LeishMANIAdb
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Squalene monooxygenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Squalene monooxygenase
Gene product:
squalene monooxygenase-like protein
Species:
Leishmania infantum
UniProt:
A4HVU0_LEIIN
TriTrypDb:
LINF_130021700
Length:
569

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, Squalene monooxygenase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVU0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVU0

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0006694 steroid biosynthetic process 5 12
GO:0008152 metabolic process 1 12
GO:0008202 steroid metabolic process 4 12
GO:0008610 lipid biosynthetic process 4 12
GO:0009058 biosynthetic process 2 12
GO:0016125 sterol metabolic process 4 12
GO:0016126 sterol biosynthetic process 5 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
GO:1901615 organic hydroxy compound metabolic process 3 12
GO:1901617 organic hydroxy compound biosynthetic process 4 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004497 monooxygenase activity 3 12
GO:0004506 squalene monooxygenase activity 5 12
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 12
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0050660 flavin adenine dinucleotide binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0071949 FAD binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 121 123 PF00675 0.473
CLV_NRD_NRD_1 204 206 PF00675 0.446
CLV_NRD_NRD_1 563 565 PF00675 0.491
CLV_NRD_NRD_1 58 60 PF00675 0.275
CLV_PCSK_SKI1_1 206 210 PF00082 0.281
CLV_PCSK_SKI1_1 284 288 PF00082 0.275
CLV_PCSK_SKI1_1 520 524 PF00082 0.402
CLV_PCSK_SKI1_1 548 552 PF00082 0.337
CLV_PCSK_SKI1_1 59 63 PF00082 0.245
CLV_PCSK_SKI1_1 66 70 PF00082 0.273
DEG_MDM2_SWIB_1 501 508 PF02201 0.221
DEG_MDM2_SWIB_1 530 537 PF02201 0.342
DEG_Nend_Nbox_1 1 3 PF02207 0.421
DOC_CYCLIN_RxL_1 60 73 PF00134 0.302
DOC_MAPK_gen_1 122 130 PF00069 0.427
DOC_MAPK_gen_1 252 260 PF00069 0.356
DOC_MAPK_gen_1 517 525 PF00069 0.441
DOC_MAPK_gen_1 562 569 PF00069 0.497
DOC_MAPK_MEF2A_6 206 215 PF00069 0.226
DOC_MAPK_MEF2A_6 517 525 PF00069 0.325
DOC_PP1_RVXF_1 22 28 PF00149 0.295
DOC_PP4_FxxP_1 536 539 PF00568 0.360
DOC_PP4_FxxP_1 69 72 PF00568 0.281
DOC_USP7_MATH_1 30 34 PF00917 0.329
DOC_USP7_MATH_1 334 338 PF00917 0.365
DOC_WW_Pin1_4 228 233 PF00397 0.309
DOC_WW_Pin1_4 25 30 PF00397 0.435
DOC_WW_Pin1_4 422 427 PF00397 0.294
DOC_WW_Pin1_4 538 543 PF00397 0.394
LIG_14-3-3_CanoR_1 205 211 PF00244 0.365
LIG_14-3-3_CanoR_1 31 35 PF00244 0.442
LIG_14-3-3_CanoR_1 368 374 PF00244 0.313
LIG_14-3-3_CanoR_1 403 412 PF00244 0.279
LIG_Actin_WH2_2 11 28 PF00022 0.400
LIG_Actin_WH2_2 366 382 PF00022 0.309
LIG_Actin_WH2_2 415 431 PF00022 0.226
LIG_Actin_WH2_2 73 91 PF00022 0.364
LIG_BRCT_BRCA1_1 128 132 PF00533 0.245
LIG_BRCT_BRCA1_1 140 144 PF00533 0.248
LIG_BRCT_BRCA1_2 140 146 PF00533 0.403
LIG_CtBP_PxDLS_1 306 310 PF00389 0.325
LIG_EH_1 187 191 PF12763 0.323
LIG_FHA_1 161 167 PF00498 0.296
LIG_FHA_1 207 213 PF00498 0.239
LIG_FHA_1 245 251 PF00498 0.325
LIG_FHA_1 261 267 PF00498 0.168
LIG_FHA_1 318 324 PF00498 0.245
LIG_FHA_1 44 50 PF00498 0.129
LIG_FHA_1 538 544 PF00498 0.274
LIG_FHA_2 150 156 PF00498 0.273
LIG_FHA_2 176 182 PF00498 0.386
LIG_FHA_2 30 36 PF00498 0.318
LIG_FHA_2 68 74 PF00498 0.351
LIG_G3BP_FGDF_1 130 135 PF02136 0.285
LIG_HP1_1 211 215 PF01393 0.304
LIG_LIR_Apic_2 181 186 PF02991 0.364
LIG_LIR_Apic_2 281 285 PF02991 0.226
LIG_LIR_Apic_2 67 72 PF02991 0.281
LIG_LIR_Gen_1 311 319 PF02991 0.356
LIG_LIR_Gen_1 33 41 PF02991 0.251
LIG_LIR_Gen_1 504 513 PF02991 0.358
LIG_LIR_LC3C_4 209 214 PF02991 0.356
LIG_LIR_Nem_3 129 135 PF02991 0.254
LIG_LIR_Nem_3 225 230 PF02991 0.304
LIG_LIR_Nem_3 238 243 PF02991 0.090
LIG_LIR_Nem_3 311 316 PF02991 0.356
LIG_LIR_Nem_3 33 39 PF02991 0.255
LIG_LIR_Nem_3 416 420 PF02991 0.223
LIG_LIR_Nem_3 504 508 PF02991 0.251
LIG_LIR_Nem_3 532 537 PF02991 0.316
LIG_LYPXL_SIV_4 481 489 PF13949 0.245
LIG_MAD2 74 82 PF02301 0.272
LIG_MYND_3 287 291 PF01753 0.270
LIG_NBox_RRM_1 363 373 PF00076 0.356
LIG_PDZ_Class_2 564 569 PF00595 0.422
LIG_Pex14_1 223 227 PF04695 0.356
LIG_Pex14_2 501 505 PF04695 0.351
LIG_Pex14_2 530 534 PF04695 0.298
LIG_PTB_Apo_2 456 463 PF02174 0.155
LIG_SH2_CRK 282 286 PF00017 0.226
LIG_SH2_CRK 36 40 PF00017 0.228
LIG_SH2_CRK 420 424 PF00017 0.155
LIG_SH2_CRK 464 468 PF00017 0.355
LIG_SH2_NCK_1 177 181 PF00017 0.369
LIG_SH2_NCK_1 183 187 PF00017 0.425
LIG_SH2_NCK_1 230 234 PF00017 0.245
LIG_SH2_NCK_1 482 486 PF00017 0.256
LIG_SH2_PTP2 107 110 PF00017 0.288
LIG_SH2_PTP2 341 344 PF00017 0.226
LIG_SH2_SRC 234 237 PF00017 0.353
LIG_SH2_STAP1 34 38 PF00017 0.240
LIG_SH2_STAP1 555 559 PF00017 0.426
LIG_SH2_STAT3 555 558 PF00017 0.424
LIG_SH2_STAT5 107 110 PF00017 0.267
LIG_SH2_STAT5 177 180 PF00017 0.323
LIG_SH2_STAT5 230 233 PF00017 0.270
LIG_SH2_STAT5 3 6 PF00017 0.424
LIG_SH2_STAT5 341 344 PF00017 0.226
LIG_SH2_STAT5 406 409 PF00017 0.255
LIG_SH2_STAT5 435 438 PF00017 0.211
LIG_SH2_STAT5 464 467 PF00017 0.231
LIG_SH2_STAT5 513 516 PF00017 0.329
LIG_SH2_STAT5 555 558 PF00017 0.486
LIG_SH3_1 183 189 PF00018 0.342
LIG_SH3_1 282 288 PF00018 0.226
LIG_SH3_1 330 336 PF00018 0.282
LIG_SH3_2 186 191 PF14604 0.424
LIG_SH3_3 114 120 PF00018 0.373
LIG_SH3_3 183 189 PF00018 0.377
LIG_SH3_3 245 251 PF00018 0.296
LIG_SH3_3 282 288 PF00018 0.224
LIG_SH3_3 300 306 PF00018 0.151
LIG_SH3_3 330 336 PF00018 0.335
LIG_SH3_3 440 446 PF00018 0.211
LIG_SH3_3 536 542 PF00018 0.385
LIG_SH3_5 232 236 PF00018 0.239
LIG_Sin3_3 14 21 PF02671 0.236
LIG_SUMO_SIM_anti_2 13 19 PF11976 0.392
LIG_SUMO_SIM_anti_2 37 42 PF11976 0.284
LIG_SUMO_SIM_par_1 60 65 PF11976 0.249
LIG_UBA3_1 286 292 PF00899 0.155
LIG_WRC_WIRS_1 498 503 PF05994 0.367
MOD_CDC14_SPxK_1 28 31 PF00782 0.425
MOD_CDK_SPxK_1 25 31 PF00069 0.435
MOD_CDK_SPxxK_3 422 429 PF00069 0.294
MOD_CK1_1 126 132 PF00069 0.417
MOD_CK1_1 138 144 PF00069 0.398
MOD_CK1_1 317 323 PF00069 0.287
MOD_CK1_1 378 384 PF00069 0.311
MOD_CK1_1 421 427 PF00069 0.356
MOD_CK1_1 549 555 PF00069 0.353
MOD_CK2_1 149 155 PF00069 0.272
MOD_CK2_1 164 170 PF00069 0.406
MOD_CK2_1 175 181 PF00069 0.282
MOD_CK2_1 487 493 PF00069 0.510
MOD_Cter_Amidation 57 60 PF01082 0.363
MOD_GlcNHglycan 12 15 PF01048 0.408
MOD_GlcNHglycan 125 128 PF01048 0.401
MOD_GSK3_1 160 167 PF00069 0.399
MOD_GSK3_1 218 225 PF00069 0.304
MOD_GSK3_1 25 32 PF00069 0.451
MOD_GSK3_1 418 425 PF00069 0.356
MOD_GSK3_1 476 483 PF00069 0.207
MOD_GSK3_1 489 496 PF00069 0.293
MOD_GSK3_1 549 556 PF00069 0.477
MOD_N-GLC_1 149 154 PF02516 0.313
MOD_N-GLC_1 544 549 PF02516 0.350
MOD_NEK2_1 135 140 PF00069 0.338
MOD_NEK2_1 260 265 PF00069 0.253
MOD_NEK2_1 369 374 PF00069 0.282
MOD_NEK2_1 476 481 PF00069 0.226
MOD_NEK2_1 515 520 PF00069 0.333
MOD_NEK2_1 553 558 PF00069 0.484
MOD_NEK2_2 375 380 PF00069 0.210
MOD_PKA_2 30 36 PF00069 0.328
MOD_PKA_2 314 320 PF00069 0.365
MOD_PKA_2 404 410 PF00069 0.275
MOD_Plk_1 149 155 PF00069 0.322
MOD_Plk_1 175 181 PF00069 0.328
MOD_Plk_1 429 435 PF00069 0.111
MOD_Plk_1 64 70 PF00069 0.282
MOD_Plk_2-3 164 170 PF00069 0.402
MOD_Plk_4 149 155 PF00069 0.302
MOD_Plk_4 418 424 PF00069 0.356
MOD_Plk_4 497 503 PF00069 0.331
MOD_Plk_4 529 535 PF00069 0.300
MOD_Plk_4 549 555 PF00069 0.200
MOD_ProDKin_1 228 234 PF00069 0.309
MOD_ProDKin_1 25 31 PF00069 0.435
MOD_ProDKin_1 422 428 PF00069 0.294
MOD_ProDKin_1 538 544 PF00069 0.393
MOD_SUMO_for_1 526 529 PF00179 0.429
MOD_SUMO_rev_2 317 323 PF00179 0.275
MOD_SUMO_rev_2 385 394 PF00179 0.272
TRG_DiLeu_BaEn_1 275 280 PF01217 0.211
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.210
TRG_ENDOCYTIC_2 107 110 PF00928 0.252
TRG_ENDOCYTIC_2 341 344 PF00928 0.218
TRG_ENDOCYTIC_2 36 39 PF00928 0.230
TRG_ENDOCYTIC_2 420 423 PF00928 0.193
TRG_ENDOCYTIC_2 464 467 PF00928 0.211
TRG_ER_diArg_1 24 27 PF00400 0.406
TRG_NES_CRM1_1 493 506 PF08389 0.353
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.211

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5K9 Leptomonas seymouri 78% 100%
A0A0S4IT90 Bodo saltans 54% 87%
A0A1X0NLC9 Trypanosomatidae 61% 100%
A0A3S7WSP8 Leishmania donovani 99% 100%
A0A422P4A3 Trypanosoma rangeli 59% 100%
A4H7F2 Leishmania braziliensis 84% 100%
B7TWW5 Panax ginseng 33% 100%
D0A6E5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 98%
E9API6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9R5G2 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 34% 100%
I1RQ76 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 31% 100%
O13306 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 31% 100%
O48651 Panax ginseng 32% 100%
O65402 Arabidopsis thaliana 27% 100%
O65403 Arabidopsis thaliana 26% 100%
O65404 Arabidopsis thaliana 26% 100%
O65726 Brassica napus 25% 100%
O65727 Brassica napus 26% 100%
O81000 Arabidopsis thaliana 34% 97%
P32476 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P52019 Mus musculus 34% 99%
P52020 Rattus norvegicus 33% 99%
Q14534 Homo sapiens 34% 99%
Q4QFZ2 Leishmania major 94% 100%
Q75F69 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 29% 100%
Q8VYH2 Arabidopsis thaliana 34% 100%
Q92206 Candida albicans (strain SC5314 / ATCC MYA-2876) 31% 100%
Q9C1W3 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
Q9SM02 Arabidopsis thaliana 33% 100%
V5BRL1 Trypanosoma cruzi 58% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS