Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HVV3_LEIIN

TriTrypDb:

LINF_140006000

Length:

523

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HVV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.513
CLV_NRD_NRD_1	13	15	PF00675	0.516
CLV_NRD_NRD_1	223	225	PF00675	0.321
CLV_NRD_NRD_1	227	229	PF00675	0.331
CLV_NRD_NRD_1	238	240	PF00675	0.341
CLV_NRD_NRD_1	303	305	PF00675	0.475
CLV_NRD_NRD_1	33	35	PF00675	0.390
CLV_NRD_NRD_1	398	400	PF00675	0.347
CLV_NRD_NRD_1	433	435	PF00675	0.448
CLV_PCSK_FUR_1	11	15	PF00082	0.409
CLV_PCSK_FUR_1	303	307	PF00082	0.464
CLV_PCSK_KEX2_1	13	15	PF00082	0.516
CLV_PCSK_KEX2_1	223	225	PF00082	0.312
CLV_PCSK_KEX2_1	227	229	PF00082	0.314
CLV_PCSK_KEX2_1	303	305	PF00082	0.416
CLV_PCSK_KEX2_1	33	35	PF00082	0.390
CLV_PCSK_KEX2_1	398	400	PF00082	0.355
CLV_PCSK_KEX2_1	432	434	PF00082	0.473
CLV_PCSK_KEX2_1	488	490	PF00082	0.373
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.396
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.383
CLV_PCSK_PC7_1	223	229	PF00082	0.409
CLV_PCSK_PC7_1	394	400	PF00082	0.354
CLV_PCSK_SKI1_1	177	181	PF00082	0.382
CLV_PCSK_SKI1_1	228	232	PF00082	0.301
CLV_PCSK_SKI1_1	263	267	PF00082	0.281
CLV_PCSK_SKI1_1	404	408	PF00082	0.439
CLV_PCSK_SKI1_1	461	465	PF00082	0.291
DEG_APCC_DBOX_1	168	176	PF00400	0.595
DEG_APCC_DBOX_1	227	235	PF00400	0.583
DEG_APCC_DBOX_1	433	441	PF00400	0.622
DEG_Kelch_Keap1_1	509	514	PF01344	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DEG_SCF_TRCP1_1	511	516	PF00400	0.689
DOC_MAPK_FxFP_2	151	154	PF00069	0.506
DOC_MAPK_gen_1	223	231	PF00069	0.546
DOC_MAPK_gen_1	303	309	PF00069	0.581
DOC_MAPK_gen_1	465	473	PF00069	0.513
DOC_MAPK_gen_1	74	81	PF00069	0.522
DOC_MAPK_JIP1_4	263	269	PF00069	0.464
DOC_MAPK_MEF2A_6	293	301	PF00069	0.537
DOC_PP4_FxxP_1	108	111	PF00568	0.508
DOC_PP4_FxxP_1	151	154	PF00568	0.506
DOC_USP7_UBL2_3	461	465	PF12436	0.544
DOC_WW_Pin1_4	27	32	PF00397	0.704
DOC_WW_Pin1_4	278	283	PF00397	0.553
DOC_WW_Pin1_4	379	384	PF00397	0.568
LIG_14-3-3_CanoR_1	132	138	PF00244	0.627
LIG_14-3-3_CanoR_1	19	28	PF00244	0.695
LIG_14-3-3_CanoR_1	33	39	PF00244	0.633
LIG_14-3-3_CanoR_1	432	440	PF00244	0.659
LIG_BRCT_BRCA1_1	339	343	PF00533	0.443
LIG_BRCT_BRCA1_1	35	39	PF00533	0.697
LIG_FHA_1	289	295	PF00498	0.512
LIG_FHA_2	380	386	PF00498	0.605
LIG_FHA_2	423	429	PF00498	0.670
LIG_FHA_2	436	442	PF00498	0.530
LIG_FHA_2	457	463	PF00498	0.446
LIG_FHA_2	96	102	PF00498	0.580
LIG_LIR_Apic_2	106	111	PF02991	0.500
LIG_LIR_Apic_2	165	171	PF02991	0.569
LIG_LIR_Gen_1	190	198	PF02991	0.520
LIG_LIR_Nem_3	190	195	PF02991	0.520
LIG_LIR_Nem_3	496	501	PF02991	0.474
LIG_Pex14_2	108	112	PF04695	0.508
LIG_Pex14_2	151	155	PF04695	0.536
LIG_Pex14_2	241	245	PF04695	0.552
LIG_Pex14_2	266	270	PF04695	0.513
LIG_Pex14_2	35	39	PF04695	0.697
LIG_SH2_CRK	498	502	PF00017	0.451
LIG_SH2_CRK	7	11	PF00017	0.575
LIG_SH2_SRC	7	10	PF00017	0.611
LIG_SH2_STAT5	140	143	PF00017	0.609
LIG_SH3_3	291	297	PF00018	0.498
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.554
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.515
LIG_SUMO_SIM_par_1	170	176	PF11976	0.511
LIG_SxIP_EBH_1	204	214	PF03271	0.488
LIG_TRAF2_1	382	385	PF00917	0.594
LIG_UBA3_1	448	454	PF00899	0.488
LIG_WRC_WIRS_1	18	23	PF05994	0.738
MOD_CDC14_SPxK_1	30	33	PF00782	0.620
MOD_CDK_SPxK_1	27	33	PF00069	0.727
MOD_CDK_SPxxK_3	27	34	PF00069	0.624
MOD_CK1_1	213	219	PF00069	0.491
MOD_CK1_1	27	33	PF00069	0.698
MOD_CK1_1	275	281	PF00069	0.549
MOD_CK1_1	509	515	PF00069	0.676
MOD_CK1_1	516	522	PF00069	0.765
MOD_CK2_1	164	170	PF00069	0.531
MOD_CK2_1	187	193	PF00069	0.523
MOD_CK2_1	216	222	PF00069	0.581
MOD_CK2_1	34	40	PF00069	0.729
MOD_CK2_1	379	385	PF00069	0.606
MOD_CK2_1	81	87	PF00069	0.569
MOD_CK2_1	95	101	PF00069	0.575
MOD_GlcNHglycan	116	120	PF01048	0.325
MOD_GlcNHglycan	164	167	PF01048	0.275
MOD_GlcNHglycan	21	24	PF01048	0.576
MOD_GlcNHglycan	340	343	PF01048	0.435
MOD_GlcNHglycan	375	378	PF01048	0.378
MOD_GlcNHglycan	455	459	PF01048	0.275
MOD_GlcNHglycan	511	514	PF01048	0.426
MOD_GlcNHglycan	515	518	PF01048	0.457
MOD_GSK3_1	115	122	PF00069	0.488
MOD_GSK3_1	13	20	PF00069	0.697
MOD_GSK3_1	179	186	PF00069	0.503
MOD_GSK3_1	23	30	PF00069	0.705
MOD_GSK3_1	241	248	PF00069	0.567
MOD_GSK3_1	273	280	PF00069	0.534
MOD_GSK3_1	428	435	PF00069	0.764
MOD_GSK3_1	509	516	PF00069	0.652
MOD_N-GLC_1	133	138	PF02516	0.477
MOD_N-GLC_1	250	255	PF02516	0.340
MOD_N-GLC_2	91	93	PF02516	0.391
MOD_NEK2_1	114	119	PF00069	0.503
MOD_NEK2_1	133	138	PF00069	0.619
MOD_NEK2_1	179	184	PF00069	0.474
MOD_NEK2_1	187	192	PF00069	0.532
MOD_NEK2_1	210	215	PF00069	0.505
MOD_NEK2_1	241	246	PF00069	0.565
MOD_NEK2_1	257	262	PF00069	0.533
MOD_NEK2_1	270	275	PF00069	0.491
MOD_NEK2_1	456	461	PF00069	0.452
MOD_NEK2_2	119	124	PF00069	0.506
MOD_PIKK_1	133	139	PF00454	0.567
MOD_PIKK_1	516	522	PF00454	0.736
MOD_PK_1	13	19	PF00069	0.726
MOD_PKA_1	13	19	PF00069	0.582
MOD_PKA_1	33	39	PF00069	0.583
MOD_PKA_1	432	438	PF00069	0.647
MOD_PKA_2	13	19	PF00069	0.652
MOD_PKA_2	203	209	PF00069	0.506
MOD_PKA_2	33	39	PF00069	0.681
MOD_PKA_2	432	438	PF00069	0.636
MOD_PKB_1	11	19	PF00069	0.637
MOD_Plk_1	250	256	PF00069	0.555
MOD_Plk_2-3	101	107	PF00069	0.494
MOD_Plk_4	13	19	PF00069	0.631
MOD_Plk_4	183	189	PF00069	0.478
MOD_Plk_4	203	209	PF00069	0.567
MOD_Plk_4	216	222	PF00069	0.508
MOD_Plk_4	241	247	PF00069	0.552
MOD_Plk_4	314	320	PF00069	0.322
MOD_Plk_4	34	40	PF00069	0.744
MOD_Plk_4	67	73	PF00069	0.603
MOD_ProDKin_1	27	33	PF00069	0.703
MOD_ProDKin_1	278	284	PF00069	0.550
MOD_ProDKin_1	379	385	PF00069	0.570
MOD_SUMO_for_1	411	414	PF00179	0.561
TRG_ENDOCYTIC_2	158	161	PF00928	0.522
TRG_ENDOCYTIC_2	445	448	PF00928	0.454
TRG_ENDOCYTIC_2	498	501	PF00928	0.451
TRG_ENDOCYTIC_2	7	10	PF00928	0.573
TRG_ER_diArg_1	10	13	PF00400	0.675
TRG_ER_diArg_1	223	225	PF00400	0.510
TRG_ER_diArg_1	227	229	PF00400	0.513
TRG_ER_diArg_1	303	306	PF00400	0.666
TRG_ER_diArg_1	33	35	PF00400	0.738
TRG_ER_diArg_1	350	353	PF00400	0.572
TRG_ER_diArg_1	397	399	PF00400	0.529
TRG_ER_diArg_1	432	434	PF00400	0.669
TRG_NES_CRM1_1	363	375	PF08389	0.509
TRG_NES_CRM1_1	462	477	PF08389	0.540
TRG_NLS_MonoExtN_4	303	308	PF00514	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	24%	100%
A0A0N1IK13	Leptomonas seymouri	79%	99%
A0A0S4ITI3	Bodo saltans	44%	100%
A0A1X0NQB1	Trypanosomatidae	57%	100%
A0A1X0NVK2	Trypanosomatidae	23%	100%
A0A3S7WSV3	Leishmania donovani	100%	100%
A0A3S7WYG6	Leishmania donovani	26%	100%
A0A422N8L2	Trypanosoma rangeli	23%	100%
A4H7H2	Leishmania braziliensis	86%	100%
A4HDG4	Leishmania braziliensis	26%	100%
C9ZT74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAM5	Leishmania major	25%	100%
Q4QFX4	Leishmania major	97%	100%
V5BD52	Trypanosoma cruzi	57%	100%
V5DSF1	Trypanosoma cruzi	22%	100%