142 146 PF00656 0.602
CLV_C14_Caspase3-7 274 278 PF00656 0.724
CLV_C14_Caspase3-7 419 423 PF00656 0.509
CLV_NRD_NRD_1 107 109 PF00675 0.437
CLV_NRD_NRD_1 131 133 PF00675 0.512
CLV_NRD_NRD_1 24 26 PF00675 0.379
CLV_NRD_NRD_1 253 255 PF00675 0.535
CLV_NRD_NRD_1 32 34 PF00675 0.463
CLV_NRD_NRD_1 369 371 PF00675 0.272
CLV_NRD_NRD_1 398 400 PF00675 0.247
CLV_NRD_NRD_1 9 11 PF00675 0.575
CLV_NRD_NRD_1 94 96 PF00675 0.538
CLV_PCSK_FUR_1 251 255 PF00082 0.582
CLV_PCSK_KEX2_1 107 109 PF00082 0.441
CLV_PCSK_KEX2_1 130 132 PF00082 0.609
CLV_PCSK_KEX2_1 24 26 PF00082 0.374
CLV_PCSK_KEX2_1 253 255 PF00082 0.588
CLV_PCSK_KEX2_1 32 34 PF00082 0.492
CLV_PCSK_KEX2_1 367 369 PF00082 0.247
CLV_PCSK_KEX2_1 398 400 PF00082 0.272
CLV_PCSK_KEX2_1 8 10 PF00082 0.558
CLV_PCSK_KEX2_1 93 95 PF00082 0.577
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.462
CLV_PCSK_PC1ET2_1 367 369 PF00082 0.247
CLV_PCSK_PC1ET2_1 398 400 PF00082 0.308
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.619
CLV_PCSK_SKI1_1 102 106 PF00082 0.488
CLV_PCSK_SKI1_1 108 112 PF00082 0.476
CLV_PCSK_SKI1_1 254 258 PF00082 0.566
CLV_PCSK_SKI1_1 390 394 PF00082 0.260
CLV_PCSK_SKI1_1 418 422 PF00082 0.272
DEG_APCC_DBOX_1 245 253 PF00400 0.403
DEG_APCC_DBOX_1 331 339 PF00400 0.533
DEG_APCC_DBOX_1 406 414 PF00400 0.521
DEG_Nend_Nbox_1 1 3 PF02207 0.597
DEG_SCF_FBW7_2 141 147 PF00400 0.620
DEG_SPOP_SBC_1 261 265 PF00917 0.625
DOC_CKS1_1 141 146 PF01111 0.627
DOC_CKS1_1 87 92 PF01111 0.639
DOC_CYCLIN_RxL_1 106 114 PF00134 0.541
DOC_MAPK_gen_1 318 327 PF00069 0.447
DOC_MAPK_gen_1 379 386 PF00069 0.533
DOC_USP7_MATH_1 17 21 PF00917 0.514
DOC_USP7_MATH_1 230 234 PF00917 0.431
DOC_USP7_MATH_1 261 265 PF00917 0.705
DOC_USP7_MATH_1 60 64 PF00917 0.637
DOC_USP7_MATH_1 74 78 PF00917 0.701
DOC_USP7_UBL2_3 316 320 PF12436 0.458
DOC_WW_Pin1_4 140 145 PF00397 0.556
DOC_WW_Pin1_4 86 91 PF00397 0.582
LIG_14-3-3_CanoR_1 32 36 PF00244 0.534
LIG_BIR_III_2 38 42 PF00653 0.589
LIG_BRCT_BRCA1_1 205 209 PF00533 0.585
LIG_BRCT_BRCA1_1 48 52 PF00533 0.572
LIG_BRCT_BRCA1_1 76 80 PF00533 0.655
LIG_CaM_IQ_9 240 256 PF13499 0.554
LIG_Clathr_ClatBox_1 290 294 PF01394 0.447
LIG_FHA_1 202 208 PF00498 0.413
LIG_FHA_1 216 222 PF00498 0.449
LIG_FHA_1 320 326 PF00498 0.447
LIG_FHA_1 406 412 PF00498 0.533
LIG_FHA_1 419 425 PF00498 0.518
LIG_FHA_1 66 72 PF00498 0.732
LIG_FHA_2 140 146 PF00498 0.610
LIG_FHA_2 272 278 PF00498 0.758
LIG_FHA_2 350 356 PF00498 0.455
LIG_FHA_2 87 93 PF00498 0.529
LIG_LIR_Gen_1 222 230 PF02991 0.494
LIG_LIR_Gen_1 292 298 PF02991 0.447
LIG_LIR_Gen_1 77 87 PF02991 0.655
LIG_LIR_Nem_3 147 153 PF02991 0.570
LIG_LIR_Nem_3 193 199 PF02991 0.402
LIG_LIR_Nem_3 222 227 PF02991 0.503
LIG_LIR_Nem_3 292 296 PF02991 0.447
LIG_LIR_Nem_3 77 83 PF02991 0.661
LIG_LIR_Nem_3 99 104 PF02991 0.442
LIG_PCNA_PIPBox_1 119 128 PF02747 0.469
LIG_Pex14_2 289 293 PF04695 0.533
LIG_SH2_CRK 101 105 PF00017 0.455
LIG_SH2_CRK 118 122 PF00017 0.415
LIG_SH2_NCK_1 2 6 PF00017 0.631
LIG_SH2_PTP2 224 227 PF00017 0.498
LIG_SH2_SRC 182 185 PF00017 0.561
LIG_SH2_SRC 2 5 PF00017 0.666
LIG_SH2_STAT3 126 129 PF00017 0.568
LIG_SH2_STAT5 199 202 PF00017 0.406
LIG_SH2_STAT5 224 227 PF00017 0.546
LIG_SH2_STAT5 242 245 PF00017 0.363
LIG_SH3_3 68 74 PF00018 0.696
LIG_SH3_3 84 90 PF00018 0.614
LIG_TRAF2_1 190 193 PF00917 0.489
LIG_TRAF2_1 352 355 PF00917 0.474
LIG_TRAF2_1 89 92 PF00917 0.562
LIG_TYR_ITIM 116 121 PF00017 0.562
LIG_TYR_ITIM 240 245 PF00017 0.474
LIG_UBA3_1 249 257 PF00899 0.603
MOD_CDK_SPxxK_3 86 93 PF00069 0.571
MOD_CK1_1 264 270 PF00069 0.696
MOD_CK2_1 299 305 PF00069 0.550
MOD_CK2_1 348 354 PF00069 0.457
MOD_CK2_1 86 92 PF00069 0.539
MOD_GlcNHglycan 167 170 PF01048 0.491
MOD_GlcNHglycan 232 235 PF01048 0.513
MOD_GlcNHglycan 264 267 PF01048 0.688
MOD_GlcNHglycan 54 57 PF01048 0.591
MOD_GSK3_1 260 267 PF00069 0.672
MOD_GSK3_1 27 34 PF00069 0.522
MOD_GSK3_1 42 49 PF00069 0.599
MOD_GSK3_1 426 433 PF00069 0.578
MOD_LATS_1 373 379 PF00433 0.533
MOD_N-GLC_1 299 304 PF02516 0.352
MOD_NEK2_1 111 116 PF00069 0.465
MOD_NEK2_1 203 208 PF00069 0.471
MOD_NEK2_1 209 214 PF00069 0.450
MOD_NEK2_1 262 267 PF00069 0.700
MOD_NEK2_1 363 368 PF00069 0.457
MOD_NEK2_1 42 47 PF00069 0.692
MOD_NEK2_1 420 425 PF00069 0.476
MOD_NEK2_1 52 57 PF00069 0.681
MOD_NEK2_1 83 88 PF00069 0.707
MOD_PIKK_1 188 194 PF00454 0.512
MOD_PKA_2 31 37 PF00069 0.633
MOD_PKA_2 42 48 PF00069 0.591
MOD_Plk_1 298 304 PF00069 0.552
MOD_Plk_1 426 432 PF00069 0.592
MOD_Plk_1 436 442 PF00069 0.604
MOD_Plk_2-3 299 305 PF00069 0.536
MOD_Plk_2-3 308 314 PF00069 0.512
MOD_Plk_2-3 31 37 PF00069 0.604
MOD_Plk_4 17 23 PF00069 0.552
MOD_Plk_4 427 433 PF00069 0.570
MOD_Plk_4 46 52 PF00069 0.693
MOD_ProDKin_1 140 146 PF00069 0.547
MOD_ProDKin_1 86 92 PF00069 0.574
MOD_SUMO_for_1 296 299 PF00179 0.447
MOD_SUMO_for_1 424 427 PF00179 0.497
TRG_DiLeu_BaEn_1 100 105 PF01217 0.438
TRG_DiLeu_BaEn_4 312 318 PF01217 0.533
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.574
TRG_ENDOCYTIC_2 101 104 PF00928 0.435
TRG_ENDOCYTIC_2 118 121 PF00928 0.435
TRG_ENDOCYTIC_2 150 153 PF00928 0.541
TRG_ENDOCYTIC_2 182 185 PF00928 0.561
TRG_ENDOCYTIC_2 2 5 PF00928 0.510
TRG_ENDOCYTIC_2 224 227 PF00928 0.576
TRG_ENDOCYTIC_2 242 245 PF00928 0.374
TRG_ER_diArg_1 130 132 PF00400 0.633
TRG_ER_diArg_1 161 164 PF00400 0.511
TRG_ER_diArg_1 239 242 PF00400 0.517
TRG_ER_diArg_1 24 26 PF00400 0.525
TRG_ER_diArg_1 245 248 PF00400 0.524
TRG_ER_diArg_1 250 253 PF00400 0.556
TRG_ER_diArg_1 368 370 PF00400 0.465
TRG_ER_diArg_1 406 409 PF00400 0.533
TRG_ER_diArg_1 8 10 PF00400 0.632
TRG_NLS_Bipartite_1 93 111 PF00514 0.568
TRG_Pf-PMV_PEXEL_1 109 113 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.568
TRG_Pf-PMV_PEXEL_1 390 395 PF00026 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC16 Leptomonas seymouri 69% 100%
A0A0S4IZV5 Bodo saltans 38% 100%
A0A1X0NPB4 Trypanosomatidae 39% 100%
A0A3S5H6Q9 Leishmania donovani 99% 100%
A0A422NXD4 Trypanosoma rangeli 37% 100%
A4H7I1 Leishmania braziliensis 81% 100%
C9ZT63 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9APL4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q2M329 Homo sapiens 30% 80%
Q4QFW4 Leishmania major 94% 100%
Q95LS7 Macaca fascicularis 30% 79%
Q9CR92 Mus musculus 29% 76%
V5BHR7 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS