LeishMANIAdb
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Putative carboxypeptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative carboxypeptidase
Gene product:
carboxypeptidase - putative
Species:
Leishmania infantum
UniProt:
A4HVW0_LEIIN
TriTrypDb:
LINF_140006700
Length:
504

Annotations

Annotations by Jardim et al.

Proteases, carboxypeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) yes yes: 3
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 2
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 9
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVW0

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 25
GO:0006807 nitrogen compound metabolic process 2 25
GO:0008152 metabolic process 1 25
GO:0019538 protein metabolic process 3 25
GO:0043170 macromolecule metabolic process 3 25
GO:0044238 primary metabolic process 2 25
GO:0071704 organic substance metabolic process 2 25
GO:1901564 organonitrogen compound metabolic process 3 25
GO:0006518 peptide metabolic process 4 1
GO:0043603 amide metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 25
GO:0004180 carboxypeptidase activity 5 25
GO:0004181 metallocarboxypeptidase activity 6 25
GO:0008233 peptidase activity 3 25
GO:0008235 metalloexopeptidase activity 5 25
GO:0008237 metallopeptidase activity 4 25
GO:0008238 exopeptidase activity 4 25
GO:0016787 hydrolase activity 2 25
GO:0140096 catalytic activity, acting on a protein 2 25
GO:0016853 isomerase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.323
CLV_NRD_NRD_1 11 13 PF00675 0.187
CLV_NRD_NRD_1 190 192 PF00675 0.191
CLV_NRD_NRD_1 336 338 PF00675 0.400
CLV_NRD_NRD_1 497 499 PF00675 0.270
CLV_PCSK_KEX2_1 101 103 PF00082 0.426
CLV_PCSK_KEX2_1 497 499 PF00082 0.270
CLV_PCSK_SKI1_1 18 22 PF00082 0.289
CLV_PCSK_SKI1_1 185 189 PF00082 0.423
CLV_PCSK_SKI1_1 259 263 PF00082 0.376
CLV_PCSK_SKI1_1 280 284 PF00082 0.412
CLV_PCSK_SKI1_1 35 39 PF00082 0.405
CLV_PCSK_SKI1_1 59 63 PF00082 0.385
CLV_PCSK_SKI1_1 65 69 PF00082 0.356
CLV_Separin_Metazoa 84 88 PF03568 0.221
CLV_Separin_Metazoa 98 102 PF03568 0.200
DEG_APCC_DBOX_1 102 110 PF00400 0.187
DEG_APCC_DBOX_1 399 407 PF00400 0.259
DEG_APCC_DBOX_1 78 86 PF00400 0.279
DEG_Nend_UBRbox_3 1 3 PF02207 0.526
DEG_SCF_FBW7_2 317 322 PF00400 0.176
DOC_CKS1_1 201 206 PF01111 0.304
DOC_CKS1_1 316 321 PF01111 0.342
DOC_CYCLIN_RxL_1 256 264 PF00134 0.336
DOC_CYCLIN_yClb5_NLxxxL_5 13 21 PF00134 0.223
DOC_MAPK_gen_1 388 395 PF00069 0.326
DOC_PP4_MxPP_1 31 34 PF00568 0.258
DOC_USP7_MATH_1 145 149 PF00917 0.293
DOC_WW_Pin1_4 148 153 PF00397 0.336
DOC_WW_Pin1_4 200 205 PF00397 0.303
DOC_WW_Pin1_4 250 255 PF00397 0.258
DOC_WW_Pin1_4 315 320 PF00397 0.319
LIG_14-3-3_CanoR_1 103 113 PF00244 0.392
LIG_14-3-3_CanoR_1 215 224 PF00244 0.240
LIG_14-3-3_CanoR_1 247 251 PF00244 0.450
LIG_Actin_WH2_2 129 146 PF00022 0.278
LIG_BRCT_BRCA1_1 309 313 PF00533 0.271
LIG_Clathr_ClatBox_1 133 137 PF01394 0.251
LIG_CSL_BTD_1 125 128 PF09270 0.373
LIG_deltaCOP1_diTrp_1 220 226 PF00928 0.367
LIG_deltaCOP1_diTrp_1 408 416 PF00928 0.311
LIG_FHA_1 256 262 PF00498 0.437
LIG_FHA_1 296 302 PF00498 0.375
LIG_FHA_1 316 322 PF00498 0.379
LIG_FHA_1 444 450 PF00498 0.253
LIG_FHA_1 472 478 PF00498 0.301
LIG_FHA_2 127 133 PF00498 0.354
LIG_FHA_2 262 268 PF00498 0.376
LIG_FHA_2 348 354 PF00498 0.230
LIG_GBD_Chelix_1 60 68 PF00786 0.357
LIG_HP1_1 58 62 PF01393 0.213
LIG_LIR_Apic_2 249 254 PF02991 0.245
LIG_LIR_Apic_2 315 319 PF02991 0.311
LIG_LIR_Gen_1 151 159 PF02991 0.421
LIG_LIR_Gen_1 170 181 PF02991 0.214
LIG_LIR_Nem_3 151 156 PF02991 0.448
LIG_LIR_Nem_3 170 176 PF02991 0.186
LIG_LIR_Nem_3 310 316 PF02991 0.278
LIG_LIR_Nem_3 391 395 PF02991 0.304
LIG_LIR_Nem_3 418 422 PF02991 0.176
LIG_NRBOX 16 22 PF00104 0.251
LIG_NRBOX 467 473 PF00104 0.351
LIG_Pex14_1 411 415 PF04695 0.394
LIG_SH2_CRK 153 157 PF00017 0.251
LIG_SH2_NCK_1 231 235 PF00017 0.251
LIG_SH2_SRC 173 176 PF00017 0.337
LIG_SH2_SRC 231 234 PF00017 0.251
LIG_SH2_STAP1 153 157 PF00017 0.295
LIG_SH2_STAP1 257 261 PF00017 0.472
LIG_SH2_STAP1 357 361 PF00017 0.346
LIG_SH2_STAT5 257 260 PF00017 0.437
LIG_SH2_STAT5 316 319 PF00017 0.360
LIG_SH2_STAT5 347 350 PF00017 0.342
LIG_SH2_STAT5 422 425 PF00017 0.320
LIG_SH2_STAT5 499 502 PF00017 0.535
LIG_SH3_3 376 382 PF00018 0.230
LIG_SH3_3 482 488 PF00018 0.276
LIG_SUMO_SIM_par_1 132 137 PF11976 0.251
LIG_SUMO_SIM_par_1 19 25 PF11976 0.311
LIG_TRAF2_1 129 132 PF00917 0.302
LIG_TRAF2_1 3 6 PF00917 0.285
MOD_CDK_SPxxK_3 200 207 PF00069 0.256
MOD_CK1_1 148 154 PF00069 0.333
MOD_CK2_1 126 132 PF00069 0.366
MOD_CK2_1 194 200 PF00069 0.319
MOD_CK2_1 261 267 PF00069 0.444
MOD_GlcNHglycan 147 150 PF01048 0.279
MOD_GlcNHglycan 291 294 PF01048 0.240
MOD_GlcNHglycan 309 312 PF01048 0.280
MOD_GSK3_1 101 108 PF00069 0.309
MOD_GSK3_1 144 151 PF00069 0.259
MOD_GSK3_1 196 203 PF00069 0.289
MOD_GSK3_1 246 253 PF00069 0.443
MOD_GSK3_1 261 268 PF00069 0.462
MOD_GSK3_1 343 350 PF00069 0.403
MOD_N-GLC_1 255 260 PF02516 0.414
MOD_NEK2_1 194 199 PF00069 0.188
MOD_NEK2_1 261 266 PF00069 0.328
MOD_PIKK_1 295 301 PF00454 0.363
MOD_PIKK_1 443 449 PF00454 0.203
MOD_PIKK_1 90 96 PF00454 0.314
MOD_PKA_1 101 107 PF00069 0.332
MOD_PKA_2 101 107 PF00069 0.401
MOD_PKA_2 246 252 PF00069 0.301
MOD_PKB_1 103 111 PF00069 0.187
MOD_PKB_1 142 150 PF00069 0.376
MOD_Plk_4 175 181 PF00069 0.315
MOD_Plk_4 246 252 PF00069 0.346
MOD_Plk_4 27 33 PF00069 0.313
MOD_Plk_4 297 303 PF00069 0.291
MOD_Plk_4 343 349 PF00069 0.376
MOD_ProDKin_1 148 154 PF00069 0.336
MOD_ProDKin_1 200 206 PF00069 0.303
MOD_ProDKin_1 250 256 PF00069 0.258
MOD_ProDKin_1 315 321 PF00069 0.319
MOD_SUMO_for_1 271 274 PF00179 0.237
MOD_SUMO_for_1 70 73 PF00179 0.476
MOD_SUMO_rev_2 170 178 PF00179 0.355
MOD_SUMO_rev_2 380 389 PF00179 0.280
MOD_SUMO_rev_2 5 10 PF00179 0.223
TRG_DiLeu_BaEn_1 297 302 PF01217 0.251
TRG_DiLeu_BaEn_1 473 478 PF01217 0.288
TRG_DiLeu_BaEn_4 5 11 PF01217 0.213
TRG_DiLeu_BaLyEn_6 316 321 PF01217 0.336
TRG_ENDOCYTIC_2 153 156 PF00928 0.302
TRG_ENDOCYTIC_2 173 176 PF00928 0.150
TRG_ENDOCYTIC_2 184 187 PF00928 0.215
TRG_ENDOCYTIC_2 392 395 PF00928 0.305
TRG_ENDOCYTIC_2 4 7 PF00928 0.359
TRG_ER_diArg_1 100 103 PF00400 0.426
TRG_ER_diArg_1 497 499 PF00400 0.270
TRG_NES_CRM1_1 315 328 PF08389 0.251
TRG_Pf-PMV_PEXEL_1 215 220 PF00026 0.293
TRG_Pf-PMV_PEXEL_1 280 285 PF00026 0.272
TRG_Pf-PMV_PEXEL_1 337 341 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 349 353 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 369 373 PF00026 0.295
TRG_Pf-PMV_PEXEL_1 489 493 PF00026 0.222
TRG_Pf-PMV_PEXEL_1 498 503 PF00026 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IZ28 Bodo saltans 46% 100%
A0A1X0NY67 Trypanosomatidae 52% 100%
A0A1X0P441 Trypanosomatidae 56% 100%
A0A1X0P598 Trypanosomatidae 57% 100%
A0A3Q8IBW2 Leishmania donovani 99% 100%
A0A3Q8IJY8 Leishmania donovani 89% 100%
A0A3Q8IU74 Leishmania donovani 52% 100%
A0A3S7WSA3 Leishmania donovani 53% 100%
A0A422P042 Trypanosoma rangeli 52% 100%
A0A422P4R1 Trypanosoma rangeli 52% 100%
A4H716 Leishmania braziliensis 54% 100%
A4HLW4 Leishmania braziliensis 52% 99%
A4HVE5 Leishmania infantum 53% 100%
A4I993 Leishmania infantum 52% 100%
A4IC85 Leishmania infantum 87% 100%
D0A656 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AP43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9B493 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
P42663 Thermus aquaticus 32% 99%
P50848 Bacillus subtilis (strain 168) 31% 100%
Q4Q0D4 Leishmania major 93% 100%
Q4Q3T3 Leishmania major 51% 100%
Q4QFW7 Leishmania major 96% 100%
Q4QGE5 Leishmania major 53% 100%
Q5SLM3 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 32% 99%
Q8U3L0 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 30% 100%
V5DQA0 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS