Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HVQ7_LEIIN

TriTrypDb:

LINF_130018100

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HVQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HVQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.631
CLV_C14_Caspase3-7	621	625	PF00656	0.424
CLV_C14_Caspase3-7	782	786	PF00656	0.567
CLV_NRD_NRD_1	264	266	PF00675	0.773
CLV_NRD_NRD_1	298	300	PF00675	0.624
CLV_NRD_NRD_1	519	521	PF00675	0.508
CLV_NRD_NRD_1	576	578	PF00675	0.690
CLV_NRD_NRD_1	583	585	PF00675	0.635
CLV_PCSK_FUR_1	262	266	PF00082	0.773
CLV_PCSK_KEX2_1	261	263	PF00082	0.661
CLV_PCSK_KEX2_1	264	266	PF00082	0.655
CLV_PCSK_KEX2_1	298	300	PF00082	0.624
CLV_PCSK_KEX2_1	519	521	PF00082	0.508
CLV_PCSK_KEX2_1	583	585	PF00082	0.696
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.650
CLV_PCSK_SKI1_1	449	453	PF00082	0.511
CLV_PCSK_SKI1_1	620	624	PF00082	0.403
CLV_PCSK_SKI1_1	680	684	PF00082	0.424
CLV_PCSK_SKI1_1	69	73	PF00082	0.678
CLV_PCSK_SKI1_1	7	11	PF00082	0.633
CLV_PCSK_SKI1_1	854	858	PF00082	0.387
DEG_APCC_DBOX_1	448	456	PF00400	0.509
DEG_APCC_DBOX_1	619	627	PF00400	0.516
DEG_SPOP_SBC_1	100	104	PF00917	0.740
DEG_SPOP_SBC_1	305	309	PF00917	0.705
DEG_SPOP_SBC_1	58	62	PF00917	0.679
DEG_SPOP_SBC_1	719	723	PF00917	0.688
DEG_SPOP_SBC_1	758	762	PF00917	0.634
DOC_ANK_TNKS_1	149	156	PF00023	0.606
DOC_ANK_TNKS_1	766	773	PF00023	0.781
DOC_CKS1_1	763	768	PF01111	0.731
DOC_CYCLIN_RxL_1	156	166	PF00134	0.610
DOC_MAPK_gen_1	43	51	PF00069	0.693
DOC_MAPK_MEF2A_6	449	456	PF00069	0.510
DOC_MAPK_NFAT4_5	449	457	PF00069	0.509
DOC_PP2B_LxvP_1	161	164	PF13499	0.612
DOC_PP2B_LxvP_1	593	596	PF13499	0.599
DOC_PP4_FxxP_1	143	146	PF00568	0.710
DOC_PP4_FxxP_1	498	501	PF00568	0.518
DOC_USP7_MATH_1	100	104	PF00917	0.740
DOC_USP7_MATH_1	12	16	PF00917	0.639
DOC_USP7_MATH_1	120	124	PF00917	0.473
DOC_USP7_MATH_1	165	169	PF00917	0.610
DOC_USP7_MATH_1	218	222	PF00917	0.786
DOC_USP7_MATH_1	301	305	PF00917	0.707
DOC_USP7_MATH_1	322	326	PF00917	0.651
DOC_USP7_MATH_1	354	358	PF00917	0.752
DOC_USP7_MATH_1	410	414	PF00917	0.678
DOC_USP7_MATH_1	415	419	PF00917	0.615
DOC_USP7_MATH_1	434	438	PF00917	0.642
DOC_USP7_MATH_1	439	443	PF00917	0.601
DOC_USP7_MATH_1	505	509	PF00917	0.647
DOC_USP7_MATH_1	58	62	PF00917	0.744
DOC_USP7_MATH_1	756	760	PF00917	0.660
DOC_USP7_MATH_1	774	778	PF00917	0.671
DOC_USP7_MATH_1	869	873	PF00917	0.519
DOC_WW_Pin1_4	167	172	PF00397	0.677
DOC_WW_Pin1_4	24	29	PF00397	0.688
DOC_WW_Pin1_4	299	304	PF00397	0.607
DOC_WW_Pin1_4	312	317	PF00397	0.645
DOC_WW_Pin1_4	339	344	PF00397	0.605
DOC_WW_Pin1_4	497	502	PF00397	0.565
DOC_WW_Pin1_4	568	573	PF00397	0.677
DOC_WW_Pin1_4	64	69	PF00397	0.731
DOC_WW_Pin1_4	685	690	PF00397	0.566
DOC_WW_Pin1_4	727	732	PF00397	0.690
DOC_WW_Pin1_4	762	767	PF00397	0.762
DOC_WW_Pin1_4	770	775	PF00397	0.616
DOC_WW_Pin1_4	841	846	PF00397	0.676
DOC_WW_Pin1_4	89	94	PF00397	0.698
LIG_14-3-3_CanoR_1	150	156	PF00244	0.635
LIG_14-3-3_CanoR_1	21	28	PF00244	0.575
LIG_14-3-3_CanoR_1	268	277	PF00244	0.704
LIG_14-3-3_CanoR_1	280	284	PF00244	0.571
LIG_14-3-3_CanoR_1	473	482	PF00244	0.510
LIG_14-3-3_CanoR_1	492	498	PF00244	0.594
LIG_14-3-3_CanoR_1	648	657	PF00244	0.676
LIG_14-3-3_CanoR_1	680	686	PF00244	0.381
LIG_14-3-3_CanoR_1	790	798	PF00244	0.309
LIG_14-3-3_CanoR_1	834	843	PF00244	0.637
LIG_14-3-3_CanoR_1	866	872	PF00244	0.404
LIG_14-3-3_CanoR_1	897	901	PF00244	0.413
LIG_Actin_WH2_2	886	904	PF00022	0.537
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_3	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	341	345	PF00533	0.643
LIG_BRCT_BRCA1_1	478	482	PF00533	0.656
LIG_BRCT_BRCA1_1	493	497	PF00533	0.486
LIG_BRCT_BRCA1_1	507	511	PF00533	0.620
LIG_Clathr_ClatBox_1	453	457	PF01394	0.505
LIG_Clathr_ClatBox_1	699	703	PF01394	0.443
LIG_deltaCOP1_diTrp_1	543	551	PF00928	0.403
LIG_EVH1_1	498	502	PF00568	0.489
LIG_FHA_1	223	229	PF00498	0.703
LIG_FHA_1	319	325	PF00498	0.753
LIG_FHA_1	371	377	PF00498	0.690
LIG_FHA_1	433	439	PF00498	0.534
LIG_FHA_1	550	556	PF00498	0.530
LIG_FHA_1	562	568	PF00498	0.578
LIG_FHA_1	639	645	PF00498	0.652
LIG_FHA_1	739	745	PF00498	0.667
LIG_FHA_1	791	797	PF00498	0.380
LIG_FHA_2	619	625	PF00498	0.520
LIG_FHA_2	712	718	PF00498	0.668
LIG_FHA_2	721	727	PF00498	0.728
LIG_GBD_Chelix_1	514	522	PF00786	0.351
LIG_LIR_Apic_2	141	146	PF02991	0.705
LIG_LIR_Apic_2	496	501	PF02991	0.531
LIG_LIR_Apic_2	683	689	PF02991	0.433
LIG_LIR_Gen_1	342	352	PF02991	0.585
LIG_LIR_Gen_1	494	503	PF02991	0.539
LIG_LIR_Gen_1	508	518	PF02991	0.472
LIG_LIR_Gen_1	837	847	PF02991	0.680
LIG_LIR_Nem_3	342	348	PF02991	0.585
LIG_LIR_Nem_3	423	428	PF02991	0.649
LIG_LIR_Nem_3	480	486	PF02991	0.637
LIG_LIR_Nem_3	494	498	PF02991	0.511
LIG_LIR_Nem_3	508	514	PF02991	0.512
LIG_LIR_Nem_3	837	843	PF02991	0.688
LIG_MLH1_MIPbox_1	479	483	PF16413	0.629
LIG_NRBOX	677	683	PF00104	0.471
LIG_PCNA_yPIPBox_3	608	620	PF02747	0.395
LIG_SH2_CRK	112	116	PF00017	0.556
LIG_SH2_CRK	798	802	PF00017	0.388
LIG_SH2_PTP2	686	689	PF00017	0.504
LIG_SH2_STAP1	911	915	PF00017	0.411
LIG_SH2_STAT5	283	286	PF00017	0.647
LIG_SH2_STAT5	541	544	PF00017	0.404
LIG_SH2_STAT5	686	689	PF00017	0.427
LIG_SH3_1	87	93	PF00018	0.728
LIG_SH3_3	143	149	PF00018	0.721
LIG_SH3_3	214	220	PF00018	0.689
LIG_SH3_3	313	319	PF00018	0.664
LIG_SH3_3	375	381	PF00018	0.697
LIG_SH3_3	48	54	PF00018	0.751
LIG_SH3_3	496	502	PF00018	0.682
LIG_SH3_3	592	598	PF00018	0.764
LIG_SH3_3	684	690	PF00018	0.608
LIG_SH3_3	728	734	PF00018	0.651
LIG_SH3_3	768	774	PF00018	0.673
LIG_SH3_3	87	93	PF00018	0.676
LIG_SH3_3	875	881	PF00018	0.496
LIG_Sin3_3	320	327	PF02671	0.573
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.443
LIG_SUMO_SIM_anti_2	674	680	PF11976	0.455
LIG_SUMO_SIM_par_1	450	457	PF11976	0.503
LIG_SUMO_SIM_par_1	563	569	PF11976	0.548
LIG_TRAF2_1	176	179	PF00917	0.648
LIG_TYR_ITIM	796	801	PF00017	0.388
LIG_Vh1_VBS_1	860	878	PF01044	0.520
LIG_WRC_WIRS_1	422	427	PF05994	0.570
LIG_WW_3	147	151	PF00397	0.606
LIG_WW_3	688	692	PF00397	0.482
MOD_CDC14_SPxK_1	688	691	PF00782	0.488
MOD_CDK_SPK_2	64	69	PF00069	0.707
MOD_CDK_SPK_2	762	767	PF00069	0.731
MOD_CDK_SPK_2	841	846	PF00069	0.613
MOD_CDK_SPxK_1	685	691	PF00069	0.470
MOD_CDK_SPxxK_3	841	848	PF00069	0.672
MOD_CK1_1	123	129	PF00069	0.655
MOD_CK1_1	204	210	PF00069	0.653
MOD_CK1_1	222	228	PF00069	0.690
MOD_CK1_1	24	30	PF00069	0.585
MOD_CK1_1	282	288	PF00069	0.754
MOD_CK1_1	304	310	PF00069	0.626
MOD_CK1_1	315	321	PF00069	0.615
MOD_CK1_1	331	337	PF00069	0.640
MOD_CK1_1	414	420	PF00069	0.748
MOD_CK1_1	437	443	PF00069	0.623
MOD_CK1_1	566	572	PF00069	0.672
MOD_CK1_1	60	66	PF00069	0.680
MOD_CK1_1	651	657	PF00069	0.652
MOD_CK1_1	67	73	PF00069	0.722
MOD_CK1_1	730	736	PF00069	0.675
MOD_CK1_1	738	744	PF00069	0.681
MOD_CK1_1	759	765	PF00069	0.683
MOD_CK1_1	904	910	PF00069	0.491
MOD_CK1_1	92	98	PF00069	0.649
MOD_CK2_1	720	726	PF00069	0.763
MOD_CK2_1	904	910	PF00069	0.415
MOD_Cter_Amidation	581	584	PF01082	0.710
MOD_GlcNHglycan	115	118	PF01048	0.691
MOD_GlcNHglycan	126	129	PF01048	0.582
MOD_GlcNHglycan	130	133	PF01048	0.539
MOD_GlcNHglycan	151	154	PF01048	0.727
MOD_GlcNHglycan	171	174	PF01048	0.594
MOD_GlcNHglycan	208	211	PF01048	0.772
MOD_GlcNHglycan	238	241	PF01048	0.695
MOD_GlcNHglycan	24	27	PF01048	0.654
MOD_GlcNHglycan	271	274	PF01048	0.702
MOD_GlcNHglycan	303	306	PF01048	0.587
MOD_GlcNHglycan	324	327	PF01048	0.751
MOD_GlcNHglycan	330	333	PF01048	0.670
MOD_GlcNHglycan	356	359	PF01048	0.749
MOD_GlcNHglycan	413	416	PF01048	0.606
MOD_GlcNHglycan	417	420	PF01048	0.686
MOD_GlcNHglycan	439	442	PF01048	0.592
MOD_GlcNHglycan	449	452	PF01048	0.371
MOD_GlcNHglycan	507	510	PF01048	0.626
MOD_GlcNHglycan	568	571	PF01048	0.675
MOD_GlcNHglycan	648	651	PF01048	0.658
MOD_GlcNHglycan	69	72	PF01048	0.674
MOD_GlcNHglycan	774	777	PF01048	0.704
MOD_GlcNHglycan	781	784	PF01048	0.662
MOD_GlcNHglycan	836	839	PF01048	0.622
MOD_GlcNHglycan	871	874	PF01048	0.523
MOD_GSK3_1	120	127	PF00069	0.688
MOD_GSK3_1	165	172	PF00069	0.637
MOD_GSK3_1	202	209	PF00069	0.703
MOD_GSK3_1	218	225	PF00069	0.754
MOD_GSK3_1	232	239	PF00069	0.602
MOD_GSK3_1	246	253	PF00069	0.592
MOD_GSK3_1	279	286	PF00069	0.706
MOD_GSK3_1	299	306	PF00069	0.691
MOD_GSK3_1	318	325	PF00069	0.685
MOD_GSK3_1	372	379	PF00069	0.654
MOD_GSK3_1	387	394	PF00069	0.354
MOD_GSK3_1	406	413	PF00069	0.658
MOD_GSK3_1	430	437	PF00069	0.576
MOD_GSK3_1	473	480	PF00069	0.568
MOD_GSK3_1	493	500	PF00069	0.447
MOD_GSK3_1	56	63	PF00069	0.659
MOD_GSK3_1	561	568	PF00069	0.586
MOD_GSK3_1	578	585	PF00069	0.526
MOD_GSK3_1	646	653	PF00069	0.726
MOD_GSK3_1	681	688	PF00069	0.476
MOD_GSK3_1	757	764	PF00069	0.669
MOD_GSK3_1	770	777	PF00069	0.644
MOD_GSK3_1	784	791	PF00069	0.428
MOD_GSK3_1	856	863	PF00069	0.559
MOD_GSK3_1	896	903	PF00069	0.471
MOD_GSK3_1	95	102	PF00069	0.684
MOD_NEK2_1	124	129	PF00069	0.548
MOD_NEK2_1	187	192	PF00069	0.627
MOD_NEK2_1	269	274	PF00069	0.688
MOD_NEK2_1	281	286	PF00069	0.699
MOD_NEK2_1	565	570	PF00069	0.781
MOD_NEK2_1	637	642	PF00069	0.545
MOD_NEK2_1	681	686	PF00069	0.520
MOD_NEK2_1	73	78	PF00069	0.713
MOD_NEK2_1	784	789	PF00069	0.629
MOD_NEK2_1	860	865	PF00069	0.517
MOD_NEK2_1	867	872	PF00069	0.408
MOD_NEK2_1	900	905	PF00069	0.522
MOD_NEK2_2	421	426	PF00069	0.568
MOD_NEK2_2	493	498	PF00069	0.522
MOD_NEK2_2	856	861	PF00069	0.447
MOD_PIKK_1	212	218	PF00454	0.634
MOD_PIKK_1	527	533	PF00454	0.543
MOD_PIKK_1	648	654	PF00454	0.633
MOD_PIKK_1	784	790	PF00454	0.621
MOD_PKA_1	577	583	PF00069	0.669
MOD_PKA_2	149	155	PF00069	0.640
MOD_PKA_2	22	28	PF00069	0.655
MOD_PKA_2	232	238	PF00069	0.758
MOD_PKA_2	279	285	PF00069	0.732
MOD_PKA_2	491	497	PF00069	0.637
MOD_PKA_2	582	588	PF00069	0.686
MOD_PKA_2	833	839	PF00069	0.729
MOD_PKA_2	896	902	PF00069	0.518
MOD_Plk_1	784	790	PF00069	0.597
MOD_Plk_4	196	202	PF00069	0.706
MOD_Plk_4	219	225	PF00069	0.656
MOD_Plk_4	421	427	PF00069	0.567
MOD_Plk_4	681	687	PF00069	0.420
MOD_Plk_4	856	862	PF00069	0.545
MOD_Plk_4	896	902	PF00069	0.446
MOD_ProDKin_1	167	173	PF00069	0.672
MOD_ProDKin_1	24	30	PF00069	0.686
MOD_ProDKin_1	299	305	PF00069	0.606
MOD_ProDKin_1	312	318	PF00069	0.645
MOD_ProDKin_1	339	345	PF00069	0.601
MOD_ProDKin_1	497	503	PF00069	0.566
MOD_ProDKin_1	568	574	PF00069	0.678
MOD_ProDKin_1	64	70	PF00069	0.730
MOD_ProDKin_1	685	691	PF00069	0.574
MOD_ProDKin_1	727	733	PF00069	0.689
MOD_ProDKin_1	762	768	PF00069	0.761
MOD_ProDKin_1	770	776	PF00069	0.617
MOD_ProDKin_1	841	847	PF00069	0.674
MOD_ProDKin_1	89	95	PF00069	0.698
MOD_SUMO_for_1	71	74	PF00179	0.699
MOD_SUMO_rev_2	717	722	PF00179	0.700
MOD_SUMO_rev_2	850	856	PF00179	0.428
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.378
TRG_ENDOCYTIC_2	798	801	PF00928	0.388
TRG_ENDOCYTIC_2	840	843	PF00928	0.718
TRG_ER_diArg_1	262	265	PF00400	0.770
TRG_ER_diArg_1	297	299	PF00400	0.600
TRG_ER_diArg_1	518	520	PF00400	0.510
TRG_ER_diArg_1	789	792	PF00400	0.458
TRG_ER_diArg_1	845	848	PF00400	0.605
TRG_NLS_MonoCore_2	260	265	PF00514	0.665
TRG_NLS_MonoExtC_3	260	265	PF00514	0.745
TRG_NLS_MonoExtN_4	258	265	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW5	Leptomonas seymouri	30%	97%
A0A3Q8I9N0	Leishmania donovani	99%	100%
A4H7B2	Leishmania braziliensis	63%	100%
E9APF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QG25	Leishmania major	87%	100%