FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVT3_LEIIN

TriTrypDb:

LINF_130020900

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.626
CLV_C14_Caspase3-7	145	149	PF00656	0.538
CLV_C14_Caspase3-7	380	384	PF00656	0.765
CLV_NRD_NRD_1	346	348	PF00675	0.588
CLV_NRD_NRD_1	356	358	PF00675	0.422
CLV_NRD_NRD_1	483	485	PF00675	0.598
CLV_NRD_NRD_1	51	53	PF00675	0.575
CLV_PCSK_FUR_1	481	485	PF00082	0.581
CLV_PCSK_KEX2_1	346	348	PF00082	0.689
CLV_PCSK_KEX2_1	483	485	PF00082	0.604
CLV_PCSK_KEX2_1	51	53	PF00082	0.643
CLV_PCSK_PC7_1	47	53	PF00082	0.572
CLV_PCSK_SKI1_1	257	261	PF00082	0.476
CLV_PCSK_SKI1_1	9	13	PF00082	0.521
DEG_APCC_DBOX_1	236	244	PF00400	0.395
DEG_APCC_DBOX_1	314	322	PF00400	0.397
DEG_APCC_DBOX_1	385	393	PF00400	0.614
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DOC_CKS1_1	394	399	PF01111	0.628
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.590
DOC_PP2B_LxvP_1	112	115	PF13499	0.574
DOC_PP2B_LxvP_1	175	178	PF13499	0.608
DOC_PP2B_LxvP_1	414	417	PF13499	0.598
DOC_PP2B_LxvP_1	467	470	PF13499	0.607
DOC_PP4_FxxP_1	170	173	PF00568	0.620
DOC_USP7_MATH_1	239	243	PF00917	0.390
DOC_USP7_MATH_1	281	285	PF00917	0.426
DOC_USP7_MATH_1	381	385	PF00917	0.670
DOC_WW_Pin1_4	135	140	PF00397	0.695
DOC_WW_Pin1_4	164	169	PF00397	0.563
DOC_WW_Pin1_4	235	240	PF00397	0.455
DOC_WW_Pin1_4	387	392	PF00397	0.626
DOC_WW_Pin1_4	393	398	PF00397	0.617
DOC_WW_Pin1_4	442	447	PF00397	0.583
DOC_WW_Pin1_4	70	75	PF00397	0.658
LIG_14-3-3_CanoR_1	117	127	PF00244	0.701
LIG_14-3-3_CanoR_1	237	245	PF00244	0.369
LIG_14-3-3_CanoR_1	51	55	PF00244	0.550
LIG_14-3-3_CterR_2	483	487	PF00244	0.695
LIG_APCC_ABBA_1	157	162	PF00400	0.583
LIG_APCC_ABBA_1	204	209	PF00400	0.575
LIG_BRCT_BRCA1_1	166	170	PF00533	0.588
LIG_Clathr_ClatBox_1	226	230	PF01394	0.395
LIG_Clathr_ClatBox_1	424	428	PF01394	0.448
LIG_FHA_1	102	108	PF00498	0.707
LIG_FHA_1	251	257	PF00498	0.487
LIG_FHA_1	394	400	PF00498	0.738
LIG_FHA_1	411	417	PF00498	0.559
LIG_FHA_1	420	426	PF00498	0.486
LIG_FHA_2	104	110	PF00498	0.514
LIG_FHA_2	250	256	PF00498	0.494
LIG_FHA_2	371	377	PF00498	0.656
LIG_FHA_2	5	11	PF00498	0.622
LIG_FHA_2	90	96	PF00498	0.585
LIG_GBD_Chelix_1	227	235	PF00786	0.476
LIG_GBD_Chelix_1	303	311	PF00786	0.404
LIG_KLC1_Yacidic_2	158	162	PF13176	0.590
LIG_LIR_Apic_2	167	173	PF02991	0.626
LIG_LIR_Gen_1	151	161	PF02991	0.588
LIG_LIR_Nem_3	151	157	PF02991	0.576
LIG_LIR_Nem_3	19	24	PF02991	0.445
LIG_NRBOX	462	468	PF00104	0.596
LIG_PDZ_Class_1	482	487	PF00595	0.697
LIG_Pex14_2	265	269	PF04695	0.401
LIG_Rb_pABgroove_1	148	156	PF01858	0.578
LIG_SH2_CRK	21	25	PF00017	0.452
LIG_SH2_CRK	218	222	PF00017	0.600
LIG_SH2_CRK	40	44	PF00017	0.579
LIG_SH2_GRB2like	317	320	PF00017	0.386
LIG_SH2_SRC	160	163	PF00017	0.593
LIG_SH2_SRC	317	320	PF00017	0.386
LIG_SH2_STAP1	218	222	PF00017	0.643
LIG_SH2_STAT3	338	341	PF00017	0.494
LIG_SH2_STAT5	160	163	PF00017	0.593
LIG_SH2_STAT5	317	320	PF00017	0.469
LIG_SH3_3	218	224	PF00018	0.581
LIG_SH3_3	307	313	PF00018	0.533
LIG_SH3_3	322	328	PF00018	0.350
LIG_SH3_3	388	394	PF00018	0.810
LIG_SUMO_SIM_anti_2	421	430	PF11976	0.520
LIG_SUMO_SIM_par_1	103	110	PF11976	0.566
LIG_SUMO_SIM_par_1	224	230	PF11976	0.413
LIG_SUMO_SIM_par_1	421	430	PF11976	0.520
LIG_WW_3	114	118	PF00397	0.611
MOD_CK1_1	118	124	PF00069	0.760
MOD_CK1_1	130	136	PF00069	0.630
MOD_CK1_1	238	244	PF00069	0.544
MOD_CK1_1	384	390	PF00069	0.600
MOD_CK2_1	185	191	PF00069	0.622
MOD_CK2_1	249	255	PF00069	0.503
MOD_CK2_1	281	287	PF00069	0.403
MOD_CK2_1	295	301	PF00069	0.420
MOD_CK2_1	370	376	PF00069	0.659
MOD_CK2_1	4	10	PF00069	0.707
MOD_CK2_1	70	76	PF00069	0.653
MOD_CK2_1	89	95	PF00069	0.577
MOD_GlcNHglycan	109	112	PF01048	0.706
MOD_GlcNHglycan	120	123	PF01048	0.726
MOD_GlcNHglycan	144	147	PF01048	0.572
MOD_GlcNHglycan	213	216	PF01048	0.687
MOD_GlcNHglycan	452	455	PF01048	0.569
MOD_GSK3_1	1	8	PF00069	0.596
MOD_GSK3_1	103	110	PF00069	0.679
MOD_GSK3_1	160	167	PF00069	0.593
MOD_GSK3_1	231	238	PF00069	0.482
MOD_GSK3_1	479	486	PF00069	0.679
MOD_GSK3_1	55	62	PF00069	0.600
MOD_N-GLC_1	118	123	PF02516	0.654
MOD_N-GLC_2	372	374	PF02516	0.579
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	107	112	PF00069	0.632
MOD_NEK2_1	231	236	PF00069	0.433
MOD_NEK2_1	356	361	PF00069	0.608
MOD_NEK2_1	436	441	PF00069	0.523
MOD_NEK2_1	452	457	PF00069	0.579
MOD_NEK2_1	88	93	PF00069	0.653
MOD_NEK2_2	381	386	PF00069	0.671
MOD_PIKK_1	185	191	PF00454	0.584
MOD_PIKK_1	436	442	PF00454	0.591
MOD_PIKK_1	77	83	PF00454	0.517
MOD_PKA_2	1	7	PF00069	0.548
MOD_PKA_2	356	362	PF00069	0.569
MOD_PKA_2	367	373	PF00069	0.553
MOD_PKA_2	50	56	PF00069	0.548
MOD_Plk_1	161	167	PF00069	0.627
MOD_Plk_1	195	201	PF00069	0.533
MOD_Plk_1	9	15	PF00069	0.510
MOD_Plk_4	217	223	PF00069	0.655
MOD_Plk_4	231	237	PF00069	0.358
MOD_Plk_4	410	416	PF00069	0.668
MOD_Plk_4	452	458	PF00069	0.549
MOD_ProDKin_1	135	141	PF00069	0.688
MOD_ProDKin_1	164	170	PF00069	0.563
MOD_ProDKin_1	235	241	PF00069	0.458
MOD_ProDKin_1	387	393	PF00069	0.623
MOD_ProDKin_1	442	448	PF00069	0.586
MOD_ProDKin_1	70	76	PF00069	0.653
TRG_DiLeu_BaEn_1	462	467	PF01217	0.589
TRG_DiLeu_BaEn_2	18	24	PF01217	0.493
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.585
TRG_ENDOCYTIC_2	21	24	PF00928	0.465
TRG_ENDOCYTIC_2	218	221	PF00928	0.606
TRG_ENDOCYTIC_2	40	43	PF00928	0.578
TRG_ER_diArg_1	210	213	PF00400	0.635
TRG_ER_diArg_1	481	484	PF00400	0.636
TRG_NES_CRM1_1	148	162	PF08389	0.532
TRG_NLS_Bipartite_1	346	361	PF00514	0.589
TRG_NLS_MonoExtN_4	355	361	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.477
TRG_PTS1	484	487	PF00515	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K4	Leptomonas seymouri	48%	83%
A0A3S7WSN4	Leishmania donovani	100%	100%
A4H7E3	Leishmania braziliensis	75%	100%
E9APH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QG00	Leishmania major	92%	100%