Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVU7_LEIIN

TriTrypDb:

LINF_140005400

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	710	714	PF00656	0.593
CLV_NRD_NRD_1	181	183	PF00675	0.455
CLV_NRD_NRD_1	371	373	PF00675	0.528
CLV_NRD_NRD_1	434	436	PF00675	0.687
CLV_NRD_NRD_1	532	534	PF00675	0.615
CLV_NRD_NRD_1	718	720	PF00675	0.598
CLV_NRD_NRD_1	76	78	PF00675	0.382
CLV_PCSK_KEX2_1	180	182	PF00082	0.452
CLV_PCSK_KEX2_1	2	4	PF00082	0.646
CLV_PCSK_KEX2_1	371	373	PF00082	0.567
CLV_PCSK_KEX2_1	415	417	PF00082	0.579
CLV_PCSK_KEX2_1	436	438	PF00082	0.630
CLV_PCSK_KEX2_1	530	532	PF00082	0.552
CLV_PCSK_KEX2_1	717	719	PF00082	0.602
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.646
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.579
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.630
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.531
CLV_PCSK_PC7_1	527	533	PF00082	0.504
CLV_PCSK_SKI1_1	143	147	PF00082	0.543
CLV_PCSK_SKI1_1	173	177	PF00082	0.343
CLV_PCSK_SKI1_1	225	229	PF00082	0.389
CLV_PCSK_SKI1_1	281	285	PF00082	0.284
CLV_PCSK_SKI1_1	371	375	PF00082	0.450
CLV_PCSK_SKI1_1	456	460	PF00082	0.514
CLV_PCSK_SKI1_1	494	498	PF00082	0.440
CLV_PCSK_SKI1_1	6	10	PF00082	0.519
CLV_PCSK_SKI1_1	614	618	PF00082	0.547
CLV_PCSK_SKI1_1	628	632	PF00082	0.656
CLV_PCSK_SKI1_1	723	727	PF00082	0.529
CLV_Separin_Metazoa	440	444	PF03568	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DEG_SCF_FBW7_2	147	154	PF00400	0.525
DEG_SPOP_SBC_1	542	546	PF00917	0.625
DOC_ANK_TNKS_1	708	715	PF00023	0.540
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.378
DOC_MAPK_gen_1	2	13	PF00069	0.482
DOC_MAPK_gen_1	252	261	PF00069	0.398
DOC_MAPK_gen_1	77	84	PF00069	0.434
DOC_MAPK_MEF2A_6	16	24	PF00069	0.426
DOC_MAPK_MEF2A_6	252	261	PF00069	0.398
DOC_MAPK_MEF2A_6	262	269	PF00069	0.298
DOC_PP1_RVXF_1	279	285	PF00149	0.342
DOC_PP1_RVXF_1	91	97	PF00149	0.381
DOC_PP2B_LxvP_1	119	122	PF13499	0.640
DOC_SPAK_OSR1_1	580	584	PF12202	0.489
DOC_USP7_MATH_1	106	110	PF00917	0.437
DOC_USP7_MATH_1	145	149	PF00917	0.539
DOC_USP7_MATH_1	210	214	PF00917	0.394
DOC_USP7_MATH_1	386	390	PF00917	0.476
DOC_USP7_MATH_1	510	514	PF00917	0.571
DOC_USP7_MATH_1	543	547	PF00917	0.748
DOC_USP7_MATH_1	597	601	PF00917	0.694
DOC_USP7_MATH_1	728	732	PF00917	0.583
DOC_WW_Pin1_4	147	152	PF00397	0.468
DOC_WW_Pin1_4	371	376	PF00397	0.495
DOC_WW_Pin1_4	472	477	PF00397	0.441
DOC_WW_Pin1_4	536	541	PF00397	0.724
DOC_WW_Pin1_4	635	640	PF00397	0.728
DOC_WW_Pin1_4	681	686	PF00397	0.726
DOC_WW_Pin1_4	692	697	PF00397	0.588
LIG_14-3-3_CanoR_1	180	185	PF00244	0.454
LIG_14-3-3_CanoR_1	225	234	PF00244	0.450
LIG_14-3-3_CanoR_1	6	12	PF00244	0.481
LIG_14-3-3_CanoR_1	614	623	PF00244	0.638
LIG_14-3-3_CanoR_1	628	637	PF00244	0.481
LIG_14-3-3_CanoR_1	702	708	PF00244	0.560
LIG_14-3-3_CterR_2	727	732	PF00244	0.542
LIG_Actin_WH2_2	342	359	PF00022	0.389
LIG_BRCT_BRCA1_1	193	197	PF00533	0.364
LIG_FHA_1	126	132	PF00498	0.587
LIG_FHA_1	186	192	PF00498	0.392
LIG_FHA_1	341	347	PF00498	0.468
LIG_FHA_1	361	367	PF00498	0.217
LIG_FHA_1	418	424	PF00498	0.482
LIG_FHA_1	426	432	PF00498	0.529
LIG_FHA_1	615	621	PF00498	0.622
LIG_FHA_1	644	650	PF00498	0.584
LIG_FHA_1	666	672	PF00498	0.725
LIG_FHA_2	332	338	PF00498	0.360
LIG_FHA_2	543	549	PF00498	0.758
LIG_FHA_2	552	558	PF00498	0.569
LIG_FHA_2	573	579	PF00498	0.680
LIG_FHA_2	588	594	PF00498	0.479
LIG_HP1_1	20	24	PF01393	0.510
LIG_IRF3_LxIS_1	20	27	PF10401	0.456
LIG_LIR_Apic_2	337	342	PF02991	0.409
LIG_LIR_Apic_2	40	45	PF02991	0.475
LIG_LIR_Gen_1	194	204	PF02991	0.385
LIG_LIR_Gen_1	334	342	PF02991	0.322
LIG_LIR_Gen_1	452	459	PF02991	0.385
LIG_LIR_Gen_1	578	589	PF02991	0.589
LIG_LIR_LC3C_4	420	425	PF02991	0.367
LIG_LIR_Nem_3	194	200	PF02991	0.383
LIG_LIR_Nem_3	578	584	PF02991	0.582
LIG_MYND_1	147	151	PF01753	0.543
LIG_NRBOX	13	19	PF00104	0.461
LIG_Pex14_2	450	454	PF04695	0.362
LIG_PTB_Apo_2	502	509	PF02174	0.455
LIG_PTB_Phospho_1	502	508	PF10480	0.452
LIG_SH2_CRK	42	46	PF00017	0.459
LIG_SH2_GRB2like	503	506	PF00017	0.435
LIG_SH2_SRC	503	506	PF00017	0.435
LIG_SH2_STAP1	324	328	PF00017	0.404
LIG_SH2_STAT3	323	326	PF00017	0.404
LIG_SH2_STAT3	721	724	PF00017	0.532
LIG_SH2_STAT5	25	28	PF00017	0.462
LIG_SH2_STAT5	335	338	PF00017	0.468
LIG_SH2_STAT5	405	408	PF00017	0.358
LIG_SH2_STAT5	449	452	PF00017	0.424
LIG_SH2_STAT5	503	506	PF00017	0.489
LIG_SH3_3	120	126	PF00018	0.599
LIG_SH3_3	128	134	PF00018	0.596
LIG_SH3_3	537	543	PF00018	0.521
LIG_SH3_3	631	637	PF00018	0.746
LIG_SH3_3	690	696	PF00018	0.558
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.349
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.531
LIG_SUMO_SIM_par_1	188	194	PF11976	0.284
LIG_SUMO_SIM_par_1	345	351	PF11976	0.390
LIG_SUMO_SIM_par_1	427	433	PF11976	0.432
LIG_TRAF2_1	151	154	PF00917	0.523
LIG_TRAF2_1	458	461	PF00917	0.409
LIG_TRAF2_1	499	502	PF00917	0.393
LIG_TRAF2_1	664	667	PF00917	0.651
LIG_WRC_WIRS_1	312	317	PF05994	0.326
MOD_CDK_SPK_2	692	697	PF00069	0.568
MOD_CK1_1	159	165	PF00069	0.520
MOD_CK1_1	235	241	PF00069	0.424
MOD_CK1_1	304	310	PF00069	0.361
MOD_CK1_1	351	357	PF00069	0.552
MOD_CK1_1	462	468	PF00069	0.462
MOD_CK1_1	513	519	PF00069	0.536
MOD_CK1_1	541	547	PF00069	0.685
MOD_CK1_1	675	681	PF00069	0.605
MOD_CK1_1	692	698	PF00069	0.607
MOD_CK2_1	331	337	PF00069	0.469
MOD_CK2_1	496	502	PF00069	0.518
MOD_CK2_1	551	557	PF00069	0.621
MOD_CK2_1	572	578	PF00069	0.673
MOD_CK2_1	599	605	PF00069	0.605
MOD_CK2_1	661	667	PF00069	0.738
MOD_Cter_Amidation	178	181	PF01082	0.390
MOD_GlcNHglycan	139	143	PF01048	0.479
MOD_GlcNHglycan	240	243	PF01048	0.435
MOD_GlcNHglycan	350	353	PF01048	0.444
MOD_GlcNHglycan	376	379	PF01048	0.425
MOD_GlcNHglycan	498	501	PF01048	0.483
MOD_GlcNHglycan	601	604	PF01048	0.734
MOD_GlcNHglycan	61	64	PF01048	0.413
MOD_GlcNHglycan	625	628	PF01048	0.691
MOD_GlcNHglycan	663	666	PF01048	0.706
MOD_GSK3_1	145	152	PF00069	0.541
MOD_GSK3_1	187	194	PF00069	0.479
MOD_GSK3_1	297	304	PF00069	0.414
MOD_GSK3_1	367	374	PF00069	0.550
MOD_GSK3_1	407	414	PF00069	0.473
MOD_GSK3_1	462	469	PF00069	0.448
MOD_GSK3_1	538	545	PF00069	0.682
MOD_GSK3_1	59	66	PF00069	0.355
MOD_GSK3_1	595	602	PF00069	0.716
MOD_GSK3_1	656	663	PF00069	0.741
MOD_GSK3_1	692	699	PF00069	0.580
MOD_N-GLC_1	296	301	PF02516	0.546
MOD_N-GLC_1	513	518	PF02516	0.536
MOD_N-GLC_1	551	556	PF02516	0.645
MOD_NEK2_1	138	143	PF00069	0.467
MOD_NEK2_1	24	29	PF00069	0.570
MOD_NEK2_1	283	288	PF00069	0.369
MOD_NEK2_1	459	464	PF00069	0.357
MOD_NEK2_1	496	501	PF00069	0.501
MOD_NEK2_1	560	565	PF00069	0.530
MOD_NEK2_1	623	628	PF00069	0.696
MOD_NEK2_1	701	706	PF00069	0.585
MOD_PIKK_1	149	155	PF00454	0.468
MOD_PIKK_1	225	231	PF00454	0.364
MOD_PIKK_1	351	357	PF00454	0.524
MOD_PIKK_1	360	366	PF00454	0.314
MOD_PIKK_1	462	468	PF00454	0.396
MOD_PKA_1	180	186	PF00069	0.375
MOD_PKA_1	660	666	PF00069	0.493
MOD_PKA_1	77	83	PF00069	0.531
MOD_PKA_2	180	186	PF00069	0.506
MOD_PKA_2	696	702	PF00069	0.556
MOD_Plk_1	37	43	PF00069	0.414
MOD_Plk_1	407	413	PF00069	0.311
MOD_Plk_1	459	465	PF00069	0.443
MOD_Plk_1	551	557	PF00069	0.531
MOD_Plk_1	587	593	PF00069	0.609
MOD_Plk_2-3	331	337	PF00069	0.419
MOD_Plk_2-3	551	557	PF00069	0.531
MOD_Plk_2-3	605	611	PF00069	0.596
MOD_Plk_4	187	193	PF00069	0.292
MOD_Plk_4	298	304	PF00069	0.517
MOD_Plk_4	311	317	PF00069	0.388
MOD_Plk_4	37	43	PF00069	0.608
MOD_Plk_4	407	413	PF00069	0.539
MOD_Plk_4	425	431	PF00069	0.238
MOD_Plk_4	459	465	PF00069	0.443
MOD_Plk_4	466	472	PF00069	0.445
MOD_Plk_4	587	593	PF00069	0.747
MOD_Plk_4	63	69	PF00069	0.372
MOD_ProDKin_1	147	153	PF00069	0.459
MOD_ProDKin_1	371	377	PF00069	0.495
MOD_ProDKin_1	472	478	PF00069	0.443
MOD_ProDKin_1	536	542	PF00069	0.726
MOD_ProDKin_1	635	641	PF00069	0.729
MOD_ProDKin_1	681	687	PF00069	0.727
MOD_ProDKin_1	692	698	PF00069	0.583
MOD_SUMO_for_1	107	110	PF00179	0.378
MOD_SUMO_rev_2	322	328	PF00179	0.413
MOD_SUMO_rev_2	487	496	PF00179	0.533
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.519
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.449
TRG_ENDOCYTIC_2	335	338	PF00928	0.405
TRG_ER_diArg_1	180	182	PF00400	0.447
TRG_ER_diArg_1	371	373	PF00400	0.533
TRG_ER_diArg_1	531	533	PF00400	0.638
TRG_ER_diArg_1	717	719	PF00400	0.478
TRG_NLS_MonoCore_2	529	534	PF00514	0.462
TRG_NLS_MonoExtC_3	434	439	PF00514	0.521
TRG_NLS_MonoExtN_4	527	534	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q1	Leptomonas seymouri	48%	96%
A0A1X0NNU6	Trypanosomatidae	26%	98%
A0A3Q8II63	Leishmania donovani	99%	100%
A0A422NXG9	Trypanosoma rangeli	27%	100%
E9APJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFY0	Leishmania major	91%	100%
V5BM90	Trypanosoma cruzi	26%	100%