LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
T-complex protein 10 C-terminus - putative
Species:
Leishmania infantum
UniProt:
A4HVT7_LEIIN
TriTrypDb:
LINF_130021400
Length:
750

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Spindle assembly abnormal 4

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005813 centrosome 3 1
GO:0005814 centriole 5 1
GO:0005815 microtubule organizing center 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVT7

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044782 cilium organization 5 1
GO:0060271 cilium assembly 6 1
GO:0061511 centriole elongation 3 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 164 168 PF00656 0.520
CLV_C14_Caspase3-7 309 313 PF00656 0.553
CLV_C14_Caspase3-7 320 324 PF00656 0.425
CLV_C14_Caspase3-7 449 453 PF00656 0.565
CLV_C14_Caspase3-7 54 58 PF00656 0.551
CLV_NRD_NRD_1 120 122 PF00675 0.648
CLV_NRD_NRD_1 22 24 PF00675 0.567
CLV_NRD_NRD_1 235 237 PF00675 0.593
CLV_NRD_NRD_1 316 318 PF00675 0.539
CLV_NRD_NRD_1 350 352 PF00675 0.477
CLV_NRD_NRD_1 385 387 PF00675 0.405
CLV_NRD_NRD_1 393 395 PF00675 0.407
CLV_NRD_NRD_1 459 461 PF00675 0.618
CLV_NRD_NRD_1 506 508 PF00675 0.507
CLV_NRD_NRD_1 515 517 PF00675 0.485
CLV_NRD_NRD_1 542 544 PF00675 0.466
CLV_NRD_NRD_1 548 550 PF00675 0.532
CLV_NRD_NRD_1 55 57 PF00675 0.551
CLV_NRD_NRD_1 561 563 PF00675 0.449
CLV_NRD_NRD_1 583 585 PF00675 0.710
CLV_NRD_NRD_1 86 88 PF00675 0.611
CLV_PCSK_FUR_1 383 387 PF00082 0.404
CLV_PCSK_FUR_1 457 461 PF00082 0.495
CLV_PCSK_FUR_1 484 488 PF00082 0.511
CLV_PCSK_FUR_1 53 57 PF00082 0.573
CLV_PCSK_FUR_1 540 544 PF00082 0.383
CLV_PCSK_KEX2_1 120 122 PF00082 0.648
CLV_PCSK_KEX2_1 22 24 PF00082 0.589
CLV_PCSK_KEX2_1 235 237 PF00082 0.593
CLV_PCSK_KEX2_1 316 318 PF00082 0.539
CLV_PCSK_KEX2_1 350 352 PF00082 0.477
CLV_PCSK_KEX2_1 385 387 PF00082 0.405
CLV_PCSK_KEX2_1 393 395 PF00082 0.407
CLV_PCSK_KEX2_1 459 461 PF00082 0.618
CLV_PCSK_KEX2_1 486 488 PF00082 0.476
CLV_PCSK_KEX2_1 505 507 PF00082 0.493
CLV_PCSK_KEX2_1 517 519 PF00082 0.499
CLV_PCSK_KEX2_1 540 542 PF00082 0.538
CLV_PCSK_KEX2_1 55 57 PF00082 0.551
CLV_PCSK_KEX2_1 582 584 PF00082 0.623
CLV_PCSK_KEX2_1 597 599 PF00082 0.426
CLV_PCSK_KEX2_1 645 647 PF00082 0.236
CLV_PCSK_PC1ET2_1 486 488 PF00082 0.500
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.433
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.633
CLV_PCSK_PC1ET2_1 597 599 PF00082 0.524
CLV_PCSK_PC1ET2_1 645 647 PF00082 0.220
CLV_PCSK_PC7_1 231 237 PF00082 0.591
CLV_PCSK_PC7_1 346 352 PF00082 0.468
CLV_PCSK_PC7_1 593 599 PF00082 0.497
CLV_PCSK_SKI1_1 637 641 PF00082 0.421
CLV_PCSK_SKI1_1 656 660 PF00082 0.124
CLV_PCSK_SKI1_1 70 74 PF00082 0.544
CLV_PCSK_SKI1_1 720 724 PF00082 0.340
DEG_APCC_DBOX_1 359 367 PF00400 0.414
DOC_CKS1_1 569 574 PF01111 0.575
DOC_MAPK_gen_1 334 343 PF00069 0.395
DOC_MAPK_gen_1 459 469 PF00069 0.584
DOC_MAPK_gen_1 523 531 PF00069 0.463
DOC_PP2B_LxvP_1 145 148 PF13499 0.609
DOC_PP4_FxxP_1 234 237 PF00568 0.525
DOC_USP7_MATH_1 14 18 PF00917 0.652
DOC_USP7_MATH_1 148 152 PF00917 0.536
DOC_USP7_MATH_1 174 178 PF00917 0.588
DOC_USP7_MATH_1 223 227 PF00917 0.573
DOC_USP7_MATH_1 244 248 PF00917 0.644
DOC_USP7_MATH_1 252 256 PF00917 0.565
DOC_USP7_MATH_1 476 480 PF00917 0.533
DOC_USP7_MATH_1 585 589 PF00917 0.645
DOC_USP7_MATH_1 716 720 PF00917 0.425
DOC_USP7_MATH_1 734 738 PF00917 0.532
DOC_USP7_UBL2_3 11 15 PF12436 0.524
DOC_USP7_UBL2_3 272 276 PF12436 0.451
DOC_WW_Pin1_4 114 119 PF00397 0.737
DOC_WW_Pin1_4 139 144 PF00397 0.637
DOC_WW_Pin1_4 199 204 PF00397 0.607
DOC_WW_Pin1_4 248 253 PF00397 0.655
DOC_WW_Pin1_4 34 39 PF00397 0.567
DOC_WW_Pin1_4 413 418 PF00397 0.600
DOC_WW_Pin1_4 422 427 PF00397 0.589
DOC_WW_Pin1_4 470 475 PF00397 0.584
DOC_WW_Pin1_4 568 573 PF00397 0.539
LIG_14-3-3_CanoR_1 212 217 PF00244 0.577
LIG_14-3-3_CanoR_1 27 31 PF00244 0.553
LIG_14-3-3_CanoR_1 3 7 PF00244 0.559
LIG_14-3-3_CanoR_1 329 335 PF00244 0.417
LIG_14-3-3_CanoR_1 350 359 PF00244 0.546
LIG_14-3-3_CanoR_1 420 426 PF00244 0.649
LIG_14-3-3_CanoR_1 437 443 PF00244 0.455
LIG_14-3-3_CanoR_1 584 594 PF00244 0.579
LIG_14-3-3_CanoR_1 70 78 PF00244 0.529
LIG_14-3-3_CanoR_1 94 99 PF00244 0.618
LIG_APCC_ABBAyCdc20_2 720 726 PF00400 0.354
LIG_APCC_Cbox_1 510 516 PF00515 0.415
LIG_BIR_II_1 1 5 PF00653 0.695
LIG_BRCT_BRCA1_1 16 20 PF00533 0.610
LIG_FHA_1 614 620 PF00498 0.444
LIG_FHA_1 652 658 PF00498 0.454
LIG_FHA_1 91 97 PF00498 0.608
LIG_FHA_2 147 153 PF00498 0.628
LIG_FHA_2 359 365 PF00498 0.579
LIG_FHA_2 367 373 PF00498 0.442
LIG_FHA_2 601 607 PF00498 0.402
LIG_FHA_2 667 673 PF00498 0.411
LIG_LIR_Apic_2 133 137 PF02991 0.607
LIG_LIR_Nem_3 16 21 PF02991 0.609
LIG_LIR_Nem_3 332 338 PF02991 0.437
LIG_LIR_Nem_3 726 732 PF02991 0.356
LIG_Rb_LxCxE_1 404 424 PF01857 0.552
LIG_SH2_CRK 198 202 PF00017 0.654
LIG_SH2_CRK 213 217 PF00017 0.384
LIG_SH2_CRK 729 733 PF00017 0.349
LIG_SH2_GRB2like 650 653 PF00017 0.411
LIG_SH2_NCK_1 30 34 PF00017 0.626
LIG_SH2_NCK_1 686 690 PF00017 0.371
LIG_SH2_SRC 218 221 PF00017 0.566
LIG_SH2_SRC 281 284 PF00017 0.461
LIG_SH2_SRC 443 446 PF00017 0.593
LIG_SH2_SRC 650 653 PF00017 0.396
LIG_SH2_STAP1 165 169 PF00017 0.480
LIG_SH2_STAT5 160 163 PF00017 0.580
LIG_SH2_STAT5 233 236 PF00017 0.639
LIG_SH2_STAT5 239 242 PF00017 0.603
LIG_SH2_STAT5 512 515 PF00017 0.487
LIG_SH3_2 592 597 PF14604 0.581
LIG_SH3_3 126 132 PF00018 0.666
LIG_SH3_3 134 140 PF00018 0.554
LIG_SH3_3 150 156 PF00018 0.624
LIG_SH3_3 566 572 PF00018 0.566
LIG_SH3_3 589 595 PF00018 0.593
LIG_SH3_3 654 660 PF00018 0.462
LIG_SH3_3 80 86 PF00018 0.580
LIG_SH3_3 93 99 PF00018 0.532
LIG_SH3_4 11 18 PF00018 0.594
LIG_SUMO_SIM_anti_2 2 8 PF11976 0.557
LIG_SUMO_SIM_par_1 422 430 PF11976 0.495
LIG_SUMO_SIM_par_1 465 471 PF11976 0.580
LIG_TRAF2_1 257 260 PF00917 0.477
LIG_TRAF2_1 330 333 PF00917 0.432
LIG_TRAF2_1 501 504 PF00917 0.524
LIG_TRAF2_1 603 606 PF00917 0.396
LIG_TRAF2_1 747 750 PF00917 0.482
LIG_UBA3_1 263 272 PF00899 0.512
LIG_UBA3_1 398 403 PF00899 0.464
MOD_CDC14_SPxK_1 37 40 PF00782 0.619
MOD_CDK_SPK_2 199 204 PF00069 0.607
MOD_CDK_SPK_2 470 475 PF00069 0.593
MOD_CDK_SPK_2 568 573 PF00069 0.539
MOD_CDK_SPxK_1 114 120 PF00069 0.511
MOD_CDK_SPxK_1 34 40 PF00069 0.623
MOD_CDK_SPxxK_3 114 121 PF00069 0.512
MOD_CDK_SPxxK_3 413 420 PF00069 0.561
MOD_CK1_1 106 112 PF00069 0.655
MOD_CK1_1 185 191 PF00069 0.701
MOD_CK1_1 2 8 PF00069 0.625
MOD_CK1_1 31 37 PF00069 0.628
MOD_CK1_1 358 364 PF00069 0.464
MOD_CK1_1 416 422 PF00069 0.693
MOD_CK1_1 425 431 PF00069 0.577
MOD_CK1_1 439 445 PF00069 0.436
MOD_CK1_1 661 667 PF00069 0.448
MOD_CK1_1 679 685 PF00069 0.231
MOD_CK1_1 737 743 PF00069 0.450
MOD_CK2_1 104 110 PF00069 0.628
MOD_CK2_1 146 152 PF00069 0.657
MOD_CK2_1 254 260 PF00069 0.521
MOD_CK2_1 358 364 PF00069 0.577
MOD_CK2_1 366 372 PF00069 0.444
MOD_CK2_1 600 606 PF00069 0.391
MOD_Cter_Amidation 643 646 PF01082 0.211
MOD_GlcNHglycan 106 109 PF01048 0.674
MOD_GlcNHglycan 169 172 PF01048 0.649
MOD_GlcNHglycan 177 180 PF01048 0.552
MOD_GlcNHglycan 204 207 PF01048 0.613
MOD_GlcNHglycan 219 224 PF01048 0.407
MOD_GlcNHglycan 226 229 PF01048 0.530
MOD_GlcNHglycan 30 33 PF01048 0.559
MOD_GlcNHglycan 338 341 PF01048 0.495
MOD_GlcNHglycan 413 416 PF01048 0.641
MOD_GlcNHglycan 432 436 PF01048 0.611
MOD_GlcNHglycan 439 442 PF01048 0.610
MOD_GlcNHglycan 564 567 PF01048 0.520
MOD_GlcNHglycan 575 578 PF01048 0.556
MOD_GlcNHglycan 585 588 PF01048 0.534
MOD_GlcNHglycan 642 645 PF01048 0.259
MOD_GlcNHglycan 660 663 PF01048 0.211
MOD_GlcNHglycan 678 681 PF01048 0.357
MOD_GlcNHglycan 96 99 PF01048 0.667
MOD_GSK3_1 100 107 PF00069 0.519
MOD_GSK3_1 161 168 PF00069 0.624
MOD_GSK3_1 219 226 PF00069 0.578
MOD_GSK3_1 244 251 PF00069 0.623
MOD_GSK3_1 416 423 PF00069 0.572
MOD_GSK3_1 427 434 PF00069 0.604
MOD_GSK3_1 573 580 PF00069 0.626
MOD_GSK3_1 658 665 PF00069 0.451
MOD_GSK3_1 676 683 PF00069 0.236
MOD_GSK3_1 704 711 PF00069 0.436
MOD_GSK3_1 90 97 PF00069 0.619
MOD_N-GLC_1 103 108 PF02516 0.653
MOD_N-GLC_1 336 341 PF02516 0.588
MOD_N-GLC_1 355 360 PF02516 0.292
MOD_N-GLC_1 651 656 PF02516 0.211
MOD_NEK2_1 161 166 PF00069 0.588
MOD_NEK2_1 28 33 PF00069 0.556
MOD_NEK2_1 366 371 PF00069 0.417
MOD_NEK2_1 640 645 PF00069 0.381
MOD_NEK2_1 666 671 PF00069 0.412
MOD_NEK2_1 705 710 PF00069 0.395
MOD_NEK2_2 14 19 PF00069 0.578
MOD_NEK2_2 577 582 PF00069 0.634
MOD_NEK2_2 651 656 PF00069 0.446
MOD_NEK2_2 662 667 PF00069 0.469
MOD_NEK2_2 688 693 PF00069 0.394
MOD_PIKK_1 350 356 PF00454 0.417
MOD_PIKK_1 358 364 PF00454 0.414
MOD_PIKK_1 623 629 PF00454 0.416
MOD_PIKK_1 691 697 PF00454 0.327
MOD_PKA_1 350 356 PF00069 0.417
MOD_PKA_1 459 465 PF00069 0.610
MOD_PKA_1 55 61 PF00069 0.472
MOD_PKA_1 562 568 PF00069 0.526
MOD_PKA_1 583 589 PF00069 0.653
MOD_PKA_2 185 191 PF00069 0.701
MOD_PKA_2 2 8 PF00069 0.558
MOD_PKA_2 26 32 PF00069 0.602
MOD_PKA_2 315 321 PF00069 0.484
MOD_PKA_2 328 334 PF00069 0.480
MOD_PKA_2 345 351 PF00069 0.353
MOD_PKA_2 419 425 PF00069 0.651
MOD_PKA_2 436 442 PF00069 0.449
MOD_PKA_2 459 465 PF00069 0.556
MOD_PKA_2 55 61 PF00069 0.472
MOD_PKA_2 583 589 PF00069 0.653
MOD_PKA_2 705 711 PF00069 0.439
MOD_PKB_1 457 465 PF00069 0.488
MOD_PKB_1 53 61 PF00069 0.544
MOD_Plk_1 161 167 PF00069 0.608
MOD_Plk_1 276 282 PF00069 0.423
MOD_Plk_1 336 342 PF00069 0.585
MOD_Plk_1 355 361 PF00069 0.333
MOD_Plk_1 737 743 PF00069 0.390
MOD_Plk_4 2 8 PF00069 0.645
MOD_Plk_4 680 686 PF00069 0.334
MOD_Plk_4 737 743 PF00069 0.392
MOD_ProDKin_1 114 120 PF00069 0.742
MOD_ProDKin_1 139 145 PF00069 0.642
MOD_ProDKin_1 199 205 PF00069 0.605
MOD_ProDKin_1 248 254 PF00069 0.652
MOD_ProDKin_1 34 40 PF00069 0.567
MOD_ProDKin_1 413 419 PF00069 0.601
MOD_ProDKin_1 422 428 PF00069 0.588
MOD_ProDKin_1 470 476 PF00069 0.580
MOD_ProDKin_1 568 574 PF00069 0.542
MOD_SUMO_for_1 216 219 PF00179 0.590
MOD_SUMO_rev_2 266 274 PF00179 0.509
MOD_SUMO_rev_2 519 525 PF00179 0.457
MOD_SUMO_rev_2 54 61 PF00179 0.534
MOD_SUMO_rev_2 556 565 PF00179 0.569
TRG_DiLeu_BaEn_1 259 264 PF01217 0.432
TRG_DiLeu_BaEn_2 15 21 PF01217 0.608
TRG_DiLeu_BaLyEn_6 140 145 PF01217 0.587
TRG_ENDOCYTIC_2 198 201 PF00928 0.691
TRG_ENDOCYTIC_2 213 216 PF00928 0.378
TRG_ENDOCYTIC_2 729 732 PF00928 0.342
TRG_ER_diArg_1 21 23 PF00400 0.597
TRG_ER_diArg_1 234 236 PF00400 0.601
TRG_ER_diArg_1 316 319 PF00400 0.540
TRG_ER_diArg_1 350 352 PF00400 0.477
TRG_ER_diArg_1 383 386 PF00400 0.408
TRG_ER_diArg_1 505 507 PF00400 0.465
TRG_ER_diArg_1 526 529 PF00400 0.517
TRG_ER_diArg_1 540 543 PF00400 0.507
TRG_ER_diArg_1 583 585 PF00400 0.733
TRG_Pf-PMV_PEXEL_1 350 354 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 511 515 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 59 63 PF00026 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HW13 Leptomonas seymouri 57% 98%
A0A3Q8I9S9 Leishmania donovani 100% 100%
A4H7E9 Leishmania braziliensis 79% 99%
E9API3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QFZ5 Leishmania major 94% 100%
V5B213 Trypanosoma cruzi 45% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS