Mitogen-activated protein kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HVU2_LEIIN

TriTrypDb:

LINF_130021900

Length:

574

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Annotations by Jardim et al.

Protein kinase, mitogen-activated kinase 7

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HVU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVU2

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0035556	intracellular signal transduction	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	15
GO:0004707	MAP kinase activity	5	10
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.483
CLV_C14_Caspase3-7	159	163	PF00656	0.321
CLV_NRD_NRD_1	100	102	PF00675	0.510
CLV_NRD_NRD_1	136	138	PF00675	0.431
CLV_NRD_NRD_1	164	166	PF00675	0.379
CLV_NRD_NRD_1	36	38	PF00675	0.399
CLV_NRD_NRD_1	374	376	PF00675	0.329
CLV_NRD_NRD_1	425	427	PF00675	0.205
CLV_NRD_NRD_1	474	476	PF00675	0.418
CLV_PCSK_FUR_1	98	102	PF00082	0.490

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E2	Leptomonas seymouri	30%	100%
A0A0N1I304	Leptomonas seymouri	68%	99%
A0A0N1II59	Leptomonas seymouri	28%	100%
A0A0S4ILC2	Bodo saltans	33%	100%
A0A0S4IUF2	Bodo saltans	25%	100%
A0A0S4IXW3	Bodo saltans	30%	100%
A0A0S4J343	Bodo saltans	24%	100%
A0A0S4J8M8	Bodo saltans	23%	71%
A0A0S4JCX8	Bodo saltans	26%	100%
A0A0S4JXW9	Bodo saltans	35%	100%

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