Ubiquitin-conjugating enzyme-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme - putative

Species:

Leishmania infantum

UniProt:

A4HVS0_LEIIN

TriTrypDb:

LINF_130021300

Length:

138

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-conjugating enzyme-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HVS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVS0

PDB structure(s): 6zm3_BBB , 6zm3_DDD

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016874	ligase activity	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.330
CLV_NRD_NRD_1	117	119	PF00675	0.274
CLV_NRD_NRD_1	126	128	PF00675	0.266
CLV_PCSK_KEX2_1	106	108	PF00082	0.330
CLV_Separin_Metazoa	3	7	PF03568	0.367
DEG_MDM2_SWIB_1	38	46	PF02201	0.338
DOC_MAPK_gen_1	106	114	PF00069	0.408
DOC_MAPK_MEF2A_6	71	78	PF00069	0.306
DOC_USP7_MATH_1	133	137	PF00917	0.544
LIG_14-3-3_CanoR_1	106	111	PF00244	0.295

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW9	Leptomonas seymouri	82%	100%
A0A0S4INP2	Bodo saltans	68%	72%
A0A1X0NJQ5	Trypanosomatidae	74%	100%
A0A3S5H6Q3	Leishmania donovani	100%	100%
A0A422P4A8	Trypanosoma rangeli	75%	100%
A4H7E8	Leishmania braziliensis	93%	100%
D0A6F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9API2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O45495	Caenorhabditis elegans	43%	99%
O74983	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	99%

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