Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVS9_LEIIN

TriTrypDb:

LINF_130019500

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.435
CLV_NRD_NRD_1	54	56	PF00675	0.498
CLV_PCSK_KEX2_1	112	114	PF00082	0.435
CLV_PCSK_KEX2_1	238	240	PF00082	0.685
CLV_PCSK_KEX2_1	54	56	PF00082	0.498
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.685
CLV_PCSK_SKI1_1	164	168	PF00082	0.467
CLV_PCSK_SKI1_1	2	6	PF00082	0.476
CLV_PCSK_SKI1_1	203	207	PF00082	0.387
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DEG_SPOP_SBC_1	74	78	PF00917	0.588
DOC_CKS1_1	44	49	PF01111	0.542
DOC_MAPK_gen_1	197	206	PF00069	0.446
DOC_MAPK_RevD_3	98	113	PF00069	0.402
DOC_PP4_FxxP_1	149	152	PF00568	0.564
DOC_USP7_MATH_1	30	34	PF00917	0.756
DOC_USP7_MATH_1	84	88	PF00917	0.501
DOC_WW_Pin1_4	135	140	PF00397	0.589
DOC_WW_Pin1_4	26	31	PF00397	0.674
DOC_WW_Pin1_4	43	48	PF00397	0.555
LIG_14-3-3_CanoR_1	119	128	PF00244	0.298
LIG_14-3-3_CanoR_1	147	152	PF00244	0.673
LIG_14-3-3_CanoR_1	54	58	PF00244	0.578
LIG_BRCT_BRCA1_1	77	81	PF00533	0.528
LIG_FHA_1	120	126	PF00498	0.452
LIG_FHA_1	5	11	PF00498	0.462
LIG_FHA_1	69	75	PF00498	0.787
LIG_FHA_2	125	131	PF00498	0.460
LIG_FHA_2	44	50	PF00498	0.531
LIG_LIR_Gen_1	111	118	PF02991	0.440
LIG_LIR_Gen_1	48	57	PF02991	0.480
LIG_LIR_Nem_3	111	117	PF02991	0.393
LIG_LIR_Nem_3	48	53	PF02991	0.470
LIG_MYND_1	140	144	PF01753	0.562
LIG_NRBOX	40	46	PF00104	0.421
LIG_SH2_STAP1	114	118	PF00017	0.452
LIG_SH2_STAT5	92	95	PF00017	0.519
LIG_SH3_3	33	39	PF00018	0.556
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.480
LIG_SUMO_SIM_par_1	124	130	PF11976	0.408
LIG_SUMO_SIM_par_1	203	209	PF11976	0.434
LIG_SUMO_SIM_par_1	40	46	PF11976	0.421
LIG_TRAF2_1	168	171	PF00917	0.554
LIG_UBA3_1	5	12	PF00899	0.495
MOD_CK1_1	231	237	PF00069	0.541
MOD_CK1_1	43	49	PF00069	0.489
MOD_CK2_1	124	130	PF00069	0.452
MOD_CK2_1	5	11	PF00069	0.427
MOD_CK2_1	53	59	PF00069	0.539
MOD_GlcNHglycan	2	5	PF01048	0.549
MOD_GlcNHglycan	33	36	PF01048	0.632
MOD_GlcNHglycan	48	53	PF01048	0.529
MOD_GlcNHglycan	68	71	PF01048	0.683
MOD_GlcNHglycan	77	80	PF01048	0.617
MOD_GSK3_1	26	33	PF00069	0.617
MOD_GSK3_1	73	80	PF00069	0.639
MOD_N-GLC_1	231	236	PF02516	0.495
MOD_NEK2_1	5	10	PF00069	0.438
MOD_PKA_2	53	59	PF00069	0.577
MOD_Plk_1	231	237	PF00069	0.496
MOD_Plk_1	48	54	PF00069	0.531
MOD_Plk_1	59	65	PF00069	0.535
MOD_Plk_2-3	124	130	PF00069	0.478
MOD_Plk_4	37	43	PF00069	0.653
MOD_Plk_4	5	11	PF00069	0.427
MOD_ProDKin_1	135	141	PF00069	0.598
MOD_ProDKin_1	26	32	PF00069	0.678
MOD_ProDKin_1	43	49	PF00069	0.547
MOD_SUMO_for_1	223	226	PF00179	0.606
MOD_SUMO_rev_2	193	198	PF00179	0.460
MOD_SUMO_rev_2	226	231	PF00179	0.622
TRG_DiLeu_BaEn_1	130	135	PF01217	0.513
TRG_ENDOCYTIC_2	114	117	PF00928	0.455
TRG_ENDOCYTIC_2	92	95	PF00928	0.461
TRG_ER_diArg_1	112	114	PF00400	0.442
TRG_ER_diArg_1	17	20	PF00400	0.494
TRG_ER_diArg_1	53	55	PF00400	0.477
TRG_NLS_MonoCore_2	237	242	PF00514	0.736
TRG_NLS_MonoExtC_3	237	243	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Q3	Leptomonas seymouri	50%	100%
A0A3S7WSS0	Leishmania donovani	98%	100%
A0A422P490	Trypanosoma rangeli	31%	100%
A4H7C4	Leishmania braziliensis	76%	100%
E9APG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG12	Leishmania major	88%	98%