Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVV9_LEIIN

TriTrypDb:

LINF_140006600

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.637
CLV_NRD_NRD_1	215	217	PF00675	0.633
CLV_NRD_NRD_1	290	292	PF00675	0.645
CLV_NRD_NRD_1	634	636	PF00675	0.735
CLV_NRD_NRD_1	663	665	PF00675	0.773
CLV_NRD_NRD_1	75	77	PF00675	0.453
CLV_PCSK_KEX2_1	215	217	PF00082	0.699
CLV_PCSK_KEX2_1	290	292	PF00082	0.645
CLV_PCSK_KEX2_1	634	636	PF00082	0.735
CLV_PCSK_KEX2_1	663	665	PF00082	0.772
CLV_PCSK_KEX2_1	75	77	PF00082	0.485
CLV_PCSK_SKI1_1	157	161	PF00082	0.574
CLV_PCSK_SKI1_1	305	309	PF00082	0.642
CLV_PCSK_SKI1_1	319	323	PF00082	0.530
CLV_PCSK_SKI1_1	368	372	PF00082	0.545
CLV_PCSK_SKI1_1	42	46	PF00082	0.583
DEG_APCC_DBOX_1	304	312	PF00400	0.602
DEG_APCC_DBOX_1	413	421	PF00400	0.601
DEG_SCF_FBW7_1	144	151	PF00400	0.553
DEG_SCF_FBW7_1	262	268	PF00400	0.799
DEG_SIAH_1	594	602	PF03145	0.749
DEG_SPOP_SBC_1	221	225	PF00917	0.738
DEG_SPOP_SBC_1	558	562	PF00917	0.709
DOC_CKS1_1	145	150	PF01111	0.552
DOC_CKS1_1	192	197	PF01111	0.674
DOC_CKS1_1	262	267	PF01111	0.709
DOC_CKS1_1	36	41	PF01111	0.596
DOC_MAPK_gen_1	425	434	PF00069	0.565
DOC_MAPK_gen_1	63	71	PF00069	0.525
DOC_MAPK_MEF2A_6	414	421	PF00069	0.600
DOC_MAPK_MEF2A_6	63	71	PF00069	0.628
DOC_MAPK_NFAT4_5	414	422	PF00069	0.594
DOC_PP1_RVXF_1	40	47	PF00149	0.553
DOC_PP1_RVXF_1	522	528	PF00149	0.603
DOC_PP2B_LxvP_1	115	118	PF13499	0.619
DOC_PP2B_LxvP_1	267	270	PF13499	0.736
DOC_PP4_FxxP_1	33	36	PF00568	0.662
DOC_USP7_MATH_1	12	16	PF00917	0.727
DOC_USP7_MATH_1	222	226	PF00917	0.807
DOC_USP7_MATH_1	26	30	PF00917	0.564
DOC_USP7_MATH_1	558	562	PF00917	0.580
DOC_USP7_MATH_1	67	71	PF00917	0.585
DOC_USP7_MATH_1	679	683	PF00917	0.842
DOC_USP7_MATH_1	91	95	PF00917	0.564
DOC_WW_Pin1_4	144	149	PF00397	0.559
DOC_WW_Pin1_4	191	196	PF00397	0.644
DOC_WW_Pin1_4	261	266	PF00397	0.799
DOC_WW_Pin1_4	300	305	PF00397	0.703
DOC_WW_Pin1_4	35	40	PF00397	0.657
DOC_WW_Pin1_4	445	450	PF00397	0.597
DOC_WW_Pin1_4	657	662	PF00397	0.666
DOC_WW_Pin1_4	675	680	PF00397	0.637
LIG_14-3-3_CanoR_1	247	252	PF00244	0.760
LIG_14-3-3_CanoR_1	425	430	PF00244	0.560
LIG_14-3-3_CanoR_1	556	564	PF00244	0.633
LIG_14-3-3_CanoR_1	625	630	PF00244	0.602
LIG_14-3-3_CanoR_1	634	640	PF00244	0.628
LIG_14-3-3_CanoR_1	646	651	PF00244	0.544
LIG_14-3-3_CanoR_1	83	88	PF00244	0.497
LIG_BRCT_BRCA1_1	560	564	PF00533	0.580
LIG_CSL_BTD_1	142	145	PF09270	0.599
LIG_DLG_GKlike_1	425	432	PF00625	0.499
LIG_FHA_1	112	118	PF00498	0.544
LIG_FHA_1	145	151	PF00498	0.554
LIG_FHA_1	171	177	PF00498	0.548
LIG_FHA_1	262	268	PF00498	0.757
LIG_FHA_1	337	343	PF00498	0.559
LIG_FHA_1	491	497	PF00498	0.502
LIG_FHA_1	56	62	PF00498	0.633
LIG_FHA_1	614	620	PF00498	0.623
LIG_FHA_1	66	72	PF00498	0.570
LIG_FHA_2	105	111	PF00498	0.473
LIG_FHA_2	160	166	PF00498	0.487
LIG_FHA_2	231	237	PF00498	0.588
LIG_FHA_2	301	307	PF00498	0.734
LIG_FHA_2	329	335	PF00498	0.656
LIG_FHA_2	349	355	PF00498	0.392
LIG_FHA_2	528	534	PF00498	0.621
LIG_FHA_2	663	669	PF00498	0.695
LIG_FXI_DFP_1	409	413	PF00024	0.659
LIG_Integrin_RGD_1	531	533	PF01839	0.596
LIG_LIR_Apic_2	191	195	PF02991	0.661
LIG_LIR_Apic_2	30	36	PF02991	0.681
LIG_LIR_Apic_2	652	657	PF02991	0.714
LIG_LIR_Gen_1	107	116	PF02991	0.556
LIG_LIR_Gen_1	415	424	PF02991	0.489
LIG_LIR_Gen_1	552	559	PF02991	0.517
LIG_LIR_Gen_1	565	574	PF02991	0.542
LIG_LIR_Nem_3	107	111	PF02991	0.534
LIG_LIR_Nem_3	140	146	PF02991	0.549
LIG_LIR_Nem_3	165	171	PF02991	0.495
LIG_LIR_Nem_3	415	419	PF02991	0.494
LIG_LIR_Nem_3	552	557	PF02991	0.691
LIG_LIR_Nem_3	561	567	PF02991	0.469
LIG_MYND_1	265	269	PF01753	0.782
LIG_NRBOX	416	422	PF00104	0.487
LIG_Pex14_2	412	416	PF04695	0.513
LIG_SH2_CRK	567	571	PF00017	0.649
LIG_SH2_SRC	355	358	PF00017	0.378
LIG_SH2_STAP1	567	571	PF00017	0.649
LIG_SH2_STAT5	158	161	PF00017	0.506
LIG_SH2_STAT5	355	358	PF00017	0.378
LIG_SH2_STAT5	504	507	PF00017	0.542
LIG_SH2_STAT5	608	611	PF00017	0.668
LIG_SH3_1	655	661	PF00018	0.698
LIG_SH3_2	207	212	PF14604	0.711
LIG_SH3_2	658	663	PF14604	0.665
LIG_SH3_3	117	123	PF00018	0.663
LIG_SH3_3	142	148	PF00018	0.550
LIG_SH3_3	20	26	PF00018	0.672
LIG_SH3_3	204	210	PF00018	0.734
LIG_SH3_3	259	265	PF00018	0.707
LIG_SH3_3	324	330	PF00018	0.627
LIG_SH3_3	33	39	PF00018	0.588
LIG_SH3_3	443	449	PF00018	0.513
LIG_SH3_3	655	661	PF00018	0.667
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.476
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.593
LIG_SUMO_SIM_par_1	67	73	PF11976	0.555
LIG_SxIP_EBH_1	549	563	PF03271	0.481
MOD_CDC14_SPxK_1	660	663	PF00782	0.670
MOD_CDK_SPK_2	300	305	PF00069	0.600
MOD_CDK_SPxK_1	657	663	PF00069	0.661
MOD_CDK_SPxxK_3	35	42	PF00069	0.642
MOD_CDK_SPxxK_3	657	664	PF00069	0.664
MOD_CK1_1	149	155	PF00069	0.604
MOD_CK1_1	224	230	PF00069	0.782
MOD_CK1_1	268	274	PF00069	0.679
MOD_CK1_1	29	35	PF00069	0.692
MOD_CK1_1	394	400	PF00069	0.574
MOD_CK1_1	448	454	PF00069	0.550
MOD_CK1_1	506	512	PF00069	0.618
MOD_CK1_1	562	568	PF00069	0.662
MOD_CK1_1	70	76	PF00069	0.531
MOD_CK2_1	149	155	PF00069	0.548
MOD_CK2_1	159	165	PF00069	0.487
MOD_CK2_1	300	306	PF00069	0.641
MOD_CK2_1	340	346	PF00069	0.545
MOD_CK2_1	469	475	PF00069	0.500
MOD_CK2_1	494	500	PF00069	0.471
MOD_CK2_1	56	62	PF00069	0.591
MOD_CK2_1	662	668	PF00069	0.707
MOD_Cter_Amidation	288	291	PF01082	0.633
MOD_GlcNHglycan	139	142	PF01048	0.558
MOD_GlcNHglycan	14	17	PF01048	0.742
MOD_GlcNHglycan	199	202	PF01048	0.725
MOD_GlcNHglycan	217	220	PF01048	0.588
MOD_GlcNHglycan	224	227	PF01048	0.670
MOD_GlcNHglycan	238	241	PF01048	0.610
MOD_GlcNHglycan	251	254	PF01048	0.727
MOD_GlcNHglycan	270	273	PF01048	0.709
MOD_GlcNHglycan	396	399	PF01048	0.577
MOD_GlcNHglycan	561	564	PF01048	0.536
MOD_GlcNHglycan	576	579	PF01048	0.546
MOD_GlcNHglycan	58	61	PF01048	0.600
MOD_GSK3_1	144	151	PF00069	0.553
MOD_GSK3_1	220	227	PF00069	0.734
MOD_GSK3_1	230	237	PF00069	0.669
MOD_GSK3_1	261	268	PF00069	0.787
MOD_GSK3_1	336	343	PF00069	0.567
MOD_GSK3_1	490	497	PF00069	0.501
MOD_GSK3_1	503	510	PF00069	0.610
MOD_GSK3_1	558	565	PF00069	0.691
MOD_GSK3_1	645	652	PF00069	0.677
MOD_GSK3_1	662	669	PF00069	0.574
MOD_GSK3_1	675	682	PF00069	0.686
MOD_GSK3_1	79	86	PF00069	0.489
MOD_N-GLC_1	507	512	PF02516	0.518
MOD_NEK2_1	196	201	PF00069	0.803
MOD_NEK2_1	373	378	PF00069	0.612
MOD_NEK2_1	420	425	PF00069	0.431
MOD_NEK2_1	45	50	PF00069	0.534
MOD_NEK2_1	487	492	PF00069	0.539
MOD_NEK2_1	527	532	PF00069	0.658
MOD_NEK2_1	559	564	PF00069	0.685
MOD_NEK2_1	606	611	PF00069	0.761
MOD_NEK2_1	633	638	PF00069	0.726
MOD_NEK2_2	67	72	PF00069	0.531
MOD_NEK2_2	91	96	PF00069	0.571
MOD_PIKK_1	224	230	PF00454	0.739
MOD_PKA_1	215	221	PF00069	0.627
MOD_PKA_2	215	221	PF00069	0.693
MOD_PKA_2	229	235	PF00069	0.820
MOD_PKA_2	574	580	PF00069	0.597
MOD_PKA_2	633	639	PF00069	0.727
MOD_PKA_2	645	651	PF00069	0.543
MOD_PKA_2	662	668	PF00069	0.599
MOD_Plk_4	111	117	PF00069	0.581
MOD_Plk_4	171	177	PF00069	0.548
MOD_Plk_4	340	346	PF00069	0.545
MOD_Plk_4	391	397	PF00069	0.624
MOD_Plk_4	487	493	PF00069	0.576
MOD_Plk_4	625	631	PF00069	0.720
MOD_Plk_4	67	73	PF00069	0.565
MOD_ProDKin_1	144	150	PF00069	0.552
MOD_ProDKin_1	191	197	PF00069	0.645
MOD_ProDKin_1	261	267	PF00069	0.795
MOD_ProDKin_1	300	306	PF00069	0.701
MOD_ProDKin_1	35	41	PF00069	0.648
MOD_ProDKin_1	445	451	PF00069	0.592
MOD_ProDKin_1	657	663	PF00069	0.671
MOD_ProDKin_1	675	681	PF00069	0.634
TRG_DiLeu_BaEn_1	566	571	PF01217	0.565
TRG_DiLeu_BaEn_2	154	160	PF01217	0.522
TRG_ENDOCYTIC_2	54	57	PF00928	0.459
TRG_ENDOCYTIC_2	567	570	PF00928	0.542
TRG_ER_diArg_1	214	216	PF00400	0.635
TRG_ER_diArg_1	295	298	PF00400	0.654
TRG_ER_diArg_1	375	378	PF00400	0.560
TRG_ER_diArg_1	424	427	PF00400	0.466
TRG_ER_diArg_1	524	527	PF00400	0.503
TRG_ER_diArg_1	633	635	PF00400	0.731
TRG_ER_diArg_1	662	664	PF00400	0.737
TRG_ER_diArg_1	74	76	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B4	Leptomonas seymouri	45%	100%
A0A3Q8I8P4	Leishmania donovani	99%	100%
A4H7H8	Leishmania braziliensis	78%	100%
E9APL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFW8	Leishmania major	95%	100%