LeishMANIAdb
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Mitogen-activated protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen-activated protein kinase
Gene product:
mitogen-activated protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HVU2_LEIIN
TriTrypDb:
LINF_130021900 *
Length:
574

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Annotations by Jardim et al.

Protein kinase, mitogen-activated kinase 7

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HVU2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVU2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 17
GO:0006793 phosphorus metabolic process 3 17
GO:0006796 phosphate-containing compound metabolic process 4 17
GO:0006807 nitrogen compound metabolic process 2 17
GO:0008152 metabolic process 1 17
GO:0009987 cellular process 1 17
GO:0016310 phosphorylation 5 17
GO:0019538 protein metabolic process 3 17
GO:0036211 protein modification process 4 17
GO:0043170 macromolecule metabolic process 3 17
GO:0043412 macromolecule modification 4 17
GO:0044237 cellular metabolic process 2 17
GO:0044238 primary metabolic process 2 17
GO:0071704 organic substance metabolic process 2 17
GO:1901564 organonitrogen compound metabolic process 3 17
GO:0007165 signal transduction 2 2
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0004672 protein kinase activity 3 17
GO:0004674 protein serine/threonine kinase activity 4 15
GO:0004707 MAP kinase activity 5 10
GO:0005488 binding 1 17
GO:0005524 ATP binding 5 17
GO:0016301 kinase activity 4 17
GO:0016740 transferase activity 2 17
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 17
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 17
GO:0017076 purine nucleotide binding 4 17
GO:0030554 adenyl nucleotide binding 5 17
GO:0032553 ribonucleotide binding 3 17
GO:0032555 purine ribonucleotide binding 4 17
GO:0032559 adenyl ribonucleotide binding 5 17
GO:0035639 purine ribonucleoside triphosphate binding 4 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:0140096 catalytic activity, acting on a protein 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 13 17 PF00656 0.483
CLV_C14_Caspase3-7 159 163 PF00656 0.321
CLV_NRD_NRD_1 100 102 PF00675 0.510
CLV_NRD_NRD_1 136 138 PF00675 0.431
CLV_NRD_NRD_1 164 166 PF00675 0.379
CLV_NRD_NRD_1 36 38 PF00675 0.399
CLV_NRD_NRD_1 374 376 PF00675 0.329
CLV_NRD_NRD_1 425 427 PF00675 0.205
CLV_NRD_NRD_1 474 476 PF00675 0.418
CLV_PCSK_FUR_1 98 102 PF00082 0.490
CLV_PCSK_KEX2_1 100 102 PF00082 0.677
CLV_PCSK_KEX2_1 135 137 PF00082 0.500
CLV_PCSK_KEX2_1 164 166 PF00082 0.327
CLV_PCSK_KEX2_1 374 376 PF00082 0.383
CLV_PCSK_KEX2_1 476 478 PF00082 0.342
CLV_PCSK_PC1ET2_1 135 137 PF00082 0.500
CLV_PCSK_PC1ET2_1 476 478 PF00082 0.364
CLV_PCSK_SKI1_1 112 116 PF00082 0.623
CLV_PCSK_SKI1_1 136 140 PF00082 0.459
CLV_PCSK_SKI1_1 151 155 PF00082 0.484
CLV_PCSK_SKI1_1 164 168 PF00082 0.313
CLV_PCSK_SKI1_1 254 258 PF00082 0.342
CLV_PCSK_SKI1_1 375 379 PF00082 0.346
CLV_PCSK_SKI1_1 550 554 PF00082 0.374
CLV_PCSK_SKI1_1 94 98 PF00082 0.463
CLV_Separin_Metazoa 498 502 PF03568 0.495
DEG_APCC_DBOX_1 163 171 PF00400 0.326
DOC_CDC14_PxL_1 343 351 PF14671 0.271
DOC_CKS1_1 391 396 PF01111 0.383
DOC_CKS1_1 400 405 PF01111 0.348
DOC_CYCLIN_RxL_1 372 379 PF00134 0.362
DOC_CYCLIN_RxL_1 465 473 PF00134 0.331
DOC_CYCLIN_RxL_1 547 556 PF00134 0.316
DOC_MAPK_gen_1 164 172 PF00069 0.327
DOC_MAPK_gen_1 254 263 PF00069 0.321
DOC_MAPK_gen_1 342 351 PF00069 0.321
DOC_MAPK_gen_1 426 437 PF00069 0.236
DOC_MAPK_HePTP_8 339 351 PF00069 0.327
DOC_MAPK_MEF2A_6 342 351 PF00069 0.327
DOC_MAPK_MEF2A_6 522 529 PF00069 0.440
DOC_PP1_RVXF_1 466 473 PF00149 0.313
DOC_PP4_FxxP_1 488 491 PF00568 0.467
DOC_USP7_MATH_1 197 201 PF00917 0.419
DOC_USP7_MATH_1 285 289 PF00917 0.573
DOC_USP7_MATH_1 296 300 PF00917 0.688
DOC_USP7_MATH_1 548 552 PF00917 0.358
DOC_USP7_UBL2_3 151 155 PF12436 0.300
DOC_WW_Pin1_4 142 147 PF00397 0.382
DOC_WW_Pin1_4 390 395 PF00397 0.364
DOC_WW_Pin1_4 399 404 PF00397 0.348
DOC_WW_Pin1_4 529 534 PF00397 0.383
LIG_14-3-3_CanoR_1 318 324 PF00244 0.705
LIG_14-3-3_CanoR_1 37 41 PF00244 0.360
LIG_14-3-3_CanoR_1 501 507 PF00244 0.480
LIG_14-3-3_CanoR_1 542 549 PF00244 0.410
LIG_14-3-3_CanoR_1 74 82 PF00244 0.420
LIG_Actin_WH2_2 153 170 PF00022 0.301
LIG_Actin_WH2_2 206 224 PF00022 0.412
LIG_Actin_WH2_2 383 399 PF00022 0.333
LIG_AP2alpha_2 486 488 PF02296 0.383
LIG_APCC_ABBA_1 49 54 PF00400 0.310
LIG_BRCT_BRCA1_1 130 134 PF00533 0.637
LIG_BRCT_BRCA1_1 199 203 PF00533 0.383
LIG_BRCT_BRCA1_1 448 452 PF00533 0.362
LIG_BRCT_BRCA1_1 531 535 PF00533 0.377
LIG_Clathr_ClatBox_1 469 473 PF01394 0.383
LIG_CtBP_PxDLS_1 459 463 PF00389 0.393
LIG_deltaCOP1_diTrp_1 305 312 PF00928 0.482
LIG_EH1_1 206 214 PF00400 0.309
LIG_EH1_1 417 425 PF00400 0.383
LIG_eIF4E_1 207 213 PF01652 0.250
LIG_eIF4E_1 344 350 PF01652 0.346
LIG_FHA_1 109 115 PF00498 0.574
LIG_FHA_1 334 340 PF00498 0.344
LIG_FHA_1 391 397 PF00498 0.296
LIG_FHA_2 11 17 PF00498 0.473
LIG_FHA_2 293 299 PF00498 0.679
LIG_FHA_2 477 483 PF00498 0.329
LIG_GBD_Chelix_1 235 243 PF00786 0.383
LIG_LIR_Apic_2 341 347 PF02991 0.298
LIG_LIR_Apic_2 486 491 PF02991 0.402
LIG_LIR_Gen_1 145 153 PF02991 0.329
LIG_LIR_Gen_1 154 161 PF02991 0.434
LIG_LIR_Gen_1 200 209 PF02991 0.396
LIG_LIR_Nem_3 145 150 PF02991 0.329
LIG_LIR_Nem_3 154 160 PF02991 0.392
LIG_LIR_Nem_3 200 206 PF02991 0.332
LIG_LIR_Nem_3 230 235 PF02991 0.317
LIG_LIR_Nem_3 305 310 PF02991 0.597
LIG_LIR_Nem_3 486 492 PF02991 0.376
LIG_NRBOX 216 222 PF00104 0.383
LIG_NRP_CendR_1 572 574 PF00754 0.499
LIG_Pex14_2 535 539 PF04695 0.433
LIG_REV1ctd_RIR_1 486 490 PF16727 0.331
LIG_SH2_CRK 64 68 PF00017 0.371
LIG_SH2_GRB2like 81 84 PF00017 0.341
LIG_SH2_NCK_1 130 134 PF00017 0.587
LIG_SH2_SRC 245 248 PF00017 0.291
LIG_SH2_STAT3 383 386 PF00017 0.273
LIG_SH2_STAT5 108 111 PF00017 0.553
LIG_SH2_STAT5 175 178 PF00017 0.335
LIG_SH2_STAT5 207 210 PF00017 0.336
LIG_SH2_STAT5 245 248 PF00017 0.307
LIG_SH2_STAT5 32 35 PF00017 0.442
LIG_SH2_STAT5 338 341 PF00017 0.315
LIG_SH2_STAT5 383 386 PF00017 0.281
LIG_SH3_1 397 403 PF00018 0.383
LIG_SH3_3 121 127 PF00018 0.590
LIG_SH3_3 185 191 PF00018 0.343
LIG_SH3_3 279 285 PF00018 0.411
LIG_SH3_3 397 403 PF00018 0.287
LIG_SH3_3 453 459 PF00018 0.467
LIG_SUMO_SIM_anti_2 348 353 PF11976 0.346
LIG_SUMO_SIM_anti_2 385 393 PF11976 0.383
LIG_TRAF2_1 223 226 PF00917 0.355
LIG_UBA3_1 166 171 PF00899 0.438
LIG_WRC_WIRS_1 469 474 PF05994 0.395
LIG_WW_1 330 333 PF00397 0.463
MOD_CDK_SPxxK_3 390 397 PF00069 0.383
MOD_CK1_1 288 294 PF00069 0.541
MOD_CK1_1 505 511 PF00069 0.637
MOD_CK2_1 220 226 PF00069 0.355
MOD_CK2_1 292 298 PF00069 0.693
MOD_CK2_1 42 48 PF00069 0.467
MOD_CK2_1 476 482 PF00069 0.308
MOD_CK2_1 492 498 PF00069 0.336
MOD_CK2_1 548 554 PF00069 0.420
MOD_Cter_Amidation 162 165 PF01082 0.321
MOD_GlcNHglycan 199 202 PF01048 0.314
MOD_GlcNHglycan 248 251 PF01048 0.334
MOD_GlcNHglycan 298 302 PF01048 0.462
MOD_GlcNHglycan 314 317 PF01048 0.633
MOD_GlcNHglycan 321 324 PF01048 0.578
MOD_GlcNHglycan 362 365 PF01048 0.466
MOD_GlcNHglycan 544 547 PF01048 0.338
MOD_GSK3_1 192 199 PF00069 0.428
MOD_GSK3_1 288 295 PF00069 0.563
MOD_GSK3_1 431 438 PF00069 0.273
MOD_GSK3_1 529 536 PF00069 0.566
MOD_NEK2_1 10 15 PF00069 0.570
MOD_NEK2_1 21 26 PF00069 0.630
MOD_NEK2_1 220 225 PF00069 0.316
MOD_NEK2_1 274 279 PF00069 0.383
MOD_NEK2_1 310 315 PF00069 0.542
MOD_NEK2_1 425 430 PF00069 0.404
MOD_NEK2_1 435 440 PF00069 0.175
MOD_NEK2_1 446 451 PF00069 0.383
MOD_NEK2_1 75 80 PF00069 0.372
MOD_NEK2_2 548 553 PF00069 0.327
MOD_PIKK_1 221 227 PF00454 0.383
MOD_PIKK_1 382 388 PF00454 0.268
MOD_PIKK_1 440 446 PF00454 0.383
MOD_PKA_1 151 157 PF00069 0.368
MOD_PKA_1 476 482 PF00069 0.340
MOD_PKA_2 36 42 PF00069 0.367
MOD_PKA_2 425 431 PF00069 0.195
MOD_PKA_2 476 482 PF00069 0.327
MOD_PKA_2 541 547 PF00069 0.481
MOD_Plk_1 286 292 PF00069 0.506
MOD_Plk_4 42 48 PF00069 0.382
MOD_Plk_4 447 453 PF00069 0.369
MOD_Plk_4 76 82 PF00069 0.523
MOD_ProDKin_1 142 148 PF00069 0.375
MOD_ProDKin_1 390 396 PF00069 0.364
MOD_ProDKin_1 399 405 PF00069 0.348
MOD_ProDKin_1 529 535 PF00069 0.375
MOD_SUMO_rev_2 249 258 PF00179 0.323
MOD_SUMO_rev_2 411 419 PF00179 0.383
TRG_DiLeu_BaEn_3 414 420 PF01217 0.383
TRG_DiLeu_BaEn_3 90 96 PF01217 0.428
TRG_ENDOCYTIC_2 237 240 PF00928 0.302
TRG_ENDOCYTIC_2 64 67 PF00928 0.388
TRG_ER_diArg_1 109 112 PF00400 0.531
TRG_ER_diArg_1 136 138 PF00400 0.445
TRG_ER_diArg_1 164 166 PF00400 0.379
TRG_ER_diArg_1 373 375 PF00400 0.333
TRG_ER_diArg_1 474 477 PF00400 0.338
TRG_ER_diArg_1 98 101 PF00400 0.667
TRG_NLS_MonoExtN_4 133 139 PF00514 0.522
TRG_NLS_MonoExtN_4 474 479 PF00514 0.410
TRG_Pf-PMV_PEXEL_1 165 169 PF00026 0.325
TRG_Pf-PMV_PEXEL_1 490 494 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 550 554 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 87 91 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E2 Leptomonas seymouri 30% 100%
A0A0N1I304 Leptomonas seymouri 68% 99%
A0A0N1II59 Leptomonas seymouri 28% 100%
A0A0S4ILC2 Bodo saltans 33% 100%
A0A0S4IUF2 Bodo saltans 25% 100%
A0A0S4IXW3 Bodo saltans 30% 100%
A0A0S4J343 Bodo saltans 24% 100%
A0A0S4J8M8 Bodo saltans 23% 71%
A0A0S4JCX8 Bodo saltans 26% 100%
A0A0S4JXW9 Bodo saltans 35% 100%
A0A0S4KIN4 Bodo saltans 37% 84%
A0A1X0NQM7 Trypanosomatidae 29% 100%
A0A1X0P018 Trypanosomatidae 28% 100%
A0A1X0P3B9 Trypanosomatidae 32% 100%
A0A3Q8IH39 Leishmania donovani 29% 100%
A0A3Q8ITZ9 Leishmania donovani 33% 100%
A0A3Q8IVR8 Leishmania donovani 31% 100%
A0A3R7K7W6 Trypanosoma rangeli 32% 100%
A0A3R7KBU3 Trypanosoma rangeli 26% 100%
A0A3R7M0A0 Trypanosoma rangeli 31% 100%
A0A3R7NAU1 Trypanosoma rangeli 25% 100%
A0A3S5H528 Leishmania donovani 30% 100%
A0A3S5H7N7 Leishmania donovani 34% 100%
A0A3S7WR45 Leishmania donovani 32% 100%
A0A3S7WSP5 Leishmania donovani 100% 100%
A0A3S7XA45 Leishmania donovani 30% 100%
A0A422N878 Trypanosoma rangeli 26% 100%
A0A451EJH2 Leishmania donovani 27% 99%
A4H601 Leishmania braziliensis 30% 100%
A4H641 Leishmania braziliensis 31% 96%
A4H7F4 Leishmania braziliensis 82% 100%
A4HFF3 Leishmania braziliensis 25% 100%
A4HIM5 Leishmania braziliensis 36% 100%
A4HLJ9 Leishmania braziliensis 33% 100%
A4HNG3 Leishmania braziliensis 32% 100%
A4HNT2 Leishmania braziliensis 31% 100%
A4HRN3 Leishmania infantum 27% 99%
A4HRT2 Leishmania infantum 30% 100%
A4HUC8 Leishmania infantum 29% 100%
A4HUG1 Leishmania infantum 32% 100%
A4I5X0 Leishmania infantum 34% 100%
A4I910 Leishmania infantum 33% 100%
A4IC54 Leishmania infantum 30% 100%
A4ICR2 Leishmania infantum 31% 100%
B5X564 Arabidopsis thaliana 31% 89%
B6DTC0 Bodo saltans 33% 100%
D0A105 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9ACB1 Leishmania major 27% 99%
E9ACG8 Leishmania major 29% 100%
E9AFX4 Leishmania major 31% 100%
E9AJJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 99%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AN59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9API8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B164 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B727 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
F4ICB6 Arabidopsis thaliana 30% 81%
G4N374 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 33% 100%
O13352 Magnaporthe oryzae 33% 100%
O23145 Arabidopsis thaliana 27% 100%
P27704 Rattus norvegicus 29% 80%
P43068 Candida albicans 28% 100%
P46551 Caenorhabditis elegans 29% 79%
P49185 Rattus norvegicus 27% 100%
Q00536 Homo sapiens 26% 100%
Q04735 Mus musculus 26% 100%
Q16659 Homo sapiens 29% 80%
Q336M2 Oryza sativa subsp. japonica 29% 100%
Q4Q204 Leishmania major 31% 100%
Q4Q449 Leishmania major 33% 100%
Q4Q701 Leishmania major 34% 100%
Q4Q7S2 Leishmania major 31% 100%
Q4QFZ0 Leishmania major 94% 100%
Q4QHG6 Leishmania major 32% 100%
Q4QHJ8 Leishmania major 31% 100%
Q4WTN5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 99%
Q5AAG6 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 100%
Q5F3W3 Gallus gallus 30% 80%
Q5R7U1 Pongo abelii 29% 80%
Q60EZ2 Oryza sativa subsp. japonica 28% 100%
Q61532 Mus musculus 29% 80%
Q80Y86 Mus musculus 33% 100%
Q8I7M8 Caenorhabditis elegans 27% 86%
Q8QHK8 Xenopus laevis 27% 100%
Q9DGD9 Danio rerio 27% 100%
Q9LWN0 Oryza sativa subsp. japonica 28% 100%
Q9TVL3 Caenorhabditis elegans 31% 100%
V5BCX5 Trypanosoma cruzi 26% 100%
V5BI43 Trypanosoma cruzi 25% 100%
V5BSG8 Trypanosoma cruzi 32% 100%
V5DA09 Trypanosoma cruzi 29% 100%
V5DCN7 Trypanosoma cruzi 27% 96%
V5DIC3 Trypanosoma cruzi 24% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS