G protein-coupled receptor

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVR1_LEIIN

TriTrypDb:

LINF_130018500

Length:

489

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HVR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.536
CLV_C14_Caspase3-7	298	302	PF00656	0.729
CLV_MEL_PAP_1	274	280	PF00089	0.450
CLV_NRD_NRD_1	130	132	PF00675	0.471
CLV_NRD_NRD_1	146	148	PF00675	0.438
CLV_NRD_NRD_1	413	415	PF00675	0.513
CLV_PCSK_FUR_1	410	414	PF00082	0.511
CLV_PCSK_KEX2_1	130	132	PF00082	0.471
CLV_PCSK_KEX2_1	146	148	PF00082	0.438
CLV_PCSK_KEX2_1	409	411	PF00082	0.543
CLV_PCSK_KEX2_1	412	414	PF00082	0.517
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.556
CLV_PCSK_SKI1_1	188	192	PF00082	0.453
CLV_PCSK_SKI1_1	232	236	PF00082	0.655
CLV_PCSK_SKI1_1	29	33	PF00082	0.609
DEG_APCC_DBOX_1	63	71	PF00400	0.584
DEG_SCF_FBW7_1	402	408	PF00400	0.735
DEG_SPOP_SBC_1	189	193	PF00917	0.453
DEG_SPOP_SBC_1	448	452	PF00917	0.474
DOC_CKS1_1	402	407	PF01111	0.735
DOC_MAPK_gen_1	62	70	PF00069	0.588
DOC_MAPK_RevD_3	398	411	PF00069	0.741
DOC_PP4_FxxP_1	217	220	PF00568	0.446
DOC_PP4_FxxP_1	291	294	PF00568	0.725
DOC_USP7_MATH_1	126	130	PF00917	0.686
DOC_USP7_MATH_1	190	194	PF00917	0.453
DOC_USP7_MATH_1	239	243	PF00917	0.521
DOC_USP7_MATH_1	253	257	PF00917	0.374
DOC_USP7_MATH_1	311	315	PF00917	0.658
DOC_USP7_MATH_1	388	392	PF00917	0.773
DOC_USP7_MATH_1	448	452	PF00917	0.432
DOC_USP7_MATH_1	479	483	PF00917	0.492
DOC_USP7_MATH_1	9	13	PF00917	0.473
DOC_USP7_UBL2_3	104	108	PF12436	0.736
DOC_WW_Pin1_4	227	232	PF00397	0.549
DOC_WW_Pin1_4	248	253	PF00397	0.432
DOC_WW_Pin1_4	307	312	PF00397	0.700
DOC_WW_Pin1_4	324	329	PF00397	0.629
DOC_WW_Pin1_4	365	370	PF00397	0.651
DOC_WW_Pin1_4	401	406	PF00397	0.731
DOC_WW_Pin1_4	419	424	PF00397	0.571
DOC_WW_Pin1_4	449	454	PF00397	0.503
DOC_WW_Pin1_4	46	51	PF00397	0.306
LIG_14-3-3_CanoR_1	130	139	PF00244	0.755
LIG_14-3-3_CanoR_1	146	151	PF00244	0.563
LIG_14-3-3_CanoR_1	188	198	PF00244	0.402
LIG_14-3-3_CanoR_1	353	363	PF00244	0.650
LIG_BRCT_BRCA1_1	271	275	PF00533	0.653
LIG_EH1_1	330	338	PF00400	0.615
LIG_eIF4E_1	331	337	PF01652	0.613
LIG_FHA_1	190	196	PF00498	0.326
LIG_FHA_1	238	244	PF00498	0.474
LIG_FHA_1	255	261	PF00498	0.231
LIG_FHA_1	290	296	PF00498	0.698
LIG_FHA_1	402	408	PF00498	0.741
LIG_FHA_1	415	421	PF00498	0.635
LIG_FHA_1	47	53	PF00498	0.457
LIG_FHA_1	481	487	PF00498	0.501
LIG_FHA_2	467	473	PF00498	0.460
LIG_LIR_Apic_2	122	128	PF02991	0.719
LIG_LIR_Apic_2	212	216	PF02991	0.483
LIG_LIR_Gen_1	154	165	PF02991	0.585
LIG_LIR_Gen_1	200	206	PF02991	0.428
LIG_LIR_Gen_1	283	291	PF02991	0.713
LIG_LIR_Gen_1	320	331	PF02991	0.623
LIG_LIR_Nem_3	154	160	PF02991	0.585
LIG_LIR_Nem_3	200	204	PF02991	0.428
LIG_LIR_Nem_3	256	261	PF02991	0.453
LIG_LIR_Nem_3	272	278	PF02991	0.660
LIG_LIR_Nem_3	283	288	PF02991	0.674
LIG_LIR_Nem_3	320	326	PF02991	0.628
LIG_LIR_Nem_3	434	440	PF02991	0.345
LIG_LIR_Nem_3	457	463	PF02991	0.517
LIG_LIR_Nem_3	469	474	PF02991	0.410
LIG_MYND_1	338	342	PF01753	0.642
LIG_PDZ_Class_2	484	489	PF00595	0.518
LIG_Pex14_1	271	275	PF04695	0.656
LIG_SH2_CRK	157	161	PF00017	0.594
LIG_SH2_CRK	182	186	PF00017	0.492
LIG_SH2_CRK	364	368	PF00017	0.603
LIG_SH2_NCK_1	364	368	PF00017	0.603
LIG_SH2_PTP2	213	216	PF00017	0.414
LIG_SH2_STAT5	213	216	PF00017	0.441
LIG_SH2_STAT5	331	334	PF00017	0.630
LIG_SH2_STAT5	474	477	PF00017	0.539
LIG_SH3_2	338	343	PF14604	0.669
LIG_SH3_3	246	252	PF00018	0.447
LIG_SH3_3	335	341	PF00018	0.700
LIG_SH3_3	366	372	PF00018	0.741
LIG_SH3_3	382	388	PF00018	0.632
LIG_SH3_3	399	405	PF00018	0.695
LIG_SH3_3	455	461	PF00018	0.537
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.415
LIG_SUMO_SIM_par_1	460	466	PF11976	0.487
LIG_SUMO_SIM_par_1	482	488	PF11976	0.381
LIG_TRAF2_1	93	96	PF00917	0.745
LIG_WRC_WIRS_1	152	157	PF05994	0.425
LIG_WRC_WIRS_1	198	203	PF05994	0.389
LIG_WRC_WIRS_1	260	265	PF05994	0.453
LIG_WW_3	340	344	PF00397	0.547
MOD_CDK_SPK_2	227	232	PF00069	0.629
MOD_CDK_SPK_2	324	329	PF00069	0.527
MOD_CDK_SPK_2	368	373	PF00069	0.606
MOD_CDK_SPK_2	454	459	PF00069	0.614
MOD_CDK_SPxxK_3	368	375	PF00069	0.679
MOD_CDK_SPxxK_3	419	426	PF00069	0.567
MOD_CK1_1	129	135	PF00069	0.611
MOD_CK1_1	197	203	PF00069	0.387
MOD_CK1_1	230	236	PF00069	0.726
MOD_CK1_1	242	248	PF00069	0.519
MOD_CK1_1	307	313	PF00069	0.548
MOD_CK1_1	368	374	PF00069	0.673
MOD_CK1_1	391	397	PF00069	0.748
MOD_CK1_1	451	457	PF00069	0.566
MOD_CK1_1	482	488	PF00069	0.619
MOD_Cter_Amidation	144	147	PF01082	0.617
MOD_GlcNHglycan	118	124	PF01048	0.646
MOD_GlcNHglycan	235	238	PF01048	0.620
MOD_GlcNHglycan	265	268	PF01048	0.335
MOD_GlcNHglycan	301	305	PF01048	0.718
MOD_GlcNHglycan	388	391	PF01048	0.794
MOD_GlcNHglycan	453	456	PF01048	0.698
MOD_GSK3_1	126	133	PF00069	0.609
MOD_GSK3_1	146	153	PF00069	0.596
MOD_GSK3_1	190	197	PF00069	0.373
MOD_GSK3_1	233	240	PF00069	0.672
MOD_GSK3_1	259	266	PF00069	0.346
MOD_GSK3_1	300	307	PF00069	0.648
MOD_GSK3_1	318	325	PF00069	0.651
MOD_GSK3_1	386	393	PF00069	0.616
MOD_GSK3_1	401	408	PF00069	0.603
MOD_GSK3_1	443	450	PF00069	0.534
MOD_N-GLC_1	254	259	PF02516	0.453
MOD_N-GLC_1	448	453	PF02516	0.541
MOD_NEK2_1	170	175	PF00069	0.426
MOD_NEK2_1	243	248	PF00069	0.656
MOD_NEK2_1	263	268	PF00069	0.335
MOD_NEK2_1	306	311	PF00069	0.619
MOD_NEK2_1	318	323	PF00069	0.588
MOD_NEK2_1	332	337	PF00069	0.421
MOD_NEK2_1	442	447	PF00069	0.506
MOD_NEK2_2	239	244	PF00069	0.601
MOD_PIKK_1	130	136	PF00454	0.641
MOD_PIKK_1	289	295	PF00454	0.607
MOD_PIKK_1	311	317	PF00454	0.620
MOD_PKA_1	130	136	PF00069	0.574
MOD_PKA_1	146	152	PF00069	0.524
MOD_PKA_2	126	132	PF00069	0.671
MOD_PKA_2	146	152	PF00069	0.486
MOD_PKA_2	352	358	PF00069	0.630
MOD_PKB_1	412	420	PF00069	0.665
MOD_Plk_1	119	125	PF00069	0.673
MOD_Plk_1	254	260	PF00069	0.453
MOD_Plk_1	433	439	PF00069	0.389
MOD_Plk_1	97	103	PF00069	0.569
MOD_Plk_4	135	141	PF00069	0.591
MOD_Plk_4	146	152	PF00069	0.550
MOD_Plk_4	197	203	PF00069	0.364
MOD_Plk_4	22	28	PF00069	0.553
MOD_Plk_4	239	245	PF00069	0.600
MOD_Plk_4	280	286	PF00069	0.516
MOD_Plk_4	318	324	PF00069	0.632
MOD_Plk_4	332	338	PF00069	0.426
MOD_Plk_4	346	352	PF00069	0.524
MOD_Plk_4	482	488	PF00069	0.508
MOD_Plk_4	9	15	PF00069	0.664
MOD_ProDKin_1	227	233	PF00069	0.689
MOD_ProDKin_1	248	254	PF00069	0.523
MOD_ProDKin_1	307	313	PF00069	0.621
MOD_ProDKin_1	324	330	PF00069	0.522
MOD_ProDKin_1	365	371	PF00069	0.563
MOD_ProDKin_1	401	407	PF00069	0.674
MOD_ProDKin_1	419	425	PF00069	0.438
MOD_ProDKin_1	449	455	PF00069	0.634
MOD_ProDKin_1	46	52	PF00069	0.306
MOD_SUMO_rev_2	25	34	PF00179	0.620
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.713
TRG_ENDOCYTIC_2	157	160	PF00928	0.550
TRG_ENDOCYTIC_2	182	185	PF00928	0.490
TRG_ENDOCYTIC_2	331	334	PF00928	0.510
TRG_ER_diArg_1	410	413	PF00400	0.661
TRG_NLS_MonoCore_2	408	413	PF00514	0.699
TRG_NLS_MonoExtC_3	408	413	PF00514	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I976	Leptomonas seymouri	43%	95%
A0A3Q8ICY4	Leishmania donovani	98%	100%
A4H7B6	Leishmania braziliensis	71%	98%
E9APF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QG21	Leishmania major	89%	100%