LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HVR4_LEIIN
TriTrypDb:
LINF_130018800
Length:
837

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 374

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HVR4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVR4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 195 197 PF00675 0.437
CLV_NRD_NRD_1 42 44 PF00675 0.437
CLV_NRD_NRD_1 598 600 PF00675 0.565
CLV_NRD_NRD_1 816 818 PF00675 0.444
CLV_PCSK_KEX2_1 42 44 PF00082 0.444
CLV_PCSK_KEX2_1 598 600 PF00082 0.565
CLV_PCSK_KEX2_1 613 615 PF00082 0.593
CLV_PCSK_KEX2_1 797 799 PF00082 0.425
CLV_PCSK_PC1ET2_1 613 615 PF00082 0.620
CLV_PCSK_PC1ET2_1 797 799 PF00082 0.425
CLV_PCSK_SKI1_1 197 201 PF00082 0.453
CLV_PCSK_SKI1_1 229 233 PF00082 0.517
CLV_PCSK_SKI1_1 254 258 PF00082 0.456
CLV_PCSK_SKI1_1 35 39 PF00082 0.425
CLV_PCSK_SKI1_1 391 395 PF00082 0.646
CLV_PCSK_SKI1_1 42 46 PF00082 0.382
CLV_PCSK_SKI1_1 557 561 PF00082 0.452
CLV_PCSK_SKI1_1 649 653 PF00082 0.522
CLV_PCSK_SKI1_1 659 663 PF00082 0.551
CLV_PCSK_SKI1_1 698 702 PF00082 0.522
CLV_PCSK_SKI1_1 733 737 PF00082 0.471
DEG_APCC_DBOX_1 487 495 PF00400 0.557
DEG_COP1_1 205 214 PF00400 0.427
DEG_MDM2_SWIB_1 768 776 PF02201 0.345
DEG_Nend_UBRbox_2 1 3 PF02207 0.455
DEG_SCF_FBW7_1 157 164 PF00400 0.531
DEG_SPOP_SBC_1 412 416 PF00917 0.609
DOC_CKS1_1 158 163 PF01111 0.533
DOC_CYCLIN_RxL_1 554 561 PF00134 0.487
DOC_CYCLIN_yCln2_LP_2 735 741 PF00134 0.464
DOC_MAPK_gen_1 289 297 PF00069 0.360
DOC_MAPK_gen_1 42 49 PF00069 0.428
DOC_MAPK_MEF2A_6 733 741 PF00069 0.477
DOC_PP1_RVXF_1 239 246 PF00149 0.451
DOC_PP2B_LxvP_1 179 182 PF13499 0.349
DOC_PP2B_LxvP_1 578 581 PF13499 0.672
DOC_PP2B_LxvP_1 735 738 PF13499 0.428
DOC_PP4_FxxP_1 749 752 PF00568 0.526
DOC_USP7_MATH_1 129 133 PF00917 0.469
DOC_USP7_MATH_1 15 19 PF00917 0.511
DOC_USP7_MATH_1 182 186 PF00917 0.458
DOC_USP7_MATH_1 247 251 PF00917 0.516
DOC_USP7_MATH_1 318 322 PF00917 0.447
DOC_USP7_MATH_1 356 360 PF00917 0.498
DOC_USP7_MATH_1 362 366 PF00917 0.565
DOC_USP7_MATH_1 412 416 PF00917 0.571
DOC_USP7_MATH_1 430 434 PF00917 0.566
DOC_USP7_MATH_1 476 480 PF00917 0.593
DOC_USP7_MATH_1 515 519 PF00917 0.675
DOC_USP7_MATH_1 550 554 PF00917 0.534
DOC_USP7_MATH_1 647 651 PF00917 0.535
DOC_USP7_UBL2_3 162 166 PF12436 0.459
DOC_USP7_UBL2_3 254 258 PF12436 0.486
DOC_USP7_UBL2_3 266 270 PF12436 0.520
DOC_USP7_UBL2_3 818 822 PF12436 0.505
DOC_WW_Pin1_4 157 162 PF00397 0.501
DOC_WW_Pin1_4 405 410 PF00397 0.641
DOC_WW_Pin1_4 497 502 PF00397 0.602
DOC_WW_Pin1_4 677 682 PF00397 0.636
DOC_WW_Pin1_4 728 733 PF00397 0.439
LIG_14-3-3_CanoR_1 194 200 PF00244 0.481
LIG_14-3-3_CanoR_1 308 313 PF00244 0.375
LIG_14-3-3_CanoR_1 458 467 PF00244 0.463
LIG_14-3-3_CanoR_1 565 569 PF00244 0.537
LIG_14-3-3_CanoR_1 620 624 PF00244 0.525
LIG_14-3-3_CanoR_1 641 651 PF00244 0.603
LIG_Actin_WH2_2 552 567 PF00022 0.491
LIG_BIR_III_4 392 396 PF00653 0.682
LIG_BIR_III_4 514 518 PF00653 0.636
LIG_BRCT_BRCA1_1 26 30 PF00533 0.589
LIG_deltaCOP1_diTrp_1 694 701 PF00928 0.427
LIG_deltaCOP1_diTrp_1 771 775 PF00928 0.505
LIG_FHA_1 148 154 PF00498 0.427
LIG_FHA_1 32 38 PF00498 0.572
LIG_FHA_1 320 326 PF00498 0.471
LIG_FHA_1 347 353 PF00498 0.522
LIG_FHA_1 461 467 PF00498 0.641
LIG_FHA_1 480 486 PF00498 0.319
LIG_FHA_1 50 56 PF00498 0.340
LIG_FHA_1 700 706 PF00498 0.375
LIG_FHA_1 732 738 PF00498 0.396
LIG_FHA_1 776 782 PF00498 0.512
LIG_FHA_1 78 84 PF00498 0.499
LIG_FHA_2 126 132 PF00498 0.483
LIG_FHA_2 184 190 PF00498 0.468
LIG_FHA_2 276 282 PF00498 0.358
LIG_FHA_2 525 531 PF00498 0.602
LIG_FHA_2 619 625 PF00498 0.588
LIG_FHA_2 800 806 PF00498 0.406
LIG_GBD_Chelix_1 825 833 PF00786 0.473
LIG_Integrin_RGD_1 371 373 PF01839 0.690
LIG_KLC1_Yacidic_2 767 771 PF13176 0.429
LIG_LIR_Apic_2 748 752 PF02991 0.514
LIG_LIR_Gen_1 213 222 PF02991 0.445
LIG_LIR_Gen_1 290 297 PF02991 0.426
LIG_LIR_Gen_1 336 345 PF02991 0.395
LIG_LIR_Gen_1 585 594 PF02991 0.643
LIG_LIR_Gen_1 612 623 PF02991 0.591
LIG_LIR_Nem_3 164 170 PF02991 0.519
LIG_LIR_Nem_3 213 217 PF02991 0.422
LIG_LIR_Nem_3 242 248 PF02991 0.409
LIG_LIR_Nem_3 280 286 PF02991 0.352
LIG_LIR_Nem_3 290 296 PF02991 0.345
LIG_LIR_Nem_3 302 307 PF02991 0.480
LIG_LIR_Nem_3 336 342 PF02991 0.462
LIG_LIR_Nem_3 520 526 PF02991 0.588
LIG_LIR_Nem_3 585 591 PF02991 0.655
LIG_LIR_Nem_3 596 600 PF02991 0.593
LIG_LIR_Nem_3 612 618 PF02991 0.484
LIG_LIR_Nem_3 88 93 PF02991 0.417
LIG_LYPXL_yS_3 167 170 PF13949 0.379
LIG_NRBOX 555 561 PF00104 0.570
LIG_PALB2_WD40_1 374 382 PF16756 0.678
LIG_PCNA_yPIPBox_3 50 58 PF02747 0.500
LIG_Pex14_1 697 701 PF04695 0.400
LIG_Pex14_2 214 218 PF04695 0.419
LIG_Pex14_2 768 772 PF04695 0.335
LIG_SH2_CRK 293 297 PF00017 0.439
LIG_SH2_CRK 523 527 PF00017 0.563
LIG_SH2_CRK 597 601 PF00017 0.602
LIG_SH2_CRK 793 797 PF00017 0.515
LIG_SH2_PTP2 283 286 PF00017 0.324
LIG_SH2_SRC 273 276 PF00017 0.474
LIG_SH2_SRC 793 796 PF00017 0.416
LIG_SH2_STAP1 125 129 PF00017 0.501
LIG_SH2_STAP1 273 277 PF00017 0.474
LIG_SH2_STAP1 293 297 PF00017 0.439
LIG_SH2_STAP1 339 343 PF00017 0.481
LIG_SH2_STAT5 136 139 PF00017 0.420
LIG_SH2_STAT5 283 286 PF00017 0.327
LIG_SH2_STAT5 769 772 PF00017 0.376
LIG_SH3_3 155 161 PF00018 0.444
LIG_SH3_3 162 168 PF00018 0.385
LIG_SH3_3 200 206 PF00018 0.402
LIG_SH3_3 675 681 PF00018 0.607
LIG_SH3_5 168 172 PF00018 0.456
LIG_Sin3_3 176 183 PF02671 0.333
LIG_SUMO_SIM_anti_2 112 118 PF11976 0.467
LIG_SUMO_SIM_anti_2 185 193 PF11976 0.457
LIG_SUMO_SIM_anti_2 230 235 PF11976 0.465
LIG_SUMO_SIM_anti_2 709 714 PF11976 0.369
LIG_SUMO_SIM_anti_2 97 102 PF11976 0.411
LIG_SUMO_SIM_par_1 230 235 PF11976 0.465
LIG_SxIP_EBH_1 150 162 PF03271 0.510
LIG_TRAF2_1 269 272 PF00917 0.467
LIG_TRAF2_1 279 282 PF00917 0.313
LIG_TRAF2_1 593 596 PF00917 0.604
LIG_TYR_ITIM 165 170 PF00017 0.386
LIG_UBA3_1 44 50 PF00899 0.350
LIG_UBA3_1 54 63 PF00899 0.402
LIG_WRC_WIRS_1 211 216 PF05994 0.468
MOD_CDK_SPK_2 157 162 PF00069 0.534
MOD_CDK_SPK_2 728 733 PF00069 0.500
MOD_CK1_1 192 198 PF00069 0.402
MOD_CK1_1 224 230 PF00069 0.510
MOD_CK1_1 23 29 PF00069 0.560
MOD_CK1_1 321 327 PF00069 0.410
MOD_CK1_1 331 337 PF00069 0.464
MOD_CK1_1 424 430 PF00069 0.628
MOD_CK1_1 479 485 PF00069 0.649
MOD_CK1_1 500 506 PF00069 0.636
MOD_CK1_1 518 524 PF00069 0.461
MOD_CK1_1 627 633 PF00069 0.553
MOD_CK1_1 731 737 PF00069 0.442
MOD_CK2_1 111 117 PF00069 0.502
MOD_CK2_1 125 131 PF00069 0.479
MOD_CK2_1 224 230 PF00069 0.514
MOD_CK2_1 275 281 PF00069 0.373
MOD_CK2_1 422 428 PF00069 0.697
MOD_CK2_1 524 530 PF00069 0.523
MOD_CK2_1 590 596 PF00069 0.603
MOD_CK2_1 618 624 PF00069 0.598
MOD_CK2_1 647 653 PF00069 0.581
MOD_CK2_1 799 805 PF00069 0.400
MOD_CMANNOS 772 775 PF00535 0.500
MOD_GlcNHglycan 225 229 PF01048 0.521
MOD_GlcNHglycan 26 29 PF01048 0.536
MOD_GlcNHglycan 330 333 PF01048 0.524
MOD_GlcNHglycan 458 461 PF01048 0.564
MOD_GlcNHglycan 478 481 PF01048 0.301
MOD_GlcNHglycan 517 520 PF01048 0.693
MOD_GlcNHglycan 547 550 PF01048 0.522
MOD_GlcNHglycan 552 555 PF01048 0.481
MOD_GlcNHglycan 626 629 PF01048 0.558
MOD_GlcNHglycan 645 648 PF01048 0.332
MOD_GSK3_1 111 118 PF00069 0.499
MOD_GSK3_1 125 132 PF00069 0.471
MOD_GSK3_1 157 164 PF00069 0.477
MOD_GSK3_1 20 27 PF00069 0.490
MOD_GSK3_1 331 338 PF00069 0.550
MOD_GSK3_1 351 358 PF00069 0.462
MOD_GSK3_1 408 415 PF00069 0.589
MOD_GSK3_1 420 427 PF00069 0.490
MOD_GSK3_1 430 437 PF00069 0.540
MOD_GSK3_1 452 459 PF00069 0.588
MOD_GSK3_1 467 474 PF00069 0.567
MOD_GSK3_1 493 500 PF00069 0.610
MOD_GSK3_1 619 626 PF00069 0.459
MOD_GSK3_1 643 650 PF00069 0.572
MOD_GSK3_1 700 707 PF00069 0.442
MOD_GSK3_1 727 734 PF00069 0.480
MOD_GSK3_1 77 84 PF00069 0.484
MOD_GSK3_1 828 835 PF00069 0.427
MOD_N-GLC_1 28 33 PF02516 0.577
MOD_N-GLC_1 356 361 PF02516 0.528
MOD_N-GLC_1 582 587 PF02516 0.628
MOD_N-GLC_1 601 606 PF02516 0.569
MOD_N-GLC_1 618 623 PF02516 0.291
MOD_N-GLC_1 64 69 PF02516 0.497
MOD_NEK2_1 115 120 PF00069 0.517
MOD_NEK2_1 190 195 PF00069 0.446
MOD_NEK2_1 22 27 PF00069 0.526
MOD_NEK2_1 232 237 PF00069 0.351
MOD_NEK2_1 261 266 PF00069 0.456
MOD_NEK2_1 319 324 PF00069 0.456
MOD_NEK2_1 341 346 PF00069 0.396
MOD_NEK2_1 351 356 PF00069 0.470
MOD_NEK2_1 37 42 PF00069 0.374
MOD_NEK2_1 426 431 PF00069 0.648
MOD_NEK2_1 456 461 PF00069 0.529
MOD_NEK2_1 467 472 PF00069 0.543
MOD_NEK2_1 533 538 PF00069 0.520
MOD_NEK2_1 618 623 PF00069 0.544
MOD_NEK2_1 739 744 PF00069 0.447
MOD_NEK2_2 161 166 PF00069 0.542
MOD_NEK2_2 460 465 PF00069 0.635
MOD_NEK2_2 647 652 PF00069 0.480
MOD_NEK2_2 775 780 PF00069 0.402
MOD_PIKK_1 102 108 PF00454 0.521
MOD_PIKK_1 129 135 PF00454 0.503
MOD_PIKK_1 249 255 PF00454 0.473
MOD_PIKK_1 434 440 PF00454 0.548
MOD_PIKK_1 660 666 PF00454 0.508
MOD_PIKK_1 784 790 PF00454 0.487
MOD_PIKK_1 828 834 PF00454 0.471
MOD_PK_1 371 377 PF00069 0.582
MOD_PKA_2 195 201 PF00069 0.431
MOD_PKA_2 307 313 PF00069 0.366
MOD_PKA_2 564 570 PF00069 0.571
MOD_PKA_2 619 625 PF00069 0.546
MOD_PKA_2 81 87 PF00069 0.458
MOD_PKA_2 816 822 PF00069 0.386
MOD_Plk_1 109 115 PF00069 0.456
MOD_Plk_1 207 213 PF00069 0.501
MOD_Plk_1 273 279 PF00069 0.401
MOD_Plk_1 28 34 PF00069 0.575
MOD_Plk_1 356 362 PF00069 0.557
MOD_Plk_1 601 607 PF00069 0.558
MOD_Plk_1 618 624 PF00069 0.288
MOD_Plk_1 64 70 PF00069 0.514
MOD_Plk_1 708 714 PF00069 0.334
MOD_Plk_1 798 804 PF00069 0.441
MOD_Plk_2-3 799 805 PF00069 0.418
MOD_Plk_4 111 117 PF00069 0.502
MOD_Plk_4 195 201 PF00069 0.412
MOD_Plk_4 299 305 PF00069 0.502
MOD_Plk_4 430 436 PF00069 0.585
MOD_Plk_4 700 706 PF00069 0.421
MOD_Plk_4 799 805 PF00069 0.468
MOD_Plk_4 85 91 PF00069 0.424
MOD_ProDKin_1 157 163 PF00069 0.496
MOD_ProDKin_1 405 411 PF00069 0.640
MOD_ProDKin_1 497 503 PF00069 0.601
MOD_ProDKin_1 677 683 PF00069 0.628
MOD_ProDKin_1 728 734 PF00069 0.438
MOD_SUMO_for_1 269 272 PF00179 0.495
MOD_SUMO_for_1 651 654 PF00179 0.447
MOD_SUMO_for_1 796 799 PF00179 0.477
MOD_SUMO_rev_2 414 424 PF00179 0.642
MOD_SUMO_rev_2 653 661 PF00179 0.515
MOD_SUMO_rev_2 690 700 PF00179 0.478
MOD_SUMO_rev_2 813 819 PF00179 0.471
TRG_DiLeu_BaEn_3 147 153 PF01217 0.456
TRG_DiLeu_BaEn_4 281 287 PF01217 0.334
TRG_DiLeu_BaLyEn_6 33 38 PF01217 0.462
TRG_DiLeu_BaLyEn_6 40 45 PF01217 0.377
TRG_DiLeu_BaLyEn_6 462 467 PF01217 0.621
TRG_ENDOCYTIC_2 167 170 PF00928 0.379
TRG_ENDOCYTIC_2 283 286 PF00928 0.324
TRG_ENDOCYTIC_2 293 296 PF00928 0.319
TRG_ENDOCYTIC_2 339 342 PF00928 0.386
TRG_ENDOCYTIC_2 523 526 PF00928 0.627
TRG_ENDOCYTIC_2 597 600 PF00928 0.607
TRG_ENDOCYTIC_2 615 618 PF00928 0.426
TRG_ENDOCYTIC_2 793 796 PF00928 0.513
TRG_ER_diArg_1 289 292 PF00400 0.497
TRG_ER_diArg_1 42 44 PF00400 0.449
TRG_ER_diArg_1 485 488 PF00400 0.600
TRG_ER_diArg_1 597 599 PF00400 0.573
TRG_Pf-PMV_PEXEL_1 465 469 PF00026 0.621

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8K9 Leptomonas seymouri 74% 100%
A0A0S4JC92 Bodo saltans 27% 98%
A0A1X0NJD7 Trypanosomatidae 42% 99%
A0A3S7WSL9 Leishmania donovani 100% 100%
A0A422P4C7 Trypanosoma rangeli 39% 100%
A4H7B9 Leishmania braziliensis 89% 100%
D0A6H6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9APG0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QG18 Leishmania major 97% 100%
V5BRN5 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS