Phosphoprotein phosphatase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoprotein phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4HVT6_LEIIN

TriTrypDb:

LINF_130021200

Length:

587

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	3
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HVT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVT6

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	8
GO:0019722	calcium-mediated signaling	5	6
GO:0019932	second-messenger-mediated signaling	4	6
GO:0035556	intracellular signal transduction	3	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6
GO:0097720	calcineurin-mediated signaling	6	6
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004721	phosphoprotein phosphatase activity	3	19
GO:0004722	protein serine/threonine phosphatase activity	4	19
GO:0016787	hydrolase activity	2	19
GO:0016788	hydrolase activity, acting on ester bonds	3	19
GO:0016791	phosphatase activity	5	19
GO:0017018	myosin phosphatase activity	5	19
GO:0042578	phosphoric ester hydrolase activity	4	19
GO:0140096	catalytic activity, acting on a protein	2	19
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	6
GO:0033192	calmodulin-dependent protein phosphatase activity	6	6
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.520
CLV_C14_Caspase3-7	154	158	PF00656	0.498
CLV_C14_Caspase3-7	260	264	PF00656	0.556
CLV_C14_Caspase3-7	467	471	PF00656	0.235
CLV_C14_Caspase3-7	53	57	PF00656	0.543
CLV_C14_Caspase3-7	574	578	PF00656	0.470
CLV_NRD_NRD_1	247	249	PF00675	0.378
CLV_NRD_NRD_1	331	333	PF00675	0.415
CLV_NRD_NRD_1	340	342	PF00675	0.242
CLV_NRD_NRD_1	453	455	PF00675	0.200
CLV_PCSK_FUR_1	338	342	PF00082	0.247
CLV_PCSK_KEX2_1	226	228	PF00082	0.443
CLV_PCSK_KEX2_1	247	249	PF00082	0.378
CLV_PCSK_KEX2_1	330	332	PF00082	0.431
CLV_PCSK_KEX2_1	340	342	PF00082	0.236
CLV_PCSK_KEX2_1	453	455	PF00082	0.200
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.443
CLV_PCSK_SKI1_1	11	15	PF00082	0.531
CLV_PCSK_SKI1_1	213	217	PF00082	0.509
CLV_PCSK_SKI1_1	226	230	PF00082	0.416
CLV_PCSK_SKI1_1	340	344	PF00082	0.420
CLV_PCSK_SKI1_1	413	417	PF00082	0.342
CLV_PCSK_SKI1_1	530	534	PF00082	0.303
CLV_PCSK_SKI1_1	63	67	PF00082	0.523
CLV_PCSK_SKI1_1	95	99	PF00082	0.676
DEG_APCC_DBOX_1	505	513	PF00400	0.235
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DEG_SPOP_SBC_1	86	90	PF00917	0.488
DOC_ANK_TNKS_1	331	338	PF00023	0.293
DOC_CYCLIN_yClb1_LxF_4	506	511	PF00134	0.269
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.370
DOC_MAPK_HePTP_8	288	300	PF00069	0.345
DOC_MAPK_MEF2A_6	291	300	PF00069	0.348
DOC_MAPK_MEF2A_6	351	360	PF00069	0.414
DOC_MAPK_MEF2A_6	413	420	PF00069	0.359
DOC_MAPK_NFAT4_5	413	421	PF00069	0.317
DOC_PP1_RVXF_1	506	512	PF00149	0.235
DOC_PP2B_LxvP_1	180	183	PF13499	0.529
DOC_PP2B_LxvP_1	416	419	PF13499	0.370
DOC_PP4_FxxP_1	535	538	PF00568	0.385
DOC_SPAK_OSR1_1	430	434	PF12202	0.317
DOC_USP7_MATH_1	102	106	PF00917	0.514
DOC_USP7_MATH_1	129	133	PF00917	0.535
DOC_USP7_MATH_1	155	159	PF00917	0.517
DOC_USP7_MATH_1	257	261	PF00917	0.647
DOC_USP7_MATH_1	35	39	PF00917	0.616
DOC_USP7_MATH_1	395	399	PF00917	0.299
DOC_USP7_MATH_1	497	501	PF00917	0.396
DOC_USP7_MATH_1	581	585	PF00917	0.595
DOC_USP7_MATH_1	86	90	PF00917	0.577
DOC_WW_Pin1_4	100	105	PF00397	0.476
DOC_WW_Pin1_4	122	127	PF00397	0.591
DOC_WW_Pin1_4	174	179	PF00397	0.647
DOC_WW_Pin1_4	229	234	PF00397	0.490
DOC_WW_Pin1_4	436	441	PF00397	0.364
DOC_WW_Pin1_4	74	79	PF00397	0.501
DOC_WW_Pin1_4	82	87	PF00397	0.799
LIG_14-3-3_CanoR_1	136	146	PF00244	0.548
LIG_14-3-3_CanoR_1	195	205	PF00244	0.706
LIG_14-3-3_CanoR_1	351	357	PF00244	0.311
LIG_14-3-3_CanoR_1	430	440	PF00244	0.320
LIG_14-3-3_CanoR_1	530	535	PF00244	0.310
LIG_BRCT_BRCA1_1	234	238	PF00533	0.387
LIG_BRCT_BRCA1_1	3	7	PF00533	0.489
LIG_BRCT_BRCA1_1	499	503	PF00533	0.376
LIG_BRCT_BRCA1_1	582	586	PF00533	0.588
LIG_BRCT_MDC1_1	583	587	PF00533	0.381
LIG_Clathr_ClatBox_1	295	299	PF01394	0.350
LIG_FHA_1	284	290	PF00498	0.360
LIG_FHA_1	303	309	PF00498	0.423
LIG_FHA_1	31	37	PF00498	0.510
LIG_FHA_1	319	325	PF00498	0.273
LIG_FHA_1	383	389	PF00498	0.389
LIG_FHA_1	394	400	PF00498	0.317
LIG_FHA_1	456	462	PF00498	0.268
LIG_FHA_1	64	70	PF00498	0.518
LIG_FHA_2	202	208	PF00498	0.552
LIG_FHA_2	292	298	PF00498	0.300
LIG_FHA_2	51	57	PF00498	0.528
LIG_FHA_2	524	530	PF00498	0.379
LIG_FHA_2	572	578	PF00498	0.403
LIG_Integrin_isoDGR_2	134	136	PF01839	0.535
LIG_Integrin_RGD_1	251	253	PF01839	0.460
LIG_IRF3_LxIS_1	194	199	PF10401	0.543
LIG_KLC1_Yacidic_2	572	577	PF13176	0.380
LIG_LIR_Apic_2	533	538	PF02991	0.376
LIG_LIR_Gen_1	318	328	PF02991	0.384
LIG_LIR_Gen_1	339	349	PF02991	0.432
LIG_LIR_Gen_1	405	416	PF02991	0.345
LIG_LIR_Gen_1	426	433	PF02991	0.405
LIG_LIR_LC3C_4	304	308	PF02991	0.317
LIG_LIR_Nem_3	235	241	PF02991	0.367
LIG_LIR_Nem_3	318	323	PF02991	0.384
LIG_LIR_Nem_3	368	372	PF02991	0.317
LIG_LIR_Nem_3	386	392	PF02991	0.407
LIG_LIR_Nem_3	405	411	PF02991	0.339
LIG_LIR_Nem_3	426	431	PF02991	0.402
LIG_LIR_Nem_3	561	565	PF02991	0.398
LIG_LYPXL_yS_3	369	372	PF13949	0.317
LIG_MAD2	530	538	PF02301	0.385
LIG_MLH1_MIPbox_1	582	586	PF16413	0.385
LIG_PCNA_PIPBox_1	517	526	PF02747	0.460
LIG_PCNA_yPIPBox_3	514	524	PF02747	0.332
LIG_PTB_Apo_2	271	278	PF02174	0.355
LIG_PTB_Phospho_1	271	277	PF10480	0.362
LIG_SH2_CRK	320	324	PF00017	0.381
LIG_SH2_CRK	389	393	PF00017	0.311
LIG_SH2_CRK	540	544	PF00017	0.384
LIG_SH2_NCK_1	267	271	PF00017	0.409
LIG_SH2_SRC	575	578	PF00017	0.402
LIG_SH2_STAP1	320	324	PF00017	0.317
LIG_SH2_STAT5	267	270	PF00017	0.417
LIG_SH2_STAT5	277	280	PF00017	0.365
LIG_SH2_STAT5	320	323	PF00017	0.374
LIG_SH2_STAT5	348	351	PF00017	0.361
LIG_SH2_STAT5	374	377	PF00017	0.341
LIG_SH2_STAT5	523	526	PF00017	0.332
LIG_SH2_STAT5	540	543	PF00017	0.438
LIG_SH2_STAT5	575	578	PF00017	0.419
LIG_SH2_STAT5	72	75	PF00017	0.547
LIG_SH3_3	107	113	PF00018	0.619
LIG_SH3_3	120	126	PF00018	0.567
LIG_SH3_3	22	28	PF00018	0.579
LIG_SH3_3	251	257	PF00018	0.528
LIG_SH3_3	287	293	PF00018	0.415
LIG_SH3_3	364	370	PF00018	0.416
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.449
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.369
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.368
LIG_SUMO_SIM_par_1	294	299	PF11976	0.415
LIG_SUMO_SIM_par_1	304	311	PF11976	0.381
LIG_SUMO_SIM_par_1	529	536	PF11976	0.380
LIG_TRAF2_1	115	118	PF00917	0.577
LIG_TYR_ITIM	367	372	PF00017	0.317
LIG_UBA3_1	165	174	PF00899	0.489
LIG_UBA3_1	360	366	PF00899	0.419
MOD_CDK_SPK_2	229	234	PF00069	0.374
MOD_CK1_1	158	164	PF00069	0.492
MOD_CK1_1	199	205	PF00069	0.586
MOD_CK1_1	34	40	PF00069	0.516
MOD_CK1_1	485	491	PF00069	0.239
MOD_CK1_1	50	56	PF00069	0.481
MOD_CK1_1	85	91	PF00069	0.570
MOD_CK2_1	291	297	PF00069	0.310
MOD_CK2_1	564	570	PF00069	0.306
MOD_GlcNHglycan	104	107	PF01048	0.517
MOD_GlcNHglycan	131	134	PF01048	0.531
MOD_GlcNHglycan	170	174	PF01048	0.658
MOD_GlcNHglycan	222	225	PF01048	0.524
MOD_GlcNHglycan	234	237	PF01048	0.352
MOD_GlcNHglycan	32	36	PF01048	0.631
MOD_GlcNHglycan	37	40	PF01048	0.583
MOD_GlcNHglycan	408	411	PF01048	0.404
MOD_GlcNHglycan	535	538	PF01048	0.385
MOD_GlcNHglycan	553	556	PF01048	0.374
MOD_GSK3_1	124	131	PF00069	0.537
MOD_GSK3_1	155	162	PF00069	0.525
MOD_GSK3_1	165	172	PF00069	0.490
MOD_GSK3_1	196	203	PF00069	0.646
MOD_GSK3_1	216	223	PF00069	0.571
MOD_GSK3_1	30	37	PF00069	0.599
MOD_GSK3_1	390	397	PF00069	0.497
MOD_GSK3_1	402	409	PF00069	0.388
MOD_GSK3_1	455	462	PF00069	0.308
MOD_GSK3_1	478	485	PF00069	0.367
MOD_GSK3_1	498	505	PF00069	0.286
MOD_GSK3_1	571	578	PF00069	0.482
MOD_GSK3_1	82	89	PF00069	0.614
MOD_N-GLC_2	539	541	PF02516	0.423
MOD_N-GLC_2	99	101	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	137	142	PF00069	0.555
MOD_NEK2_1	169	174	PF00069	0.553
MOD_NEK2_1	215	220	PF00069	0.543
MOD_NEK2_1	319	324	PF00069	0.289
MOD_NEK2_1	431	436	PF00069	0.370
MOD_NEK2_1	484	489	PF00069	0.359
MOD_NEK2_1	7	12	PF00069	0.529
MOD_NEK2_2	575	580	PF00069	0.450
MOD_NEK2_2	581	586	PF00069	0.400
MOD_OFUCOSY	573	579	PF10250	0.396
MOD_PIKK_1	257	263	PF00454	0.690
MOD_PIKK_1	265	271	PF00454	0.474
MOD_PKA_2	196	202	PF00069	0.638
MOD_Plk_1	1	7	PF00069	0.521
MOD_Plk_1	31	37	PF00069	0.528
MOD_Plk_1	55	61	PF00069	0.501
MOD_Plk_1	571	577	PF00069	0.399
MOD_Plk_2-3	447	453	PF00069	0.258
MOD_Plk_4	138	144	PF00069	0.494
MOD_Plk_4	268	274	PF00069	0.607
MOD_Plk_4	291	297	PF00069	0.527
MOD_Plk_4	302	308	PF00069	0.472
MOD_Plk_4	319	325	PF00069	0.202
MOD_Plk_4	368	374	PF00069	0.420
MOD_Plk_4	423	429	PF00069	0.468
MOD_Plk_4	530	536	PF00069	0.307
MOD_Plk_4	571	577	PF00069	0.403
MOD_Plk_4	581	587	PF00069	0.450
MOD_ProDKin_1	100	106	PF00069	0.478
MOD_ProDKin_1	122	128	PF00069	0.591
MOD_ProDKin_1	174	180	PF00069	0.649
MOD_ProDKin_1	229	235	PF00069	0.489
MOD_ProDKin_1	436	442	PF00069	0.364
MOD_ProDKin_1	74	80	PF00069	0.502
MOD_ProDKin_1	82	88	PF00069	0.798
MOD_SUMO_for_1	365	368	PF00179	0.317
MOD_SUMO_rev_2	381	386	PF00179	0.383
TRG_DiLeu_BaEn_1	357	362	PF01217	0.321
TRG_DiLeu_BaEn_1	368	373	PF01217	0.264
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.528
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.502
TRG_DiLeu_LyEn_5	237	242	PF01217	0.346
TRG_ENDOCYTIC_2	320	323	PF00928	0.396
TRG_ENDOCYTIC_2	369	372	PF00928	0.317
TRG_ENDOCYTIC_2	389	392	PF00928	0.335
TRG_ENDOCYTIC_2	428	431	PF00928	0.305
TRG_ENDOCYTIC_2	540	543	PF00928	0.406
TRG_ER_diArg_1	194	197	PF00400	0.537
TRG_ER_diArg_1	246	248	PF00400	0.377
TRG_ER_diArg_1	330	332	PF00400	0.297
TRG_ER_diArg_1	340	342	PF00400	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IM33	Bodo saltans	28%	77%
A0A3Q8I8M6	Leishmania donovani	80%	100%
A0A3Q8II54	Leishmania donovani	99%	100%
A0A3S7XAY3	Leishmania donovani	31%	100%
A0A422N1U7	Trypanosoma rangeli	31%	98%
A4H7E7	Leishmania braziliensis	68%	100%
A4HF98	Leishmania braziliensis	29%	100%
A4HP65	Leishmania braziliensis	31%	100%
A4HVT0	Leishmania infantum	80%	100%
A4IDH0	Leishmania infantum	31%	100%
E9APH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9API1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q1M5	Leishmania major	32%	100%
Q4QFZ7	Leishmania major	90%	100%
Q4QG03	Leishmania major	79%	100%
V5BBS3	Trypanosoma cruzi	31%	98%