Leucine-rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies) - putative

Species:

Leishmania infantum

UniProt:

A4HVS1_LEIIN

TriTrypDb:

LINF_130019700

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HVS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.590
CLV_NRD_NRD_1	108	110	PF00675	0.609
CLV_NRD_NRD_1	320	322	PF00675	0.790
CLV_NRD_NRD_1	331	333	PF00675	0.494
CLV_NRD_NRD_1	401	403	PF00675	0.534
CLV_NRD_NRD_1	514	516	PF00675	0.532
CLV_NRD_NRD_1	553	555	PF00675	0.637
CLV_PCSK_FUR_1	512	516	PF00082	0.503
CLV_PCSK_KEX2_1	108	110	PF00082	0.629
CLV_PCSK_KEX2_1	320	322	PF00082	0.790
CLV_PCSK_KEX2_1	331	333	PF00082	0.494
CLV_PCSK_KEX2_1	401	403	PF00082	0.534
CLV_PCSK_KEX2_1	512	514	PF00082	0.506
CLV_PCSK_KEX2_1	553	555	PF00082	0.590
CLV_PCSK_SKI1_1	119	123	PF00082	0.654
CLV_PCSK_SKI1_1	162	166	PF00082	0.480
DEG_SPOP_SBC_1	597	601	PF00917	0.676
DOC_CKS1_1	573	578	PF01111	0.614
DOC_CKS1_1	63	68	PF01111	0.517
DOC_PP4_FxxP_1	115	118	PF00568	0.642
DOC_USP7_MATH_1	243	247	PF00917	0.424
DOC_USP7_MATH_1	342	346	PF00917	0.572
DOC_USP7_MATH_1	424	428	PF00917	0.628
DOC_USP7_MATH_1	452	456	PF00917	0.630
DOC_USP7_MATH_1	457	461	PF00917	0.564
DOC_USP7_MATH_1	562	566	PF00917	0.638
DOC_USP7_UBL2_3	609	613	PF12436	0.612
DOC_WW_Pin1_4	354	359	PF00397	0.636
DOC_WW_Pin1_4	407	412	PF00397	0.627
DOC_WW_Pin1_4	417	422	PF00397	0.782
DOC_WW_Pin1_4	572	577	PF00397	0.606
DOC_WW_Pin1_4	62	67	PF00397	0.557
LIG_14-3-3_CanoR_1	108	116	PF00244	0.546
LIG_14-3-3_CanoR_1	119	129	PF00244	0.563
LIG_14-3-3_CanoR_1	162	170	PF00244	0.410
LIG_14-3-3_CanoR_1	320	330	PF00244	0.608
LIG_14-3-3_CanoR_1	341	349	PF00244	0.587
LIG_14-3-3_CanoR_1	500	506	PF00244	0.498
LIG_14-3-3_CanoR_1	87	93	PF00244	0.614
LIG_14-3-3_CanoR_1	94	101	PF00244	0.640
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	430	434	PF00533	0.621
LIG_BRCT_BRCA1_1	96	100	PF00533	0.583
LIG_CaM_IQ_9	505	521	PF13499	0.497
LIG_Clathr_ClatBox_1	531	535	PF01394	0.488
LIG_FHA_1	130	136	PF00498	0.482
LIG_FHA_1	152	158	PF00498	0.438
LIG_FHA_1	454	460	PF00498	0.552
LIG_FHA_1	467	473	PF00498	0.456
LIG_FHA_1	477	483	PF00498	0.416
LIG_FHA_1	526	532	PF00498	0.478
LIG_FHA_1	538	544	PF00498	0.505
LIG_FHA_2	404	410	PF00498	0.532
LIG_FHA_2	463	469	PF00498	0.488
LIG_FHA_2	5	11	PF00498	0.462
LIG_Integrin_RGD_1	466	468	PF01839	0.476
LIG_LIR_Gen_1	221	230	PF02991	0.411
LIG_LIR_Nem_3	221	225	PF02991	0.480
LIG_NRP_CendR_1	624	625	PF00754	0.679
LIG_PCNA_PIPBox_1	488	497	PF02747	0.425
LIG_PTB_Apo_2	472	479	PF02174	0.471
LIG_RPA_C_Fungi	336	348	PF08784	0.512
LIG_SH2_CRK	14	18	PF00017	0.563
LIG_SH2_CRK	473	477	PF00017	0.462
LIG_SH2_GRB2like	473	476	PF00017	0.430
LIG_SH2_SRC	222	225	PF00017	0.374
LIG_SH2_STAP1	527	531	PF00017	0.477
LIG_SH2_STAT3	277	280	PF00017	0.481
LIG_SH2_STAT5	180	183	PF00017	0.382
LIG_SH2_STAT5	222	225	PF00017	0.422
LIG_SH2_STAT5	277	280	PF00017	0.439
LIG_SH2_STAT5	527	530	PF00017	0.478
LIG_SH3_1	355	361	PF00018	0.567
LIG_SH3_1	613	619	PF00018	0.625
LIG_SH3_2	421	426	PF14604	0.563
LIG_SH3_2	619	624	PF14604	0.653
LIG_SH3_3	154	160	PF00018	0.489
LIG_SH3_3	355	361	PF00018	0.567
LIG_SH3_3	405	411	PF00018	0.590
LIG_SH3_3	418	424	PF00018	0.529
LIG_SH3_3	564	570	PF00018	0.663
LIG_SH3_3	602	608	PF00018	0.800
LIG_SH3_3	613	619	PF00018	0.577
LIG_SH3_CIN85_PxpxPR_1	619	624	PF14604	0.653
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.472
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.536
LIG_SUMO_SIM_par_1	528	535	PF11976	0.492
LIG_TRAF2_1	604	607	PF00917	0.548
LIG_TRAF2_1	7	10	PF00917	0.455
LIG_TYR_ITIM	220	225	PF00017	0.376
LIG_UBA3_1	531	536	PF00899	0.468
LIG_WW_3	374	378	PF00397	0.608
LIG_WW_3	621	625	PF00397	0.657
MOD_CDK_SPK_2	407	412	PF00069	0.576
MOD_CK1_1	120	126	PF00069	0.599
MOD_CK1_1	246	252	PF00069	0.444
MOD_CK1_1	306	312	PF00069	0.669
MOD_CK1_1	363	369	PF00069	0.646
MOD_CK1_1	525	531	PF00069	0.534
MOD_CK1_1	549	555	PF00069	0.608
MOD_CK1_1	595	601	PF00069	0.670
MOD_CK2_1	305	311	PF00069	0.587
MOD_CK2_1	4	10	PF00069	0.468
MOD_CK2_1	403	409	PF00069	0.521
MOD_CK2_1	75	81	PF00069	0.665
MOD_GlcNHglycan	110	113	PF01048	0.630
MOD_GlcNHglycan	119	122	PF01048	0.574
MOD_GlcNHglycan	124	127	PF01048	0.552
MOD_GlcNHglycan	311	314	PF01048	0.558
MOD_GlcNHglycan	321	324	PF01048	0.561
MOD_GlcNHglycan	365	368	PF01048	0.785
MOD_GlcNHglycan	370	374	PF01048	0.622
MOD_GlcNHglycan	377	380	PF01048	0.528
MOD_GlcNHglycan	417	420	PF01048	0.663
MOD_GlcNHglycan	430	433	PF01048	0.584
MOD_GlcNHglycan	458	462	PF01048	0.548
MOD_GlcNHglycan	524	527	PF01048	0.494
MOD_GlcNHglycan	54	57	PF01048	0.643
MOD_GlcNHglycan	564	567	PF01048	0.637
MOD_GSK3_1	120	127	PF00069	0.689
MOD_GSK3_1	246	253	PF00069	0.577
MOD_GSK3_1	303	310	PF00069	0.670
MOD_GSK3_1	40	47	PF00069	0.661
MOD_GSK3_1	403	410	PF00069	0.588
MOD_GSK3_1	413	420	PF00069	0.682
MOD_GSK3_1	424	431	PF00069	0.584
MOD_GSK3_1	453	460	PF00069	0.549
MOD_GSK3_1	462	469	PF00069	0.507
MOD_GSK3_1	476	483	PF00069	0.593
MOD_GSK3_1	48	55	PF00069	0.595
MOD_GSK3_1	521	528	PF00069	0.573
MOD_GSK3_1	545	552	PF00069	0.490
MOD_GSK3_1	591	598	PF00069	0.663
MOD_GSK3_1	95	102	PF00069	0.542
MOD_N-GLC_1	174	179	PF02516	0.409
MOD_N-GLC_1	228	233	PF02516	0.504
MOD_N-GLC_1	250	255	PF02516	0.465
MOD_N-GLC_1	424	429	PF02516	0.663
MOD_N-GLC_1	591	596	PF02516	0.559
MOD_NEK2_1	100	105	PF00069	0.554
MOD_NEK2_1	174	179	PF00069	0.380
MOD_NEK2_1	250	255	PF00069	0.413
MOD_NEK2_1	462	467	PF00069	0.524
MOD_NEK2_2	13	18	PF00069	0.513
MOD_NEK2_2	326	331	PF00069	0.608
MOD_PIKK_1	129	135	PF00454	0.543
MOD_PIKK_1	193	199	PF00454	0.467
MOD_PIKK_1	476	482	PF00454	0.451
MOD_PK_1	614	620	PF00069	0.628
MOD_PKA_1	108	114	PF00069	0.616
MOD_PKA_2	108	114	PF00069	0.616
MOD_PKA_2	319	325	PF00069	0.616
MOD_PKA_2	546	552	PF00069	0.597
MOD_PKB_1	426	434	PF00069	0.567
MOD_Plk_1	174	180	PF00069	0.410
MOD_Plk_1	457	463	PF00069	0.556
MOD_Plk_1	496	502	PF00069	0.434
MOD_Plk_2-3	218	224	PF00069	0.420
MOD_Plk_4	136	142	PF00069	0.439
MOD_Plk_4	218	224	PF00069	0.502
MOD_Plk_4	527	533	PF00069	0.534
MOD_Plk_4	64	70	PF00069	0.555
MOD_Plk_4	96	102	PF00069	0.511
MOD_ProDKin_1	354	360	PF00069	0.634
MOD_ProDKin_1	407	413	PF00069	0.627
MOD_ProDKin_1	417	423	PF00069	0.781
MOD_ProDKin_1	572	578	PF00069	0.606
MOD_ProDKin_1	62	68	PF00069	0.562
MOD_SUMO_rev_2	442	449	PF00179	0.692
TRG_DiLeu_BaEn_1	136	141	PF01217	0.540
TRG_DiLeu_BaEn_1	190	195	PF01217	0.469
TRG_DiLeu_BaEn_1	390	395	PF01217	0.475
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.505
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.535
TRG_ENDOCYTIC_2	14	17	PF00928	0.486
TRG_ENDOCYTIC_2	222	225	PF00928	0.405
TRG_ENDOCYTIC_2	473	476	PF00928	0.464
TRG_ER_diArg_1	107	109	PF00400	0.612
TRG_ER_diArg_1	330	332	PF00400	0.588
TRG_ER_diArg_1	400	402	PF00400	0.526
TRG_ER_diArg_1	512	515	PF00400	0.503
TRG_ER_diArg_1	623	625	PF00400	0.671
TRG_NES_CRM1_1	193	207	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P881	Leptomonas seymouri	41%	100%
A0A3S7WSM9	Leishmania donovani	100%	100%
A4H7C5	Leishmania braziliensis	65%	99%
E9APG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QG11	Leishmania major	88%	100%