Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVV0_LEIIN

TriTrypDb:

LINF_140005700

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.400
CLV_NRD_NRD_1	100	102	PF00675	0.372
CLV_NRD_NRD_1	106	108	PF00675	0.360
CLV_NRD_NRD_1	267	269	PF00675	0.489
CLV_NRD_NRD_1	95	97	PF00675	0.381
CLV_PCSK_KEX2_1	106	108	PF00082	0.381
CLV_PCSK_KEX2_1	51	53	PF00082	0.514
CLV_PCSK_KEX2_1	95	97	PF00082	0.371
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.533
CLV_PCSK_SKI1_1	116	120	PF00082	0.394
CLV_PCSK_SKI1_1	148	152	PF00082	0.417
CLV_PCSK_SKI1_1	167	171	PF00082	0.339
CLV_PCSK_SKI1_1	91	95	PF00082	0.403
CLV_PCSK_SKI1_1	96	100	PF00082	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_CKS1_1	18	23	PF01111	0.524
DOC_PP2B_PxIxI_1	242	248	PF00149	0.399
DOC_PP4_FxxP_1	5	8	PF00568	0.567
DOC_USP7_MATH_1	162	166	PF00917	0.537
DOC_WW_Pin1_4	127	132	PF00397	0.531
DOC_WW_Pin1_4	17	22	PF00397	0.556
DOC_WW_Pin1_4	77	82	PF00397	0.385
LIG_14-3-3_CanoR_1	10	19	PF00244	0.592
LIG_14-3-3_CanoR_1	67	72	PF00244	0.428
LIG_14-3-3_CanoR_1	83	88	PF00244	0.517
LIG_14-3-3_CanoR_1	95	101	PF00244	0.377
LIG_deltaCOP1_diTrp_1	60	68	PF00928	0.439
LIG_EVH1_1	18	22	PF00568	0.470
LIG_FHA_1	18	24	PF00498	0.617
LIG_FHA_2	140	146	PF00498	0.344
LIG_FHA_2	219	225	PF00498	0.480
LIG_FHA_2	37	43	PF00498	0.503
LIG_FHA_2	51	57	PF00498	0.466
LIG_LIR_Gen_1	117	125	PF02991	0.504
LIG_LIR_Gen_1	183	192	PF02991	0.331
LIG_LIR_Gen_1	198	205	PF02991	0.283
LIG_LIR_Gen_1	216	227	PF02991	0.352
LIG_LIR_Gen_1	241	250	PF02991	0.357
LIG_LIR_Nem_3	109	113	PF02991	0.501
LIG_LIR_Nem_3	117	122	PF02991	0.487
LIG_LIR_Nem_3	132	137	PF02991	0.481
LIG_LIR_Nem_3	165	169	PF02991	0.512
LIG_LIR_Nem_3	183	188	PF02991	0.339
LIG_LIR_Nem_3	198	203	PF02991	0.286
LIG_LIR_Nem_3	224	228	PF02991	0.300
LIG_LIR_Nem_3	241	247	PF02991	0.433
LIG_SH2_CRK	84	88	PF00017	0.378
LIG_SH2_NCK_1	84	88	PF00017	0.391
LIG_SH2_STAP1	178	182	PF00017	0.430
LIG_SH2_STAT3	191	194	PF00017	0.325
LIG_SH2_STAT5	84	87	PF00017	0.414
LIG_SH3_3	16	22	PF00018	0.710
LIG_SH3_3	233	239	PF00018	0.512
LIG_TYR_ITIM	82	87	PF00017	0.373
LIG_UBA3_1	149	154	PF00899	0.505
LIG_WRC_WIRS_1	182	187	PF05994	0.345
MOD_CDK_SPxK_1	77	83	PF00069	0.391
MOD_CK1_1	165	171	PF00069	0.531
MOD_CK1_1	36	42	PF00069	0.492
MOD_CK2_1	139	145	PF00069	0.357
MOD_CK2_1	173	179	PF00069	0.559
MOD_CK2_1	218	224	PF00069	0.390
MOD_CK2_1	36	42	PF00069	0.548
MOD_GSK3_1	123	130	PF00069	0.382
MOD_GSK3_1	42	49	PF00069	0.537
MOD_N-GLC_1	33	38	PF02516	0.493
MOD_NEK2_1	201	206	PF00069	0.320
MOD_NEK2_1	271	276	PF00069	0.425
MOD_NEK2_1	33	38	PF00069	0.600
MOD_PIKK_1	10	16	PF00454	0.667
MOD_PIKK_1	193	199	PF00454	0.450
MOD_PIKK_1	258	264	PF00454	0.441
MOD_PIKK_1	42	48	PF00454	0.596
MOD_PK_1	83	89	PF00069	0.400
MOD_PKA_2	138	144	PF00069	0.367
MOD_PKA_2	211	217	PF00069	0.586
MOD_PKA_2	82	88	PF00069	0.427
MOD_PKA_2	9	15	PF00069	0.660
MOD_Plk_1	33	39	PF00069	0.503
MOD_Plk_2-3	181	187	PF00069	0.461
MOD_Plk_2-3	218	224	PF00069	0.409
MOD_Plk_4	218	224	PF00069	0.414
MOD_ProDKin_1	127	133	PF00069	0.525
MOD_ProDKin_1	17	23	PF00069	0.554
MOD_ProDKin_1	77	83	PF00069	0.391
TRG_ENDOCYTIC_2	225	228	PF00928	0.328
TRG_ENDOCYTIC_2	84	87	PF00928	0.400
TRG_ER_diArg_1	106	108	PF00400	0.356
TRG_ER_diArg_1	209	212	PF00400	0.378
TRG_ER_diArg_1	94	96	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I365	Leptomonas seymouri	79%	100%
A0A0S4IUM2	Bodo saltans	57%	82%
A0A1X0NNS4	Trypanosomatidae	71%	100%
A0A3S5H6Q6	Leishmania donovani	100%	100%
A0A3S5IS70	Trypanosoma rangeli	67%	100%
A4H7G9	Leishmania braziliensis	90%	100%
C9ZT77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9APK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QFX7	Leishmania major	97%	100%
V5AXQ5	Trypanosoma cruzi	71%	100%